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Elevated Iga From Celiac Disease Test. I Do Not Have Celiac Disease…


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#1 Astrongtower

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Posted 04 April 2014 - 05:01 PM

Hello Everyone,

 

I have a curious question. What essentially is Elevated IGA? I have look all around google and there is not much information on it.

 

Let me tell you my story…

 

I went to an Endocrinologist to check on my testosterone because I am 33. I told him I was feeling okay maybe not the best so he did complete blood work on me. I did tell him that my Father was recently diagnosed with Celiac Disease so he went ahead and ran that as well.

 

Long story short … the endocrinologist said that everything was perfect on me except that my IGA was elevated. His nurse at first gave me a call and said that this is probably no big deal and he just wants me to see a specialist. I was not understanding her so she just had the Doctor call me. He said that he had no idea what this mean and that “I would just not ignore it” kind of hinting that this could be a big deal.

 

So then he refers me to a hematologist. I am like sure okay, and then I call the office and it is like, hello thanks for calling the Cancer Center … I was like what??? I have cancer now?

 

Well I see the Hematologist and he gives me this look like I am crazy and why am I even here. He is literally baffled and acting shocked because he is wondering why this test was even ran on me. Well he says give me a minute and goes back into his office just to check the latest research in their system on elevated IGA and he said there is nothing on it. He presumes to say that I am healthy as a boar. He said that he is going to send my blood work out again to see if he can duplicate it and check for other stuff to because I was complaining about joint pain but insinuated that everything is going to come normal.

 

So then the next day I went to my Primary Doctor and he did a blood test on me little under a year ago also test for Celiac Disease. I did not have those results but I got them today. They showed that I had elevated IGA and he didn’t even bother telling me about it. He was like it didn’t excite me; I guess meaning no big deal. He said IGA is such a basic protein to the system that it is just not that important. Only when levels are low is when people start getting concerned. His blood test just like the last blood test came back perfectly fine, literally everything else, the last blood work was like 1500 bucks, they must have had a field day checking on that IGA levels or something.

 

I guess the Endocrinologist was wondering how someone would have elevated IGA and not have Celiac. He did confess that he had no idea what this meant and wanted me to see a specialist. It is just the way he told me that it sounded important and that he scared me a little bit. Also the fact that when you call the Hematologist they answer the phone Cancer line how may I help you…

 

Anxiety. I think I really have anxiety I think. My doctor just prescribed me Lexapro. I have been acting such like a Hypochondriac and have been having multiple high level stressors in my life like going back to college, moving, marriage, in-laws, and not working.

 

I could have sworn I read somewhere that high IGA could be caused by Anxiety and or allergies to which I have both to where I am living at the moment. I have a lot of anxiety and there are dogs and cats where I live and when I touch one I break out in hives. Also my skin seems to be a lot more sensitive than it used to be like when I work out at the gym and sometimes I will get marks on where I press too hard on stuff. Like one time I was bent pressing and got a couple of bruises on my back that went away, and recently I just did calves raises and had some heavy weight on my shoulders have very slight red line bruise so small doesn’t seem like a big deal but just doesn’t seem like this use to ever happen before.

 

My Doctor says that I cannot lower my IGA. What if my IGA gets to like 5000 or something? My Doctor did have a very good point. He said blood test values are like a bell curve and that sometimes there can be outliers. I am currently in school and taking statistics so this makes perfect sense to me. He said that your body is just different in this area and this what makes you, you. If it was something low or critical we would take action.

 

I guess what he is saying is that this outlier is a non-essential concern.

 

Here are my results below…

 

Results 05/2013

 

Solstats

 

Result                   Range

 

IgA = 682              68-379                  

 

tTG IgA                 = 8.3      <20        

tTG IgG = 6.5      <20

Endomysial = Negative

 

Results 04/2014

 

LabCorp

 

Result                   Range

 

IgA = 710              91-414  

 

tTG IgA                 = 0-3      <2

tTG IgG = 0-5      <2

Endomysial = Negative

 

Questions:

 

What is IGA?

 

What does it mean to have High Levels of IGA?

 

What is the worst case scenario of High Levels of IGA?

 

How do I lower my IGA?

 

Is this a precursor of Cancer or anything like that? Or is this simply an outlier like the Doctor says and is absolutely nothing to worry about?

 

Help:

 

My main point is that I am going to my follow up visit in a week to the Hematologist and I know what is going to happen. He is going to say everything is absolutely fine. We ran a ton of blood work, not sure why that test was done, but have a nice day. And give me a look of why am I even here.

 

I do not want to leave still not knowing exactly what this is, and that is why I posted this topic here. I was hoping someone out there could elaborate on this so I can know that this is not a big deal. Is there anything I can do? Should I be watching out for anything? You know. So please if you can help me out and sooth my Anxiety that would be great. Thank you so much for reading and have a wonderful day.

 

Thank You!

 

 


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#2 RMJ

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Posted 04 April 2014 - 08:02 PM

I don't know abut the IgA level, but I can say that you don't need to worry about the Hematology department phone being answered as a Cancer center. I see a hematologist because I have a bleeding disorder (totally unrelated to celiac). Hematology and Oncology are grouped together as specialties. It seems that most hematologists are also oncologists, but not all oncologists are also hematologists. Hematologists deal with bleeding and clotting problems, and also blood cancers like leukemia. I always feel a little guilty in the waiting room for my hematologist because my particular bleeding disorder, now that it is diagnosed and controlled, isn't anywhere near as serious as any cancer that the other patients may have. Hope this helps.
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#3 nvsmom

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Posted 04 April 2014 - 09:16 PM

I was in the cancer unit for a blood disorder too.... Totally freaked out some friends who came to visit me. Lol

I don't know a lot about elevated IgA except that it can be benign, or a sign of problems. http://www.webmd.com...lobulins?page=2. Hopefully it is an innocent thing for you. It can be a sign of SLE, RA, liver issues or cancer. Just don't lose sight of the fact that it could be just the way you are.

I would consult dr google and bring a lst of questions to the doctor, and then monitor it if you are not satisfied.

Best wishes.
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#4 LauraTX

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Posted 04 April 2014 - 11:42 PM

If you want to keep reaching out for answers, you may consider a doctor with a specialty in Allergy, Asthma, and Immunology.  If you can, get someone who is a "Fellow of The American Academy of Allergy, Asthma and Immunology (AAAAI)  who has FAAAAI after their name.  The only reason I know this is I have an immunodeficiency and see an immunologist who is a FAAAAI and also has a pediatric fellowship attached.  Basically they handle anything wrong with the immune system whether it is low levels, high levels, allergies, asthma, or anything else of the sort.  If it truly is nothing, they will be the person to know.

 

I personally have low levels of IGA and IGG, which means I am missing a chunk of my immune system.  I don't know what it means to have too much, though.  But if the hematologist discharges you I would definitely seek out a consultation with an immunologist.


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I am my husband's "Silly Yak Girl" :)
I was diagnosed with Celiac Disease in January 2013. I also have Lupus and Common Variable Immunodeficiency(CVID) for which I am on IVIG.

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#5 Astrongtower

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Posted 05 April 2014 - 11:15 AM

I don't know abut the IgA level, but I can say that you don't need to worry about the Hematology department phone being answered as a Cancer center. I see a hematologist because I have a bleeding disorder (totally unrelated to celiac). Hematology and Oncology are grouped together as specialties. It seems that most hematologists are also oncologists, but not all oncologists are also hematologists. Hematologists deal with bleeding and clotting problems, and also blood cancers like leukemia. I always feel a little guilty in the waiting room for my hematologist because my particular bleeding disorder, now that it is diagnosed and controlled, isn't anywhere near as serious as any cancer that the other patients may have. Hope this helps.

 

I am certainly glad you were able to be diagnosed and your bleeding disorder controlled, that must be a great feeling. Thank you so much for contributing to my thread and yes your posted has helped. I am getting some feedback and a lot of people are telling me it is nothing to worry about. You know though that sometimes when you go to the Doctors office and they tell you straight to your face what is going on and later you leave you still feel like you don’t. That is just kind of like how I feel at the moment.

 

I was in the cancer unit for a blood disorder too.... Totally freaked out some friends who came to visit me. Lol

I don't know a lot about elevated IgA except that it can be benign, or a sign of problems. http://www.webmd.com...lobulins?page=2. Hopefully it is an innocent thing for you. It can be a sign of SLE, RA, liver issues or cancer. Just don't lose sight of the fact that it could be just the way you are.

I would consult dr google and bring a lst of questions to the doctor, and then monitor it if you are not satisfied.

Best wishes.

 

I bet my friends would freak out too. That must have been funny.

 

I would think this is benign according to all of my Doctors reactions and them testing for everything else to make sure all coming back negative. I do really think that it is just the way I am because that is what my primary Doctor said. When he saw that it was high a year ago he didn’t even bother telling me he thought it was that not big of a deal.

 

If you want to keep reaching out for answers, you may consider a doctor with a specialty in Allergy, Asthma, and Immunology.  If you can, get someone who is a "Fellow of The American Academy of Allergy, Asthma and Immunology (AAAAI)  who has FAAAAI after their name.  The only reason I know this is I have an immunodeficiency and see an immunologist who is a FAAAAI and also has a pediatric fellowship attached.  Basically they handle anything wrong with the immune system whether it is low levels, high levels, allergies, asthma, or anything else of the sort.  If it truly is nothing, they will be the person to know.

 

I personally have low levels of IGA and IGG, which means I am missing a chunk of my immune system.  I don't know what it means to have too much, though.  But if the hematologist discharges you I would definitely seek out a consultation with an immunologist.

 

I do want to keep reaching out for answers, I guess I am a hypochondriac or something. I definitely think it is allergy related. I think you are on to something here. I moved in with some family and they have a dog and two cats with horrible dander and shedding problems; the hair and dander is all over the place. I used to never have any allergic reactions but if I touch this one cat or dog to much I begin to break out in small hives in that area and they quickly go away when I stop.

 

I would love to find a FAAAAI certified Doctor who is an immunologist to get to the bottom of this. I am really excited about this information and I will be finding one and setting up an appointment asap. I also have nose and eye issues a lot because of allergies as well. My theory is that my system is on high alert because of all this allergy stuff at the house. Even though it is not bad enough for me to have an inhaler or something I think I have a form of something that if I knew what it was I could get it under control and live a better life.

 

If you see your immunologist before I find one maybe you could ask him what the opposite levels mean of IGA. I am sure the Hematologist is going to discharge me because he acted so shocked to why I was even there but I guess my other Doctor just wanted me to be sure; or like he said he had no idea what that meant.

 

I really appreciate your help and please keep me in the loop to anything else that you may find. I do however believe that I am just an outlier to the bell curve on this particular measurement but let’s hope that is all that it is.


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#6 LauraTX

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Posted 05 April 2014 - 12:38 PM

If you see your immunologist before I find one maybe you could ask him what the opposite levels mean of IGA. I am sure the Hematologist is going to discharge me because he acted so shocked to why I was even there but I guess my other Doctor just wanted me to be sure; or like he said he had no idea what that meant.

Oh, I will do that!  I should see him at my next IVIG infusion on the 17th.  Sometimes I don't get to see him but I think I didn't last time so I should see him this time definitely.  I am kind of like you, I can't just let things lie if something may possibly be wrong.  That led to me finally getting everything properly diagnosed so I could treat the problem, not just the sickly symptoms I had.  Even if it is likely nothing I would do the same!  And of course seeing an allergy specialist will help you get your allergy stuff possibly under better control so there could be a plus.


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I am my husband's "Silly Yak Girl" :)
I was diagnosed with Celiac Disease in January 2013. I also have Lupus and Common Variable Immunodeficiency(CVID) for which I am on IVIG.

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#7 Astrongtower

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Posted 08 April 2014 - 05:53 AM

Are you seriously asking questions about a single elevated antibody on the misc?
 
I wouldn't care about it.
 
IgA is the antibody that protects your gastrointestinal tract and respiratory tract among other things.
 
In the medical setting I am in, we see elevated levels of IgA before someone turns up with either gluten-sensitivity or celiac disease. We tend to look at it as the body is in the initial stages of ramping up and fighting the incoming gluten - and it's doing a great job. But at some point it just isn't able to continue the 'fight' and the total levels of IgA plummet. Somewhere in there, we typically find that IgA-gliadin levels rise.
 
It can take many years for someone with celiac disease to actually 'show' damage in the duodenum that allows a doc to be suspicious and take biopsies that result in a diagnosis. In some cases, I've heard it takes up to 10 years. A lot could be going on during that time including the changes in IgA levels.
 
You might want to consider doing a gene test for gluten to see what genes you're carrying. It might give you an early idea of whether or not you're current elevated levels of IgA could be correlated with a diagnosis of celiac disease that may be made at a later date. Enterolab has a decent gene test. Take a look.

I don't know abut the IgA level, but I can say that you don't need to worry about the Hematology department phone being answered as a Cancer center. I see a hematologist because I have a bleeding disorder (totally unrelated to celiac). Hematology and Oncology are grouped together as specialties. It seems that most hematologists are also oncologists, but not all oncologists are also hematologists. Hematologists deal with bleeding and clotting problems, and also blood cancers like leukemia. I always feel a little guilty in the waiting room for my hematologist because my particular bleeding disorder, now that it is diagnosed and controlled, isn't anywhere near as serious as any cancer that the other patients may have. Hope this helps.


I was in the cancer unit for a blood disorder too.... Totally freaked out some friends who came to visit me. Lol
 
I don't know a lot about elevated IgA except that it can be benign, or a sign of problems. http://www.webmd.com...lobulins?page=2. Hopefully it is an innocent thing for you. It can be a sign of SLE, RA, liver issues or cancer. Just don't lose sight of the fact that it could be just the way you are.
 
I would consult dr google and bring a lst of questions to the doctor, and then monitor it if you are not satisfied.
 
Best wishes.


If you want to keep reaching out for answers, you may consider a doctor with a specialty in Allergy, Asthma, and Immunology.  If you can, get someone who is a "Fellow of The American Academy of Allergy, Asthma and Immunology (AAAAI)  who has FAAAAI after their name.  The only reason I know this is I have an immunodeficiency and see an immunologist who is a FAAAAI and also has a pediatric fellowship attached.  Basically they handle anything wrong with the immune system whether it is low levels, high levels, allergies, asthma, or anything else of the sort.  If it truly is nothing, they will be the person to know.
 
I personally have low levels of IGA and IGG, which means I am missing a chunk of my immune system.  I don't know what it means to have too much, though.  But if the hematologist discharges you I would definitely seek out a consultation with an immunologist.


Oh, I will do that!  I should see him at my next IVIG infusion on the 17th.  Sometimes I don't get to see him but I think I didn't last time so I should see him this time definitely.  I am kind of like you, I can't just let things lie if something may possibly be wrong.  That led to me finally getting everything properly diagnosed so I could treat the problem, not just the sickly symptoms I had.  Even if it is likely nothing I would do the same!  And of course seeing an allergy specialist will help you get your allergy stuff possibly under better control so there could be a plus.

 
Hi there welcome to the site. Firstly all your questions can not be answered here as we are not medical professonals. Those numbers make no sense to me. I'm sure if there was anything that needed treatment your doctor would be working on it
 
Hello from a fellow statistician!
 
Following from what your doctor was saying about a bell curve, using stats look at it that way. Say we take everyone's test scores, and normalise the mean to zero. If we treat the mean as an expected value, that value has a massive standard deviation. As such you end up with a normal range within that normal distribution, which could be calculated using the T-Distribution. Now you have the statistical distribution of what's normal, and your own test result, you can use ANOVA tables to find whether your test result is statistically significantly different to the normal range, i.e. ask the question "is the two-tailed t-stat >1.96?" And the answer will be no. Normal has such a huge variance that even outside the "normal range" you're still not statistically different from normal.
 
In human terms, neither you or I are qualified to evaluate medical test results. That's what we pay doctors for, and the doctors say you're absolutely fine.
 
As to your referral, you're from the US and there is quite a suing culture over there, so even if a doctor thinks someone's fine he might refer anyone with a test result outside of normal ranges to a specialist just so in the unlikely event he is wrong it's not his responsibility. The specialist said you're absolutely fine too. Also don't forget healthcare is privately provided in the US as well so it may well be in the company's interest to run superfluous tests and make needless referrals.
 
You have my every sympathy for your shock at calling the specialist to find it was a cancer specialist, I'm guessing this is what kicked off your anxiety. I was genuinely ill to begin with on my journey, it was only doctors mentioning they needed to "rule out" strokes, brain tumours and other things that really ****ed my head up. My only advice is stop trying to evaluate information you don't have the necessary prerequisites to evaluate. Would you trust a hairdresser with a laptop with your investment decisions? Would you trust a doctor with google to represent you in court? No? Then don't trust a statistician with google to professionally evaluate your health, just because that statistician is you.
 
Now this I am VERY interested in, I tested high for serum igA level too, this was after testing high for Vitamin B12 on 3 different blood tests without supplementation..
 
I also saw a Hematologist about these readings because as I am sure you have read one immunoglobin being high might indicate multiple myeloma....however that is a fake high caused by paraprotein, I got informed that that was also tested with the other immunoglobins shortly after and was fine.
 
The hematologist found nothing wrong with me by the way, felt my nodes, spleen and tapped my whole body lol then ran lots of blood testing but all was clear and fine and I was discharged.
 
I also like you had a celiac panel done, but that was negative just the iga alone high.
 
Have you tried going gluten free? There is a lot of research going on at the moment into gluten intolerance as opposed to celiac and you could fit that catergory. The only way to know would be to cut out gluten for a few months and see how you feel. Going gluten free has helped me a lot in terms of pain and anxiety, and digestion of course.
 
I was tested for celiac disease but my test was negative, but I tried gluten free diet anyway and it made a huge difference to how I felt
 
Happy to help where I can. I'm not expert, but I have suffered from anxiety all my life and was recently diagnosed with Chronic Fatigue. I have suffered from pretty much every symptom out there including aches and pains, fatigue, irritability, brain fog, severe anxiety, unable to digest food etc etc. I have been tested for celiac and the test was negative, but I decided to change my diet anyway after reading a lot about it and how diet changes have helped many people. I'm pretty much on a primal/paleo style diet now and it has helped me so much. I wouldn't go back to eating the way I did before. I haven't found doctors to be very helpful as they don't know about a lot of this stuff and certainly aren't experts in terms of nutrition. I have found the Perfect Health Diet book to be a huge help. Going gluten free is definitely a good start. That is what celiacs are told to do - they must avoid anything with gluten in it as it attacks their bodies. So I guess eating what celiacs eat and avoiding gluten are one in the same in that respect. There is hidden gluten in a lot of processed food, so you have to be really careful. Good luck and feel free to stay in touch if you want to keep discussing as I'm pretty passionate about this stuff after finding it helped me so much.
 
I had a lot of symptoms including dizziness, visual disturbances, pains in my upper abdomen and back, muscle spasms, nausea, bloating, pins and needles, low blood sugar. Chest pains the pain got so bad I ended up in a and e a few times! I also used to feel very tired and used to fight sleep during the day at work when I stopped gluten most of it stopped although I have Ibs so still have some issues I also felt a lot more alert. Hope this helps
 
I don't think its a "false high" I mean in the case of Myeloma its a false high because its a cloned immunoglobin but as you are clear of Myeloma like me it isnt the case.
 
I have kind of put this to one side personally over the past few months but I am interested in this answer too.
 
I am unsure if it is linked to celiac disease, especially since we both have had clear celiac blood tests. But the other abnormal test found in me is Vitamin B12 was also high, I was tested for most things that cause that too and again nothing was found.
 
B12 is also absorbed via the small intestine, where celiac disease happens.
 
I sometimes get lower abdominal cramps, that can last for hours to almost a whole day which seem to be wind related but again in the area of my small intestine.
 
other so far unexplained symptoms I have are:
 
fatigue
headaches
dizziness
muscle pain/fatigue
pins and needles
high blood pressure
 
 
I am going to try to see my dr again 2moro, to talk over this yet again but one test I want is an MMA urine test to see if I have some kind of functional B12 defiency.
 
Going Gluten free seems like quite hard work, but maybe its worth a try?
 
You know these aren't "unexplained" right? These are the classic tell-tail physical signs of severe anxiety, especially when grouped together.
 
But "anxiety" isn't an explanation, it's just a word for a group of symptoms. I think the original poster and a lot of others like myself are interested in understanding the root cause, which is something doctors are usually unable to help with.
 
Astrongtower - The book I have is called The Perfect Health Diet, by Paul and Shou-Ching Jaminet. It explains a lot of this stuff and what you can do about it.
 
Well personally I think there's two aspects. Firstly, depression. My doctor suggested I was depressed and this seemed utterly obtuse. Then I took the NHS depression test, then every other online test, and every single one told me I was "severely depressed". For me, scary symptoms of what was then a genuine (but non-serious) health concern kicked all this off, and I understand it is well documented that those with depression can slip into severe anxiety following a traumatic event.
 
In terms of the symptoms of anxiety, I think these are generally well understood. Certainly the ones in the quote above are.
 
However the reason anxiety manifests in the first place, I think, is rooted in the gut. There's a massive correlation between GERD and anxiety, just as there is with ME/CFS, the physical symptoms of which are pretty much identical to anxiety. I recently read a book written by one of the members of PheonixRising called Autoimmune: the Cause and the Cure which explains a hypothesised connection between digestive issues and various autoimmune illnesses and how to overcome them. I've altered my diet accordingly the last week and feel a lot better. But I am genuinely suffering a post-viral illness as well as the anxiety, so perhaps this isn't relevant to the majority on here, but it's certainly worth a read for anyone.
 
Yes, I totally agree with you there about the auto-immune stuff and the core of health being with our guts. There is a very strong brain/gut connection and they both effect each other - so anxious feelings can bring on digestive problems and vice versa. It's very interesting as well as all the stuff they are now finding out about gut bacteria. The book you read sounds interesting and very similar to a lot of the stuff I have been reading lately. YOu would probably enjoy reading The Perfect Health Diet also as it looks at all the actual scientific evidence for nutrition and how it can cause or prevent disease and comes up with a diet based on that, which I'm pretty much following. There is also the GAPS diet which is recommended for people with auto-immune conditions and aspergers and autism etc, and is also helpful for people with IBS. Lots of info out there if you're prepared to look huh!
 
Well this book is great as it's split into two parts: first the science and then the diet. I know very little about science but I know quite a bit about stats, and I have to say the relationships hypothesised in the book definitely stand up in terms of the maths.
 
All very interesting! I do firmly believe that "normal" diets these days are bad for you, a few years ago before my daughters were born I wa sin the best shape of my life through eating better choices, like quinoa, rice, sweet potatoes instead of pasta, chips.
 
I have not read these diets you have suggested yet but I assume they are similar, no wheat? no hydro fats?, no coffee?, and more caveman style?
 
I need to get myself on track diet wise again somehow, there was a period of about 3-4 days when I didn't eat gluten and went out for sunday lunch, after eating that I went straight to tired and headache within 30 mins of finishing it.
 
as i said above I was negative for celiac.
 
I will report back again later because I have made an appointment to talk to my doctor again on this subject, about the iga and b12 levels and about the likes of cfs/me, sle, autoimmune problems. The b12 one interests me a lot at the moment because I have had 3 blood tests show levels of 800-900 when the range is 300-600ish. I do not take b12 supplements, any multi vit or even eat cereals that have added vitamins, and practically all causes of high b12 have been ruled out so its a mystery.
 
Although on some pages like pheonix rising I have seen it mentioned that the cause could actually be a functional b12 problem, the body not being able to absorb and use the b12 and it keeps getting exported back into the blood.
 
I have tried mentioning this to my doctors but have been refused tests to check this so far, one test that I know of is MMA urine test. or there is blood testing for the active form of b12 rather then the standard blood test which is active and non active forms.
 
I still believe that the b12 and iga results are linked, and most likely linked to the gut somehow.
 
I'm increasingly of the opinion that most of these modern illnesses, be they mental health problems, autoimmune problems or cancer, are far more to do with the gut than we realise. Certainly the book I mentioned above gives some intuition as to why certain diets seem to work, which before now hasn't been explained.
 
A good family friend who lives in one of the more undeveloped islands of the Caribbean was diagnosed with pancreatic cancer fifteen years ago. They don't have access to the sort of healthcare we do, so his only option was to educate himself and manage it with diet. He's alive and well and in better overall health than me!
 
Just ordered the perfect health diet, Am I right in thinking this is a Paleo diet? I am planning on starting this weekend coming and staying on it.
 
Where is the like button?!
 
From my own experience with changing diet and from what I've read, I'd say you guys are definitely on the right track. I think things are changing and there is a lot of research going into this stuff. It's a shame it's not mainstream yet, but I believe it will get there. At the moment, I want to be ahead of the game, not told by doctors that there's nothing they can do for me or offer me drugs to cover up symptoms. I know that what I'm doing is working and there are thousands of other people out there who have been helped by this approach. A couple of good websites if anyone's interested:
 
http://www.marksdail....#axzz2yER0hSvC
 
http://perfecthealthdiet.com/about/
 
http://chriskresser.com/
 
I forgot to mention the doctor I seen yesterday also tried to claim the high iga and b12 test results are "nothing" and just me, I do not agree with her in fact I think she needs to get an education as do most GPs.
 
In her case she is chasing around looking for things on me which are 500,000/1 odds like Phaeochronoctyoma and not chasing tests which have actually showed an abnormality.
 
I have had to do 2 x 24 hour urine collections after she wanted it done then researched how to do it and still gave me the wrong bottle for the tests....
 
I do not believe they will find anything in this test.
 
questions about medical test results.........whether they be MRI's or CT scans or blood work. There are several blood test results sources on the internet if you really are that curious but I strongly suggest that you follow up with your doctor for the most accurate information .
Having a consultation with a hemotologist is no different than any other specialty doctor, except he specializes in blood disorders. Unfortunately a lot of them also deal with blood cancers so that is why you got the greeting you got on the phone, not necessarily for any other reason.
 
So, here's the thing.
1. Get the test results for all these tests from the doctor.
2. Go online and find out what tests they are SUPPOSED to do for celiac disease. There are some tests, like elevated IgA, which can indicate celiac disease but may indicate other problems. There are some tests, however, that are more specific to celiac disease and if they are negative it makes it less likely (but not impossible) that you have celiac disease.
 
But what many doctors don't know (like, you wouldn't even believe how many) is that for most of the testing, a negative test for celiac disease does not mean much. There's something like a 20% false negative rate, which is why there are a number of tests done altogether. So the elevated IgA, even with okay tests results otherwise, IS a concern. Especially if it's been on both blood tests - something is going on.
 
That doesn't mean it's celiac disease, but yes, I would be looking for what can cause elevated IgA, honestly. Sometimes it can be inflammation or other issues in the gut, or recurrent infections, for example (here are a number of doctors responding to what it means, actually. You'll notice that some think it's fine, like your doc did, while others know of possible problems (like my doc did, when I had this. And had a problem, actually). https://www.healthta.../topics/what-do... )
 
3. A lot of specialists work at cancer centers and seeing them doesn't necessarily mean that they're seeing you for cancer. I had the same issue with my endocrinologist who works at a cancer center and it freaked me out to realize that's where I was sent, too. I think most people would be a bit concerned to reach the cancer center, seriously.
 
4. Your endo is very celiac ignorant - the specialist who deals with celiac disease is a gastroenterologist. Not a hematologist. Hem docs do blood. Celiac disease is a disease of the gut. You'll need to see a gastro to get more testing for celiac disease, if warranted.
 
Some experts in celiac disease believe that elevated IgA can be indicative of non-celiac gluten intolerance. this sensitivity/intolerance has no verified test for it, yet, but like I said, some doctors believe this may be related. Gluten free diet is the only way to test that, but once you go gluten free the celiac testing becomes invalid until you've been on gluten again for a few weeks, so you might want to take that into consideration.
 
From what I just skimmed off the net, it sounds like IgA (immunoglobin A) is just an immune system protein secreted by mucous membranes. It could certainly be linked to your allergies (stop living with pets if you're allergic to them).
 
And the cancer center thing is because your hematologist works in a cancer clinic, as most cancer patients need a hematologist as well as an oncologist.
 
This could easily be a one-off result due to something you have some into contact with in the air (allergens or pathogens), or something similar and transient upsetting your stomach.
 
The haematologist might choose to do a few more tests just to make sure it's nothing more serious, but it's not likely to be anything to worry about.
 
High IGA can be indicative of autoimmune diseases such as Rumatoid Arthritis or Celiac disease (can be high, normal or low in celiac).  Also it is high in multiple myeloma and a few other things.  See here:  http://www.m.webmd.c...lobulins?page=4
 
I would get checked for RA and see a gastroenterologist to get a biopsy to check for celiac. Blood tests are often unreliable.  Also, celiac can develop at anytime the gene turns on (once on, always on).  That is why experts recommend that if you are at risk, to get screened every 2-3 years or if symptoms develop.
 
Also, if the testing is done is negative for celiac, then I would try to go gluten free for a trial to see if it helps you feel better.  just stay on gluten for the testing or else it will definately be negative.
 
I say to try going gluten-free bc I've seen many people at risk for celiac who do much better off gluten.  It's worth a try.  Gluten can cause terrible inflammation and joint pain.
 
 
Good luck!
 
 
And beware, most doctors are very misinformed about celiac disease!
 
               
 
    IGA can be a sign of infection, usually mucosal membranes. Gut infection maybe?? can also be from sinus infections too or chest infection, even eye infection.
 
    Dr's probably ignoring it as they dont know how to treat it, only treat something like that when its low.
 
    The problem with specialists is that they only know their speciality so anything outside of that they dont see alot of??
 
    Sometimes its best to see a good gp who has been around awhile, they have generally seen alot bigger variety of conditions then a specialist, if that makes sense.
 
    Antidepressants can be helpful but also given out to shut people up to, can make one feel better about feeling like shit, not a bad thing but not really getting to the issue.
 
IgA is immunoglobulin A. It is one of the groups of proteins that is part of our immune function.
 
Your results for tTG IgA, tTG IgG and Endomyosial antibodies indicate that you do not have Celiac Disease. They are results for specific antibodies that relate to Celiac.
 
Total IgA should always be tested when testing for Celiac Disease because some people have very low total IgA and that makes the results of the antibody test unreliable for those people.
 
Elevated IgA may or may not turn out to be important, you can only find that out by being tested further which is what the haemotologist will do. A haemotologist can be thought of as a blood specialist and a lot, but certainly not all, of what they do is in the area of cancer so it is not unusual that you would find one working at a cancer centre.
 
You should be treated respectfully whether this result turns out to be something that needs treating or whether the doctor does decide it is just normal for you. It is always worth ruling out problems.


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#8 kareng

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Posted 08 April 2014 - 09:56 AM

Are you seriously asking questions about a single elevated antibody on the misc?
 
I wouldn't care about it.
 
IgA is the antibody that protects your gastrointestinal tract and respiratory tract among other things.
 
In the medical setting I am in, we see elevated levels of IgA before someone turns up with either gluten-sensitivity or celiac disease. We tend to look at it as the body is in the initial stages of ramping up and fighting the incoming gluten - and it's doing a great job. But at some point it just isn't able to continue the 'fight' and the total levels of IgA plummet. Somewhere in there, we typically find that IgA-gliadin levels rise.
 
It can take many years for someone with celiac disease to actually 'show' damage in the duodenum that allows a doc to be suspicious and take biopsies that result in a diagnosis. In some cases, I've heard it takes up to 10 years. A lot could be going on during that time including the changes in IgA levels.
 
You might want to consider doing a gene test for gluten to see what genes you're carrying. It might give you an early idea of whether or not you're current elevated levels of IgA could be correlated with a diagnosis of celiac disease that may be made at a later date. Enterolab has a decent gene test. Take a look.




 
Hi there welcome to the site. Firstly all your questions can not be answered here as we are not medical professonals. Those numbers make no sense to me. I'm sure if there was anything that needed treatment your doctor would be working on it
 
Hello from a fellow statistician!
 
Following from what your doctor was saying about a bell curve, using stats look at it that way. Say we take everyone's test scores, and normalise the mean to zero. If we treat the mean as an expected value, that value has a massive standard deviation. As such you end up with a normal range within that normal distribution, which could be calculated using the T-Distribution. Now you have the statistical distribution of what's normal, and your own test result, you can use ANOVA tables to find whether your test result is statistically significantly different to the normal range, i.e. ask the question "is the two-tailed t-stat >1.96?" And the answer will be no. Normal has such a huge variance that even outside the "normal range" you're still not statistically different from normal.
 
In human terms, neither you or I are qualified to evaluate medical test results. That's what we pay doctors for, and the doctors say you're absolutely fine.
 
As to your referral, you're from the US and there is quite a suing culture over there, so even if a doctor thinks someone's fine he might refer anyone with a test result outside of normal ranges to a specialist just so in the unlikely event he is wrong it's not his responsibility. The specialist said you're absolutely fine too. Also don't forget healthcare is privately provided in the US as well so it may well be in the company's interest to run superfluous tests and make needless referrals.
 
You have my every sympathy for your shock at calling the specialist to find it was a cancer specialist, I'm guessing this is what kicked off your anxiety. I was genuinely ill to begin with on my journey, it was only doctors mentioning they needed to "rule out" strokes, brain tumours and other things that really ****ed my head up. My only advice is stop trying to evaluate information you don't have the necessary prerequisites to evaluate. Would you trust a hairdresser with a laptop with your investment decisions? Would you trust a doctor with google to represent you in court? No? Then don't trust a statistician with google to professionally evaluate your health, just because that statistician is you.
 
Now this I am VERY interested in, I tested high for serum igA level too, this was after testing high for Vitamin B12 on 3 different blood tests without supplementation..
 
I also saw a Hematologist about these readings because as I am sure you have read one immunoglobin being high might indicate multiple myeloma....however that is a fake high caused by paraprotein, I got informed that that was also tested with the other immunoglobins shortly after and was fine.
 
The hematologist found nothing wrong with me by the way, felt my nodes, spleen and tapped my whole body lol then ran lots of blood testing but all was clear and fine and I was discharged.
 
I also like you had a celiac panel done, but that was negative just the iga alone high.
 
Have you tried going gluten free? There is a lot of research going on at the moment into gluten intolerance as opposed to celiac and you could fit that catergory. The only way to know would be to cut out gluten for a few months and see how you feel. Going gluten free has helped me a lot in terms of pain and anxiety, and digestion of course.
 
I was tested for celiac disease but my test was negative, but I tried gluten free diet anyway and it made a huge difference to how I felt
 
Happy to help where I can. I'm not expert, but I have suffered from anxiety all my life and was recently diagnosed with Chronic Fatigue. I have suffered from pretty much every symptom out there including aches and pains, fatigue, irritability, brain fog, severe anxiety, unable to digest food etc etc. I have been tested for celiac and the test was negative, but I decided to change my diet anyway after reading a lot about it and how diet changes have helped many people. I'm pretty much on a primal/paleo style diet now and it has helped me so much. I wouldn't go back to eating the way I did before. I haven't found doctors to be very helpful as they don't know about a lot of this stuff and certainly aren't experts in terms of nutrition. I have found the Perfect Health Diet book to be a huge help. Going gluten free is definitely a good start. That is what celiacs are told to do - they must avoid anything with gluten in it as it attacks their bodies. So I guess eating what celiacs eat and avoiding gluten are one in the same in that respect. There is hidden gluten in a lot of processed food, so you have to be really careful. Good luck and feel free to stay in touch if you want to keep discussing as I'm pretty passionate about this stuff after finding it helped me so much.
 
I had a lot of symptoms including dizziness, visual disturbances, pains in my upper abdomen and back, muscle spasms, nausea, bloating, pins and needles, low blood sugar. Chest pains the pain got so bad I ended up in a and e a few times! I also used to feel very tired and used to fight sleep during the day at work when I stopped gluten most of it stopped although I have Ibs so still have some issues I also felt a lot more alert. Hope this helps
 
I don't think its a "false high" I mean in the case of Myeloma its a false high because its a cloned immunoglobin but as you are clear of Myeloma like me it isnt the case.
 
I have kind of put this to one side personally over the past few months but I am interested in this answer too.
 
I am unsure if it is linked to celiac disease, especially since we both have had clear celiac blood tests. But the other abnormal test found in me is Vitamin B12 was also high, I was tested for most things that cause that too and again nothing was found.
 
B12 is also absorbed via the small intestine, where celiac disease happens.
 
I sometimes get lower abdominal cramps, that can last for hours to almost a whole day which seem to be wind related but again in the area of my small intestine.
 
other so far unexplained symptoms I have are:
 
fatigue
headaches
dizziness
muscle pain/fatigue
pins and needles
high blood pressure
 
 
I am going to try to see my dr again 2moro, to talk over this yet again but one test I want is an MMA urine test to see if I have some kind of functional B12 defiency.
 
Going Gluten free seems like quite hard work, but maybe its worth a try?
 
You know these aren't "unexplained" right? These are the classic tell-tail physical signs of severe anxiety, especially when grouped together.
 
But "anxiety" isn't an explanation, it's just a word for a group of symptoms. I think the original poster and a lot of others like myself are interested in understanding the root cause, which is something doctors are usually unable to help with.
 
Astrongtower - The book I have is called The Perfect Health Diet, by Paul and Shou-Ching Jaminet. It explains a lot of this stuff and what you can do about it.
 
Well personally I think there's two aspects. Firstly, depression. My doctor suggested I was depressed and this seemed utterly obtuse. Then I took the NHS depression test, then every other online test, and every single one told me I was "severely depressed". For me, scary symptoms of what was then a genuine (but non-serious) health concern kicked all this off, and I understand it is well documented that those with depression can slip into severe anxiety following a traumatic event.
 
In terms of the symptoms of anxiety, I think these are generally well understood. Certainly the ones in the quote above are.
 
However the reason anxiety manifests in the first place, I think, is rooted in the gut. There's a massive correlation between GERD and anxiety, just as there is with ME/CFS, the physical symptoms of which are pretty much identical to anxiety. I recently read a book written by one of the members of PheonixRising called Autoimmune: the Cause and the Cure which explains a hypothesised connection between digestive issues and various autoimmune illnesses and how to overcome them. I've altered my diet accordingly the last week and feel a lot better. But I am genuinely suffering a post-viral illness as well as the anxiety, so perhaps this isn't relevant to the majority on here, but it's certainly worth a read for anyone.
 
Yes, I totally agree with you there about the auto-immune stuff and the core of health being with our guts. There is a very strong brain/gut connection and they both effect each other - so anxious feelings can bring on digestive problems and vice versa. It's very interesting as well as all the stuff they are now finding out about gut bacteria. The book you read sounds interesting and very similar to a lot of the stuff I have been reading lately. YOu would probably enjoy reading The Perfect Health Diet also as it looks at all the actual scientific evidence for nutrition and how it can cause or prevent disease and comes up with a diet based on that, which I'm pretty much following. There is also the GAPS diet which is recommended for people with auto-immune conditions and aspergers and autism etc, and is also helpful for people with IBS. Lots of info out there if you're prepared to look huh!
 
Well this book is great as it's split into two parts: first the science and then the diet. I know very little about science but I know quite a bit about stats, and I have to say the relationships hypothesised in the book definitely stand up in terms of the maths.
 
All very interesting! I do firmly believe that "normal" diets these days are bad for you, a few years ago before my daughters were born I wa sin the best shape of my life through eating better choices, like quinoa, rice, sweet potatoes instead of pasta, chips.
 
I have not read these diets you have suggested yet but I assume they are similar, no wheat? no hydro fats?, no coffee?, and more caveman style?
 
I need to get myself on track diet wise again somehow, there was a period of about 3-4 days when I didn't eat gluten and went out for sunday lunch, after eating that I went straight to tired and headache within 30 mins of finishing it.
 
as i said above I was negative for celiac.
 
I will report back again later because I have made an appointment to talk to my doctor again on this subject, about the iga and b12 levels and about the likes of cfs/me, sle, autoimmune problems. The b12 one interests me a lot at the moment because I have had 3 blood tests show levels of 800-900 when the range is 300-600ish. I do not take b12 supplements, any multi vit or even eat cereals that have added vitamins, and practically all causes of high b12 have been ruled out so its a mystery.
 
Although on some pages like pheonix rising I have seen it mentioned that the cause could actually be a functional b12 problem, the body not being able to absorb and use the b12 and it keeps getting exported back into the blood.
 
I have tried mentioning this to my doctors but have been refused tests to check this so far, one test that I know of is MMA urine test. or there is blood testing for the active form of b12 rather then the standard blood test which is active and non active forms.
 
I still believe that the b12 and iga results are linked, and most likely linked to the gut somehow.
 
I'm increasingly of the opinion that most of these modern illnesses, be they mental health problems, autoimmune problems or cancer, are far more to do with the gut than we realise. Certainly the book I mentioned above gives some intuition as to why certain diets seem to work, which before now hasn't been explained.
 
A good family friend who lives in one of the more undeveloped islands of the Caribbean was diagnosed with pancreatic cancer fifteen years ago. They don't have access to the sort of healthcare we do, so his only option was to educate himself and manage it with diet. He's alive and well and in better overall health than me!
 
Just ordered the perfect health diet, Am I right in thinking this is a Paleo diet? I am planning on starting this weekend coming and staying on it.
 
Where is the like button?!
 
From my own experience with changing diet and from what I've read, I'd say you guys are definitely on the right track. I think things are changing and there is a lot of research going into this stuff. It's a shame it's not mainstream yet, but I believe it will get there. At the moment, I want to be ahead of the game, not told by doctors that there's nothing they can do for me or offer me drugs to cover up symptoms. I know that what I'm doing is working and there are thousands of other people out there who have been helped by this approach. A couple of good websites if anyone's interested:
 
http://www.marksdail....#axzz2yER0hSvC
 
http://perfecthealthdiet.com/about/
 
http://chriskresser.com/
 
I forgot to mention the doctor I seen yesterday also tried to claim the high iga and b12 test results are "nothing" and just me, I do not agree with her in fact I think she needs to get an education as do most GPs.
 
In her case she is chasing around looking for things on me which are 500,000/1 odds like Phaeochronoctyoma and not chasing tests which have actually showed an abnormality.
 
I have had to do 2 x 24 hour urine collections after she wanted it done then researched how to do it and still gave me the wrong bottle for the tests....
 
I do not believe they will find anything in this test.
 
questions about medical test results.........whether they be MRI's or CT scans or blood work. There are several blood test results sources on the internet if you really are that curious but I strongly suggest that you follow up with your doctor for the most accurate information .
Having a consultation with a hemotologist is no different than any other specialty doctor, except he specializes in blood disorders. Unfortunately a lot of them also deal with blood cancers so that is why you got the greeting you got on the phone, not necessarily for any other reason.
 
So, here's the thing.
1. Get the test results for all these tests from the doctor.
2. Go online and find out what tests they are SUPPOSED to do for celiac disease. There are some tests, like elevated IgA, which can indicate celiac disease but may indicate other problems. There are some tests, however, that are more specific to celiac disease and if they are negative it makes it less likely (but not impossible) that you have celiac disease.
 
But what many doctors don't know (like, you wouldn't even believe how many) is that for most of the testing, a negative test for celiac disease does not mean much. There's something like a 20% false negative rate, which is why there are a number of tests done altogether. So the elevated IgA, even with okay tests results otherwise, IS a concern. Especially if it's been on both blood tests - something is going on.
 
That doesn't mean it's celiac disease, but yes, I would be looking for what can cause elevated IgA, honestly. Sometimes it can be inflammation or other issues in the gut, or recurrent infections, for example (here are a number of doctors responding to what it means, actually. You'll notice that some think it's fine, like your doc did, while others know of possible problems (like my doc did, when I had this. And had a problem, actually). https://www.healthta.../topics/what-do... )
 
3. A lot of specialists work at cancer centers and seeing them doesn't necessarily mean that they're seeing you for cancer. I had the same issue with my endocrinologist who works at a cancer center and it freaked me out to realize that's where I was sent, too. I think most people would be a bit concerned to reach the cancer center, seriously.
 
4. Your endo is very celiac ignorant - the specialist who deals with celiac disease is a gastroenterologist. Not a hematologist. Hem docs do blood. Celiac disease is a disease of the gut. You'll need to see a gastro to get more testing for celiac disease, if warranted.
 
Some experts in celiac disease believe that elevated IgA can be indicative of non-celiac gluten intolerance. this sensitivity/intolerance has no verified test for it, yet, but like I said, some doctors believe this may be related. Gluten free diet is the only way to test that, but once you go gluten free the celiac testing becomes invalid until you've been on gluten again for a few weeks, so you might want to take that into consideration.
 
From what I just skimmed off the net, it sounds like IgA (immunoglobin A) is just an immune system protein secreted by mucous membranes. It could certainly be linked to your allergies (stop living with pets if you're allergic to them).
 
And the cancer center thing is because your hematologist works in a cancer clinic, as most cancer patients need a hematologist as well as an oncologist.
 
This could easily be a one-off result due to something you have some into contact with in the air (allergens or pathogens), or something similar and transient upsetting your stomach.
 
The haematologist might choose to do a few more tests just to make sure it's nothing more serious, but it's not likely to be anything to worry about.
 
High IGA can be indicative of autoimmune diseases such as Rumatoid Arthritis or Celiac disease (can be high, normal or low in celiac).  Also it is high in multiple myeloma and a few other things.  See here:  http://www.m.webmd.c...lobulins?page=4
 
I would get checked for RA and see a gastroenterologist to get a biopsy to check for celiac. Blood tests are often unreliable.  Also, celiac can develop at anytime the gene turns on (once on, always on).  That is why experts recommend that if you are at risk, to get screened every 2-3 years or if symptoms develop.
 
Also, if the testing is done is negative for celiac, then I would try to go gluten free for a trial to see if it helps you feel better.  just stay on gluten for the testing or else it will definately be negative.
 
I say to try going gluten-free bc I've seen many people at risk for celiac who do much better off gluten.  It's worth a try.  Gluten can cause terrible inflammation and joint pain.
 
 
Good luck!
 
 
And beware, most doctors are very misinformed about celiac disease!
 
               
 
    IGA can be a sign of infection, usually mucosal membranes. Gut infection maybe?? can also be from sinus infections too or chest infection, even eye infection.
 
    Dr's probably ignoring it as they dont know how to treat it, only treat something like that when its low.
 
    The problem with specialists is that they only know their speciality so anything outside of that they dont see alot of??
 
    Sometimes its best to see a good gp who has been around awhile, they have generally seen alot bigger variety of conditions then a specialist, if that makes sense.
 
    Antidepressants can be helpful but also given out to shut people up to, can make one feel better about feeling like shit, not a bad thing but not really getting to the issue.
 
IgA is immunoglobulin A. It is one of the groups of proteins that is part of our immune function.
 
Your results for tTG IgA, tTG IgG and Endomyosial antibodies indicate that you do not have Celiac Disease. They are results for specific antibodies that relate to Celiac.
 
Total IgA should always be tested when testing for Celiac Disease because some people have very low total IgA and that makes the results of the antibody test unreliable for those people.
 
Elevated IgA may or may not turn out to be important, you can only find that out by being tested further which is what the haemotologist will do. A haemotologist can be thought of as a blood specialist and a lot, but certainly not all, of what they do is in the area of cancer so it is not unusual that you would find one working at a cancer centre.
 
You should be treated respectfully whether this result turns out to be something that needs treating or whether the doctor does decide it is just normal for you. It is always worth ruling out problems.

 

 

We tried to make some sense of this post and were able to fix a few parts into "quotes".  But I am afraid it didn't help much.  Sorry. I am not really sure if there is a question in there.


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#9 LauraTX

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Posted 08 April 2014 - 11:22 AM

That looks like a spammer got ahold of that account to me.  Their "good" tactic on message boards is to throw a bunch of random S--- copied and pasted from random sources together to make it look like something and include links and hope people will click it.

 

Edit: either that or many errors made with copy/paste or drunk posting... lol


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I was diagnosed with Celiac Disease in January 2013. I also have Lupus and Common Variable Immunodeficiency(CVID) for which I am on IVIG.

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#10 SkyBlue4

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Posted 08 April 2014 - 11:42 AM

Thank goodness! I thought it was just me!   :D  


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Celiac Disease 2013

~Elevated tTG IgA despite insufficient Total IgA~

Autoimmune Gastritis 2013   

LADA 2010

Hashimoto's Disease 2003

and...

 


#11 Astrongtower

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Posted 08 April 2014 - 06:44 PM

I apologize I just got a lot of this information from other threads that I have created and wanted to put all the information on one post so people could read everything I know so we could relate.


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#12 kareng

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Posted 08 April 2014 - 06:47 PM

I apologize I just got a lot of this information from other threads that I have created and wanted to put all the information on one post so people could read everything I know so we could relate.


But that isn't possible. You have only made this thread and not commented on any other people's threads.
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#13 Astrongtower

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Posted 09 April 2014 - 05:16 AM

But that isn't possible. You have only made this thread and not commented on any other people's threads.

 

From other websites ...


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#14 kareng

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Posted 09 April 2014 - 07:22 AM

From other websites ...

 

 

Well... they don't make much sense to us and we want to help you.  Maybe you could re-post what you are asking?  Or the specific part you would like comments on?  I don't think you will get much discussion with that disjointed post.


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#15 GF Lover

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Posted 09 April 2014 - 09:00 AM

And start a new thread with your question.  This thread is done.  If you happen to forget and pose your question in this thread, I will start a new one for you and move it myself.  Threads need to be cohesive for future readers.

 

Thanks

 

Colleen


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