Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Celiac Sprue Vs Tropical Sprue Vs Whipple Disease
0

5 posts in this topic

The other day I was reading an article regarding these three diseases that can be confused especially celiac and tropical sprue, all of them cause malabsortion and therefore similar symptoms, this is what I understood:

Celiac sprue (disease): Positive antigladin, endomysial and transglutaminase antibodies, biopsy shows villi blunting, histology (villi) and symptoms improve with a gluten free diet.

Tropical sprue: Negative antigladin, endomysial and transglutaminase antibodies, biospy shows villi blunting, histology (villi) and symptoms don't improve with a gluten free diet. The disease is though to be cause by an infectious agent wich can be treated with some antibiotics for 6 months. Maybe this could be the reason why some people have villi blunting, negative antibodies and their symptoms don't improve with the gluten free diet, in fact, they can be cured with a antibiotics.

Whipple disease: Malbasortion syndrome caused by Tropheryma Whippleii wich obstucts lymphatics in the intestine which in turn cause malabsortion. I understand it doesn't present with villi blunting. It can be treated with antibiotics and can be cured. It doesn't improve with a gluten free diet.

I hope it helps. :D

0

Share this post


Link to post
Share on other sites


Ads by Google:

Thank you for sharing, that's interesting.

0

Share this post


Link to post
Share on other sites

Tropical Sprue is regional and treatable and not an autoimmune response.:

http://en.wikipedia.org/wiki/Tropical_sprue

[edit] Cause

The cause of tropical sprue is not known.[1] It has been suggested that it is caused by bacterial, viral, amoebal, or parasitic infection. Folic acid deficiency and rancid fat have also been suggested as possible causes. In a condition called coeliac (also: celiac) disease (also known as coeliac sprue), which has similar symptoms to non tropical sprue, the flattening of the villi and small intestine inflammation is caused by an autoimmune disorder.

[edit] Affected Regions

The disease was first described by William Hillary[2] in 1759 in Barbados. Tropical sprue is endemic to India and southeast Asia, Central and South America, and the Caribbean.

[edit] Treatment

Once diagnosed, tropical sprue can be treated by a course of the antibiotic tetracycline(Doxycycline) or Sulfamethoxazole/Trimethoprim(Co-trimoxazole) and vitamins B12 and folic acid for at least 6 months.

[edit] Prevention

Preventive measures include drinking only bottled water, brushing teeth, washing food, avoiding fruits washed with tap water (or consuming only peeled fruits, such as bananas and oranges), and altogether avoidance of travel to the affected regions.

[edit] Prognosis

The prognosis for tropical sprue is excellent. It usually does not recur in patients who get it during travel to affected regions. The recurrence rate for natives is about 20%.

0

Share this post


Link to post
Share on other sites

I don't know but I have also a "gut feeling" (ironic) that one person can have celiac and tropical sprue or whipple disease at the same time, though the chances would be pretty slim, it would be worth that every and each of these disease be ruled out by the GI doctor to be completley sure, also, pancreatic deficiency can cause the same malabsortion symtoms but I have read that one has to have a trypsin digestive and a secretin blood workup. Carbohydrite malabsortion can cause GI symptoms as well. Good luck to those having problems with the correct diagnosis.

0

Share this post


Link to post
Share on other sites

Interesting... I have seen improvements avoiding gluten but not all completely since I know there are other health problems that I have. I now also will avoid yeast, which I'm also seeing many improvements. Next doctor visit I'll see about getting my thyroids check, since I have all those symptoms plus more.... and think it's only a logical move. If results for thyroid conclude that there is something wrong I will suspect they will start checking for other health issues. Tropical and Whipple are two I will keep in mind, maybe they will come across it. Though I'm sure if I get a thyroid test with conclusion there is a health problem, a biopsy may also be done ( to thyroid and/ or intestine near stomach), maybe?

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,357
    • Total Posts
      920,528
  • Topics

  • Posts

    • Well, I have never cruised on Carnival, but I am sure they can accommodate you.  I assume that you have already alerted them that you require gluten free meals.  If not, please contact Carnival immediately. Here are my own tips.  Some folks eat off the buffet line, but not me or hubby except for coffee/drinks and baked potatoes (jacketed) and fruit that we wash in the restroom (people touch everything!)  Okay, I am OCD, but my last glutening which occurred the previous summer made me sick for three months (GI tested my antibodies to prove it).   When we board, I go to the buffet restaurant ASAP and ask to speak to the Head Waiter (they are usually there greeting customers and often trying to up sell to specialty restaurants.   Let them know you have celiac disease and must be gluten free.  They may try to tell you that each dish is clearly marked gluten free, but really?  Who's to say that some other passenger is not going to switch spoons (or I have seen passengers wandering around with serving spoons...I kid you not!  The staff usually will  go downstairs and fetch a gluten free meal for me from the main dining room's kitchen as there is usually a dedicated area for allergies.  We have to wait up to 20 minutes or so but it is worth it.  Starving?  Get a baked potato wrapped in foil until your gluten-free meal arrives.  Now, do not do this every single time.  Those folks have to go down several levels to fetch food and you don't want to be a pain.  But if the main dining area is closed, they need to make an effort to keep you safe.  On our last cruise, we were advised not to eat anywhere but the main dining room and that included room service (they are not trained to handled allergies).  My headwaiters have sent goodies (prepackaged gluten free rolls and cookies for us to keep in our room.  We can always grab whole fruit (I wash it first) to snack on.  I bring gluten-free non-perishable items with me to eat while at port in case we can't find anything (which can be often).  Again, when we get back to our ship, we contact our headwaiter and he/she can prepare some snacks until we have dinner.   Be grateful and not picky.   We eat all meals in the dining room (or at least as much as possible).  Our headwaiter had a few other celiacs on our cruise this summer, so they prepared some gluten-free waffles, etc. for our breakfast!  What a treat!  At breakfast, we'd have different waiters, so our headwaiter would always instruct our waiters each and every time!  They even let me tour the kitchen and showed me the allergy section.   The only time I did not feel safe was at the buffet.  We once ordered gluten-free pizza and I realized (I watched) that that restaurant didn't really have the gluten-free thing down), do I called him on it.  Got the manager etc.  So, be careful.  Other cruises made us frozen Udi"s which was just fine with us.  They covered it up in foil so that we would not get any cross contamination from their pizza oven. So, have fun!   Tipping?  We prepaid our gratuities, but we gave our headwaiter an extra $200.00 for his time.  For us, it was well worth the service and safety of our food.  It does not hurt to slip some of the tip ahead of time (like after your first meal!)  
    • <strong>Celiac Disease & Gluten-free Diet Information at Celiac.com. Gluten Free Diabetes ::The 3 Step Trick that Reverses Diabetes Permanently in ... View the full article
    • I had a biopsy done (2 samples, 1 on a lesion and 1 next to lesions), and also more bloodwork done. All came back negative. However, I only had been eating gluten for 2 weeks prior, and it took a week of gluten for lesions to reappear. I also used a topical steroid off and on (1x a week approximately) for a month or so before testing. The dermatologist told me to stay off gluten though, and said she wants to do more allergy testing (her next open testing appt is in 6 months!!). I know I'm not the DR, but I dont think it's allergies...without a doubt, my skin begins clearing about 2 weeks post gluten-free diet...this is without changing anything else in my lifestyle. And when i had to go back on gluten before my biopsy, it took about a week, but did reappear. Now, about 2 weeks post biopsy and gluten-free, it had begun clearing until i worked outside all day in heat, humidity,  sweat etc and it has definitely irritated all the places that were healing (not new breakouts, just aggravating what was going away!). All that being said, i have a friend who is an MD( who's hobby is to attend conferences on skin conditions!), and she has told me that without a doubt, I have celiac/DH.  I think I just feel like I need test results and paperwork to show for it...especially to show family members who are unsupportive (gross understatement!) of the extreme changes I've had to make!
    • Sorry ! I have never cruised before.  Just wanting to follow your topic.  Good luck! Have a great,  safe vacation.  
    • Hi there, I hope you're all having a good day! I'll be heading on a week-long Carnival cruise shortly and had a few questions: -What is the tipping protocol? I've prepaid gratuities, but feel like the food request will warrant something extra. Should I tip the headwaiter? Hostess? Regular waiter? Chef? Those cooking at, say, the sandwich or pasta bars? If so, how much is appropriate, and should I tip at the beginning of the cruise, the end, or split it up? -It looks like the main dining room will be closed during lunch hours on most days. Any recommendations on safe bets for midday meals? I'll be on the Carnival Sunshine, for what that's worth. Thank you so much for any information you can share!  
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,432
    • Most Online
      1,763

    Newest Member
    rbeckler60
    Joined