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Titer Test And Celiac Disease Ige Response

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I am Rh- and pregnant. Baby is doing fine; kicking, punching, rolling, growing. Have not had an ultrasound to check for swelling of the liver or heart yet. Will do soon.


My main interest here with this situation is this:


I had a titer test done to see my antibody response sensitivity results. My baby is more than likely O+. I am obviously O-. This is my second child, first was O+ and born perfectly, a natural healthy home birth with nothing wrong with him at all, of course he was the first and the immune system would more than likely not attack his blood cells. Second pregnancy is however the kicker. My husband and I do not plan on having another and are prepared to avoid a third pregnancy. So the focus here is on the titer test at hand.


The titer test checks the antibody response to a potential viral threat in the body (sometimes seen as the O+ blood of the baby). The test shows that it is the IgE that is being tested. The IgE is also one of two major white blood cell responses that are tested for in a celiac panel. In fact, my titer results came back that my white blood cell count is a little high and my red is low.The results of the antibody response were D8. I have had another titer done but must wait for results for 10 days. Which is a very low result, not enough to be concerned with the baby safety, if you disagree you need to do further research. I am concerned that the celiac immune response is affecting the titer test results. I am concerned that doctors will not do further research and push a pregnant woman and her baby too far and too fast into: induction, intervention, C-section, or worse. Causing an even GREATER risk of the baby's life than allowing the child at a titer level of D8 to reside in his safety and further develop under close monitoring by ultra sound and titer tests until he or she is fully developed and ready to enter the world through a vaginal birth. I say a vaginal birth because intervention often causes the mother's blood and baby's blood to mix and that is the danger at hand. If the blood mixes, mother's white blood cells could kill the baby's red blood cells, causing him to starve of oxygen and nutrients leading to a whole slew of serious health risks and possible death of the baby. Intervention at this time is NOT the answer of course, being the titer is so low.


I'm going into detail, but the main questionable problem I see is the same immune response of the IgE for both cases: celiac disease and titer test results.


Doctors have not done enough research to know how to answer this question: Is celiac disease affecting the IgE immune response or am I getting conclusive results from the titer test? Can I trust the titer test to be accurate? Accurate enough to risk my baby's life?


SO far my conclusion is: No.


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Have you tried contacting the University of Chicago Celiac Center via email with your questions? They may be able to point you to an expert who has death with this.


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I sent them an email, hope it gets to them soon. Got test results back and my D8 has skyrocketed to D64, although I have had several including one bad gluten reaction between those tests. I am very very sensitive to gluten and other things. Now I am informed that the area where my husband and I live can no longer accommodate such a high risk baby. We will be shipped out to Spokane WA. Sigh, I want more information before being rushed into something that could potentially be dangerous for me and the baby, besides my immune system reacting to his blood. For a child to die peacefully on his mother's breast would be a greater gift I could give him than to die stuck with drugs and tubes in a plastic case away from mom's touch. I don't want my child to be forced through this in his last days. Now we need some prayer from people who are dead serious that they care.


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    • I understand. Poor thing, made doubly rough because 13 is a really hard age even in the best of times. OK, at 13 she should show the damage in the biopsies. I didn't know if she was 2 or 3 yrs. old & in those cases sometimes they just plain haven't lived long enough to be damaged where the biopsies pick it up - it can be so patchy then.  Gosh, I'm really feeling for her & you both and I so want to say take her off gluten the moment the endoscopy is over but I'm afraid to say that b/c I've seen some pretty weird things go on that you would never expect. Docs can be so uninformed! Please let us know how things turn out & send your daughter some hugs from me and tell her I believe her. Please let her know that most of us had been told by doctors they think it's all in our heads, didn't believe us, blew us off so we know exactly how she feels. Remind her her pedi believes her & he's been more helpful than the GI has.  Press the GI for 6-8 biopsies but a bare minimum of 6.  {{{{{{{{{{{{{{{{{{{{{{HUGS}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}
    • I have seen articles linking celiac to Barretts and esophagitis.  I've actually been subtly hinting to my boyfriend to get tested for celiac as well because he has some strange Autoimmune arthritis as well as Barrett's  and some white spots on brain MRI Not MS). One of the articles I read on Celiac and Barrett's actually suggested that most of the patient did not have actual acid reflux symptoms. Not sure if you ever did antibody testing for celiac, but sounds like you certainly want to avoid gluten. 
    • Ahh good point! She is 13 and has been miserable for over two years. It started with chronic hives. We have been to a dermatologist, and a allergist and they brushed it off to her seasonal allergies and now she has joint pain,bloating,constipation,fatigue,headaches just all around miserable. I just want answers quick. she is getting depressed and says she hates her life cause she doesn't think anyone believes her. It's heart breaking . I hope we get answer soon. Thanks for the advice I will keep her on gluten. She is just miserable and I figured the sooner she is off gluten the sooner she will feel better. 
    • Welllllllll, in this particular case it would be best to keep her on gluten until the results come back. The reason I say this is b/c this GI seems whacky. There's a chance you may need to go to a different GI & have the endoscopy redone. I was going to say get a new GI but since the endoscopy is on Monday then I would go forth with it rather than waiting the time it would take to get a new GI & schedule an endoscopy. This GI seems set that it's not celiac & when they get that in their brain it's usually pretty darn hard for them to admit they were wrong. My concern is that she won't take enough biopsies from the right places b/c she's either dumb about how many & where or letting her personal (already formed) opinion influence what she will do. The problem is that you can't be there in the OR with them standing on the GI's shoulders making her do the right thing. Not knowing your daughters age, the other concern is that there may not be "enough" damage just yet, it may be patchy, etc..... that with the mindset this doc has, she will poo poo the dx.  Let me say that it would be a travesty & wholly awful IF you had to put your daughter through another endoscopy but we know how very important it is for her to have an official, dyed in the wool dx. So I'm just trying to think down the line & prevent problems before they come up. I mean, this doc may not even take any biopsies. That sounds insane I realize, but really, it happens more often than you would think. I can't tell you the number of times we've had people come on here after having an endoscopy for celiac where the doc didn't take any biopsies b/c the doc is so stupid as to think they can see the damage & doesn't realize there MUST be biopsies! If you take her off gluten & heaven forbid, you have to end up putting her back on it to get further testing then chances are she's going to get much, much sicker when she's put back on gluten. That most often happens with us and I'm talking about radically sick. See, I'm basing all my thinking on the fact that despite ALL the positive celiac blood work, this dimwit doc doesn't think it's celiac & instead it's all related to the constipation. That is just so far out there, it's NUTS! She's flying in the face of hard evidence! Every test you listed was positive. I can't even begin to understand how this GI comes to her insane conclusion. THAT'S why I am so concerned. 
    • Thanks for your reply. That's what my husband and I thought too. She has a ton of symptoms that's fit celiac. Also I was going to start her gluten free diet after her biopsy on Monday cause the dr said the results take two weeks. Is there a reason I should keep her eating gluten until we get the results? Thanks for your help.
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