Jump to content



   arrowShare this page:
   

   Get email alerts  Subscribe to FREE Celiac.com email alerts

 
Ads by Google:
Celiac.com Sponsor:                                    


Photo
- - - - -

Can Someone Explaim My Test Results?


  • Please log in to reply
18 replies to this topic

#1 cookiestastegood

cookiestastegood

    New Community Member

  • Advanced Members
  • Pip
  • 10 posts

Posted 17 July 2014 - 03:05 AM

My test results from Kaiser Permanente finally posted to my account. Specific numbers aren't provided for 2 out of 3 tests. They just say "negative." My question is -- what is IGA and why would my result be so far outside the standard range? 

 

Name

Standard range

My result on 7/7/14  

 

GLIADIN IGA

NEG UNITS

NEGATIVE...  

 

IGA

70-400 MG/DL

39  

 

TISSUE TRANSGLUTAMINASE IGA

NEG UNITS

NEGATIVE...
 


  • 0

Celiac.com Sponsor:

#2 SMRI

SMRI

    Advanced Community Member

  • Advanced Members
  • PipPipPipPipPipPip
  • 463 posts

Posted 17 July 2014 - 04:18 AM

My test results from Kaiser Permanente finally posted to my account. Specific numbers aren't provided for 2 out of 3 tests. They just say "negative." My question is -- what is IGA and why would my result be so far outside the standard range? 

 

Name

Standard range

My result on 7/7/14  

 

GLIADIN IGA

NEG UNITS

NEGATIVE...  

 

IGA

70-400 MG/DL

39  

 

TISSUE TRANSGLUTAMINASE IGA

NEG UNITS

NEGATIVE...
 

 

A low IgA is one test used to check for immune deficiency. The problem with a low IgA is that it can nullify your tissue IgA test.  I have to look back to remember everything else that is going on but you may want to have a full immune deficiency panel run, IgA, IgG (and it's subclasses), IgM, etc.  Low IgG subclass 3 can cause the bowel issues seen with celiac disease as well.  The other subclasses relate to infections, usually upper respiratory.  I'm not sure who you are seeing, but you might want to get with a specialist and get a complete workup.


  • 0

#3 kareng

kareng

    Yum!

  • Moderators
  • PipPipPipPipPipPip
  • 13,858 posts

Posted 17 July 2014 - 04:33 AM

Here is some info:

 

 

http://www.curecelia...a&submit=Search


  • 0

Celiac.com - Celiac Disease Board Moderator
 

LTES

 

5 out of 4 people struggle with math.

 

math-problem-smiley-emoticon.gif


#4 cookiestastegood

cookiestastegood

    New Community Member

  • Advanced Members
  • Pip
  • 10 posts

Posted 17 July 2014 - 06:28 AM

Thanks for the responses. I was just curious what it meant. I'm glad that shouldn't invalidate my tests. Though based on what I read, it seems my lower than normal IgA levels could explain why i tend to easily get sick.

 

Regardless, I don't want more blood work. I've had more blood work in the past year for my iron levels than all the rest of my life combined. I have no desire to request more. 


  • 0

#5 SMRI

SMRI

    Advanced Community Member

  • Advanced Members
  • PipPipPipPipPipPip
  • 463 posts

Posted 17 July 2014 - 09:06 AM

Sick how? Is it just bathroom issues or other illnesses?
  • 0

#6 beth01

beth01

    Advanced Community Member

  • Advanced Members
  • PipPipPipPipPipPip
  • 341 posts

Posted 17 July 2014 - 09:44 AM

You are IgA deficient so that does invalidate the IgA based tests.  You need to have IgG based tests run.  They can't rule you out as a celiac based on the IgA tests.


  • 0

Diagnosed at age 37 after a lifetime of symptoms and other diseases: migraines, joint pain, muscle aches, nerve pain, IBS, chronic constipation, chronic ear infections/strep throat, weight fluctuations ( most weight lost >150 pounds), acid reflux, stomach pain, nausea/vomiting, inactive gallbladder, stool impacted appendix, multiple miscarriages, premature births, depression, anxiety, OCD, arthritis of the spine, Grave's disease(treated with radioactive iodine)- hypothyroid, multiple drug and environmental allergies, numbness in the hands and feet, possible multiple TIA's, brain fog, dyslexia, extreme thirst, bouts of insomnia rotated by extreme fatigue, multiple vitamin deficiencies, chronic UTI's and vaginal infections, Fibromyalgia, and I'm sure there are more I am forgetting.

Diagnosed April 7th, 2014 by EGD and tTg IgA.  Marsh IIIb and 35.7 respectively, Starting what seems to be a very long recovery process.

11 year old daughter diagnosed a month later by a tTg IgA of >100 and a positive EMA.  Nine year old son has since tested negative, only had tTg IgA drawn,  Will have a full panel drawn in two years unless symptoms present. 


#7 kareng

kareng

    Yum!

  • Moderators
  • PipPipPipPipPipPip
  • 13,858 posts

Posted 17 July 2014 - 10:03 AM

Here is some info:
 
 
http://www.curecelia...a&submit=Search

  

You are IgA deficient so that does invalidate the IgA based tests.  You need to have IgG based tests run.  They can't rule you out as a celiac based on the IgA tests.



You might want to check out my link. A bit below the normal seems to be fine for Celiac tests.
  • 0

Celiac.com - Celiac Disease Board Moderator
 

LTES

 

5 out of 4 people struggle with math.

 

math-problem-smiley-emoticon.gif


#8 SMRI

SMRI

    Advanced Community Member

  • Advanced Members
  • PipPipPipPipPipPip
  • 463 posts

Posted 17 July 2014 - 01:28 PM

  

You might want to check out my link. A bit below the normal seems to be fine for Celiac tests.

 

It's all in the numbers.  If you have a 20 on your IgA tissue test but your IgA total is 5, your 20 tissue test might come back in the normal range.  Low IgA in itself can cause a lot of issues, but there is really not much you can do for low IgA other than ingest extra protein to help bump that number.  The OP could very well not be celiac disease, but should still have the immune tests run because many of the symptoms are the same, and if he has had numerous sinus infections, bronchitis, pneumonia, etc. his IgG subclasses may be low too.  If they are too low, then gamma globulin therapy might be indicated.


  • 0

#9 kareng

kareng

    Yum!

  • Moderators
  • PipPipPipPipPipPip
  • 13,858 posts

Posted 17 July 2014 - 01:33 PM

It's all in the numbers.  If you have a 20 on your IgA tissue test but your IgA total is 5, your 20 tissue test might come back in the normal range.  Low IgA in itself can cause a lot of issues, but there is really not much you can do for low IgA other than ingest extra protein to help bump that number.  The OP could very well not be celiac disease, but should still have the immune tests run because many of the symptoms are the same, and if he has had numerous sinus infections, bronchitis, pneumonia, etc. his IgG subclasses may be low too.  If they are too low, then gamma globulin therapy might be indicated.


I was just linking to Celiac experts about low IGA and Celiac tests. It was not meant as a comment on any other health issues.
  • 0

Celiac.com - Celiac Disease Board Moderator
 

LTES

 

5 out of 4 people struggle with math.

 

math-problem-smiley-emoticon.gif


#10 beth01

beth01

    Advanced Community Member

  • Advanced Members
  • PipPipPipPipPipPip
  • 341 posts

Posted 17 July 2014 - 02:46 PM

It is actually all in the numbers and the testing that each person has done.  You can go to ten different labs and get ten different tests results for the same tests.  It is all on the instrumentation and methodologies that laboratories are using.  Each lab has to come up with their own "normal" by testing known patient values from old instrumentation or methodology against the new ones.  We all know from experience that the "normal" reference ranges vary.  From what I have seen on here, the tTg IgA normal vary from <4 being considered negative to the highest I have seen as <20 being normal.  So patient A could go to one institution and have antibody levels of 10 but the normal value for their methodology is <20 so doctor at that institution are going to tell them they are negative for celiac.  Patient B could go to the next town's lab and get tested and have an antibody level of 10 but their lab's reference ranges are <4 being normal so their doctor is going to say they have probable celiac, off to GI they go and get the EGD.  We also know from others' experiences that some people test negative on their antibody levels but still have symptoms of celiac so they go to get the EGD and find out they have celiac that way. A lot of the institutions in my area only test the tTg Iga antibodies and nothing else, so if the patient has a result of <4 they tell them they are negative for celiac and don't do further testing.  I have two different hospitals in my town and they both use Mayo as a reference lab for these tests meaning that they don't do them in house they send them to Mayo to be tested.  People with celiac don't always show up positive on the same tests either.  Some are negative on their IgA based tests and are positive on the IgG tests even with a normal Total IgA, some are negative on the tTg testing but come back positive on the EMAs and so on. It really is spotty.  If they just did the whole panel to begin with a lot more people would get diagnosed sooner, but sadly they do not.

 

We also know that everyone has come about their diagnosis differently and everyone has varying symptoms.  Some only have low iron or hgb with little or no digestive symptoms, some have none at all and some have the whole kit and caboodle.  Everything varies.

 

The University of Chicago Celiac disease center might have different instrumentation than Mayo.  It doesn't state in the link if all IgA levels >20 will validate IgA testing in all institutions or on all instrumentation or methodologies.  I have worked in two different labs and been to countless others for training or my clinicals, there are a wide variety of instruments and methodologies that vary from lab to lab. The threshold for the lower and upper limit of each tests varies greatly also.  Some labs can test some components accurately down to zero while some labs won't be able to based on the instrumentation.

 

What I am going to say next is my opinion - I would want the full panel to rule it all out.  If I was a male in what looks like excellent physical health by the picture and had an unexplainable low Iron ( unless you have uncontrolled bleeding that you haven't shared or are a woman) I would want to figure out why.  Especially if a disease like celiac is suspected where if not properly diagnosed can cause serious health related issues the longer it goes undiagnosed.


  • 0

Diagnosed at age 37 after a lifetime of symptoms and other diseases: migraines, joint pain, muscle aches, nerve pain, IBS, chronic constipation, chronic ear infections/strep throat, weight fluctuations ( most weight lost >150 pounds), acid reflux, stomach pain, nausea/vomiting, inactive gallbladder, stool impacted appendix, multiple miscarriages, premature births, depression, anxiety, OCD, arthritis of the spine, Grave's disease(treated with radioactive iodine)- hypothyroid, multiple drug and environmental allergies, numbness in the hands and feet, possible multiple TIA's, brain fog, dyslexia, extreme thirst, bouts of insomnia rotated by extreme fatigue, multiple vitamin deficiencies, chronic UTI's and vaginal infections, Fibromyalgia, and I'm sure there are more I am forgetting.

Diagnosed April 7th, 2014 by EGD and tTg IgA.  Marsh IIIb and 35.7 respectively, Starting what seems to be a very long recovery process.

11 year old daughter diagnosed a month later by a tTg IgA of >100 and a positive EMA.  Nine year old son has since tested negative, only had tTg IgA drawn,  Will have a full panel drawn in two years unless symptoms present. 


#11 IrishHeart

IrishHeart

    Warrior Princess

  • Advanced Members
  • PipPipPipPipPipPip
  • 10,449 posts

Posted 17 July 2014 - 03:02 PM

Getting back to the original question and cutting to the chase here:

 

the  Total serum IgA: This test is used to check for IgA deficiency, a harmless condition associated with celiac disease that can cause a false negative tTG-IgA or EMA result.  

 

 

get this one run:

 

  • Deaminated gliadin peptide test (DGP IgA and IgG): This test can be used to further screen for celiac disease in individuals with IgA deficiency or people who test negative for tTg or EMA antibodies.

and if that, too is negative, it is extremely unlikely that you have celiac. 

 

from the U of Chicago celiac disease center that Karen linked to:

 

IgA deficiency doesn’t lead to any clinical issues. If you are attempting to get an accurate diagnosis for celiac disease and you know you’re IgA deficient, or if there is some other equivocating factor to potentially compromise the blood test, then an EMA blood test should also be taken….

 

 

 

***I edited my post after re-reading the OP's first post.


Edited by IrishHeart, 17 July 2014 - 03:30 PM.

  • 0

"Life is not the way it's supposed to be. It's the way it is. The way we cope with it makes the difference." Virginia Satir

"The strongest of all warriors are these two - time and patience." Leo Tolstoy

"If you want to lift yourself up, lift up someone else" Booker T. Washington

“If idiots could fly, the sky would be like an airport.”― Laura Davenport 

"Do or do not. There is no try. "-  Yoda.

"LTES"  Gem 2014

 

Misdiagnosed for 25+ years; Finally Diagnosed with Celiac  11/01/10.  Double DQ2 genes. This thing tried to kill me. I view Celiac as a fire breathing dragon --and I have run my sword right through his throat.
I. Win. bliss-smiley-emoticon.gif


#12 cookiestastegood

cookiestastegood

    New Community Member

  • Advanced Members
  • Pip
  • 10 posts

Posted 17 July 2014 - 04:50 PM

OK, so there's a lot here to digest (no pun intended). 

 

When I said I have a tendency to get sick, I meant illnesses like the common cold. When I was younger, during grade school and college, I had frequent sinus infections. Younger than that, I had frequent ear infections.

 

When I first sought medical treatment last summer for fatigue, I did not have any digestive problems. That's when the anemia was found. At that time, my hemoglobin was 10.4 and my hematocrit was 34%. Those are low values for a male, especially considering blood work from 6 years prior had my hemoglobin at 16.7 and my hematocrit at 49%. Obviously, something changed. My iron levels were subsequently found to be very low.

 

I've been taking an iron supplement for most of the past year. From July to February, I was taking 130mg of elemental iron per day. During that time, my hemoglobin and hematocrit rebounded to normal levels. I then stopped taking the iron supplement for 30-45 days. Following increasing lethargy, I restarted it in mid-to-late April. I did not have blood work again until this month. My hemaglobin, hematocrit, and iron are now uniformly down from their February highs, but still normal. This caused my doctor to conclude that a daily iron supplement of 65mg was needed to maintain my current levels.

 

My current iron supplement is 6x the recommended daily iron intake for an adult male. That is in addition to iron consumed in my diet, which is low in red meat, but not vegetarian.

 

I do occasionally have digestive discomfort now, but I think it could be attributable to the iron supplement. On Mother's Day, I got what seemed liked an intestinal virus. with intermittent diarrhea and a 100.3 fever on successive nights. The diarrhea continued well after the fever subsided, but had mostly stopped after 2 weeks.

 

I am in good shape. I can run long distances at a relatively fast pace. It's not world class, but I can post good times. I also lift weights. 

 

So there seems to be some question to how my IgA might influence the other celiac tests. They are listed above, but I have no experience with them and only know what I read today. I was not given the exact numbers for those tests, just a "negative" value. My doctor didn't seem very concerned, but did counsel that I continue a minimal or gluten free diet to see how I progress. 

 

I know it's unusual for a male to become anemic or need an iron supplement. I don't donate blood. I never have tarry colored stools or any visible blood in my stools. I was tested last summer for occult blood loss and that was negative. There is no evidence to suggest bone marrow dysfunction or blood cancer. There is even no evidence to suggest malabsorption, as all other values (calcium, potassium, sodium, folate, and b12) were normal and I seem to readily absorb the oral iron supplement.

 

I don't know. I'm willing to just wait and see what happens. I don't want to seem like a hypocondriac, though my doctor told me to have a short threshold for alerting him if something is wrong. 

 

Last week I did have an odd episode where I had chest pain for a minute or two, but I think it was just indigestion. What concerned me about it at the time was there was a pressure feeling accompanied my shortness of breath, lightheadedness, and discomfort that radiated to my left jaw.  I KNOW what that sounds like and I panicked for a minute. But then I burped a few times and figured it was nothing. I did have an EKG, enzyme tests, and an electrocardiogram last year, all which found nothing wrong with my heart. That was done last summer after it was determined I was anemic, but before it was found I was iron deficient. It followed an episode where I ended up in the ER because I passed out, slammed my head into some furniture, and bled substantially from my nose. 

 

Yeah, that was a mess. I don't want to tell my doctor about that recent episode though because I really don't think there's anything wrong with my heart, despite it sometimes feeling like there's soreness there after I exercise. 


  • 0

#13 LauraTX

LauraTX

    Advanced Community Member

  • Moderators
  • PipPipPipPipPipPip
  • 1,118 posts

Posted 17 July 2014 - 05:04 PM

Hi Cookies,

(I am eating annies gluten-free bunnie cookies as I type this by the way)

 

Your IgA being low by itself isn't too big of a deal, but I highly recommend asking to be screened for any further immunodeficiencies.  Your regular doctor can test your other Ig levels.  I just picked up on your ability to catch everything, and although it is rare, sometimes there can be an underlying cause.  The other posters seem to have answered your original question well so I don't have too much to add there, except don't give up and push for good screening.  Better to be safe than sorry, especially when you have a gut feeling something is wrong.


  • 0
I am my husband's "Silly Yak Girl" :)
I was diagnosed with Celiac Disease in January 2013. I also have Lupus and Common Variable Immunodeficiency(CVID) for which I am on IVIG.

Celiac.com - Celiac Disease Board Moderator

#14 IrishHeart

IrishHeart

    Warrior Princess

  • Advanced Members
  • PipPipPipPipPipPip
  • 10,449 posts

Posted 17 July 2014 - 05:15 PM

My doctor didn't seem very concerned, but did counsel that I continue a minimal or gluten free diet to see how I progress. 

 

But why would he suggest that if the tests are negative and he has not done a biopsy yet? Were you eating gluten free at the time of testing?

 

If you were gluten-free at the time of testing, the test results are invalid anyway.


  • 0

"Life is not the way it's supposed to be. It's the way it is. The way we cope with it makes the difference." Virginia Satir

"The strongest of all warriors are these two - time and patience." Leo Tolstoy

"If you want to lift yourself up, lift up someone else" Booker T. Washington

“If idiots could fly, the sky would be like an airport.”― Laura Davenport 

"Do or do not. There is no try. "-  Yoda.

"LTES"  Gem 2014

 

Misdiagnosed for 25+ years; Finally Diagnosed with Celiac  11/01/10.  Double DQ2 genes. This thing tried to kill me. I view Celiac as a fire breathing dragon --and I have run my sword right through his throat.
I. Win. bliss-smiley-emoticon.gif


#15 beth01

beth01

    Advanced Community Member

  • Advanced Members
  • PipPipPipPipPipPip
  • 341 posts

Posted 17 July 2014 - 05:35 PM

I don't know what to tell you. 

 

I will tell you up front I don't have a lot of faith in doctors right now.  I have been going to them for 37 years trying to find out what was wrong with me.  But then again the more I read and research, the more I find out about just how hard this disease is to diagnose with all the variables it presents.

 

With symptoms you never know either, there are over three hundred.  Is someone with celiac who had chronic ear infections going to consider that a symptom in someone else?  Probably.  Same with every thing else.  I have had every "symptom" you have stated but the low iron.

 

Really if you don't want to do more tests, just change the diet.  Go gluten-free for six months and see how you feel, have your iron levels rechecked.

 

With all the testing you listed there isn't any mention of thyroid testing, did they do any?  It really has nothing to do with your iron levels, but sometimes over or underactive thyroids can cause some really weird chest problems.


  • 0

Diagnosed at age 37 after a lifetime of symptoms and other diseases: migraines, joint pain, muscle aches, nerve pain, IBS, chronic constipation, chronic ear infections/strep throat, weight fluctuations ( most weight lost >150 pounds), acid reflux, stomach pain, nausea/vomiting, inactive gallbladder, stool impacted appendix, multiple miscarriages, premature births, depression, anxiety, OCD, arthritis of the spine, Grave's disease(treated with radioactive iodine)- hypothyroid, multiple drug and environmental allergies, numbness in the hands and feet, possible multiple TIA's, brain fog, dyslexia, extreme thirst, bouts of insomnia rotated by extreme fatigue, multiple vitamin deficiencies, chronic UTI's and vaginal infections, Fibromyalgia, and I'm sure there are more I am forgetting.

Diagnosed April 7th, 2014 by EGD and tTg IgA.  Marsh IIIb and 35.7 respectively, Starting what seems to be a very long recovery process.

11 year old daughter diagnosed a month later by a tTg IgA of >100 and a positive EMA.  Nine year old son has since tested negative, only had tTg IgA drawn,  Will have a full panel drawn in two years unless symptoms present. 



0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users

Celiac.com Sponsors: