Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Fructose Malabsorption Is Assocated With Low Tryptophan
0

7 posts in this topic

I suspect there are a few people here with fructose malabsorption, I'm pretty sure I'm one of them. Here's some food for thought...

I have been doing some research, and came across a paper called "Fructose malabsorption is associated with decreased plasma tryptophan" (tryptophan is a precursor to serotonin).

It turns out that *women* diagnosed with fructose malabsorption by breath test were found to have lower levels of tryptophan than those who could absorb the dose of fructose. They also had higher scores on a self report measure of depression. This wasn't the case for men. Men have higher levels of tryptophan than women in general (according to cited papers), which may account for the differences.

They concluded that "high intestinal fructose concentration seems to interfere with L-tryptophan metabolism, and it may reduce availability of tryptophan for the biosynthesis of serotonin (5-hydroxytryptamine)." So, the fructose malabsorption is directly causing depletion of tryptophan, possibly by binding to amino acids and proteins in the bowel.

I just thought it was fascinating, I had no idea to this point that it caused anything other than bloating/gas/gi problems.

Thought some of you might find it interesting too :)

0

Share this post


Link to post
Share on other sites


Ads by Google:

thanku for that- very interesting

FM- check

Depression- check

i feel so much better physically after taking out the major fructose culprits... but still having some trial and error with other fruits & veggies

0

Share this post


Link to post
Share on other sites

Could you please post the full reference? I'd like to read it. Mom has FM and depression and this might help her out!

0

Share this post


Link to post
Share on other sites

Could you please post the full reference? I'd like to read it. Mom has FM and depression and this might help her out!

Fructose Malabsorption is Associated with Decreased Plasma Tryptophan

M. Ledochowski, B. Widner, C. Murr, B. Sperner-Unterweger & D. Fuchs

Scand J Gastroenterol 2001 (4) p 367-71

The abstract and citing articles are free to view.

0

Share this post


Link to post
Share on other sites

Fructose Malabsorption is Associated with Decreased Plasma Tryptophan

M. Ledochowski, B. Widner, C. Murr, B. Sperner-Unterweger & D. Fuchs

Scand J Gastroenterol 2001 (4) p 367-71

The abstract and citing articles are free to view.

Thanks so much. I have full text access. It's a shame nothing more seems to have been done in the last ten years. There is no clear mechanism for the lower tryptophan in this small cohort, and it's not clear whether adding dietary tryptophan might help Mom.

0

Share this post


Link to post
Share on other sites




Thanks so much. I have full text access. It's a shame nothing more seems to have been done in the last ten years. There is no clear mechanism for the lower tryptophan in this small cohort, and it's not clear whether adding dietary tryptophan might help Mom.

I know it's not much to guide any real world treatment, but the possibility that the fructose may bind to proteins or animo acides in the intestines is at least interesting.

It's annoying that there isn't any further follow up, you'd think recruiting a sample of fructose malabsobers, testing their blood levels/depression, then getting half to follow a higher tryptophan diet and repeating the tests wouldn't be too hard a follow up.

Did you read some of the related articles? I read over a few, but I wasn't sure if there were any recommendations about adding in more tryptophan, as my depression thankfully lifted a while after going gluten-free.

0

Share this post


Link to post
Share on other sites

I know it's not much to guide any real world treatment, but the possibility that the fructose may bind to proteins or animo acides in the intestines is at least interesting.

It's annoying that there isn't any further follow up, you'd think recruiting a sample of fructose malabsobers, testing their blood levels/depression, then getting half to follow a higher tryptophan diet and repeating the tests wouldn't be too hard a follow up.

Did you read some of the related articles? I read over a few, but I wasn't sure if there were any recommendations about adding in more tryptophan, as my depression thankfully lifted a while after going gluten-free.

I looked at a couple of the other articles too. When that research was published, supplemental tryptophan was banned because of the EMS, and dietary manipulation in a clinical trial long enough to assess depression would be much more involved than just testing blood levels. It's a shame they didn't follow up when the supplements became available again.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,644
    • Total Posts
      921,579
  • Topics

  • Posts

    • Three years ago I lost about 40kgs (Aussie lol) by better diet & exercise. All was going great til I stopped losing. I upped my exercise but bizarrely started gaining weight. One night a week of not being able to sleep soon became two, then virtually every night with either 1-2hrs tops or none at all. These weird symptoms started about two years ago, becoming worse in say, the last 9mnths. Then I started to get diarrhea. Occasionally then weirdly 2-3 days with multiple occurences then a day or two with nothing, then back to loose & offensive. My GP ran tests, including the TTga (hope that's  right) antibody blood test. Negative so he tells me that's not it. After 9mnths of this he shrugs and says, "I don't know what it is I've run out of ideas what ideas do you have?" Finally refers me to a gastrointerogist.  Private, of course and can't really afford it but we (my fiance and I) go. Stools and blood samples are ordered, basically bye, see you in a month. I have looked my symptoms up and they seem to point to Celiac. Today we went back. I have been having bloated stomach, sore back and limbs,  lovely burps, constant urination and crushing anxiety attacks folowed by depression (which I have never had before in my life). Admitted over the last weekend I didn't sleep for two and a half days and found myself hallucinating and crying to just be able to sleep. Mr fancy pants gastrointerogist says," Hey great news, the stools samples rule out parasites and Crohns!" I tell him how excrutiating the last month has been to which he replies, "It's not Celiac disease, (points at negative blood test results). Celiac doesnt present with diarrhea, anxiety and frquent urination all together." I also had a fecal occult blood test which showed positive & notes say are maybe due to a lower gi bleed, and a ct scan that says shows some damage which, in their words, could be due to a condition such as Celiac disease. He has booked me for a double scope as the next step, has a few ideas what it could be (won't tell me because he doesn't want me to be 'anxious'). Told me to consider that all these symptoms could be me just worrying and being anxious. Told him when this started I was not worried about anything, shrugged and said, It could stil have happened, hey, sometimes we never find out what causes it and your just stuck with diarrhea forever." Then as I was leaving he slapped me on the back and said, "Don't worry so much, see you soon." I need to have the scopes done but is it me or are the things I was told today not true?  I would honestly love it not to be Celiac disease but could he be wrong?
    • Sigh. I totally do love the packs of stretch pants at Costco though...
    • hey, i'm vegetarian and gluten free as well
      have you tried making any recipes with cashew nuts like cashew cheese or pasta sauce? they're really good, easy to make and an excellent way to get more protein/iron
      i can send you some of the easy recipes if you like  
    • Right, fistulas or fissures are usually associated with Crohns, but not celiac.  It is not impossible to have both conditions though.
    • Bravo for being strong enough to bring this topic up.  Depression, anxiety, and other mental or neurological issues are common in celiacs and those with NCGI.  Science is finally catching up to what many of us have already known to be true.   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641836/ I have suffered from anxiety and still have some neuropathies.  At first I blamed menopause (that alone can make you crazy), but my symptoms tend kick in after a Gluten exposure and improve as I heal.   You are not crazy!  Gluten can cause so many problems.  What other disease requires that the patient be in charge of "medicating" and caring for themselves?  Most of us after a diagnosis get a "Well, just avoid gluten.  Lucky you that there are so many restaurants that offer a gluten free menu!", speech from our doctors.  We never get time off from thinking about food, our next meal and will it be safe?  Our relationship with food changes dramatically and it can be exhausting.   We do need more resources and support from medical, but for now, at least this forum is helpful!    
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,651
    • Most Online
      3,093

    Newest Member
    Kricket73
    Joined