Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

This Celiac Testing Confusing
0

8 posts in this topic

Hi

Sometime ago I posted my blood test results as follows

Anti-Gliadin IgG: 4 units - negative

Anti-Gliadin IgA: 31 units - positive

Tissue Transglutaminase Iga: 7 units - negative

Interpretation

0 - 20 Negative

20 - 30 Weak Pos

>30 - Positive

My doctor then sent me off for a biopsy which came back negative. I since have had a follow up with my GP and she stated that medically I'm not cased as a Celiac because of the negative biopsy.

I then asked her why would I test positive for Anti-Gliadin IGA. Is there any other health issue which would make you test positive for the same blood test. She said no, more likely that it was a false positive. (After already reading on this forum, I told her it's rare it's more likely to be a false negative with my biopsy)

She said that the Anti-Gliadin IGA is only 95% specific for celiac while the TTG IGA is 100% specific which I tested negative. I'm confused.........

I have been on my gluten-free diet for 4 weeks now and I just feel pretty much the same. I really didn't have huge symptoms before (slight IBS symptoms, more prominent about 10 years ago) but I was excited to start my gluten-free diet because I thought some symptoms might come alight after years of me thinking it was just normal. But no earth shattering changes. The only thing I have had though is that I haven't have a UTI since being gluten-free, I was getting these at least once a month, so very happy about that.

I'm going to stick to the gluten-free diet for some time yet but I'm confused to know if I actually have celiac's or even a gluten intolerance with my results.. Just want to know for future reference so that I might not need to be as strict on a gluten-free diet, which makes for an easier lifestyle.

Can anyone give me any insight in what you think my results mean?

Thanks

0

Share this post


Link to post
Share on other sites


Ads by Google:

I don't understand the testing.

I thought like you that any postive is positive.

I just want to encourage you on the note of the UTI infections.

I had chronic UTI and bladder spasms for years prior to going gluten free.

5 months into this gluten free, and I have not had one.

It IS related to gluten in my opinion.

Just wanted you to know others with that symptom have said the same thing.

And they get the symptoms of a UTI when glutened. I haven't had that yet.

I would get a second opinion from another Dr. if I were you. Another Dr. may know that any postive is a positive for Celiac.

0

Share this post


Link to post
Share on other sites

Thanks eatmeat4good. I agree I too don't understand the testing and also I thought like you that any postive is positive, so you can see why I'm confused.

That is fantastic to know about other people how also suffered UTI's. The UTI is something I have suffered many times over the years and it has become extremely frustrating.

So if the only phyiscal change I get from going gluten-free is not having any more UTI's, I still be extremely happy. I have been gluten-free now for the 4 weeks & I would of normally had 2 in that period of time.....

0

Share this post


Link to post
Share on other sites

Ok. Just want to say that I'm getting my information from only one source, but here goes.

Gliadin is a protein in gluten. You have tested positive for an antibody to the protein in gluten, which means that your immune system thinks that gluten is like a virus and will attack it.

Testing positive for antibodies to transglutaminase means that your body is attacking itself (i.e. the villi).

So, it seems to me that although you don't have celiac, you DO have gluten intolerance, which is just as important to treat through a gluten-free diet. Being gluten intolerant is no less serious than having celiac. According to the book I read, celiac is just one of many end results of gluten intolerance. You body is reacting to gluten through your immune system. When your immune system is constantly triggered to react (i.e. by eating gluten in your case), you will have chronic inflammation and chronic inflammation can cause a MULTITUDE of problems, from joint pain to lymphoma.

Go read "Healthier Without Wheat." It was a really enlightening book and will answer a lot of the questions you have.

0

Share this post


Link to post
Share on other sites

Thanks Zu888, that makes some sense. So I'm thinking that I'm gluten intolerance because the positive Gliadin antibody in my blood.

Interesting.

Thanks also for the book recommendation I will definitely check it out.

I appreciate your reply. Thankyou

0

Share this post


Link to post
Share on other sites




Amplifying what zus888 said:

What It Is

A tissue transglutaminase IgA and/or IgG test is used as part of an evaluation for certain autoimmune conditions, most notably celiac disease.

An autoimmune disease can occur when the body's immune system mistakenly perceives a nonthreatening substance

1

Share this post


Link to post
Share on other sites

Just thought I would post an update. After the suggestion from Zu888 (thank you for that), I have read the book Healthier without Wheat and it really has confirmed in my mind I am not Celiac Disease but I do have non-celiac gluten intolerance.

The only thing that I tested positive for was Anti-gliadin IGA, everything else was negative including the biopsy..

As per the book it states

"Gliadin is a type of gluten. When the immune system attacks gluten, it produces gliadin antitbodies. If you have gliadin antibodies, then it is apparent that your immune system has interpreted that gluten is not food; it is a foreign invader that must be eliminated from the body. It attacks any gluten you eat. If either your IgA or IgG gliadin antibody test is positive, then you have a strong immune reaction to gluten and thus a gluten intolerance".

This book was great and thanks again for the recommendation Zu888, it really gave me such a better understanding of my condition and I can confidently say that I have non-celiac gluten intolerance. Which basically has the same lifestyle outcome as Celiac, gluten free diet for life...

0

Share this post


Link to post
Share on other sites

If you listen to Dr. O'Bryan in this podcast, you'll hear him say that only 50% of celiacs react to Transglutaminase, the other 50% react to another protein. You may still be positive and have a negative Transglutaminase result.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      103,342
    • Total Posts
      917,394
  • Topics

  • Posts

    • Weird Reaction
      Thank  you Flowerqueen and Cristiana for your replies. I'm actually feeling much better today. I got my appetite back yesterday lunchtime (a few hours after I typed the original post) and managed to keep in/hold down some chicken and lettuce!!! I also had a "fat" coffee (as I call it) before work with MCT Oil and butter (your probably going "yuk" right now but it's really nice...really haha) and started feeling a bit better after that. The nausea went away almost immediately after that although just the thought of having all that fat nearly made me sick but I just wanted to get back to normal asap. I usually have a lot of fat in my diet anyway which is normal for me so the coffee choice isn't unusual. Plus it was also the third day which was when I started feeling better after the first time. I didn't eat til lunchtime and I was good and hungry by then so I knew I was coming out of it. That nausea and trembling feeling is something I don't want ever again. I think after the workout and tearing down muscle tissue (which is a form of stress) and then not being able to hold the nutrients in for repair affected my nervous system. My theory only but to me it makes sense. Although Vitargo also comes in flavors I always get the Natural / Unflavored one so the barley is the only ingredient. As for there being something wrong with that particular batch, well, you be on to something there. Also I'm not knocking the product because as I said, I have used it before and it did exactly what it was supposed to do. But, I will never have it again. Cristiana, my last blood test revealed I had slight anaemia which really surprised me with the amount of red meat I've eaten during my life and the anxiety thing is also new as I'm usually a happy, positive person. Life is good but after this recent reaction I think it is an indirect cause of the glutening. I'm also surprised at how sensitive I've become to it and how quickly. Also what is DX? I also follow a FODMAP eating plan (I can give you more info if you haven't heard of it) which also eliminates certain foods. It's a plan directed mostly at IBS but is well worth looking into if you are suffering any gut health, digestion issues or any ailment you may have which you can't get to the bottom of. Broccoli was one of the foods which I have cut back on and I've eaten HUGE amounts of broccoli so it is a superfood for some but apparently not for others. (I even think I read somewhere it has MSG naturally in it) It's hard to find any bad articles on broccoli so this also really surprised me. It also answered a few other questions I had. Many, many thanks again to you both for your replies. It actually settled me just reading them. I'm glad I found these forums so I don't think i'll be a stranger around here for long.   Richard
    • Confused
      Okay, I get that you are not going to follow the advice from some stranger on the internet, but please read the links that I gave you.  Your doctor is not following the standard level of care.  I am dead serious.  I have Kaiser.  My own GP doesn't have a clue about celiac disease, but my Kaiser GI does.  Please, I urge you to get properly diagnosed.  All celiac testing requires you to be on a gluten diet.  If you go gluten free even for two weeks (it will take time to get the referral and appointment), it will mess up the tests.  Your GI will put you back on a gluten diet (called a gluten challenge) for 8 to 12 weeks.    Chances are (almost 100%) you will feel more miserable!  That will just delay your diagnosis.   Symptoms not bad you say?  I had pretty severe anemia, but no tummy issues.  Two months after my diagnosis, I fractured my back DOING NOTHING!  Yep, I have osteoporosis from undiagnosed celiac disease and I am an athlete!   Please take this seriously!    
    • Silent Celiac or Non-digestive symptoms
      Oh, you might learn how to tell if you had been glutened.  I just had anemia as my main symptom.  I did not have any tummy issues at all.  I was in shock when my doctor even suggested testing me for celiac disease!   Glutenings can vary as we are all different.  For some it is just a few days, others a few weeks and others months (that would be me).  My last official glutening as supported by follow-up antibody testing lasted for three months.  Guess what?  I had vomiting, abdominal pain, the works!  Funny how celiac disease can change and evolve over time.   Welcome to the forum!  Have some patience and learn all that you can.  The good news is that you can feel better and no medications are required!  
    • Confused
      Thank you for the information. I've been not sure if I should eat gluten or not right now. Dr. said I should watch what I eat when I emailed him the question. My symptoms aren't very bad (I understand that doesn't matter for celiac disease), so I can definitley tolerate the food. But I have been starving myself the last few days due to not knowing what the heck is going on. Thanks again.
    • Could this possibly be related to celiac or a gluten intolerance?
      If you did actually have celiac disease, it can take weeks, months and years to recover from some of your symptoms, especially neurological ones.   Best to get screened for celiac disease.  It's a simple blood test.  Any medical doctor can do it.  But a GI doctor is needed for a diagnosis, since an endoscopy is part of the diagnostic procedure.  BUT you have to be consuming gluten to get accurate results! http://www.cureceliacdisease.org/screening/ http://gi.org/guideline/diagnosis-and-management-of-celiac-disease/ Keep on researching.  I wish you well!    
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

    • ChiaChick  »  Peaceflower

      Hi Peaceflower, Just wanted to say thank you for the chat.
      · 0 replies
    • ukuleleerika

      Hello! I am new to this Celiac website... Is there anyone out there with Celiac AND extensive food allergies? My allergies include shellfish, dairy, eggs, cantaloupe, kiwi, mango, nuts, oranges, red dye, and more I can't think of. I went to the allergist about a year ago to see why I wasn't feeling well, and once everything was eliminated, I still didn't feel well. We did more testing to find out I had celiac as well as allergies to cattle as well as rye grass (I live on a farm basically). This was back in January 2016. I recently had my endoscopy with the gastroenterologist a week ago. I have no idea what to do or what to eat... So fish and potatoes for me!
      · 2 replies
    • SLLRunner

      Week 4 of the gluten challenge- wheat cereal every morning, regular bread every day, and wheat tortillas for my lunch wraps. Right now, body aches that seem exercise related (weight lifting and running), even though I am doing the same intensity of weight lifting and running I've always done.  Just a few more weeks until my blood test. Counting down the days.
      · 0 replies
  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      60,477
    • Most Online
      1,763

    Newest Member
    Andrew Miller
    Joined