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Test Results Help Please

results help celiac

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5 replies to this topic

#1 veryami1

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Posted 26 March 2014 - 02:35 PM

Hi,

 

I just returned from an appointment with my GI. She said I am negative for celiac, however, the copy of the test results I received said "supports a diagnosis of celiac." I am obviously confused. I went back to ask her why she said it was negative, and she didn't have time for me. Suffice to say, I won't be going back. But I do have these results and I'd like your opinion on how to interpret them.

 

Deamidated Gliadin Peptide Antibody - IgG - 43.0 EU

Deamidated Giagin Peptide Antibody IgA - 9.3 EU

Anti-hunman tissue transglutaminase igA - 75.0 EU

Anti-endomysial igA IFA - positive

total serum iGA by Nephelometry, total igA - 129

 

One ellele HLA DqA1*05 of Dq2.5 detected, HLA DQB81*02 not detected.

Celiac risk haplotype not detected

 

I suspect because I do not test positive for the gene, she said I was negative for celiac? Any opinions? Would really appreciate any help!

 

For some reference, I blood test positive for a wheat allergy and I've been avoiding gluten for almost three weeks because I suspet celiac.

 

thank you!

 

Ami


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-Ami

 

gluten-free since March 8, 2014

Positive for celiac antibodies and EMA

Diagnosed with Celiac on April 8, 2014


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#2 GottaSki

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Posted 26 March 2014 - 03:20 PM

Hi,

 

I just returned from an appointment with my GI. She said I am negative for celiac, however, the copy of the test results I received said "supports a diagnosis of celiac." I am obviously confused. I went back to ask her why she said it was negative, and she didn't have time for me. Suffice to say, I won't be going back. But I do have these results and I'd like your opinion on how to interpret them.

 

Deamidated Gliadin Peptide Antibody - IgG - 43.0 EU

Deamidated Giagin Peptide Antibody IgA - 9.3 EU

Anti-hunman tissue transglutaminase igA - 75.0 EU

Anti-endomysial igA IFA - positive

total serum iGA by Nephelometry, total igA - 129

 

One ellele HLA DqA1*05 of Dq2.5 detected, HLA DQB81*02 not detected.

Celiac risk haplotype not detected

 

I suspect because I do not test positive for the gene, she said I was negative for celiac? Any opinions? Would really appreciate any help!

 

For some reference, I blood test positive for a wheat allergy and I've been avoiding gluten for almost three weeks because I suspet celiac.

 

thank you!

 

Ami

 

Welcome Ami!

 

Looks like your doctor is wrong and you do have Celiac Disease in addition to your wheat allergy - Make sure your primary doc gets copies of all these tests -- unless you want to proceed with an endoscopy, there is no need for a celiac specialist.  If you decide to proceed with an endo -- try to find another GI that has training/experience with Celiac Disease.

 

Do you have the ranges for these tests -- they certainly look like they support a diagnosis of Celiac Disease - especially the positive Anti-Endomysial IgA -- also known as EMA-IgA.

 

Were you already gluten free for a time before these antibody tests were run?

 

Let us know the ranges if you have them.


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-Lisa

Undiagnosed Celiac Disease ~ 43 years

3/26/09 gluten-free - dignosed celiac - blood 3/3/09, biopsy 3/26/09, double DQ2 / single DQ8 positive

10/25/13 - MCAD

Health history since celiac diagnosis became too long -- moved to the "about me" section of my profile

My children and I all have multiple copies of the genes for Celiac Disease, along with large variety of symptoms/resolution gluten-free

Current tally from me, three kids and two grands: 4 diagnosed with Celiac Disease, 2 NCGS

Get PROPERLY tested BEFORE REMOVING GLUTEN.

ALWAYS independently research health related information found on internet forums/blogs.

"LTES" a Gem :)


#3 veryami1

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Posted 26 March 2014 - 03:37 PM

Hi Lisa,

Thanks for the quick reply. These are the ranges listed on the paperwork, in parenthesis.

 

Deamidated Gliadin Peptide Antibody - IgG - 43.0 EU  (<4.9 EU)

Deamidated Giagin Peptide Antibody IgA - 9.3 EU  (<6.1 EU)

Anti-hunman tissue transglutaminase igA - 75.0 EU (<10.3)

Anti-endomysial igA IFA - positive  (range, negative)

total serum iGA by Nephelometry, total igA - 129   (<3 years, 8-220, 3-13 years 41-395, >13, 44-441)

 

I don't know how to interpret any of the above!

 

I've been wheat/gluten free for 3 weeks, on Saturday. At the time of the above blood test, I was about 2 weeks free.

 

What leads you to quickly say that yes, I am celiac positive?

 

Thanks for any help! I found another doctor for a follow up in two weeks, will stay gluten-free regardless of all of this! My allergies seem to be clearing although my stomach issues are roughly the same since starting gluten-free.

 

Ami


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-Ami

 

gluten-free since March 8, 2014

Positive for celiac antibodies and EMA

Diagnosed with Celiac on April 8, 2014


#4 cmc811

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Posted 26 March 2014 - 03:54 PM

Every one of your tests was positive. Get a new GI or like Lisa said make sure your PCP has these results.


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Misty

 

Myself: tTg-IgA was 7 (>4 positive), normal total IgA, Unspecified anemia, low magnesium, really low Vitamin D, normal thyroid with no antibodies, slightly positive ANA (1:40 speckled) but confirmation panel all negative, so no explanation. No other celiac tests ordered, Endoscopy appeared normal, Biopsy showed increased lymphocytes - Marsh I. She called biopsy "equivocal" but diagnosed Celiac anyway based on high specificity of tTg test.

Son (born in 2008): Alopecia Areata, Chronic constipation, vague abdominal pain, waves of nausea that have been occurring for months with no other cause identified,always tired even though he sleeps 10+ hours per night. Behavior change. Jekyll and Hyde type tantrums that are triggered by the silliest things. Totally uncharacteristic for him. Mild asthma, ezcema, wierd skin rashes that don't appear to be DH. Slow weight gain, normal height. His weight for age percentile is dropping but slowly so doesn't concern pediatrician. His BMI, however, has dropped from 33rd percentile to the 5th in 2 years. Low red blood cell count, low-normal hemoglobin/hematocrit - not being called anemia. His number looks just like mine used to and mine have continued to get worse. Normal total Iga, Negative tTg. Result was <1 with >4 being positive. Negative EMA. TSH 2.91 at 22 months and now at 5.75 yrs is 4.7 but still being called normal.

Son (born in 2011): Enamel issues on baby teeth, Keratosis pilaris, Toenail fungus since birth on both small toes. Normal total IgA, negative tTg (<1).


#5 GottaSki

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Posted 26 March 2014 - 03:59 PM

Every one of these tests is strong positive, which is what it looked like - but I do like to see ranges because ranges vary between labs.

 

Glad you'll be seeing another doctor soon.

 

It takes time for symptoms to improve gluten-free.  Sometimes it is days, weeks, months and sadly even years....but things do improve.  Healing happens.

 

The tTG-IgA and EMA-IgA both indicate there is damage within your small intestine caused by an autoimmune reaction that your body has to gluten.  This is not an allergy, but a person can be both celiac and allergic to wheat, barley or rye.

 

The  Deamidated Gliadin Peptide (DGP-IgA and IgG) are tests that measure the antibodies your body is producing to one of the peptides in the protein of Gluten - called Gliadin.

 

Hope that make sense.  

 

If there is a chance that you will be having an endoscopic biopsy you will need to continue to consume gluten each day -- it can be very tough to add it back in, so talk to the new doctor about your options.

 

Here is a great thread for those newly diagnosed and those new to living gluten-free:

 

http://www.celiac.co...ewbie-info-101/

 

Hang in there :)


  • 0

-Lisa

Undiagnosed Celiac Disease ~ 43 years

3/26/09 gluten-free - dignosed celiac - blood 3/3/09, biopsy 3/26/09, double DQ2 / single DQ8 positive

10/25/13 - MCAD

Health history since celiac diagnosis became too long -- moved to the "about me" section of my profile

My children and I all have multiple copies of the genes for Celiac Disease, along with large variety of symptoms/resolution gluten-free

Current tally from me, three kids and two grands: 4 diagnosed with Celiac Disease, 2 NCGS

Get PROPERLY tested BEFORE REMOVING GLUTEN.

ALWAYS independently research health related information found on internet forums/blogs.

"LTES" a Gem :)


#6 veryami1

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Posted 26 March 2014 - 04:05 PM

Thank you all SO much! What do the allelle results mean?

 

Do you think that she interpreted the results as negative simply because I did not test positive for both genes? How can she be so stupid, to put it not so mildly?

 

With these results, is there ANY WAY I can not have celiacs, not taking into account possible testing errors or such?

 

Looking forward to getting to know everyone here more, since I think I'll be staying around :)

 

Ami


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-Ami

 

gluten-free since March 8, 2014

Positive for celiac antibodies and EMA

Diagnosed with Celiac on April 8, 2014




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