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Elevated Bilirubin Count Warning Sign Of Celiac? (gilbert's Syndrome)
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Hello all,

well, I've tried to stop stressing about the possibility of having celiac for a bit, but I just got my most recent blood test results back and my liver bilirubin count is still high. Normals are 2-18, but mine is currently 29. There is no real danger caused by this elevation of bilirubin, but could it possibly a sign or symptom of celiac disease? The reason why I suspect this is because my mother, who was diagnosed with celiac over a year ago, had elevated bilirubin counts since she was my age (early 20's). Our doctor has always said that it was a mild form of a rare condition called Gilbert's sydrome (which when severe can cause jaundice), which is hereditary. Anyway, now that she is on an gluten free diet, my mother's bilirubin counts have gone down more or less to normal, suggesting a link to celiac disease.

now, of course we have mentioned this possibility to our doctor and he thinks it's coincidence (though he's not overly informed about celiac), but it is yet another sign that I could be the next on the list of family members with celiac.

If anyone has any information about this possible link, I would love to know.

For those who are bound to ask. Both my mother and my only sister both have the disease. It's on both my mother and father's side of the family, I have so far tested negative in 2 successive IgA,IgG blood tests, but am nevertheless suffering increasing gastrointestrinal problems, including stomach pains, bloating, hemrhoids (fun fun), and all kinds of other possibly related stuff.

as always, any help and information is greatly appreciated.

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Hello all,

well, I've tried to stop stressing about the possibility of having celiac for a bit, but I just got my most recent blood test results back and my liver bilirubin count is still high. Normals are 2-18, but mine is currently 29. There is no real danger caused by this elevation of bilirubin, but could it possibly a sign or symptom of celiac disease? The reason why I suspect this is because my mother, who was diagnosed with celiac over a year ago, had elevated bilirubin counts since she was my age (early 20's). Our doctor has always said that it was a mild form of a rare condition called Gilbert's sydrome (which when severe can cause jaundice), which is hereditary. Anyway, now that she is on an gluten free diet, my mother's bilirubin counts have gone down more or less to normal, suggesting a link to celiac disease.

now, of course we have mentioned this possibility to our doctor and he thinks it's coincidence (though he's not overly informed about celiac), but it is yet another sign that I could be the next on the list of family members with celiac.

If anyone has any information about this possible link, I would love to know.

For those who are bound to ask. Both my mother and my only sister both have the disease. It's on both my mother and father's side of the family, I have so far tested negative in 2 successive IgA,IgG blood tests, but am nevertheless suffering increasing gastrointestrinal problems, including stomach pains, bloating, hemrhoids (fun fun), and all kinds of other possibly related stuff.

as always, any help and information is greatly appreciated.

Hello. I just wanted to say that my 8 year old daughter's liver enzymes were drastically elevated prior to diagnosis (total bilirubin 1.1 w/ o.o-o.7 range, ALT 715 w/ 24-49 range, AST 303 w/ 15-37 range). My child was negative for all hepatitis screenings. All numbers have returned to normal with gluten free diet. Below is a link to read over suggesting the celiac/liver disease connection--scroll down to the pdf page for hepatitis. I call celiac the "Equal Opportunity Destroyer".

http://celiachealth.org/pdf/clinical_manifestations.pdf

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Hello all,

well, I've tried to stop stressing about the possibility of having celiac for a bit, but I just got my most recent blood test results back and my liver bilirubin count is still high. Normals are 2-18, but mine is currently 29. There is no real danger caused by this elevation of bilirubin, but could it possibly a sign or symptom of celiac disease? The reason why I suspect this is because my mother, who was diagnosed with celiac over a year ago, had elevated bilirubin counts since she was my age (early 20's). Our doctor has always said that it was a mild form of a rare condition called Gilbert's sydrome (which when severe can cause jaundice), which is hereditary. Anyway, now that she is on an gluten free diet, my mother's bilirubin counts have gone down more or less to normal, suggesting a link to celiac disease.

now, of course we have mentioned this possibility to our doctor and he thinks it's coincidence (though he's not overly informed about celiac), but it is yet another sign that I could be the next on the list of family members with celiac.

If anyone has any information about this possible link, I would love to know.

For those who are bound to ask. Both my mother and my only sister both have the disease. It's on both my mother and father's side of the family, I have so far tested negative in 2 successive IgA,IgG blood tests, but am nevertheless suffering increasing gastrointestrinal problems, including stomach pains, bloating, hemrhoids (fun fun), and all kinds of other possibly related stuff.

as always, any help and information is greatly appreciated.

I am still getting used to this whole glutten thing so I can't advise you too much on that. That being said elavated billirubin levels can be a problem. Having been through that with my mother. There is a little known probable autoimune disease called Primary Billalilary Chirrosis (PBC). It too is like celiacs in that it is often undiagnosed or misdiagosed for years. It took my mom about 15 years to get a definative diagosis. There also appears to be a link between celiac's and even thyroid disease. Oh and one of the symtoms is incessant itching. You need to see a hepatoligist who knows something about this disease to rule it out.

Please don't let the word cirrosis scare you is isn't caused by drinking or exteral factors. It's an autoimune response to something unknown.

Good luck.

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I have had a high bilirubin count for years, and doctors always ignored it since it wasn't dangerously high. I am due for blood test soon to see if my vitamin D level has returned to normal (it was very low) so I am anxious to see what the bilirubin will look like now that I am gluten-free.

I went gluten free last April but it took about 3 months to start to see real positive changes... it is well worth the effort. really. I pretty much blame all my medical problems on celiac - as I was undiagnosed for 30 yrs and now am seeing so many problems disappear.

Yes, thyroid disease is linked to celiac - have that too.

good luck.

erin

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If any of you find out your results and any possible connexion between the two I would really like to know! I've been experiencing a slew of Coeliac-like symptoms for a couple of years now with no other explanation, and I have also been diagnosed with Gilbert's (my last 2 rounds of blood work showed levels in the 40s and 50s). I had a requisition for IgA IgG blood tests in November, but unfortunately moved to the other side of the country before I could get it done, and haven't followed up with a doctor since moving.

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I have celiac and are intolerant to salicylates, histamine, etc.

I found this research yesterday in my own quest for answers as how this is all related.

While googling more I also found this topic, so I registered to post this:

Gilbert's syndrome is caused by approximately 70%-75% reduced glucuronidation activity of the enzyme Uridine-diphosphate-glucuronosyltransferase isoform 1A1 (UGT1A1).

http://en.wikipedia.org/wiki/Gilbert%27s_syndrome

http://www.ncbi.nlm.nih.gov/sites/entrez?D...p;Term=16393303

Deficient UDP-glucuronosyltransferase detoxification enzyme activity in the small intestinal mucosa of patients with coeliac disease.

Department of Gastroenterology, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands

Background Small intestinal malignancies in humans are rare; however, patients with coeliac disease have a relatively high risk for such tumours. Intestinal UDP-glucuronosyltransferases are phase II drug metabolism enzymes also involved in the detoxification of ingested toxins and carcinogens. As many toxins and carcinogens are ingested via food, the human gastrointestinal tract not only has an important role in the uptake of essential nutrients, but also acts as a first barrier against such harmful constituents of the food. Therefore, the gastrointestinal mucosa contains high levels of detoxification enzymes such as cytochromes-P450, glutathione S-transferases and UDP-glucuronosyltransferases.

Aim To compare the UDP-glucuronosyltransferase detoxification capacity in small intestinal mucosa of patients with coeliac disease vs. that in normal controls.

Methods We assessed UDP-glucuronosyltransferase enzyme activities towards 4-methylumbelliferone in small intestinal biopsies of patients with coeliac disease (n = 22) and age- and sex-matched controls (n = 27).

Results Small intestinal UDP-glucuronosyltransferase enzyme activity in controls was significantly higher than in patients with coeliac disease: 0.55

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    • You're welcome! Yes, I too, hate waiting for lab results. Ugh!
    • I understand this is not a doctor's office and that I need proper testing done to rule out Celiac disease, however, I am stuck waiting until November to even see a GI doctor. So I need some suggestions soon on which test to go for first and what to do as I wait. Also do note, I am 28 years old.

      Right now, the most suspecting culprits to my symptoms have been Gallbadder, Celiac disease, and IBS. I have also been recently diagnosed with pre-diabetes and I am obese.  My Ultrasound and CT scan have all come up as normal and no signs of gallstones. However, I was in extreme pain as my upper abdomen was examined during the ultra sound. My white blood cell count also seems to be high at 12,000 but all blood work came back normal for liver and everything else.

      Symptoms included are: diarrhea
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      light gnawing pain in area a few inches above belly button
      burning in chest
      sometimes pain below upper right rib cage.
      Tenderness all around the upper abdomen, but more so on the right and center.
      burping frequently after meals
      Gassy
      bloating in abdomen The pains used to come and go for the past few years as something very mild, but then the yellow stools happen at least four months ago and at a constant rate. Everyday it is either yellow or orange.  Sometimes the stools are lose and other times they are not. Two months in, I was finally diagnosed with pre-diabetes and have been having a strict low calorie and non fatty diet.

      So far the upper right pain has subsided but the pain above my belly button would continue. The gassy and bloated feeling would come and go as well. I get severe heart burn after almost every meal. But I felt it especially after eating whole wheat sandwiches or whole wheat pasta. I however don't feel it when I eat a Nature Valley granola bar, or pack of peanut butter crackers. I also had a chicken and vegetable stir fry with soy sauce cooked in that also had little effect on me. A bowl of cereal also made the heart burn act up pretty bad. I sometimes feel numb or light headed after various meals. Especially larger ones. In fact, it seems the more I eat, the worse I feel. But the less in the stomach, the more the pain above my belly button starts to act up.

      It is usually in the morning and afternoon I feel the most with gas and bloating. Especially after any large meals from the previous day. Despite the diet and work outs I have had, nothing has changed the stools. However, taking fish oil pills has greatly reduced the pain in my upper abdomen as well as the pain  in the the area above my belly button. My question now is, is there a very likely chance of this being celiac disease? Should I go on a gluten free diet to test since I Have to wait so long? Also, which test should I ask the doctor for first, as it will take a GREAT deal of time to pay off each one. Colonoscopy, HIDA scan, or endoscopy. 

      Again, I understand this isn't a site to get compete medical advice or to know exactly what my illness is, but I am trying to narrow down the possibility or what is most likely. If this has a chance of being celiac disease, I would rather know sooner than later.
    • Thank you very much for all the info Squirmingitch. The doctor told me as we were talking he was going to order some tests with urine so I don't know why he didn't mark that. Maybe he forgot as we were talking? Duly noted about the bladder Cancer to watch out for too. Doctor said it will take about a week to get the lab results back usually from this lab. The wait will seem like forever I'm sure. Yes I will press to have the other tests done too if this one comes back negative.
    • http://www.cureceliacdisease.org/screening/ Was your hubs tested for total IgA to see if he's IgA deficient? Read this thread: http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83660
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