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Iga Deficiency

mela14

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mela14 Enthusiast
mela14
Posted

As a lot of you know I got my results form Columbia presb. I "do not have the celiac gene so cannot have celiac disease". I was told this by Dr Lee there.

Just curious what you guys think.

I had the genetic blood test done by her last month which was about 4-5 months after going gluten-free. I also had a biopsy done at the same time which was negative.

About 5 months ago my initial blood work showed a high positive for gliadin IGg AB. That's when my dr suggested going gluten-free. This all came about at a time when I didn't know why I was getting so sick with GI problems and lots of other symtpoms.

I was also receiving monthly IGG infusions for an Immune Deficiency that was discovered a year prior.

They also discovered an IGA deficiency but they cannot do replacement therapy for that.

So, my concern is this: can the IGA deficiency be throwing off the actual results of the tissue transglutaminase test? those results came back normal when they were taken 5 months ago. And can I still have a gluten problem even if I don't have the gene? also, is the genetic blood test always 100% accurate and is it different from the Enterolab test? I was thinking about doing the gene test through Enterolab but don't want to be spending more money if it's going to be a waste of time.

I guess I am confused about the certainty of all these tests in light of all my set backs with different foods.

I did the York Testing about 4 months ago and they were right on the money with the food intolerances that I have. It just has been very difficult to fine tune my diet given all the things that make me sick.

What are your thoughts on this? I have Primary Immune Deficiency (IGG def - 3 of the subclasses, IGA deficiency and high IGM) I was told that the IGM is usually high when you are sick or fighting an infection. In my case it is always high and they thing that reason for this is that my IGM is overcompensating for the IGG and IGA deficiencies.

I was also told that with IGG deficiencies you run the risk of getting more intestinal infections...which has happened to me so often in the past. With IGG replacement it has been better though. right now, I haven't had an infusion in about 3 and half months because of insurance..but..........I am getting one tomorrow! wish me luck....I am having it done at a new hospital, new people and a new product (I hope I don't react).

Thanks guys...........don't mean to ramble ....just thought I would give you some food for thought and get some opinions. afterall, we have to be our own doctors.

:blink:

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cdford Contributor
cdford
Posted

My IGA was so low that they had to adjust the reading of the other tests. My daughter's was so low that they could not even use her blood work for diagnosis. Yes, it apparently can effect the results of the testing.

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Happycat Rookie
Happycat
Posted

Hi Mel,

My son is IgA deficient. He had a positive IgG. I think about 115, over 20 being positive. I e-mailed Dr. Fine of Enterolab. He emailed me back and said that high serum IgG is a diagnostic of gluten sensitivity. He said his symptoms warranted a gluten free diet now. He also said sometimes IgA will be in stool but not blood but usually not. The malabsorbtion and gene tests would be unaffected.

OK, that being said my son (19) tested positive for EVERYTHING. IgA included. He also has 2 copies of the gluten sensitive gene.

I hope this helps

Lisa :rolleyes:

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gf4life Enthusiast
gf4life
Posted

This is an excellent article about IgA deficiency. Open Original Shared Link

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