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Another Pill Possibility


celiac3270

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celiac3270 Collaborator

Another possibilitiy for that miracle pill--for celiac and diabetes:

Open Original Shared Link

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Carriefaith Enthusiast

2006! wow that's soon

Thanks for the link :)

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MySuicidalTurtle Enthusiast

""The only real reservation is that it's only been tested in rats," Dr Anderson said. "Rats don't suffer coeliac disease. But it's a major development and it's important work.""

I was wondering that.

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celiac3270 Collaborator

I know....so soon if it actually worked. Two sad things, though:

  • We'd be relying on a pill when we could feel fine through dietary restriction and no drugs.
  • Boards such as this one, though not becoming obsolete, would be less popular, since people could just pop pills....and we wouldn't make all the friends that we have on here :)

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Carriefaith Enthusiast

When I really think about it, I really can't see a pill coming out that soon. Maybe 8-10 years I mean if the test animals (rats) don't get celiac disease then how can it work on humans? I think there is going to be a lot of trial and error. I'm sure the researchers are doing a good job but I am skeptical.

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red345 Apprentice

Thanks for the link, buddy. Great work, and that's exciting news, isn't it.

The interesting part of this is that if I've learned anything at all, it has been to recognize that the concepts promoted here are probably the best type of suggestions that you could ever act on for the benefits of your own health. And for whatever reason, I believe this only the marks the beginning.

Mr. Adams and all of excellent specialists that have contributed to this website are only beginning to unlock the door to something I believe may just be the main mystery behind just about everything having to do with our health.

So whether or not a cure is ever found, or that magic pill is invented, etc, it would certainly come as wonderful news for everyone here. To take away those major concerns is something that everybody would like to see happen, afterall.

However, I also tend to believe this diet is something everybody should consider if they want to remain healthy in the long run, I really do. Infection or not, DQ2 gene or not, it would definitely seem to me that consuming these types of foods would be better for you than loading up on those crispey cremes like everybody else does, you know?

We're always going to consume sugar, you can't get away from that. But the key is to approach that with some moderation, and I think that your odds are better to keep yourself in check on that end if you stick to many of the concepts involved with this diet. In the long run, I believe that all of you will come out of this with better health than the rest of society, I really do.

I also think we're only getting into the heart of it with this. That said, this place is only going to get more popular, and it'll be that way for a very long time to come. If there is any medical condition that explains for more of the unsolved mysteries that we find today, it would appear that it all starts right here, and that is why all of you that stop by celiac.com should write down the website and pass it onto as many people as you can.

Whether or not I'm right about any of my personal beliefs, I don't know that answer. But what I do know is that one way or the other, it all seems to start right here. Let me just say that if Adams was offering IPO's into his website, I'd buy them all up overnight~. The effort he has made to bring attention to this disease has really come as a Blessing to so many. He, along with the wonderful specialists that have contributed to this site, have done a lot more for people than a hospital full of other doctors could ever do, that much is for sure.

Happy to see that you're coming along well after surgery, buddy. I bet mom's breathing some sighs of relief that her little pal is gonna be a lot better very soon, isn't she. Take care.

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tarnalberry Community Regular

I saw this take on it on LJ; seems people have started touting this as a cure for celiac and diabetes after a few weeks of the articles circulating, and it seems like we've got nothing than a game of "telephone" gone wrong.

Here's the original study abstract with reference to diabetes: Open Original Shared Link and here is the original abstract discovering its role in celiac: Open Original Shared Link and here is the press release from the work Dr. Fasano's doneOpen Original Shared Link

They've tested it in rats for trying to prevent T1 diabetes. The immune reaction of celiac disease occurs _in_ the intestines, so mediating a chemical that prevents things from getting _outside_ the intestines could help deal with some things, but it's not dealing with the full set of chemical reactions that cause the damage.

I'm not saying that this isn't good news, I just don't want people to get their hopes up that they'll definitely be eating bagels again in four or five years.

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MySuicidalTurtle Enthusiast

I was thining, what about other reactions?

I know reac to gluten touching my kin for long periods of time and sometimes get rashes. How is this pill going to stop that?

I know I will never knowingly eat gluten even with a pill.

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plantime Contributor

I'm not seeing where this will cure celiac. I do see where it will cure many food allergies, the ones that manifest in symptoms other than anaphlylaxia. For example, it could allow me to eat eggs without getting the horrific migraines. But I do not see where stopping the gut permeability problem will allow my body to digest gluten. The gluten will remain undigested, my body will continue to attack it, and my small intestine will be wiped out. I will still have celiac.

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jknnej Collaborator

Good luck finding humans with celiac disease to test this pill! LOL

No one would eat gluten on purpose, not even for the hope of a cure..too bad.

Red is right, anyway; we are MUCH healthier.

Since I stopped eating out (because I'm afraid of cross contamination) I have energy again like I haven't in years. And no tummy aches.

I don't ever want to go back. Yes, I miss those foods horribly but the trade off is how I feel. Everytime I think of a Jack and the Box Ultimate Cheeseburger I just think of the horrible tummy ache I get after eating it! 5 minutes of pleasure just isn't worth a week of pain!

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celiac3270 Collaborator

I agree--there's no way I would intentionally eat gluten at this point--even for the sake of other celiacs who may be hoping for a cure.

I'm skeptical--we've heard things like this in years past that never ended up working. Besides which, we're better off not eating all the food we were before.

Additionally, Dr. Green, in a radio segment awhile ago, made some comment how he estimates that about a decade from now there will be a pill that will reduce/ameliorate the reactions celiacs have to gluten accidents--he didn't seem to think a cure would be coming anytime soon.

I agree also in that I wouldn't want to go back to eating gluten, either. Though I think there's no way we'd convince future celiacs who would just want their bagles back and not realize how much healthier this is.

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ianm Apprentice

I know a few diabetics who would rather pump themselves full of insulin than change their eating and lifestyle habits. For us celiac disease'ers the only solution is to stop eating gluten and live healthier lifestyles. Even if a pill was available I prefer to live the lifestyle I am living know. A pill would be good for those that are extra sensitive to gluten and have serious reactions to it. Something to keep the reaction from being as bad as it normally would be when accidentally glutened. Being able to take a pill so I can eat junk food and not exercise just isn't the right way to go.

Ianm

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      I made an account just to reply to this topic. My story resembles yours in so many ways that it is truly amazing. I also suddenly became lactose intolerant, went a little under 10 years attributing all my symtoms to different body parts, never thinking it was something systemic until much later. I had the same mental problems - anxiety, depression, fatigue, etc. In fact, the only real difference in our story is that I was never formally diagnosed. When I discovered that my myriad symtoms, that had been continuous and worsening for years, all rapidly subsided upon cessation of consuming gluten, I immediately took it upon myself to cut gluten out of my diet completely. I live in America, and had lost my health insurance within the year prior to my discovery, so I could not get tested, and I will never willingly or knowingly consume gluten again, which I would have to do in order to get tested now that I have insurance again. But that is not the point of this reply. I also had extreme TMJ pain that began within months of getting my wisdom teeth out at - you guessed it - 17 years old. I was in and out of doctors for my various symptoms for about 5 years before I gave up, but during that time I had also kept getting reffered to different kinds of doctors that had their own, different solutions to my TMJ issue, an issue which I only recently discovered was related to my other symptoms. I began with physical therapy, and the physical therapist eventually broke down at me after many months, raising her voice at me and saying that there was nothing she could do for me. After that saga, I saw a plastic surgeon at the request of my GP, who he knew personally. This palstic surgeon began using botox injections to stop my spasming jaw muscles, and he managed to get it covered by my insurace in 2011, which was harder to do back then. 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The muscles spasm less, stress is taken off the joint, as the joint slowly moves back into its proper position. The pain reduces each month, each week, sometimes even each day you go in for a visit. The joint has to be moved in this manner with the splint BEFORE the modification to the teeth begins. They then add to your tooth structure with small bits of composite, to keep the joint in its proper place after it has been sucessfully repositioned. Subtracting from your teeth, by grinding down bits of your natural tooth structure, is done very conservatively, if they have to do it at all. This process worked for me - after six months, my face, jaw, neck all felt normal, and I had no more pain - a feeling I had not had in a long time. It also made my face look better. I had not realized the true extent that the spasming muscles and the joint derangement had effected the shape of my face. The pain began to return after a few months, but nowhere near where it had been before. This immense reduction in pain lasted for a little over two years. The treatment still ultimately failed, but it is not their fault, and it is still the treatment that has given me the most relief to this day. Later on, I even went about three years with very, very good pain reduction, before the joint severely destabilized again. This field of dentistry is the last line treatment for TMJ issues before oral surgery on the TMJ. There aren't as many denists around who practice this anymore, and the practice is currently shrinking due to dentists opting for less espensive, additional educations in things like professional whitening, which have a broader marketability. Getting this treatment is also very expensive if not covered by insurance (in America at least). My first time was covered by insurance, second time was not, though the dentist took pity on me due to the nature of my case and charged like a quarter of usual pricing. Most cases seen by these dentists are complete successes, and the patient never has to come back again. But occasionally they get a case that is not a success, and I was one of those cases. A little over a year ago, I began seeing the second dentist who keeps my TMJ stable in this manner. The first dentist retired, and then died sadly. A shame too, because he was a truly amazing, knowledgable guy who really wanted to help people. The new dentist began to get suspicious when my joint failed to stay stable after I was finished with the bite splint and his modifications, so he did another scan on me. This is ten years after the first scan (remember, I said the surgeon saw "slight" damage to the tissue on the first scan). This new scan revealed that I now no longer have cartilage in the joint, on both sides - complete degeneration of the soft tissues and some damage to the bone. 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I didn't inform him because I thought it would be inappropriate due to not having a formal diagnosis. I was disappointed, because I had believed I had caught it BEFORE it had done permanent damage to my body. I had never suspected that my TMJ issues may be related to my other symptoms, and that the damage would end up complete and permanent. Luckily, I caught it about 6 months after my other joints started hurting, and they stopped hurting right after I went gluten free, and haven't hurt since. I of course did the necessary research after the results of the second scan, and found out that the TMJ is the most commonly involved joint in autoimmune disease of the intestines, and if mutliple joints are effected, it is usually the first one effected. This makes complete sense, since the TMJ is the most closely related joint to the intestines, and literally controls the opening that allows food passage into your intestines. I am here to tell you, that if anyone says there is no potential relationship between TMJ issues and celiac disease, they are absolutely wrong. Just google TMJ and Celiac disease, and read the scientific articles you find. Research on issues regarding the TMJ is relatively sparse, but you will find the association you're looking for validated.
    • trents
      Welcome to the forum, @SuzanneL! Which tTG was that? tTG-IGA? tTG-IGG? Were there other celiac antibody tests run from that blood draw? Was total IGA measured? By some chance were you already cutting back on gluten by the time the blood draw was taken or just not eating much? For the celiac antibody tests to be accurate a person needs to be eating about 10g of gluten daily which is about 4-6 pieces of bread.
    • SuzanneL
      I've recently received a weak positive tTG, 6. For about six years, I've been sick almost everyday. I was told it was just my IBS. I have constant nausea. Sometimes after I eat, I have sharp, upper pain in my abdomen. I sometimes feel or vomit (bile) after eating. The doctor wanted me to try a stronger anti acid before doing an endoscopy. I'm just curious if these symptoms are pointing towards Celiac Disease? 
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