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Help Understanding Genetic Test Results


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#1 cblack

 
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Posted 07 July 2010 - 06:14 AM

Please, if anyone can help me to understand these test results from genetic testing on my son:

Molecular Analysis of DQA1 Genotype:
0501 (HLA-DQ2) Gluten Sensitivity Positive: Yes

Molecular Analysis of DQB1 Genotype:
0201 (HLA-DQ2) Gluten Sensitivity Positive: Yes
0202 (HLA-DQ2) Gluten Sensitivity Positive: Yes

Genetic Analysis of your HLA-DQ genes reveals that you have three positive gene alleles for gene gluten sensitivity.

We had genetic testing done on him because I was diagnosed with celiac disease three months ago after 13 years of numerous gastro problesm. He doesn't have very many gastro issues other than being lactose intolerant. He does however have issues with gaining weight (very thin but eats like a horse!), brain fog, diagnosed as a child with ADD, canker sores, and fatigue. Based off the genetic testing, would it be prudent to go ahead and find a doctor to do the celiac blood testing panel? Thank you in advance for any help understanding the above genetic numbers! This board has been a blessing!
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#2 Kay DH

 
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Posted 07 July 2010 - 08:24 AM

People with gluten intolerance almost always have the HLA-DQ2 and (or) DQ8 genetic markers. Absence of both of these makers indicated a very low chance of having Celiac or DH. Their presence indicated a greater potential of Celiac than for the general populace. Celiac panel blood test is a very good idea; make sure he is being glutened for some weeks before the test or he can get a false negative. I tested negative on all but my genetic tests (HLA-DQ8), but I was on gluten, and elimination of this nasty molecule cured my GI, mood, stiffness, and other problems. It is a hard choice to go gluten-free and follow the diet, but important to life.
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#3 Korwyn

 
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Posted 07 July 2010 - 09:33 AM

Please, if anyone can help me to understand these test results from genetic testing on my son:

Molecular Analysis of DQA1 Genotype:
0501 (HLA-DQ2) Gluten Sensitivity Positive: Yes

Molecular Analysis of DQB1 Genotype:
0201 (HLA-DQ2) Gluten Sensitivity Positive: Yes
0202 (HLA-DQ2) Gluten Sensitivity Positive: Yes

Genetic Analysis of your HLA-DQ genes reveals that you have three positive gene alleles for gene gluten sensitivity.

We had genetic testing done on him because I was diagnosed with celiac disease three months ago after 13 years of numerous gastro problesm. He doesn't have very many gastro issues other than being lactose intolerant. He does however have issues with gaining weight (very thin but eats like a horse!), brain fog, diagnosed as a child with ADD, canker sores, and fatigue. Based off the genetic testing, would it be prudent to go ahead and find a doctor to do the celiac blood testing panel? Thank you in advance for any help understanding the above genetic numbers! This board has been a blessing!



Just out of curiosity, what company did your testing? I'm looking to get retested to see what is on the DQA and also to validate the other lab I used.
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Undiagnosed for 20 years since first symptoms.
March 2009 - Negative Blood work
April 24, 2009 - Gluten-free
April 29, 2009 - Notably positive response to gluten-free Diet.
May 2, 2009 Dairy Free
May 6, 2009, Soy Free
May 27, 2009 Enterolab Results: Positive Anti-gliadin IgA, tTG IgA, Casein, HLA DQ2.2, HLA DQ8
June 4, 2009 Refined sugar free (except Raw Honey, pure Maple syrup)
June 29, 2009, Dad diagnosed Celiac by GI specialist via blood work and dietary response.
July 2009, Dad's gene test: double DQ8! Thanks Dad - I'll try to get you something nice for Christmas! :)
August 8, 2009 Really Soy free this time - Thanks Blue Diamond for the soy lecithin in the almond milk! :(




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