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Is Celiac Disease Sex-linked? Dominant Or Recessive?


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#1 B R I A N A

 
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Posted 05 January 2009 - 05:59 PM

I'm doing a biology project on genetic disorders on celiac disease and I need to know if it is sex linked, dominant, or recessive. Thank you.
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B R I A N A

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#2 nasalady

 
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Posted 06 January 2009 - 12:18 AM

I'm doing a biology project on genetic disorders on celiac disease and I need to know if it is sex linked, dominant, or recessive. Thank you.


Hi Briana,

Most of the online articles say that celiac disease is more common in women than in men. This is certainly the case with many other autoimmune diseases, such as lupus or Hashimoto's thyroiditis.

The genetics of celiac disease are rather complicated, and I don't think you can explain things as being merely dominant or recessive. I don't know enough about to give you an answer on that part.

JoAnn
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Multiple autoimmune diseases, including celiac, Hashimoto's, psoriasis, autoimmune hepatitis, RA, SLE. Also have fibromyalgia.

Tested Fall 2008: bloodwork, biopsy negative; HLA DQ8. Doctor believes results negative due to prednisone and Imuran taken for autoimmune hepatitis.

Dx with celiac disease because of dietary response, genetics, and family history of celiac disease.


Dx with Lyme Disease Jan 2010; Lyme likely triggered some of the AI diseases.

Gluten free since 25 Nov 2008

#3 ravenwoodglass

 
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Posted 06 January 2009 - 07:16 AM

Celiac is not sex linked. One reason for more women having it would be childbirth. Celiac requires a trigger and for many women childbirth will bring it on. It is also neither dominant or recessive it is more of a genetic difference than a defect. I believe it is more of a haplogroup rather than a genetic mutation.
Your best way to get accurate research would be to enter Celiac and genes into a search engine and then look for .org, .gov and .edu in the results.
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Courage does not always roar, sometimes courage is the quiet voice at the end of the day saying
"I will try again tommorrow" (Mary Anne Radmacher)


celiac 49 years - Misdiagnosed for 45
Blood tested and repeatedly negative
Diagnosed by Allergist with elimination diet and diagnosis confirmed by GI in 2002
Misdiagnoses for 15 years were IBS-D, ataxia, migraines, anxiety, depression, fibromyalgia, parathesias, arthritis, livedo reticularis, hairloss, premature menopause, osteoporosis, kidney damage, diverticulosis, prediabetes and ulcers, dermatitis herpeformis
All bold resoved or went into remission with proper diagnosis of Celiac November 2002
Some residual nerve damage remains as of 2006- this has continued to resolve after eliminating soy in 2007

Mother died of celiac related cancer at 56
Twin brother died as a result of autoimmune liver destruction at age 15

Children 2 with Ulcers, GERD, Depression, , 1 with DH, 1 with severe growth stunting (male adult 5 feet)both finally diagnosed Celiac through blood testing and 1 with endo 6 months after Mom


Positive to Soy and Casien also Aug 2007

Gluten Sensitivity Gene Test Aug 2007
HLA-DQB1 Molecular analysis, Allele 1 0303

HLA-DQB1 Molecular analysis, Allele 2 0303

Serologic equivalent: HLA-DQ 3,3 (Subtype 9,9)




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