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      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Does Everyone Have Two Copies Of Gluten Sensitive Genes?
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5 posts in this topic

I've now had four tests taken with Enterolab - mine, both of my parents, and my husband. We all end up with the statement that although we do not possess the main genes predisposing to celiac sprue, we have two copies of a gene that predisposes to gluten sensitivity. I'm beginning to wonder if everyone has two copies of the gluten sensitive gene??? How common is it? What are all the possible combinations of these genes anyway? Any help is appreciated.

Amy

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I've now had four tests taken with Enterolab - mine, both of my parents, and my husband. We all end up with the statement that although we do not possess the main genes predisposing to celiac sprue, we have two copies of a gene that predisposes to gluten sensitivity. I'm beginning to wonder if everyone has two copies of the gluten sensitive gene??? How common is it? What are all the possible combinations of these genes anyway? Any help is appreciated.

Amy

I had one gluten sensitive gene and one celiac gene. So, no - everyone does NOT have two copies of the gluten sensitive gene. ;)

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You will have either one Celiac gene and one "gluten sensitive" gene, or 2 Celiac genes, or 2 "gluten sensitivity" genes.

Since pretty much the entire population carry either Celiac genes or what Enterolab considers to be "gluten sensitive" genes...you are pretty much guaranteed to have either 2 celiac genes, 2 gluten sensitivity genes...or one of each. I havent seen it happen any other way.

Personally, I was only really concerned with whether or not I had Celiac genes.....as the others arent recognized at this point.

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So, Rachel, are you saying that Enterolab will always report at least one gluten sensitive gene or one Celiac gene? In that case, will some people test with the genes, but not have above normal IgA levels?

You will have either one Celiac gene and one "gluten sensitive" gene, or 2 Celiac genes, or 2 "gluten sensitivity" genes.

Since pretty much the entire population carry either Celiac genes or what Enterolab considers to be "gluten sensitive" genes...you are pretty much guaranteed to have either 2 celiac genes, 2 gluten sensitivity genes...or one of each. I havent seen it happen any other way.

Personally, I was only really concerned with whether or not I had Celiac genes.....as the others arent recognized at this point.

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So, Rachel, are you saying that Enterolab will always report at least one gluten sensitive gene or one Celiac gene? In that case, will some people test with the genes, but not have above normal IgA levels?

Yes, you can have these genes in any combination and not have elevated antigliadin IgA.

You can have one or both Celiac genes and still never develop Celiac Disease.

Having the genes only predisposes you to the disease......it doesnt mean that you have it....or will ever have it.

As far as the gluten sensitivity genes....I believe that Enterolab is the only lab testing for those.

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