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Mechanisms Behind The Leaky Gut
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Haven't seen this here yet, so I thought I'd post this. I was doing some research on zonulin and came across this document:

http://www.autismone.org/uploads/Owens%20Susan.doc

Haven't examined all the science/research, but a quick look at a few parts of the science look very sound.

Mike

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hey mike---looks great! thanks for the link. i am currently trying to find a doctor who has a clue about leaky gut, actually!

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This is kind of like 'the theory of everything' for Celiac disease! Very interesting paper.

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Ok, I've been reading a lot more about zonulin and what I've read thus far is pretty darn amazing.

Of course we all know by now that Zonulin causes these tight junctions, the barrier from the contents of the GI to the other side of the cells, to open.

It appears that in folks with celiac disease and even treated celiac disease folks that the tjs are open a lot more than normal folks. And that when exposed to gliadin that zonulin causes these tjs to open even more, a lot more in celiac disease and celiac disease-treated, but also (news to me) in folks without celiac disease. It also appears that bacteria that reside in the gut also opens these tjs (even newer news to me).

http://gut.bmjjournals.com/cgi/content/full/48/4/503

BACKGROUND AND AIMSAltered intestinal permeability is a key pathogenetic factor of idiopathic bowel inflammation. We investigated in the rat if changes in the composition of the bowel flora can alter colonic permeability.

METHODSA colonic segment was surgically excluded from faecal transit and brought out as a loop to the abdominal wall through two colostomies. The loop was used for colonisation with specific bacterial strains after eradication of the native flora with antibiotics. Lumen to blood clearance of dextran (molecular weight 70 000) and mannitol (molecular weight 182) was measured in rats recolonised with a single bacterial strain from rat colonic origin, and in control rats whose colonic loop was kept free of bacteria by antibiotics. Actual colonisation was confirmed by culture of segment effluents.

RESULTSColonisation with Escherichia coli, Klebsiella pneumoniae, and Streptococcus viridans significantly increased lumen to blood clearance of mannitol. Colonisation with Lactobacillus brevis had the opposite effect and reduced permeability to mannitol. Bacteroides fragilis did not induce significant changes. Permeability to dextran was not altered by any of the strains tested.

CONCLUSIONSCertain commensal bacteria can modify colonic wall permeability to luminal substances.

Didn't realize that even bacteria had the key to our bodies.

Here's this one that shows that zonulin was part of the key for the bacteria.

http://www.ncbi.nlm.nih.gov/entrez/query.f...t_uids=12404235

Once the tjs are open more than normal this allows stuff to pass through, in some cases gliadin and in others other food proteins or even bacteria. Once they pass through we develop the antibodies to these pathogens and all heck breaks loose.

Now I'm wondering why the gut would allow this bacteria to do this. Perhaps gliadin looks to what ever is turning on the zonulin like the bacteria and thus lets stuff on in.

Mike

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Mike-

You are on the colitis board, right? I thought I remembered your picture and your posts. I had posted there and will probably be going back....tested negative for colitis but tested positive (via enterolab and modified elimination diet) for soy, casein, eggs, and corn.

I am Dr. Fassano's #1 fan. Love the man. Heard his partner at Alba Therapeutics talk to the Richmond, VA GIG group this fall....brought me to tears at the end. It was so enlightening and so encouraging. Due to my now numerous intolerances/Celiac, I'm pretty sure I am classic leaky gut. I am hoping zonulin is the key to this all.

PM me anytime if you want to discuss zonulin. Hope you are doing well!

Laura

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    • I just now saw the second reply and I see what you mean. Again, the issue is that I may have to go with the gluten until close to the end of the year.

      However, an idea did just come to mind, and that is, can my primary care doctor do such a test? I had normal blood work done, but they didn't really say anything about testing for celiacs. I can get an appointment with my primary care doctor much sooner than a GI.

      When I was talking to my PCP last, I asked her what I should expect as far as testing goes or what she may have been concerned about. Her reply was about a HIDA scan for the gallbladder but also any test needed in case of IBS or Celiacs. Just the way she threw that in there like an after thought and left me hanging kinda had me worried.
    • I am not a doctor that's for sure.  So, I can't even answer your questions.  If you know you have pre-diabetes, you probably are working with a doctor.  Can you email them and ask for a celiac blood panel?   You can work on the weight loss and diabetes -- that you can handle yourself now and take action.  I have diabetes and my glucose readings are fairly normal now without medication and I'm thin.  Being overweight does not cause diabetes.  It's either autoimmune (type 1) or you become insulin resistant (type 2).  You can cut out all sugar and  processed stuff ASAP to help take action and start walking 10,000 steps (helps with the insulin resistance).    But the prediabetes is not going to kill you in the next year.  Whatever's in your gut is more likely going to get you much sooner.  But heck, I'm not a doctor and I don't even know you!    
    • Hi Steph, Yes, celiac disease can cause a myriad of symptoms and damage to the body,  Have you completed all celiac disease testing?  Usually they do the blood antibodies test first and then do an endoscopy.   You shouldn't go gluten-free until all testing is completed. Gluten is in many processed foods.  But if you stick with whole foods it is not hard to avoid gluten.  Getting used to eating gluten-free may take some time, as we need to adjust our preferences in diet.  But there are many foods that are naturally gluten-free.  Gluten is the protein found in wheat, rye and barley.  Some celiac disease organizations recommend avoiding oats also for the first 18 months of the gluten-free diet. Celiac disease impairs the ability of the body to absorb nutrients (including vitamins).  That can make it hard for the body to maintain itself and heal/repair damage.  So celiac can easily impact any part of the body. Sardines, tuna, mackeral and salmon have good amounts of vitamin D in them.  There are supplements available also, but not all are good.  You can check them at the labdoor website.  Nature Made is a good one and not expensive.  Internal damage from celiac can cause liver issues.  Those will probably clear up after being on the gluten-free diet a while. Recovery from celiac can take  months, and can be a rocky road.  The more you stick with whole foods and avoid cross-contamination issues the sooner you will heal IMHO. You may find that dairy causes problems for your digestion at first.  But it make stop being a problem after you have healed up some. welcome to the forum!
    • Will this be dangerous considering how long I have to wait for any testing? I may not even get a blood test in November but here is hoping. I just worry having to wait so long will cause serious issues, not to mention delay of weight loss which I need for the pre-diabetes. Do ulcers have a chance to cause yellow stools though? I suppose a stool test will be needed for that for any signs of blood in stools but visually it does not seem so. The biggest issue is not knowing what else could be causing the yellow stools as this would not be a diabetic or ulcer thing. And without negative signs on the gallbladder or liver, it is narrowing down the list.

      At the very least this is making me assume I can wait on a final scan of gallbladder and attempt blood tests and endoscopy if they recommend it.
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