Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Elevated Ttg Igg, Everything Else Normal
0

7 posts in this topic

Hello,

 

I received my celiac test results today, and my doctor wasn't very helpful in explaining any of it.  I have an appointment with a GI in a couple weeks, but was hoping to get some insight before then.  My doctor said I was positive for celiac, which kind of surprised me because I have not had an endoscopy.  

 

As background, my daughter has celiac disease, confirmed with an endoscopy.  I eat mostly gluten free at home, but have been trying to eat gluten in the weeks leading up to my test.  I am not sure if I ate enough gluten, though.  Some days I would eat a slice of regular bread, or maybe a handful of pretzels, or some crackers with gluten.  If I was at a restaurant, I would order a regular meal with gluten (such as a hamburger with a bun), but I don't go out often.   Here are my test results:

 

tTG IgA <1.2 (negative <4)

 

tTG IgG 23.8 (Positive >9)  The comment after this one said, "tTG antibody, especially the IgA, is sensitive and specific for untreated Celiac Disease.  The IgG assay is used mainly to detect celiac patients who are IgA deficient.  Verified my repeat analysis."  However, looking at my IgA level below, it doesn't seem as though I am IgA deficient, right?

 

Gliadin Ab, IgA (DGP) 3.7 (negative <20)

 

Gliadin Ab, IgG (DGP) 2.2 (negative <20)

 

IgA 166 (range 71-397)

 

Is it odd that my IgG levels were positive on one test and negative on the other?  Should I eat lots more gluten before my next appointment?

0

Share this post


Link to post
Share on other sites


Ads by Google:

welcome, aclcs322!

 

You are correct, you are not IgA deficient based on your results.  With your daughter having celiac disease, that should be a red flag to your health care provider.  I'm in a similar situation as you except my DGP IgG was positive, and my TTG IgG was negative.  I am a normal IgA producer and all of my IgA results were negative.  All of the IgG based tests say they should be used for individuals with IgA deficiency or young children.  I fit neither description, and it seems neither do you.  Since your result is double what is considered positive, I would say it is definitely valid.

 

I've done a lot of research on the DGP IgG testing over this past year, and I can tell you from experience there isn't near as much research on the TTG IgG test as the TTG IgA version :(  Obviously there is something going on in your body, and unfortunately the celiac research doesn't include studies on IgG based tests if you're not IgA deficient.  To say it's frustrating is an understatement, but hopefully with continued research things will become clearer.  I've kept an extremely strict gluten-free diet this last year, and my DGP level is still in the slightly positive range.  I still have a deficiency of Vitamin K and recently my GI diagnosed me with fat malabsoprtion.  Yesterday I got another test back that indicates pancreatic insufficiency, so I've been up researching for my follow-up GI appointment because I can't sleep and that's what I do to cope :) Continue to eat gluten until all testing is completed.  

 

I wish I could provide a little more concrete information, but sometimes it just helps to know you're not alone  :)

 

http://www.cureceliacdisease.org/archives/faq/what-is-a-gluten-challenge

 

http://www.ncbi.nlm.nih.gov/pubmed/19333755

 

http://www.jfponline.com/index.php?id=22143&tx_ttnews[tt_news]=172034

0

Share this post


Link to post
Share on other sites

Welcome to the board. :)

I would guess that roughly half of our board members had at least one negative test during their diagnosis, whether it be an endoscopy, tTG IgA, DGP IgG, or EMA IgA....but they (usually) had at least one positive test before being diagnosed as a celiac. Getting negative tests is not that unusual - that's why they run so many types of tests.

Doctors tend to think that one needs positive IgA based sets as they re based on the mucosal linings of your body, the IgG has more of an overall autoimmune function but the tests have about the same specificity (how likely a positive indicates celiac) as the IgA ones. The sensitivity (how likely it s to show an accurate positive result) is sometimes less in the IgG based tests but that did nt affect you.

With a family history of celiac disease, and a positive result that is over double the normal limit, I would say it is pretty likely that you have celiac disease. That being said, you should continue eating gluten until testing is complete, as long as the appointment and testing occurs in a timely manner. No doubt the GI will want to do further testing.

Good luck!

0

Share this post


Link to post
Share on other sites

Thank you both for your input!  It is so hard to wait for my GI appointment to get here, but I am going to take advantage of the wait and eat all of my favorite foods before I can't have them anymore!

0

Share this post


Link to post
Share on other sites

I have a situation very similar to aclcs322. All other values in Celiac panel OK except elevated TTG AB IGG. (Value of 14).

Would like to know if aclcs322 was confirmed with Celiac and how he/she is doing?

Also does a value of 14 indicate developing or early Celiac?

Would greatly appreciate any information or news.

Waiting anxiously.

0

Share this post


Link to post
Share on other sites




Unfortunately aclcs322 has not posted for over a year and is not active on the board.  Perhaps try starting your own topic and you'll find more advice.

 

Generally speaking, it is pretty common for a celiac to be negative in some tests but not others.  I don't think your situation is that uncommon.

0

Share this post


Link to post
Share on other sites

I was just barely positive on my blood test, yet my biopsy revealed moderate to severe intestinal damage. Plus, my only symptom at the time was anemia! No tummy issues.

The next step is usually an endoscopy, but some skip this step because of long wait times. So, keep eating gluten until you are sure all testing is complete.

I am just two years into my diet and I am feeling great! So, you can get well or at least have significant improvement. I am old, so I am dealing with issues that are unrelated really to celiac disease. Nothing big, just annoying!

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,142
    • Total Posts
      919,559
  • Topics

  • Posts

    • Mnoosh,    Can you give us a link to the article you read about the increased risk after being diagnosed and maintaining a strict gluten-free diet??       IMO,   You are over reacting to a misprint or most likely a misread article.
    • Yes!  With dairy, celiacs can often have a temorary lactose intolerance due to damaged intestinal villi (where the enzymes normally are released to digest lactose).  Of course you could be naturally lactose intolerant based on race or age.  It is best to stick to a whole foods diet while you are healing.  Really, is ice cream or potato chips going to provide you with nutritional value?  Stick with naturally gluten free foods like meat, fish, fats,  veggies (even those with carbs like sweet potatoes or winter squash) and fruit.  Avoid that processed junk as you may react to the additives right now.  Later, you can add back in dairy (test) and other foods you miss and crave.   Good luck!  
    • Take a deep breath and calm down!    The incidence of cancer with Celiac Disease is rare.......it can happen but the vast majority of people never have that experience.  You may have somewhat enlarged lymph nodes due to inflammation from undiagnosed Celiac but that will all calm down and go away once you get going on the diet.  Believe me, there are many of us that have things happen during the diagnosis and early recovery period and everything turned out just fine.  There is an elevated risk for some cancers with Celiac but that risk goes back to that of the general population after a couple of years on the gluten-free diet. I cannot remember the exact time frame but it is somewhere between 2-4 years, I think.  So many of us went years without a diagnosis and when it was all figured out, we have gone on to be healthy with little complications.  Really...do  not worry about this.  Concentrate on learning all the ins and outs of this disease and how to live gluten free happily.  We are here to help you and guess what? The diet is not as bad as some make it out to be. Many things can be made gluten free and are every bit as good as their gluten counterparts. The diet may not be convenient but it is not hard. I would not lie to you!   
    • Well....one common symptom that most celiacs have when they are diagnosed (or undiagnosed) is anxiety.  So, there is a risk of cancers, but science has demonstrated that that risk goes down on a gluten free diet (if you have celiac disease).  In goes down to the same risk as those without celiac disease.   I kind of was a basket case.  I drive my family a bit crazy because I was anxious.  I felt a bit stupid too.  I guess I had a little brain fog going on too.  All that resolved after I healed. Welcome to the fourum.  Read our Newbie 101 thread under "Coping" (pinned at the top of the page) and learn about hidden sources of gluten and cross contamination.  I think most of us do not worry about cancer. We mourn the freedom to eat anything anywhere!   I did not have swollen lymph nodes, but I am sure others have and they did not have cancer.  Hopefully, they will chime in and set your mind at ease.  If not, you can search for "lymph nodes" at the top of the page (little magnifying glass).  There are lots of members with the same issue!  
    • I was recently diagnosed as having celiac and to be honest the part I'm having the most trouble with isn't the change in food or lifestyle. I'm really upset about what I've read about the risk of cancer increasing with celiac disease. I think this is playing into my fears because I currently have lymph nodes all over my body-my Doctor says they are not considered swollen or concerning, but I don't usually feel nodes. The lymph nodes and horrible diarrhea for the last 3 weeks were what got me into the the doctor for lab work. My blood work came great so I'm wondering if anyone else experienced lymph nodes reacting when they found out they were celiac? Also how do you deal with anxiety surrounding the increased risk of cancer? Thanks!
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,174
    • Most Online
      1,763

    Newest Member
    Mnoosh
    Joined