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Enzyme Cure

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Donna F

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Posted 01 December 2004 - 05:54 AM

Future Enzyme Treatment Possible for People with Celiac Disease  See your ad here!

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J Pharmacol Exp Ther. 2004 May 13
Piper JL, Gray GM, Khosla C. Stanford University.
Celiac.com 11/28/2004 - A study by researchers at Stanford University looked at the ability of Prolyl endopeptidase (PEP)--a specific type of enzyme--to break down gliadin peptides in a living organism--rats. In an effort to determine whether a resistance to the break down of proteins by proteases enzymes is the cause of toxicity of the Pro- and Gln-rich peptides, the scientists analyzed the digestive resistance of a panel of alpha and gamma-gliadin peptides that are believed to induce gluten toxicity--all of which happen to be very resistant to gastric and pancreatic protease digestion--but can be broken down by intestinal brush border peptidases. The researchers determined that supplementation of PEP substantially reduced the concentrations of these peptides, and they determined a pharmacologically useful PEP dosage. According to the researchers: “This data verifies and extends our earlier proposal that gliadin peptides, while resistant to proteolysis, can be processed efficiently by PEP supplementation. Indeed, PEP may be able to treat Celiac Sprue by reducing or eliminating such peptides from the intestine.”

Okay, so how do I get me some? I've been following this since Stanford started doing the research, and now it sounds definitive, so.... where do we get these enzymes? Is this something that can be bought over the counter, or are we still waiting for someone to produce it?

Impatient for a cure,
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Posted 01 December 2004 - 06:28 AM

Read the last line. It says MAY be able to treat... This is still along way from being a definite treatment (and it's definitely NOT a cure of any kind -- with a cure you simply no longer have the disease or condition).

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Posted 01 December 2004 - 01:40 PM

Please don't call it a cure. It's in no way related to a cure any more than shaving is a cure for whiskers.

As far as how to get some - the 1st step is to become a rat. It's only been tried on rats.
I was w/ Dr Gray just yesterday and he did say i may be a candidate for future testing, but don't forget this study is related only to gliadin - not secalinin or hordein (rye, barley) or the other grains' prolamine fractions.

While it's nice to be hopeful, i'd suggest finding a way to temper your impatience.
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>>>>>>> tom <<<<<<<

Celiac 1st diagnosed as a toddler, in the 60s. Docs then, between bloodletting & leech-tending, said "he'll grow out of it" & I was back on gluten & mostly fine for 30yrs.

Gluten-free since 12-03
Dairy-free since 10-04
Soy-free since 5-07



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Posted 01 December 2004 - 03:00 PM

Based on that study synposis, I'm taking a guess that we're at least 10 years away from production - IFF a company decides to go to production with it. They need to do further animal studies, human safety studies, human efficacy studies, and get it past the FDA - all assuming there's a manufacturer who wants to make it.
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Tiffany aka "Have I Mentioned Chocolate Lately?"
Inconclusive Blood Tests, Positive Dietary Results, No Endoscopy
G.F. - September 2003; C.F. - July 2004
Hiker, Yoga Teacher, Engineer, Painter, Be-er of Me
Bellevue, WA

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