Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Low Total Igg--What Does This Mean?
0

8 posts in this topic

Hello, I posted a few months ago, and have a new question.

My son (almost five) who has low total IgA (45.6, range is 66-120) had his total IgG also tested by the GI. As it turns out, his total IgG is around 460 (reference 600-1000). They want him to see a pediatric immunologist before going forward with an endoscopy (they may well still do one, but the immunologist might be looking for things as well).

Is low total IgG common with celiac? (I didn't take the call; my husband did, so I might not get to speak to the GI myself for a while.)

To recap a bit, my son is small for his age (and small for our family) and has had eczema and GI issues. He's had antibiotics 9x (at least).

Thank you!

0

Share this post


Link to post
Share on other sites


Ads by Google:

Hello, I posted a few months ago, and have a new question.

My son (almost five) who has low total IgA (45.6, range is 66-120) had his total IgG also tested by the GI. As it turns out, his total IgG is around 460 (reference 600-1000). They want him to see a pediatric immunologist before going forward with an endoscopy (they may well still do one, but the immunologist might be looking for things as well).

Is low total IgG common with celiac? (I didn't take the call; my husband did, so I might not get to speak to the GI myself for a while.)

To recap a bit, my son is small for his age (and small for our family) and has had eczema and GI issues. He's had antibiotics 9x (at least).

Thank you!

See a pedi immunologist. Low IgG means something's going on w/the immune system & is most often related to Primary Immune Deficiency Disorders. My son has the exact same thing- low IgA & low IgG but normal subsets (if those haven't been tested, get them done b/c they give a better picture of what's going on). He also has low neutrophils which is another component of the immune system. So far, Evan's undergone celiac testing 2 different times & last Sept had an EGD w/biopsy done- all is negative. The immunologist diagnosed him with: Selective IgA Deficiency & Transient Hypogammaglobulinemia of Infancy because he makes antibodies to vaccines (they did a prevnar vaccine challenge). His main symptom that started this ball rolling was chronic diarrhea (now ongoing for over a year), irritibility, waking during the night SCREAMING. Turns out, in addition to his immune system issues, he also has moderate reflux & is on 30mg of prevacid. Right now, Evan's immune system issues are being treated w/ 125mg omnicef daily- unless he gets an ear infection (he's had 8 in the past year), then he's put on Septra 2x daily for 10 days.

It's difficult but if you can successfully coordinate care between the pedi GI & immunologist, you'll hopefully start to find answers. Also, I would recommend doing a LOT of research! If you want more immune system information- esp on Primary Immune Difficiency Disorders (or PIDD), I suggest visiting www.primaryimmune.org. There is a TON of relevent information.

Feel free to as me any questions! Hope that helps!

0

Share this post


Link to post
Share on other sites

See a pedi immunologist. Low IgG means something's going on w/the immune system & is most often related to Primary Immune Deficiency Disorders. My son has the exact same thing- low IgA & low IgG but normal subsets (if those haven't been tested, get them done b/c they give a better picture of what's going on). He also has low neutrophils which is another component of the immune system. So far, Evan's undergone celiac testing 2 different times & last Sept had an EGD w/biopsy done- all is negative. The immunologist diagnosed him with: Selective IgA Deficiency & Transient Hypogammaglobulinemia of Infancy because he makes antibodies to vaccines (they did a prevnar vaccine challenge). His main symptom that started this ball rolling was chronic diarrhea (now ongoing for over a year), irritibility, waking during the night SCREAMING. Turns out, in addition to his immune system issues, he also has moderate reflux & is on 30mg of prevacid. Right now, Evan's immune system issues are being treated w/ 125mg omnicef daily- unless he gets an ear infection (he's had 8 in the past year), then he's put on Septra 2x daily for 10 days.

It's difficult but if you can successfully coordinate care between the pedi GI & immunologist, you'll hopefully start to find answers. Also, I would recommend doing a LOT of research! If you want more immune system information- esp on Primary Immune Difficiency Disorders (or PIDD), I suggest visiting www.primaryimmune.org. There is a TON of relevent information.

Feel free to as me any questions! Hope that helps!

Thank you so much for your response. The Children's GI doc definitely wants him to see an immunologist before doing the endoscopy, and she's even finding us one over there, so they should be well coordinated. Since our son is almost 5, we're guessing that the vaccine thing was ok (though, he reacted badly to all that he's had so far--did you find that?) There is celiac in the family but not low IgA or low IgG (that we know of), but I know it doesn't always work that way. It sounds like the GI still believes there is reason we might find celiac, but didn't exactly explain whether there's a connection with low IgG and celiac (on that helpful site you suggested, it doesn't look like total IgG and celiac have a connection).

I hope your son is feeling better now! What a relief it must have been to know what was going on, finally. Do they think your son will grow out of it? I saw that it can be the case with many kids.

We will take your words to heart and research before we see the immunologist (I've already been looking up quite a bit since reading your post yesterday).

Thank you again!

0

Share this post


Link to post
Share on other sites

Hi

I have been all over the place trying to find some one with who has similar symptoms too my 2 year old. When he was about 9months old he stated to get alot of ear infections, so his doctor kept putting him on antibiotics he then started having chronic diarrhea and would throw up at least once a day normally in the middle of the night while he was sleeping but everyone and a while it would happen during the day. We were sent to an ENT who wanted to put tubes in but i was to crazy about jumping right to surgery so she suggested going to an asthma and allergist who ran all sorts of test and came back with he has some kind of Immune Deficiency and has now sent us to an Immunologist. His IgG levels are around 450. At this point i am begining to get worn out from going to doctor to doctor when each new one says we are going to figure this out and then they can't and we get passed off to someone else who can't see him for months. The throwing up and diarrhea have stopped but at this point he is waking up screaming in the middle of the night and he is always drained and tired. He has good days and bad days, playing with his friends makes his so over tired. reading your posts sounded kind of like my son so i guess pretty much i was going to see if either one of you had gotten an answer as to what your children had

Thanks

0

Share this post


Link to post
Share on other sites

If the kids that have low IGA and IGG are continueing to have issues with D and other possible celiac related issues I would strongly advise going ahead and giving the diet a good strict try. Those low values could very well cause a false negative in testing for celiac, IMHO, and the diet won't hurt them. It may not help all their issues but if it relieves the tummy issues and helps with growth it certainly won't hurt.

1

Share this post


Link to post
Share on other sites




My son had an endoscopy and sigmoidoscopy in June (at Children's in Boston, where they have a lot of experience doing these). He was 100% negative--there was nothing to indicate anything wrong with him. At the follow-up appointment they said that he wasn't THAT small, and if his growth dropped, to see an endocrinologist in a few years (i.e., he could be finding his curve at a small end). They also offered us testing for intolerances (as carbohydrate malabsorption was seen in his stool). We declined since we already know that we're lactose intolerant. Also, he's not been that ill to take him off all fructose. Since it's summer, he no longer has eczema either. The immunologist has ordered further immunological panels for him. We're sort of turned off by the idea of more tests since he's pretty much fine...and since he went through all the other tests. (This doctor didn't seem too concerned, just wanted to close the loop.)

One remaining doubt I have with the diagnosis of no celiac: my son nursed for a long time...would that have provided gut protection to make an endo 100% clear? I didn't really go into that with the GI, though they did know that he nursed for some time.

(I think about this still because I have food issues, and do feel better when I don't eat gluten, but I feel like a fake, especially since I've had negative blood work (though, granted, I was gluten-free at the time). I've been eating all gluten, all the time lately, and have been tempted to get the blood work repeated before I go off of gluten once again.)

0

Share this post


Link to post
Share on other sites

(I think about this still because I have food issues, and do feel better when I don't eat gluten, but I feel like a fake, especially since I've had negative blood work (though, granted, I was gluten-free at the time). I've been eating all gluten, all the time lately, and have been tempted to get the blood work repeated before I go off of gluten once again.)

How has your body reacted to going back on gluten? Usually if we have a gluten issue, go gluten free and then add it back in our body will react badly to the challenge.

0

Share this post


Link to post
Share on other sites

How has your body reacted to going back on gluten? Usually if we have a gluten issue, go gluten free and then add it back in our body will react badly to the challenge.

I've felt better overall without gluten, but don't typically feel worse when I go back to eating it. I don't know if that makes sense. I don't have certain painful intestinal/GI symptoms when I'm not eating gluten (but those symptoms don't happen all the time anyway and can be caused by corn, bananas, etc.). I have more energy for exercise without gluten. With it, I've felt my legs turn to rubber while running, and I have to stop immediately or I feel like I'll fall over. Nutritionists have no answer, and say to eat more, eat more protein, eat more carbs, etc. I am less bloated without gluten. I just had a baby in May, and ate gluten throughout...and didn't have issues, though I gained a lot with all three pregnancies and never have energy to go for walks, etc. I have had panic symptoms that seem to come only when I've had gluten. I used to think it was from coffee, but I don't really drink that much. The combination of a bagel and coffee (and little other food) can do it (but not all of the time).

I was diagnosed with IBS in 1994 after a barium enema/lower GI. I am lactose intolerant. I have been hypothyroid since my first child was born in 2002. I am somewhat sugar-sensitive, which made me wonder if it wasn't gluten, but just things high in simple carbs.

I looked into gluten being an issue after talking to the acupuncturist--my stomach was bad in winter 2008, I think. I don't know if I had a low-level bug for a few weeks, whether it was the occasional dairy I was then eating, or if it was gluten. Anyway, I went off of gluten around the same time I came down with the regular flu. (Easier then, in a way, since nothing sounds good but soup.)

I thought I could stop eating it for however long a food challenge should be, then have it again after that time period and see if there's a difference. (My stomach hasn't been great for about two weeks now, not as bad as that winter, but not great either.)

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,655
    • Total Posts
      921,622
  • Topics

  • Posts

    • Below is copied & pasted from this thread:   My celiac doctor is Dr. Syed Jafri, in Webster, TX (just south of Houston -- basically the Clear Lake City area), saved my LIFE.  I would recommend him to the whole, entire world.  I was desperately ill, and am still struggling, and he's a wonderful, sweet man who listens and is very proactive in helping you solve whatever problems you're having.  I wish all doctors were like him.  I have to fight and struggle with too many doctors to just listen to me and what I live with, day in and day out.  He's not like that.  Good luck to you.     There are recommendations on this thread too:  
    • I never worried about cross contamination because i was originally told i was just intolerant. after going gluten free i felt so much better up until this last march. dairy and fructose have been giving me problems but both lactose and fructose test came back negative.  this is what my gi doctor emailed me today 
    • Any place you know of to find more info? Seems like I am still in so much pain/bloat, I am not even sure if I would pick the right 5 foods!
    • Don't freak out worrying about other maladies yet. You would be absolutely amazed at the things that can/will resolve on the gluten free diet. Some take longer than others -- neurological seem to take the longest for most people but really, I guarantee, there will be things you had no idea or expectation of resolving will. There were tons for me and then there were things I sort of "woke up one day" & said, "hey, that's gone and that & that & that". Other, larger things had taken my attention so I hadn't paid attention to the smaller things until...... On the other hand, not everything is related to celiac but I bet you wouldn't find a handful of celiacs who didn't say something very similar to what I said above. Yes, thyroid problems are common with celiac but I'll also tell you there are/have been people on here who were hypothyroid before dx but after being gluten-free for a while they actually went back to normal thyroid numbers. My husband is one (yes, we both are celiac - it happens). He was on synthroid for 20 years or more. Guess what? He's not on it anymore. We've had his thyroid panel done several times since about a year gluten-free & he is no longer hypothyroid. 
    • Yes please, that'd be awesome Having a fun time trying to reply on my phone due to broken screen but will be back on tomorrow after results of doctor appointment to get to the bottom of why they've given me seemingly wrong advice re: next steps. Yup I'll admit to pity, anger, frustration and outright fear, been through the mill of emotions in this first week that's for sure. One thing before I go for that; back when I was self-diagnosing I wanted a full thyroid panel (T3, T4 etc.) and also ESR & CRP checks for vasculitis and similar maladies. Now it seems from my reading they can often follow celiac so my worry level of those has gone up a notch, more blood tests ahoy it seems? Main reason for worrying about those is the nearly constant tight / tender head I have at the moment. Top and sides of scalp. Could be the stress tensing the shoulders and occipital muscles at back of head but after the celiac diagnosis being missed I'm fearful of anything else being missed. Did anyone else have this tight head feeling at the start? Feels like the skin is being pulled inwards, sometimes goes down for a few minutes here and there and gets worse when sitting I think. I see the term "brain fog" a lot but luckily don't seem to have too much of that at present, this is more a physical sensation.
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,656
    • Most Online
      3,093

    Newest Member
    bentcreekmom
    Joined