Get email alerts Get E-mail Alerts Sponsor: Sponsor:

Ads by Google:

   Get email alerts  Subscribe to FREE email alerts

Cannabis-like Drugs May Help Bowel Disease

1 post in this topic

News in Science

Health & Medical News - Cannabis-like drugs may help bowel disease - 15/08/2005]

Cannabis-like drugs may help bowel disease


Monday, 15 August 2005

Derivatives of the active compound in cannabis may one day treat inflammatory bowel diseases, new research suggests.

In preliminary laboratory experiments published in the latest issue of the journal Gastroenterology, UK scientists show that cannabinoids prompt gut cells to repair themselves.

And as gut damage is central to Crohn's disease and ulcerative colitis, this early work may pave the way to using cannabinoid drugs to treat these conditions.

"Cannabinoids, which we make ourselves, as well as synthetic cannabinoids, can promote wound healing in the gut, which is extremely interesting given that inflammatory bowel disease involves damaged gut linings," says lead researcher Dr Karen Wright, of the University of Bath.

Wright and her colleagues found cannabinoid receptors CB1 and CB2 in human colon tissue.

They then used human colon cell lines to investigate the binding of cannabinoid compounds and in wound-healing experiments.

The team found that CB2 was increased in colonic tissue characteristic of inflammatory bowel disease.

And cannabinoids enhanced surface wound closure via mechanisms involving the CB1 receptor.

"The system that responds to cannabis in the brain is present and functioning in the lining of the gut," says Wright.

"There is an increased presence of one component of this system during inflammatory bowel diseases."

Although results are not available yet, she adds, studies of cannabinoids' role in gut disorders are taking place in the UK and a clinical trial is being conducted in Germany.

For more information about gut problems, including symptoms and therapies, see the Gastroenterological Society of Australia's website.

with ABC Science Online


Share this post

Link to post
Share on other sites

Ads by Google:

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

  • Forum Statistics

    • Total Topics
    • Total Posts
  • Topics

  • Posts

    • This salad of roasted beets, carrots and apples is perfect for fall. View the full article
    • I have to tell you that, about 3 years ago, I went to the International Celiac Disease Symposium.  The coffee cross-reactive myth was discussed as we were all consuming vast quantities of Starbucks coffee provided by the Sheraton.  Needless to say, it was good for a laugh.    
    • Yeah, I looked for real scientific studies on gluten cross activity and couldn't find any. I did read something about barely being found in instant coffee--so who knows.
    • Gluten Cross-reactive foods is some sort of odd internet myth.  It started with a company that wanted to sell bogus medical tests.  They have even admitted that the coffee thing isn't true - they used gluten contaminated instant coffee.  However, you have to look at the small print in a lot of nonsense in a large binder of stuff to find that fact.  I did it with one of their company reps.. anyway....   If coffee bothers you, it may just be that it is hard on your system.  Maybe you can get it back after some healing.  And it doesn't sound like you had much protein that week.   edit - just looked at the ingredients- that isn't just coffee - who knows what part of it bothered you?  ingredients on GMO Dark Roast Coffee, Chlorogenic Acid, Garcinia Cambogia 95%,Phaseolamin, Cassiolamine Green Tea 100:1 Extract, Ginseng 100:1 Extract, L-Carnitine with Chromium.
    • Thanks for pointing that out. I just learned about things that are cross reactive with gluten--that have a similar protein structure and the body reacts as if it is a gluten protein: the list of cross reactors includes: Eggs, coffee most other grains corn, potato, rice, yeast, chocolate coffee, corn, butter soy, eggplant, bell pepper and chili pepper and tomatoes. Son of a !!!! This explains a lot. I would be faithfully gluten-free and still have DH flare ups when I certain things. So I just ate sprouted rice with beans, fruit and oolong tea--and I was fine. Then last week I tried this weight loss coffee called SlimRoast which worked UNBELIVABLE (LOST 3 POUNDS IN 2 DAYS) I was eating potato soup with lots of chili paste and soon I noticed I was depressed, I couldn't focus and began to feel that crawling flesh thing I get when I know I have been glutened.  I did more research on how I could love my body and read about glutamine: "Glutamine is also a critical part of our digestive system. It is the primary nutrient for the cells of the intestinal lining where it helps regulate cellular reproduction. Through this mechanism, glutamine helps prevent and rebuild a leaky gut which is common in people with inflammatory and auto-immune conditions. For this reason glutamine supplementation has been shown to be very effective in individuals with ulcerative colitis, CELIAC DISEASE, Crohn's disease, & irritable bowel syndrome." So now have removed everything but the sprouted rice, back on fruit and beans and have added those things that are high in glutamine. Since I eat plant based I can't get glutamine from meat so lots of raw spinach beets parsley cabbage celery kale brussel sprouts and especially red cabbage --in salads and smoothies. So hopefully I am on the mend--miss my weight loss coffee but its not worth getting sick over.     
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
    • Most Online

    Newest Member
    IPS Support