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The Dq1 Gene


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#1 confused

 
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    Just cause i cant have gluten doesnt mean im dying

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Posted 25 July 2007 - 01:07 PM

I have been reading and thinking about everyone and their enterolab test. I seem to find that most of us that have a dq1 gene have malabsorption when we get tested threw enterolab. Has anyone else noticed this.

So if you have the dq1, what was your malabsorption score.

paula
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gluten, casein and soy free
on low carb/low sugar diet

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#2 hathor

 
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Posted 25 July 2007 - 02:21 PM

See below.
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McDougall diet (low fat vegan) since 6/00
Gluten free since 1/6/07
Soy free and completely casein and egg free since 2/15/07
Yeast free, on and off, since 3/1/07 -- I can't notice any difference one way or the other

Enterolab results -- 2/15/07
Fecal Antigliladin IgA 140 (Normal Range <10 units)
Fecal Antitissue Transglutaminase IgA 50 (Normal Range <10 units)
Quantitative Microscopic Fecal Fat Score 517 (Normal Range <300 units)
Fecal anti-casein (cow's milk) IgA antibody 127 (Normal Range <10 units)
HLA-DQB1 Molecular analysis, Allele 1 0501
HLA-DQB1 Molecular analysis, Allele 2 06xx
Serologic equivalent: HLA-DQ 1,1 (subtype 5,6)
Fecal anti-ovalbumin (chicken egg) IgA antibody 11 (Normal range <10 units)
Fecal Anti-Saccharomyces cerevisiae (dietary yeast) IgA 11 (Normal range <10 units)
Fecal Anti-Soy IgA 119 (Normal Range < 10 units)

#3 zarfkitty

 
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Posted 25 July 2007 - 02:29 PM

(edit)

My daughter had malabsorption somewhere in the low 300's range. She's double dq1.
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gluten-free May 17, 2007; casein-light since June 2007

Dx'ed gluten/casein intolerant by Enterolab. Family doc dx'ed "gluten sensitive" after dietary response. DQ 6 & DQ 7

8 year old daughter dx'ed gluten/casein intolerant & malabsorption by Enterolab and has been GFCL since June 12, 2007. Excellent response to diet, including growth! Tummyaches & irritability are gone! DQ 5 & DQ 6

Husband has DQ 5 (elementary, my dear Watson!). Self-diagnosed gluten-intolerant by diet response and challenge.

#4 confused

 
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    Just cause i cant have gluten doesnt mean im dying

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Posted 25 July 2007 - 02:44 PM

I only carry one and had i think 374 i would have to look it up, but my stepson had no malabsorption but the celiac gene wiht dq1, i just find it odd that dq1 seem to have an high malabsorption compared to others.

what do others think about this.

paula
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gluten, casein and soy free
on low carb/low sugar diet

#5 k-amy32

 
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Posted 25 July 2007 - 02:46 PM

Hi! I am a double DQ1 and my score was 1480!
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#6 bugstabber

 
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Posted 26 July 2007 - 07:11 PM

I have double DQ1, malabsorbtion is 487.
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#7 stephanie19

 
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Posted 27 July 2007 - 09:38 PM

I don't mean to hijack this thread, but since it's about double DQ1, which I am as well, I hope you don't mind. I had a mildly elevated malabsorption score (346), but in addition to this question of malabsorption, I'm wondering if any of you know of any further characteristics associated with double DQ1. I've heard it's associated with neurological symptoms, but I don't really know what that means. Anyone know anything further about this or any other problems related to these genes? I'm trying to learn as much as I can about the genetics of this, so any input would be helpful.
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Enterolab results 6/07:
Fecal Antigliadin IgA 24 (Normal Range <10 Units)
Fecal Antitissue Transglutaminase IgA 16 Units (Normal Range <10 Units)
Quantitative Microscopic Fecal Fat Score 346 Units (Normal Range <300 Units)

Fecal Anti-Casein (cow's milk) IgA antibody 21 Units (Normal Range <10 Units)
Fecal Anti-Soy IgA 18 Units (Normal Range <10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0501
HLA-DQB1 Molecular analysis, Allele 2 06xx
Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6)

#8 zarfkitty

 
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Posted 28 July 2007 - 04:33 AM

I don't mean to hijack this thread, but since it's about double DQ1, which I am as well, I hope you don't mind. I had a mildly elevated malabsorption score (346), but in addition to this question of malabsorption, I'm wondering if any of you know of any further characteristics associated with double DQ1. I've heard it's associated with neurological symptoms, but I don't really know what that means. Anyone know anything further about this or any other problems related to these genes? I'm trying to learn as much as I can about the genetics of this, so any input would be helpful.



I can't answer this question with any level of authority. But, my daughter is a very cranky, uncooperative, DRAMATIC little girl on gluten. I mean hysterics of gargantuan proportions, completely inappropriate for her age. When we started the diet, her true personality came back.
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gluten-free May 17, 2007; casein-light since June 2007

Dx'ed gluten/casein intolerant by Enterolab. Family doc dx'ed "gluten sensitive" after dietary response. DQ 6 & DQ 7

8 year old daughter dx'ed gluten/casein intolerant & malabsorption by Enterolab and has been GFCL since June 12, 2007. Excellent response to diet, including growth! Tummyaches & irritability are gone! DQ 5 & DQ 6

Husband has DQ 5 (elementary, my dear Watson!). Self-diagnosed gluten-intolerant by diet response and challenge.

#9 hathor

 
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Posted 28 July 2007 - 11:45 AM

I don't mean to hijack this thread, but since it's about double DQ1, which I am as well, I hope you don't mind. I had a mildly elevated malabsorption score (346), but in addition to this question of malabsorption, I'm wondering if any of you know of any further characteristics associated with double DQ1. I've heard it's associated with neurological symptoms, but I don't really know what that means. Anyone know anything further about this or any other problems related to these genes? I'm trying to learn as much as I can about the genetics of this, so any input would be helpful.


Here are a couple abstracts. I don't know if the disorders mentioned exhaust the possibilities of neurological reactions to gluten. Probably not. I recall seeing one article, I think it was by the doctor here with the long name that mentioned the prevalence of DQ1 in the population he was examining, not just the typical "celiac genes." I don't recall him mentioning double DQ1, though. I wish I could figure out how I got access to that article for free one time! I should have printed it or bookmarked it.

http://tinyurl.com/2jndwd
http://tinyurl.com/2teclo

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McDougall diet (low fat vegan) since 6/00
Gluten free since 1/6/07
Soy free and completely casein and egg free since 2/15/07
Yeast free, on and off, since 3/1/07 -- I can't notice any difference one way or the other

Enterolab results -- 2/15/07
Fecal Antigliladin IgA 140 (Normal Range <10 units)
Fecal Antitissue Transglutaminase IgA 50 (Normal Range <10 units)
Quantitative Microscopic Fecal Fat Score 517 (Normal Range <300 units)
Fecal anti-casein (cow's milk) IgA antibody 127 (Normal Range <10 units)
HLA-DQB1 Molecular analysis, Allele 1 0501
HLA-DQB1 Molecular analysis, Allele 2 06xx
Serologic equivalent: HLA-DQ 1,1 (subtype 5,6)
Fecal anti-ovalbumin (chicken egg) IgA antibody 11 (Normal range <10 units)
Fecal Anti-Saccharomyces cerevisiae (dietary yeast) IgA 11 (Normal range <10 units)
Fecal Anti-Soy IgA 119 (Normal Range < 10 units)

#10 BensMom

 
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Posted 28 July 2007 - 11:53 AM

My son is a double DQ1, and he was in the low 300 range. He has been dairy and wheat free for over a year and now we are pulling out gluten.
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#11 confused

 
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    Just cause i cant have gluten doesnt mean im dying

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Posted 28 July 2007 - 01:02 PM

It is interesting to read how many dq1 people have malabsorption scores that are high or above the 300 mark. It just makes me wonder if maybe we have some sort of diease that is not proven yet but correlates with celiac. I am having a hard time putting what im thinking into words here. Im still ercovering from being glutened this week. When i can think more clearly i will type it all out. But do oyu all think, or am i just pulling at straws trying to figure this out.

paula
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gluten, casein and soy free
on low carb/low sugar diet

#12 Rachel--24

 
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Posted 28 July 2007 - 02:40 PM

Single DQ1 gene.....malabsorption score = 912.

Even though Enterolab tests were positive (IgA and tTG) the cause of malabsorption was/is unrelated to gluten. Not to say that gluten didnt contribute...but there were other issues causing the malabsorption in my case.
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