Celiac Sprue Vs Tropical Sprue Vs Whipple Disease
Posted 03 July 2009 - 03:26 PM
Celiac sprue (disease): Positive antigladin, endomysial and transglutaminase antibodies, biopsy shows villi blunting, histology (villi) and symptoms improve with a gluten free diet.
Tropical sprue: Negative antigladin, endomysial and transglutaminase antibodies, biospy shows villi blunting, histology (villi) and symptoms don't improve with a gluten free diet. The disease is though to be cause by an infectious agent wich can be treated with some antibiotics for 6 months. Maybe this could be the reason why some people have villi blunting, negative antibodies and their symptoms don't improve with the gluten free diet, in fact, they can be cured with a antibiotics.
Whipple disease: Malbasortion syndrome caused by Tropheryma Whippleii wich obstucts lymphatics in the intestine which in turn cause malabsortion. I understand it doesn't present with villi blunting. It can be treated with antibiotics and can be cured. It doesn't improve with a gluten free diet.
I hope it helps.
Posted 04 July 2009 - 06:27 AM
dx fibromyalgia '02
dx lupus '03
dx raynauds '05
but luckily i'm much more than my disease(s)!
may '09: tested neg. for celiac but have extremity numbness, ataxia, headaches etc. -- in other words enough reason to go gluten free to test my response
Posted 04 July 2009 - 06:36 AM
The cause of tropical sprue is not known. It has been suggested that it is caused by bacterial, viral, amoebal, or parasitic infection. Folic acid deficiency and rancid fat have also been suggested as possible causes. In a condition called coeliac (also: celiac) disease (also known as coeliac sprue), which has similar symptoms to non tropical sprue, the flattening of the villi and small intestine inflammation is caused by an autoimmune disorder.
 Affected Regions
The disease was first described by William Hillary in 1759 in Barbados. Tropical sprue is endemic to India and southeast Asia, Central and South America, and the Caribbean.
Once diagnosed, tropical sprue can be treated by a course of the antibiotic tetracycline(Doxycycline) or Sulfamethoxazole/Trimethoprim(Co-trimoxazole) and vitamins B12 and folic acid for at least 6 months.
Preventive measures include drinking only bottled water, brushing teeth, washing food, avoiding fruits washed with tap water (or consuming only peeled fruits, such as bananas and oranges), and altogether avoidance of travel to the affected regions.
The prognosis for tropical sprue is excellent. It usually does not recur in patients who get it during travel to affected regions. The recurrence rate for natives is about 20%.
Gluten Free - August 15, 2004
"Not all who wander are lost" - JRR Tolkien
Posted 07 July 2009 - 10:56 AM
Posted 07 July 2009 - 12:48 PM
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