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Question On How To Read Bloodwork.
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9 posts in this topic

I know there are two threads currently about blood work, but I wasn't sure how to post this in one of those, without stealing the creator's thunder so to speak.. so starting yet another one, sorry!

I had these taken last Fall, seeing the doctor again, and just want to sound intelligent when I point out to him how this could mean celiac disease (or gluten intolerance, lol) to him.

Gliadin Ab (IgG) = 64

Gliadin Ab (IgA) = 34

Transglutaminase Ab (IgA) = 5

Under 20, Neg. Over 20, weak positive. Over 30, positive.

Reticulin Ab (IgA) = Negative

So, if I understand this right. The IgG is raised in people with celiac disease, but also other diseases. The IgA, my test results say can be with celiac disease or other diseases too, but I read on the boards that IgA is better at showing celiac disease than IgG?

And the other two, obviously appear to be negative according to the lab results. Do those other two have more to do with a damaged small intestines than the first? Just a guess..

But when my doctor rails on about me not having to be gluten-free, I can say pretty positively to him, if I'm not mistaken that no matter what he thinks, having Gliadin Anti-Bodies showing up as strong positives mean I am gluten intolerant and would be dumb to go back to eating it?

Thanks! And yes, I know getting another doctor could be good to do.. but so far, he seems willing to learn, and better for his patients if I can educate him somehow. Don't think my insurance would allow a switch anyway, LOL.

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I know there are two threads currently about blood work, but I wasn't sure how to post this in one of those, without stealing the creator's thunder so to speak.. so starting yet another one, sorry!

Alexolua,

I don't know if we could ever have enough of these questions, to be honest with you.

But when my doctor rails on about me not having to be gluten-free, I can say pretty positively to him, if I'm not mistaken that no matter what he thinks, having Gliadin Anti-Bodies showing up as strong positives mean I am gluten intolerant and would be dumb to go back to eating it?

That's how I see it too!

Gretchen

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That's how I see it too!

Okay, so I am right in assuming those mean I'm gluten intolerant, no matter what he thinks? =)

And hey.. looking at your tag, you were negative on the last two, too? Well Borderline for that other one.. with a certain number, looks like my lab didn't do numbers for that one.

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Alexolua,

I have read that encouraging a patient to go gluten-free before diagnois is discouraged because of the difficulty of receiving a diagnosis later in life. I personally consider an auto-immune response to gluten as intolerance... irregardless of what condition might be causing it. A year after my Igg was elevated and I didn't go gluten-free, my levels just increased.... real good that did. <_<

I have read about the destructive nature of gluten in the bloodstream and knowing I have a problem, don't want to risk the results of non-treatment.

Okay, so I am right in assuming those mean I'm gluten intolerant, no matter what he thinks? =)

I'd say "yes" to that. ... you wouldn't be the first one to disagree with a doctor

Gretchen

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Thanks for the reply again. =)

you wouldn't be the first one to disagree with a doctor

I know that! Pretty sure a good amount of us here have disagreed with doctors before, LOL.

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So just for another question on blood work...

Seems your blood tests are a little more detailed than mine was.

It tested for anti-IgA, which when I went searching on the net had similar results to that stated below - would this be the transglutaminase Ab???

I had a reading off the scale at 190, but inconclusive/negative biopsy.

Although keeping to the diet pretty well, and have a new, amazingly supportive partner, I am still trying to get a handle on all this and what everything means.

What are the other tests for? still gluten, or something else?

QUOTE

Gliadin Ab (IgG) = 64

Gliadin Ab (IgA) = 34

Transglutaminase Ab (IgA) = 5

Under 20, Neg. Over 20, weak positive. Over 30, positive.

Reticulin Ab (IgA) = Negative

Cheers, Peta

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have a new, amazingly supportive partner

Peta,

I know how important that is... that's wonderful.

Was it the Iga that you tested in that was 190 or another test?

There are many different blood tests that they use in the celiac profile. Some have less/more specificity & sensitivity than the others, but pretty much if you tested positive on any, it's an indication that your body is having a response to gluten (protein found in wheat, barley, rye, oats). Some of the tests, like the Ttg are specific to intestinal damage... which will most likely be negative in someone who's gluten intolerance hasn't caused intestinal damage yet. Celiac is diagnosed when that damage appears. Many go gluten-free before that happens, though.

Gretchen

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Thanks for that Gretchen

Yes, he's been great!! Putting up with the "I can't eat that", and the mood that followed a caterers erm... mistake!?

Yep. Has got me a little confused though. I'm not quite sure what it was testing. All it had on the result sheet was anti-IgA - 190. When I got home I did a search on the web, and found something that said over 30 was high indication of positive for celiac disease. Seems over there you're testing is more detailed?!

Glad my doc has a view of avoiding problems, and suggested gluten-free for 6 wks. The GI said don't do it unless definite celiac disease.

As for waiting till you get to the point where you've got intestinal damage if you can avoid it... you gotta be kidding me. not if you know how to avoid it

Peta

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wow, reading others blood results that have been posted on here, makes me think do I really have celiac disease? My results were IgG 20, IgA negative, and Ttg negative. My doctor considered that number of 20 to be enough for me to be gluten intolerant...now I'm questioning. I guess it is better to trial it with the diet and go by how I feel!

Rachel

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    • by the way, I do find the lab who does the gluten sensitive test Gluten Allergy IgE Test This test is used to determine if a person has an allergic reaction to gluten, a protein found in wheat, barley, and rye.  Roughly 1 in 30 adults and 1 in 40 children suffer from a Gluten Allergy.  An IgE test looks for antibodies which develop in a person who has a particular allergy.  Gluten Allergy can display symptoms similar to other conditions such as Celiac Disease.  Unlike an allergy, Celiac Disease can do permanent harm to the body if left untreated.  Allergy testing when a person is experiencing symptoms can help identify or rule out an allergy as the cause.

      Gluten Allergy is typically less severe than other Gluten related conditions like Celiac Disease.  People with Gluten Allergy will often experience abdominal discomfort, bloating, gas, constipation, or diarrhea when they eat products containing gluten.  These symptoms usually stop when a person cuts gluten out of their diet.

      A Gluten Allergy IgE test can be ordered to help determine if someone allergic to gluten.  This test can also be ordered when a person is testing for Celiac Disease and has had negative results on Celiac specific antibody tests.  An allergy test can also be ordered prior to Celiac testing to rule out Gluten Allergy as a likely cause for a person’s symptoms.
    • so does it mean a person who carry dq2 or dq8 gene will have high chance to develp celiac disease if they continue to eat gluten or some other stuff trigger it??      
    • I just wanted to share my experience. I started with the endoscopy because I was having symptoms of a hernia + I had a colonoscopy at the same time to test for Chron's. While getting the scope the doctor noticed damage of the small intestine and did biopsies and they came back positive for Celiac disease. We followed up with the necessary blood work to confirm and those all came back like yours, negative, however my genetic testing was positive. So although rare, it is possible to test negative on the blood work and still have damage and be a positive. I don't know why my blood work was off, but I am glad I had the scope first because I would have never known the damage I was doing if I relied solely on the blood work. 
    • You're welcome. Good that you're having the gene test as well. If you DO have the gene(s) then you realize one can present with celiac at any point in life -- any age -- so you would need to be tested like you were, every 2 years in the absence of symptoms. If one develops symptoms then they need to be tested right away instead of waiting for the 2 yr. mark. It's not common, but is possible to test negative on the blood and still have villi damage on endoscopic biopsy. So depending on the results of the gene test....... you might see if your doc will do a endoscopy for you OR you might be what they refer to as something like a pre-celiac where you're not testing positive yet but most likely will soon.
    • Just don't give up.  Good luck and best wishes to you.  Let me know how it's going for you.  Been there, done this.  It ain't fun.
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