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"gluten Challenge"
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Has anyone heard of a "gluten challenge"? Where you have to be eating gluten for a certain amout of time before the biopsy for the biopsy to be correct. I had a blood test about 6 years ago and one of the antibodies was positive so I went on a gluten free diet and I also had a biopsy done 4 years ago and it came back inconclusive, but now I'm finding out that you have to have the gluten in your sytem to determine if you're really celiac or not. Is this correct?

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To have any chance at an accurate test you have to eat gluten every day for up to three months. Why are you considering this? Do you doubt that you have celiac?

richard

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I'm considering getting another endoscopy b/c it's not 100% sure that I have celiac. 6 years ago I went to an allergist and found out that I'm allergic to wheat, then I got a blood test and one of the antibodies was positive, but they said that only way to be 100% sure is to get an endoscopy. I didn't want to do that at the time, so I went on the gluten free diet and then I wound up getting the endoscopy 2 years later and the results came back inconclusive, and I'm wondering if that's b/c I wasn't eating gluten before the test (well, I may have been eating trace amounts in modified food starch, etc) So, I guess I would just like some concrete answers as to if I have celiac disease or not. I just made an appt. w/ a GI, but the earliest appt. isn't until Oct. 4th, so I'm not sure if I should try to get gluten in my system before the dr. appt. or just wait to see what he has to say.

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Did you have some sort of health problems that went away after you went gluten-free? If so, in some circles your postive blood test plus improvement on the diet would be considered proof.

Anyway, eating gluten from now until Oct. 4 might or might not be long enough. Everybody is different, but I think the top experts say you need to eat it for three months.

richard

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If you feel better on the gluten-free diet then you don't need to have the biopsy but if you have had no imporovement then you may want to have the biopsy to make sure this is actually what you have.

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What does anyone else know about how long you have to be eating gluten before a correct biopsy can be done?

Thanks

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Most experts seem to agree you need to eat gluten for at least two months, preferably three. And even then damage depends on the individual.

richard

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I just got the results from my bloodwork that was taken in 1998 while I was still eating gluten and the IGG antibody was 17.1 and the normal range was <7

I sent this to my dr. to see what he has to say. I'm hoping that I might not have to have another endoscopy done.

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Just my two cents: If you've got the antibodies for sure, skip the endoscopy. Let that be proof-I don't believe anyone should suffer the "Gluten Challenge"--that just prolongs your symptoms.

Thanks for listening,

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After 6 years of being 100% gluten free (or as close to it as possible!) it might take longer than 3 months back on gluten to cause enough damage to be seen with the endoscopy. Chances of your biopsy showing positive damage by October are pretty slim.

I did a gluten challenge this last winter and was back on gluten for two months. (I had only been gluten free off and on for a total of about two months over a two year period) My biopsy still came back negative, since most doctor will only look for complete damage. I am considering having my biopsy slides reevaluated for signs of early stages of damage, but not sure I can afford the expense.

You could try a few days back on gluten and see if it makes you feel sick. I personally wouldn't risk it, but I can understand your need for a concrete answer. That is why I had the Enterolab tests done, since the conventional tests kept coming back inconclusive and I could not commit myself to a lifelong diet if I didn't really have a problem with gluten. Well, I got so sick during that two month gluten challenge that I would never purposefully go back on gluten EVER!

Let us know what you decide to do. We'll all be here to support you no matter what you decide! :)

God bless,

Mariann

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Another thing on top of the fact that I was positive for the IGg antibodies back in 1998, I also went to an allergist then and they told me that I'm allergic to wheat. I'm just confused as what I should do.

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Well, this past weekend I did my own "gluten challenge", I ate some stuff like pizza and wheat bread and I got my answer b/c both Sat. and Sunday I had gas and integestion/acid reflux, basically I felt the way I did before I went on the gluten free diet. So my husband and I just decided that I'll stay on the gluten free diet and forget about doing the endoscopy again. If I felt this bad eating gluten for 2 days I don't want to have to eat it for 3 months before the endoscopy!

So...on with the gluten-free diet!

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    • Hello, I see you posted this a long while ago, and perhaps--I hope-- it's no longer a matter of concern, but I thought I'd mention that shortly before I was diagnosed for celiac's, I had distinct yellow blotches on the corners of my eyelids toward my nose. Some months after I had stopped eating gluten, the yellow gradually went away, and--as it just reappeared now several years later, I googled the issue again.  I am only speculating here, but I do believe it is related to liver problems, which, in turn, are related to celiac's. I don't think liver function tests cover all aspects of liver health. I say this because when I was pregnant I developed a temporary liver condition called interhepatic colestasis of pregnancy (ICP), but my liver function tests had been fine. (The condition is diagnosed based on bile levels in the blood, not on liver function). I discovered upon some research that (of course!) ICP  can be associated with celiac's disease.  My hunch is this-- that celiac's presents two problems to the liver: 1) the malabsorption of nutrients--esp. Vit. K2-- that are vital liver health; 2) since gluten registers as a toxin to the immune system (I think?), perhaps the liver gets overloaded processing so much toxic material. Or perhaps there's some other reason. At any rate, poor liver health and celiac's do seem to be linked, according to a few articles I've found. Anyway, hope your problems are resolved now.  
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      Gluten Allergy is typically less severe than other Gluten related conditions like Celiac Disease.  People with Gluten Allergy will often experience abdominal discomfort, bloating, gas, constipation, or diarrhea when they eat products containing gluten.  These symptoms usually stop when a person cuts gluten out of their diet.

      A Gluten Allergy IgE test can be ordered to help determine if someone allergic to gluten.  This test can also be ordered when a person is testing for Celiac Disease and has had negative results on Celiac specific antibody tests.  An allergy test can also be ordered prior to Celiac testing to rule out Gluten Allergy as a likely cause for a person’s symptoms.
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