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      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Iga Deficiency?
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5 posts in this topic

Background:

I was tested for Celiac Disease a year ago at my request. Honestly, I don't know how valid the results are. I had been on a gluten free diet for almost a month and a half but off for about 10 days before the test. But I was a little leary of eating gluten at that point and so not consuming it everyday and certainly not in heavy amounts. I have Hashimotos and upon going on a gluten free diet, those antibodies decreased a significant amount. My husband says we are not going to try the blood test again because he can't take 3-6 weeks of me gluten loading and I'm not sure I can either.

I have been on a gluten free diet now for the most part for 3 months and see a huge difference. My brainfog is gone , I have energy, less moodswings, less acne, and I suddenly get extremely painful constipation when I eat gluten that I didn't notice before. However I wasn't regular before going gluten free either; just wasn't in pain and therefore did not care. I have always had eczema and haven't noticed any at all since I have been on a gluten free diet but we have also made other changes in the last few years that are supposed to help such as a water softener, etc. My mother and brother show a lot of the symptoms of Celiac disease including constant D, lactose intolerance, and ADHD symptoms (brother is on an insane amount of medication for this). My dad shows a lot of the neurological signs of Gluten Intolerance and is lactose intolerant. He goes off of gluten when eating at home and is back on when eating at restaurants and can tell a huge difference though he just thinks is because grains of any kind are bad for EVERYBODY. In addition, autoimmune diseases have occurred on both sides of the family including RA, Lupus, a rare autoimmune liver disease, myasthenia gravis, chronic blood clotting, chronic bronchitis (was told autoimmunie related), etc.

When my youngest daughter was a baby, the doctor wanted to test for IGA Deficiency because she was very small (from birth and still is) and got sick frequently. After doing research, I couldn't see where knowing would make a difference and declined. She had some things as a baby that made us think about the possibility of being Celiac but appears fine now.

So, I am probably going to get the gene test done by enterolab to test for non Celiac Gluten Intolerance just for peace of mind.

So... if a person is IGA deficienty, are their IGA levels just a flat zero or could it be very low?

My blood results were:

Tissue Transglutaminase Ab, IgA 0.1 Normal <7 U/ml

Gliadin Peptide Ab, IgG 2.9 Normal < 7 U/ml

Gliadin Peptide Ab, IgA .5 Normal < 7 U/ml

I have a great doctor who I'm sure would have looked into IgA deficiency if she thought it was a possibility but I just thought I'd check since you guys seem to know so much.

Thanks in advance.

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The test that should be run in conjunction with the other tests is total serum IGA. If this is deficient it will throw the other results off. Also, the results are not valid because you had not been consuming enough gluten at the time.

With your family history I think having the genetic testing for both you and your daughter is a good idea. Is your daughter gluten free? If not, you could have the full blood panel run on her:

Anti-Gliadin (AGA) IgA

Anti-Gliadin (AGA) IgG

Anti-Endomysial (EMA) IgA

Anti-Tissue Transglutaminase (tTG) IgA

Total Serum IgA

This will give you a better idea of where you are at as a family. It is highly likely that your daughter has the same problem you do, whether diagnosable celiac or non-celiac gluten intolerlance..

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I just want to point out that there are no identified "Celiac genes". You can be tested for HLA haplotype of which certain ones are associated with celiac disease, but not causal.

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Thanks for the responses! While my daughter is not gluten free, she isn't getting a ton of it either. We don't have a lot of breads in the house for my sake. Sometimes, my husband will cook with gluten for the three of them and I'll have a substitute that kind of goes with what they are having but it happens less and less. So I don't know if the tests will be that much better for her.

I have thought about doing Enterolabs complete panel but already have negative results, I'm not sure it would be worth it with the negative blood tests.

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I am IgA deficient. For the lab my doctor used, the normal range was somewhere around 88-200 or something like that. My number was 19. So, it was pretty safe to say that my low number obviously had a negative effect on my test results. My GI did a gene test on me to determine what my risk was, and we went from there. For me, the genetic test was very helpful, but it may not be for everyone. He really wanted to do an endo, but I had been gluten-free for 6 months and was doing remarkably better, so we couldn't come to an agreement on that :D

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    • Weird Reaction
      Hi Richie I've put the above in quotes as you have described in the first and second sentence how I felt six months prior to my DX.   In my own case, in the end I concluded it was anxiety after consulting Dr Google!  It was such an alien feeling to me, I couldn't even think what it was, particularly as life was pretty good at the time.  Anxiety is a problem for a lot of celiacs prior to diagnosis, and often after glutening after going gluten-free. You mention breathlessness, this of course can be for reasons such as anaemia (again a common celiac problem, I had this prior to DX) but of course also can arise if you are anxious.   Re 'gluten free' - Flowerqueen is right, from what I have read on this forum some people really do seem to react with less than 20ppm.    But perhaps some other things to consider...  could there be something wrong with the batch you have consumed?  Might it be worth contacting the manufacturers?   That said, you could , as Flowerqueen suggests, have a problem with another ingredient, in the product or something else you consumed. In the past I have had a terrible reaction - fever, trembling, diarrhea, stomach cramps that lasted up to three hours the last three times I ate..... broccoli, of all things.    Who would have thought that possible?  I have often thought I should try it again, just to be sure it was the broccoli, as it is a 'super food' that I ought to have in my diet, that I like very much, but the thought of having such a reaction again has put me off. I do hope you will find some answers soon.  
    • Weird Reaction
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    • Confused
      I have not. I'll talk to my doctor about it
    • High Positive Test Results - Your thoughts please...
      With blood results like these, your husband most definitely has Celiac Disease.  The biopsy is just to check to see how much damage.  Keep in mind that even with high, high test scores like these, damage can still be patchy. Although I would be very surprised if they didn't find enough with numbers like these!  Thank goodness he was able to have a definitive diagnosis and reason for his symptoms!  Good luck!
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