Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Celiac Disease Related Articles
0

4 posts in this topic

Change in lipid profile in celiac disease: beneficial effect of gluten-free diet.

Brar P, Kwon GY, Holleran S, Bai D, Tall AR, Ramakrishnan R, Green PH.

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.

PURPOSE: Celiac disease is associated with hypocholesterolemia, which is thought to contribute to a favorable cardiovascular risk profile. This led to suggestions that the diagnosis of celiac disease and its treatment with a gluten-free diet may result in elevation of the serum cholesterol level and worsen this risk profile. However, no study proves this in adults. We therefore examined the effect of a gluten-free diet on the lipid profile in patients with celiac disease. SUBJECTS AND METHODS: We identified 132 patients with celiac disease who adhered to a gluten-free diet and had lipid profiles performed before and after a median of 20.5 months on the diet. The patients lacked diseases that may affect serum lipids. RESULTS: There were significant increases in total cholesterol and high-density lipoprotein (HDL) cholesterol (P < .0001) but not low-density lipoprotein (LDL) cholesterol (P=.06). The LDL/HDL ratio decreased by 0.36+/-0.7 (P < .0001). Both men and women had a significant increase in total cholesterol and HDL and a significant decrease in the LDL/HDL ratio. Only men had increases in LDL (P=.02). The greatest increase in lipid values was seen in those with the lowest initial values. The largest increase in HDL was seen in subjects with more severe disease as indicated by low albumin level and presence of total villous atrophy. CONCLUSIONS: Diagnosis of celiac disease and its treatment with a gluten-free diet resulted in improvement in the lipoprotein profile, which included an increase in HDL and a decrease in the LDL/HDL ratio.

PMID: 16945614 [PubMed - in process]

Bowel sonography in adult celiac disease: diagnostic accuracy and ultrasonographic features.

Castiglione F, Rispo A, Cozzolino A, Camera L, D'Argenio G, Tortora R, Grassia R, Bucci C, Ciacci C.

Department of Gastroenterology, Facolta di Medicina e Chirurgia, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy, fabcasti@unina.it.

BACKGROUND: Celiac disease (celiac disease) is a chronic intolerance to gluten, which induces intestinal mucosal lesions in genetically predisposed individuals. Transabdominal bowel sonography (TABS) is a safe and noninvasive procedure that allows to detect intestinal abnormalities in many conditions, but actually is not routinely part of the diagnostic management of celiac disease. AIM: To evaluate the diagnostic accuracy of TABS in celiac disease patients. PATIENTS AND METHODS: Fifty celiac disease patients and 50 dyspeptic subjects (control group) underwent TABS. The presence of fluid-distended small bowel loops with thickened valvulae conniventes and increased peristalsis was considered a TABS sign of celiac disease. All clinical, biochemical, and TABS features were assessed at the diagnosis and revaluated after 1 year of gluten-free diet. RESULTS: TABS signs were present in 66% of celiac disease patients. Sensitivity, specificity, positive and negative predictive value were 66%, 96%, 94%, and 74%, respectively. TABS findings were recorded in 82% of patients with endoscopical markers of celiac disease, in 87.5% of symptomatic patients, and in 61% of patients without symptoms. After 1 year of gluten-free diet TABS was still abnormal in 20% patients, with no correlation with laboratory tests e/o symptoms. CONCLUSIONS: Patients with celiac disease frequently present TABS signs of the disease and operators performing sonography every day have to consider the possibility to suggest celiac disease diagnosis and aTTG determination in these subjects.

PMID: 16944036 [PubMed - as supplied by publisher]

0

Share this post


Link to post
Share on other sites


Ads by Google:

Thanks for posting this.

The lipid profile describes my experience when retested at 3.5 years gluten-free.

The sonogram sounds like it could be a great noninvasive test method to include when they suspect celiac. I hope they pay attention to it on this continent. We seem to be so far behind many other countries in our understanding of celiac and spectrum of disorders it is linked to. I recently had a sonogram of my lower abdominal cavity. At one point the tech said my intestines were misplaced, that's an exact quote. No explination for how or why and I wonder if this test was done in Italy what the tech might have said, I doubt it would have been that.

0

Share this post


Link to post
Share on other sites

Hypocholesterolemia runs in my family. My father's was always low, mine has been between 112 and 165, and the last time my daughter was tested it was so low the doctor told her somebody might want to do research on her.

0

Share this post


Link to post
Share on other sites

Current epidemiology and accessibility to diet compliance in adult celiac disease.

[Article in English, Spanish]

Casellas F, Lopez Vivancos J, Malagelada JR.

Service of Digestive Diseases, University Hospital Vall d'Hebron, Barcelona, Spain.

BACKGROUND: The widespread of serologic diagnosis for celiac disease has brought about an epidemiologic shift. Little up-to-date information is available on relevant epidemiologic issues regarding diagnosis, information, and therapy. OBJECTIVE: To examine forms of presentation, diagnostic difficulties, follow-up, information sources, and treatment-related issues regarding celiac disease. METHOD: A cross-sectional observational study using a self-completed questionnaire. RESULTS: Seventy-three adult patients were included; 15.0% of cases were diagnosed over 60 years of age. Most were non-smokers (91.8%). The rate of first-degree relatives with celiac sprue was 10.9%. The disease had a classic presentation in only 54.7% of cases. A functional gastrointestinal disorder was initially suspected in 42.4% of patients. Diet adherence is adequate, with unintentional lack of compliance in 15.5% of patients. Diet results in absent or improved symptoms in virtually all patients, but most of them consider compliance a challenge. Forty percent had difficulty finding gluten-free food, and 50.8% had problems in labelling recognition. CONCLUSIONS: Celiac disease presents at any age, has a great variety of manifestations, and responds very well to gluten-free diet. It is crucial that patients be highly motivated and informed, and that they know for certain which foods and manufactured products are to be to used. Therefore, adequate control will result from coordination and cooperation regarding all resources involved, including medical care, and information provided by associations and other sources such as the Web.

PMID: 16948540 [PubMed - in process]

Oral proteases: a new approach to managing coeliac disease.

Cerf-Bensussan N, Matysiak-Budnik T, Cellier C, Heyman M.

INSERM U793, Paris, France.

A constraining life-long gluten-free-diet is the only current treatment for celiac disease. The human gastrointestinal tract does not possess the enzymatic equipment to efficiently cleave the gluten-derived proline-rich peptides driving the abnormal immune intestinal response in coeliac patients. Oral therapy by exogenous prolyl-endopeptidases able to digest ingested gluten was therefore propounded as an alternative treatment to the diet. The feasibility of this approach is discussed by confronting recent data on the intestinal transport of gliadin peptides, properties of available enzymes and preliminary clinical assays. Development of new enzymes or enzymatic cocktail offers potentially more potent therapeutic tools that need however meticulous evaluation based on clinical, biological and histological criteria.

Abnormal fatty acid pattern in intestinal mucosa of children with celiac disease is not reflected in serum phospholipids.

Steel DM, Ryd W, Ascher H, Strandvik B.

Department of Paediatrics, Goteborg University, Goteborg, Sweden. dsteel@fy.chalmers.se

OBJECTIVE: Celiac disease (celiac disease) is characterized by chronic inflammation of the small intestinal mucosa with disturbed epithelial transport. The fatty acid (FA) composition of intestinal membranes is important for epithelial function, and disturbances may contribute to the pathophysiology of the disease. We aimed to evaluate whether the intestinal mucosal FA status was reflected in serum phospholipids of patients with celiac disease. PATIENTS AND METHODS: Samples were obtained from 7 pediatric patients with active celiac disease showing mucosal atrophy, 6 pediatric patients with celiac disease in remission, and 11 control pediatric patients with morphologically healthy intestinal mucosa. Small intestinal biopsies were obtained using a Watson biopsy capsule under fluoroscopic control. Blood samples were collected on the same morning after an overnight fast. Tissue phospholipids were isolated by high-performance liquid chromatography, and FAs were analyzed by capillary gas-liquid chromatography. RESULTS: Serum phospholipid FA showed marginal differences between the patients with celiac disease and the controls. Significant differences were observed in mucosa with active celiac disease compared with controls. Linoleic acid (18:2n-6) level was decreased, whereas those of its derivatives were elevated, indicating increased transformation of n-6 FA. Mead acid (20:3n-9) level was increased, with an increased ratio of Mead acid to arachidonic acid (20:4n-6) levels, suggesting essential fatty acid deficiency. The n-3 FA levels were not significantly changed. During remission, the FA pattern of the intestinal mucosa was mainly similar to that in controls. CONCLUSIONS: The FA abnormality of intestinal mucosa in patients with active celiac disease was not reflected in serum values. Altered FA content may contribute to the pathophysiology of the disease because FAs are important for enzymes and for the transport and receptor functions of epithelial membranes.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      103,370
    • Total Posts
      917,529
  • Topics

  • Posts

    • celiac disease is psychosomatic
      after nearly 6 years gluten free, i still have some balance/anxiety/neuro issues.  they're the last to leave the symptom party, i'm afraid.  i attribute this to the years and years i went undiagnosed and untreated (25 years~! )  i don't have much faith in the medical field's intelligence or in their ethics. funny story:  my obgyn bill had a charge on it that my insurance denied - $25.00 for 'smoking cessation intermediate 5-8 min'  WHAAAAAT?!  (the doctor said it would be a good idea if i quit smoking.  i'm like 'no shit, sherlock')  called the billing office and told them i'm not paying it.  WHY?  1.  do you have any idea how much money i would owe my dad????!!!  2.  i don't smoke with my vagina.  they took off the charge
    • 9 year Old going through testing
      because they make more $$ treating symptoms   every time i see the new 'miracle' pills for 'ibs-c' and 'ibs-d' it just makes me crazy.  ibs is just a symptom..........  as are all these other things that can be reversed just by changing the diet.  but shhhh let's not talk about it, keep the patient ill and miserable, and keep that $$ rolling in.   and to leave a child ill and in pain is just deplorable.  i'm sorry for him.  go git 'em, mama!
    • Do I have Celiac?
      My IgG is 37.6.  B12, D3, and iron deficient.  Hashimoto's thyroid.  Do I have Celiac?  
    • Newbie Mom - How is my son feeling?
      Not really. She just got out of the hospital for the 2nd time. Upon discharge, they said she will continue to vomit. Makes it very hard to go to school. 
    • celiac disease is psychosomatic
      You are misunderstanding the term hidden gluten.  A food item, of which probiotics are not covered under, can legitimately have trace amounts of gluten and still be gluten free.  There is no test that can test down to zero, regardless of what you hear.  Most testing generally tests down to 5ppm and the vast majority........  most likely 99% of Celiac's, will not have an autoimmune reaction to the food.  I am an extremely sensitive, diagnosed Celiac and I eat some processed foods, from reputable companies, and I am doing phenomenal, 11 years gluten-free.  Lots and lots of other people have this experience also. This is not an example of hidden gluten. There can be food ingredients that may be made from a gluten component that may not be as easy to distinguish but if you learn label reading as you should, with time you will be easily able to identify what is safe or something that is questionable. Can it be daunting at first to learn all this new information?  Absolutely, but if you can read, you can learn. There are also many probiotics which are completely safe.  I have been taking them for 30 years and have never been glutened once from them.  The news reports (for what they are worth now) say that there was gluten discovered in probiotics.  That does not mean all probiotics are suspect. You can find out from the Gluten Free Watchdog which ones failed and which ones did not, then make your choice to buy.  Supplements are not covered under the food laws but again.....read those labels and check with manufacturers!
      https://www.csaceliacs.org/label_reading_101.jsp   This is a pretty good page that explains it well.  
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

    • Larry Gessner  »  cyclinglady

      Hi There, I don't know if there is a place for videos in the forum. I just watched "The Truth About Gluten" I think it is a good video. I would like to share it somewhere but don't know where it should go. Any help would be greatly appreciated.
      Here is the link if you have never watched it.
      https://youtu.be/IU6jVEwpjnE Thank You,
      Larry
      · 2 replies
    • ChiaChick  »  Peaceflower

      Hi Peaceflower, Just wanted to say thank you for the chat.
      · 0 replies
    • ukuleleerika

      Hello! I am new to this Celiac website... Is there anyone out there with Celiac AND extensive food allergies? My allergies include shellfish, dairy, eggs, cantaloupe, kiwi, mango, nuts, oranges, red dye, and more I can't think of. I went to the allergist about a year ago to see why I wasn't feeling well, and once everything was eliminated, I still didn't feel well. We did more testing to find out I had celiac as well as allergies to cattle as well as rye grass (I live on a farm basically). This was back in January 2016. I recently had my endoscopy with the gastroenterologist a week ago. I have no idea what to do or what to eat... So fish and potatoes for me!
      · 2 replies
  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      60,516
    • Most Online
      1,763

    Newest Member
    milliew
    Joined