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Sulfur Metabolism


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#1 Nanjkay

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Posted 17 June 2008 - 09:04 AM

Hi all-

Recently I wrote about many reactions to liver cleanses, glutathione cream and various meds. When people wrote back sulfur metabolism issues was listed as a possible cause. I have read up on it and I am sure I have this. I recently thought I was having issues with balsamic vinegar because of gluten, but I now only realize it was the sulfites.

I have done many searches and have joined the sulfur yahoo group, but I still have many questions and I would appreciate any help.

1) What kind of doctor is well equipped to treat this with supplements, diet changes etc? My naturopath knew very little.

2) Does Molybdenum help any of you that have this issue? (my blood minerals came back low for molybdenum).

3) What other supplements may help?

4) Could this issue also be responsible for why I am having bad reactions to my thyroid meds?

5) What tests OTHER than the liver enzyme test are helpful in detecting these kind of issues...like sulfur level tests, etc.

Thanks and please share!!!

Nancy
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Hip surgeries for chronic pain in glute muscles -1989
Sciatica and hip pain - 1991-1993, diagnosed with fibromyalgia - 1993
Diagnosed with Grave's disease - 1995, radioactive iodine - 1996
Gained 60 lbs., depression, low energy, terrible PMS - 1997-2000, diagnosed with PCOS - 2001
Diagnosed with Endometriosis - 2004
Stopped working from severe dizziness, eye pain and fatigue - Thanksgiving 2006
Diagnosed with Vestibular Neuritis caused by Fibromyalgia - 2007
Gluten free - September 2007

Diagnosed with Lyme, Babesia and possibly Bartonella - June 2008

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#2 Rachel--24

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Posted 17 June 2008 - 06:30 PM

1) What kind of doctor is well equipped to treat this with supplements, diet changes etc? My naturopath knew very little.

2) Does Molybdenum help any of you that have this issue? (my blood minerals came back low for molybdenum).

3) What other supplements may help?

4) Could this issue also be responsible for why I am having bad reactions to my thyroid meds?

5) What tests OTHER than the liver enzyme test are helpful in detecting these kind of issues...like sulfur level tests, etc.


Nancy,

None of these questions can be easily answered. If you do have a problem with sulfur metabolism it can be quite complex and correcting it would more than likely depend on getting to the root of the problem.

I see in your signature that you have alot of other issues as well? Some of those things may be a factor....chronic infections or heavy metals or other problems which might lead to an imbalance could be causing/contributing to the problems with sulfur metabolism. There could also be a genetic weakness.

I'm working on this problem with one of my Dr.'s. Unfortunately, there is not a ton of research on this and what we do know is from very recent studies involving Autism. The vast majority of autistic kids have problems with the sulfation pathway....a major detox pathway. My Dr. is primarily treating Autism and although they have come a long way in treating this condition....there are still some things that they dont know at this time.

I dont know what types of things you've learned through your own research but some things to look into would be the "sulfur oxidase enzyme"....which is one of three very important enzymes requiring molybdenum as a cofactor. Also "phenol sulfur-transferase (PST)".....this is the enzyme used to process/detox many chemicals including food chemicals (phenols) as well as neurotransmitters and hormones.

Do you know if you have high copper levels? This would be a good place to start as copper is an antagonist of molybdenum and vice versa. High copper can cause a deficiency of molybdenum and a deficiency of molybdenum can inhibit the sulfur oxidase enzyme. If you are unable to convert sulfur to sulfate (because the enzyme is deficient) this could result in a cascade of additional problems with the sulfation pathway. Also, sulfate is necessary for maintaining the integrity of the intestinal lining...so a deficiency of sulfate leads to leaky gut.

The phenol sulfur-transferase (PST) enzyme needs an adequate supply of sulfate to function.

There are urine strip tests that can be ordered to check levels of both sulfites and sulfates in urine (2 seperate tests). High sulfites in the urine indicates that the body is unable to convert to sulfate. When there is a problem metabolising sulfur it can build up to toxic levels which can cause symptoms....there can also be symptoms when consuming any sulfur/sulfites in food as well as supplements.

If you test your copper...make sure its a RBC (red blood cell) test.

I wouldnt expect your naturopath to know much about this (if anything). Its mostly the doctors who are treating autism using biomedical treatments who are figuring this stuff out....and its very complicated. The problems arent limited to Autism but until now there just hasnt been alot of research in this area.

My Dr. is communicating constantly with other doctors across the country...trying to learn everything they can about Autism. The sulfation pathway is where my problems seem to be and this is where we're focusing our attention right now....but like I said...answers dont come easy. Theres alot of kids with the same issues but they are non-verbal which makes it even harder for the doctors. Since I'm able to do my own research and to communicate what is going on with my body we're hoping to learn some things.

Metals can be involved....mercury can damage sulfur metabolism. This might not be the case with me and I'm still being tested for various things.

I have high copper and I'm taking molybdenum but this isnt exactly a "cure" (at least not for me). I also was doing chelation treatments to bring the copper down.

Yeast and other infections are involved somehow (I think). For me yeast has been a big issue.

Are you sensitive to other foods in addition to those containing sulfur/sulfites? If you're sensitive to high phenol foods such as cocoa, milk, apples, red grapes, tomato, mint, spices, food dyes, banana, peanuts, oranges, colored fruits, etc...that would indicate a problem with the PST/sulfation pathway.

I have problems with sulfur as well as all phenolic foods.

Do your thyroid meds contain dyes? Usually the synthetic ones are colored according to doasge. You can request "white" pills...although they only come in certain dosages so you might not be able to get a pill with your exact dose. I take Armour thyroid. I was reacting to my synthetic pills and I suspected the dyes but this was a long time ago...before I knew anything about phenols.

When talking with other doctors and even those practitioners who do "allergy" desensitization treatments (such as NAET) my doctor was shocked at how little they know about phenols and sulfation issues. They really are in the early stages of research as far as this stuff goes.

Its good to educate yourself as much as you can. I have good doctors but they dont know *everything* and they appreciate any "light" that I may be able to shed on all of this.....since noone knows my body better than me. We wouldnt even be looking at the phenol/sulfation issue if I hadnt researched it and brought it their attention.

Some of my Dr.'s use alternative methods of testing such as autonomic response testing (ART), electrodermal screening or applied kinesiology. They can test anything and determine whether or not its a problem. We already were aware that my sulfation pathway was weak because it did show up in the testing they did. They were unsure as to what might be burdening the system. I also tested poorly for phenols many times but no connection was made between the two until I started researching everything and putting those pieces together. When I was recently tested for these issues (ART) it was pretty eveident that the phenols were a huge issue and more than likely the cause of high toxicity in my body.

As far as the 3 enzymes which require molybdenum...the most important in maintaining good health is the sulfur oxidase enzyme.

1. Sulfite oxidase catalyzes the transformation of sulfite to sulfate, a reaction that is necessary for the metabolism of sulfur-containing amino acids (methionine and cysteine).

2. Xanthine oxidase catalyzes the breakdown of nucleotides (precursors to DNA and RNA) to form uric acid, which contributes to the plasma antioxidant capacity of the blood.

3. Aldehyde oxidase and xanthine oxidase catalyze hydroxylation reactions that involve a number of different molecules with similar chemical structures. Xanthine oxidase and aldehyde oxidase also play a role in the metabolism of drugs and toxins

Deficiencies of molybdenum are identified by the absence of the three molybdenum enzymes. The deficiency of this element and the metabolic disorders are accompanied by abnormal excretion of sulfur metabolites, low uric acid concentrations, and elevated hypoxanthine and xanthine excretion.


The indications that I have (with regards to a deficiency of these enzymes) are elevated RBC copper, inability to tolerate sulfur/sulfites, low uric acid and a sensitivity to "aldehydes"....which includes toxins produced by yeast (candida). I'm still being tested for other things.

The low uric acid actually showed up in bloodwork done by my HMO during the first or second year of my illness. The lab reported that the findings had been retested and duplicated....so it wasnt an error. However, every doctor I asked during that time dismissed these results stating that only HIGH uric acid would be of concern...but low uric acid means nothing significant.

In doing my own research a few months back I came accross this info.

Several issues are raised when levels of serum uric acid (a natural antioxidant) are low. It has previously been thought that lower uric acid levels were not associated with any problems but that may not be the case. Low uric acid levels may be associated with a molybdenum deficiency, copper toxicity, and a worsening of multiple sclerosis.


This was what prompted me to test my copper levels...since there was already some indication of high copper in urine tests I'd done.

If you suspect problems with phenols let me know and I'll post some info. as to what I'm doing to try to reduce the toxic load of phenols. Everything I'm currently doing is to "help" the situation but in order to correct it we will have to determine the cause and correct the imbalances that have developed.

Hope this helps.
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Rachel


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