Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Low Iga
0

9 posts in this topic

My 2 1/2 year old son had some blood work done to rule out Celiac since he's underweight and not gaining and actually gone down in weight over the last few months. He's 26lbs and 36in. His IgA came back low, about 39 and our lab range is 66 to 436. What does a low reading like his mean?

Thanks,

Megan

0

Share this post


Link to post
Share on other sites


Ads by Google:

Selective IgA defiency is 10-20 times more common in patients with celiac disease than in the general population. Many of the tests for Celiac Disease are based on measuring levels of certain specific types of IgA antibodies (like antigliadin-Iga or endoymysial-IgA) - but if your *total* IgA is low then you will not tend to have enough IgA antibodies to make these tests positive - thus the phenomenon of false negatives.

That's one reason why "serum IgA" or "Total IgA" is included in some labs' panels for Celiac disease. If it comes back low, it is supposed to be a warning sign to the physician that the other test results in the panel cannot be trusted and he/she needs to seek an alternate method of diagnosing. A low serum IgA should tend to point the physician in the direction of suspecting Celiac Disease, not ruling it out.

The issue of low or absent IgA can be considered an autoimmune condition just by itself, but sometimes it occurs with other autoimmune conditions like Celiac Disease.

I assume the lab's ranges of normal were age-based and your child was still low?

0

Share this post


Link to post
Share on other sites

I think that children tend to be low in IgA anyway, which makes the Celiac tests done on children so inconclusive.

I had a low IgA (19) and the range was 80-200something. The doctor said it was fine. (She is not too Celiac savvy though) Since then, I have read that somewhere around 30% of the population is IgA deficient, so if you are being tested for Celiac and your IgA is already low, your test will most likely turn out negative since you are not producing within normal ranges anyway. This made a lot of sense to me and could be the case of your son.

I read that in "Living Gluten-Free for Dummies" by Danna Korn. (in case you are wondering) who is the founder (I believe) R.O.C.K.

0

Share this post


Link to post
Share on other sites

Good points and info! I reread my post and I definitely don't want to scare you or make you jump to the conclusion that your child has selective IgA deficiency - which lots of people live with just fine anyway. It's just something I would ask your doctor about, as I definitely think low IgA can skew other IgA-based test results, like the last poster mentioned.

0

Share this post


Link to post
Share on other sites

I certainly don't mean to tread on the thread... but, does anyone have any clue what it means when the IgA levels are far off the other end.... much *higher* than the normal range?

That happened with my son, who was 8 at the time of his testing. The high end of the reference range was about 100 LESS than what my son's actual level was.

I've never found anyone knowledgeable enough, with regards to IgA, to ask!

0

Share this post


Link to post
Share on other sites




does anyone have any clue what it means when the IgA levels are far off the other end.... much *higher* than the normal range?

I don't know. I did a quick search for two phrases, "elevated serum iga" and "hyper iga" and came up with lots of links that referenced a variety of autoimmune things. So you might just try searching for these phrases and reading the first few pages of links that come up.

Good luck!

0

Share this post


Link to post
Share on other sites

Well, I am really confused. I know the IGA says 39 (range 66-436), then under TTGA there is nothing, which I guess it means it is not back yet, it was a send out test, and then it says CELIA and under that IGA, Serum and it is 33 range 14-122. So is there something different with CELIA IGA, Serum as compared to IGA?

Thanks!

Megan

0

Share this post


Link to post
Share on other sites

This site may be helpful for you

http://www.celiacdiseasecenter.columbia.ed...C05-Testing.htm

The blood tests that comprise the Celiac panel are:

Anti-gliadin antibodies (AGA) both IgA and IgG

Anti-endomysial antibodies (EMA) - IgA

Anti-tissue transglutaminase antibodies (tTG) - IgA

Total IgA level.

If you are confused with the results, it may be worth it to call the doctor and ask to speak to the nurse. Specifically ask what tests where run, and for each tests, what were the reference ranges and the result of the test. Lab tests pages can be very confusing to read!

0

Share this post


Link to post
Share on other sites

I agree, you need to speak with your DR to help with the interpretation of the results. I find it sad that DR's just give the results to people and don't feel the need to offer any explanation... mine did just that. In her case, I'm not sure that she herself knew what they meant. :(

I found more information by doing exactly what you are... googling and posting on this forum. Sometimes, we have to really seek the answers to help figure out what is wrong with us. I hope you find your answers.

Liz

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      103,880
    • Total Posts
      919,460
  • Topics

  • Posts

    • Depression / anxiety issues
      i am wondering if those who get that initial "rush" of a day or twos relief of symptoms are "flying" on adrenaline?  wonder about adrenal fatigue?  not sure that is considered a real thing in western medicine... just a thought.  and you return of sym suggest a glutening.  Anything new in the diet?  even a new package of an already  checked product?  soap and shampoo need to be checked, or used very carefully.  is wife still eating gluten?  if so make sure sh is not bringing it to you.  kisses are nice, but make sure she brushes first, lol skipping products that are "made in shared buildings"  for at least a while. take the B12 on an empty stomache
    • Depression / anxiety issues
      Excellent. The chances are your body won't absorb some of this however so get as many good B sources in your diet as possible in addition. Get some sunshine as well, I know it does rain sometimes in Melbourne but believe me on that score you do a lot better than the poms.   Try and note these positive things, it's so easy when you're down to forget them. There will be more to come. Imagine yourself climbing a mountain. There are points at which you have to travel laterally or even down in order to follow the right path but your overall trajectory is upwards. You're actually lucky to have found it now at 28 with so much time ahead for healing and enjoying the fruits of it.  For me the gluten reaction is the initial cause of the depression but once that's removed it doesn't automatically lift like magic. Whilst the brain fog lifted soon on gluten-free diet, (there was a physical perceptible feeling in my head whilst I had that, a kind of thickness sort of like wearing a diving mask all the time that distances you from the world), the longer term depression isn't so easily shifted. I think this is because there are negative pathways that have been reinforced over many years. That's what living in a constant state of anxiety can do. It wrecks your self esteem which isn't magically repaired as your diet changes, sadly! As my physical symptoms lifted but I still felt depression, if on a different level, I realised I'd have to heal my mind as well as my gut. So I'm currently seeing a counsellor and it is helping. Not there yet though Yes I also get this and the mental side for me is also by far the worst side of it. I used to think I may die every time I got the chest pains but that wasn't as bad as feeling like shit 24/7 or having to fake a good time when feeling awful inside.  The single best thing about realising my gluten problem was that it explained that the underlying cause of that depression and anxiety was physical, not a defect of character, just some bad luck in the makeup of my gut and immune system. Hope that knowledge helps you also, when the anxiety strikes recognise it for what it is. A misdirected fight or flight response to an internal attack on your body.  Have a look at some cognitive behavioural therapy techniqes for challenging negative thoughts, that may be helpful? CBT has a very good success rate here in UK, better than anti depressants or talking therapy I think and it focuses on the practical,.  As you realise there's a load of bulls**t in society about how we view and discuss mental health. Don't buy into it. A lot of 'strong' people out there are simply bottling up their suffering through misguided pride. If people stigmatise you they're doing you the favour of letting you know they're not worth bothering with.  I got a lot of support on here when I was in your position and I'm sure you will too. I wish you the best of luck and I'm sure you'll be seeing more improvements in the weeks and months to come.      
    • Celiac - How many symptoms can there be?
      As you doubtless know now, there are so many ways celiac can present, here's as big a list as I could find online. It would probably be quicker to list what isn't a factor For me personally, nausua, check, left sided back hip pain (my laymans theory here is that celiac is affecting the sciatic nerve which runs from lower back down leg) , check, chest pain also - but for me this comes in short bursts more I guess like heartburn - I thought I was having heart attacks... Check to the rest too... And, for what its worth, other things like being prone to bronchial infection oh hell yes.  I'm currently in the glutened / affected by something group myself so I can only share the advice I've been given. Start a food diary and see if you can track down anything diet related that may be affecting you. Eat as clean as you can, ease up on alcohol, just try and give yourself the best chance of recovery. Have a google of 'heal my gut' diet tips too, you're in the recovery phase at the moment. All the best, at least there's comfort in knowing you're not alone!   Matt  
    • Depression / anxiety issues
      Thanks for the advice Matt, I will be sure to take it all onboard. It's really good to talk to others that have had similar experiences. I'm currently upping my b12 and also taking a additional (gluten free) multi and b complex, also omega 3s and Vitiam D3. I had been noticing small improvements that I forgot to mention in my previous post. I noticed that I fall asleep now much easier than before going gluten-free, I also have moments where my body feels more calm, then blood in my stool has stopped I haven't had any in 10 weeks. My mind was constantly fixated on negative thoughts for the past 2 years and they slowly began lifting from all day negative thoughts to maybe half a day of negative thoughts if that makes sense, but this pass week and a half they have come back, I'm also finding my self very nervous again around other people I'm hoping this will pass. The anxiety / depression is the worst symptom for me I would not wish it on my worst enemy, if that went away I would be the happiest man in the world. I found it very hard to talk to people about my mental health issues at work before I lost my job as I found some people stigmatise me and don't understand or really care, but I figure i don't need narrow minded people like that anyway, and as a man its hard to open up but my wife is very supportive and encouraging. Thanks again for the advice really apricate it
    • Depression / anxiety issues
      G'day Chris and welcome to the forum. You have found what I think is the single best resource on the web for advice, support and understanding for this condition. There is so much info here it's difficult to know where to start, but that's what this thread is for, please check it out. I think I got the recommendation for 'Real life with Celiac Disease' by Dennis and Leffler there, I'll second that, there's a lot of very useful info in there which helps to answer a lot of your questions. May be useful for your partner also. Chapters are short and informative so you can dip in and out.  There will doubtless be more advice to come from others with more experience but there's a few things which occur. Firstly, 10 weeks is very early days. Your body has been under an assault for many, many years. Your immune system has been working overtime and like so many others you've only reached diagnosis after reaching a crisis point. You are now healing but it won't be instant and it won't be without ups and downs, speedier and slower phases.  Second, being strict on gluten is essential, but it's only one part of the puzzle. You also need to eat really healthily and try to heal your gut. As you remove gluten you may find that your body starts telling you that other foods are also an issue. Don't panic, it doesn't mean that will always be the case. But you need to approach the next 6 months as a period where you're giving your body the easiest ride possible. That may mean taking probiotics, bone broths or it could also mean avoiding dairy or other foods, at least until your body has had a chance to heal. If you think you may still be getting gluteny effects keeping a food diary, noting what you eat, when and how you feel would help to track down any further issues.  I too battled through the anxiety, had an all too brief moment of bliss as the diet kicked in, then faced a bumpier recovery period in the weeks that followed. It gets easier but it's still difficult for me from time to time. I tried to articulate some of this recently here, it's a long read but maybe some of it will strike a chord. It will get better and you will become better equipped to deal with it. If you're like me you'll find other things getting better over time that you would never have thought to connect to gluten. Now, I've been exceedlingly nice here and not mentioned the England Rugby drubbing but I can feel my self control beginning to slip. So I'll leave it there   Matt
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

    • Jmg  »  admin

      Hello Admin!
      I don't know whether this is of interest to post on your articles feed:
      http://pratt.duke.edu/about/news/window-guts-brain
      Kind Regards,
      Matt
      · 2 replies
    • celiac sharon  »  cyclinglady

      Hello cycling lady, have you noticed my picture is showing up as you?  Have no idea why but it's rather disconcerting to see my picture and your words 😉  Do you know how to fix it?  You seem to have far more experience with this board than I do
      · 1 reply
    • Larry Gessner  »  cyclinglady

      Hi There, I don't know if there is a place for videos in the forum. I just watched "The Truth About Gluten" I think it is a good video. I would like to share it somewhere but don't know where it should go. Any help would be greatly appreciated.
      Here is the link if you have never watched it.
      https://youtu.be/IU6jVEwpjnE Thank You,
      Larry
      · 2 replies
  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      60,926
    • Most Online
      1,763

    Newest Member
    tr2v12
    Joined