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Celiac Disease Vaccine Shows Promising Results in Phase I Trial - Science Daily (press release)
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Celiac Disease Vaccine Shows Promising Results in Phase I Trial

Science Daily (press release)

ScienceDaily (May 8, 2011) — The world's first potential vaccine for celiac disease has shown promising results for treating celiac disease in a Phase I clinical trial and is expected to move to Phase II trials within the next year. ...

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I'm having difficulty understanding this--how can they make a vaccine when Celiac is not caused by a virus? Also will this help those that already have active celiac or only possibly prevent it from presenting in those with the most common genes? If it works, will they withhold it from people that are not formally diagnosed? And what are the risks? I think I will stick with just eating a mostly whole food gluten-free diet instead....

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I'm having difficulty understanding this--how can they make a vaccine when Celiac is not caused by a virus? Also will this help those that already have active celiac or only possibly prevent it from presenting in those with the most common genes? If it works, will they withhold it from people that are not formally diagnosed? And what are the risks? I think I will stick with just eating a mostly whole food gluten-free diet instead....

Makes you wonder huh? Kind of like the vaccine for cervical cancer? Hmmm....Who knows? I know they are trying things for diabetes too though. Weird. Don't get it. Would it really work? I guess we'll see.

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Makes you wonder huh? Kind of like the vaccine for cervical cancer? Hmmm....Who knows? I know they are trying things for diabetes too though. Weird. Don't get it. Would it really work? I guess we'll see.

It does make one wonder. The vaccine for cervical cancer is a vaccine for the HPV virus. Or rather for a couple of the strains of the HPV as there are more than just one. It is thought that the HPV virus is a contributing factor in the development of cervical cancer. It is however not the only cause of cervical cancer and selling it as a cancer 'vaccine' is IMHO kind of dishonest use by big pharma of a scare factor to sell more of the vaccine.

Since celiac is not a virus I also wonder how they are going to develop a vaccine for it and if they do what will be the side effects. It seems to me that money would be better spent in trying to develop more sensitive tests for celiac and educational programs for doctors and the general population. It is Celiac Disease Awareness Month, or is it? I know I haven't seen any news blurbs about it.

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It sounds to me to be similar to those de-sensitizing trials they do with some peanut allergy sufferers. They give the patient a minute amount of peanut, and gradually up the dosage until the body is used to it and more and more can be tolerated. With this, it sounds like they've found a way to gradually de-sensitize patients to gluten.

From the article, I wonder whether people would have to do these shots all the time? It mentions a once-weekly shot for three weeks... If that's the case, staying gluten free might be preferable! Also - it only mentions that it'll work for 90% of DQ2 people - nothing about DQ8 markers or those who are 'just' gluten intolerant.

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It sounds to me to be similar to those de-sensitizing trials they do with some peanut allergy sufferers. They give the patient a minute amount of peanut, and gradually up the dosage until the body is used to it and more and more can be tolerated. With this, it sounds like they've found a way to gradually de-sensitize patients to gluten.

From the article, I wonder whether people would have to do these shots all the time? It mentions a once-weekly shot for three weeks... If that's the case, staying gluten free might be preferable! Also - it only mentions that it'll work for 90% of DQ2 people - nothing about DQ8 markers or those who are 'just' gluten intolerant.

Not to mention that even if they successfully reintroduce gluten without negative reactions this study has no way of predicting the long term effects. Drs used to think that kids outgrew celiac disease, now they know differently and for the kids that were told they outgrew it and then later had worse symptoms the consequences to their heatth could be great if they don't realize they need to go gluten free again. IMO, eating gltuen without any short-term consequences is not worth the risk of the long term developments like cancer.

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Even if it does work it wouldn't help me with my avenin sensitivity...

"In our Phase I trial, we saw a Nexvax2®-specific T-cell response that confirms the desired bioactivity in HLA-DQ2 genotype patients," Dr Anderson said. "We expect the vaccine to enter Phase II trials within the next 10 months, and hope to demonstrate a dramatic reduction in the body's rejection of dietary gluten so patients can resume a normal diet and return to good health."

I really didn't like the last sentence. Gluten free diet can in most cases return people to good health also. It also stated that it is to have a reduction in reactions. So does that mean on some level there is autoimmunity still going on? I don't miss gluten filled food that bad.

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It seems to me that money would be better spent in trying to develop more sensitive tests for celiac and educational programs for doctors and the general population. It is Celiac Disease Awareness Month, or is it? I know I haven't seen any news blurbs about it.

I agree but then there would not be any money in it for the pharmaceutical companys would there. :angry:

The treatment for celiacs is a gluten free diet,the pharmaceutical companies can not make money off of that so, IMHO, celiacs does NOT get their support(money for research,better testing ,awareness campaigns,ect... ), instead they opt for something they can make money off of ( a vaccine )instead of what is in the best interest of the general population (awareness,better testing,information )

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I really didn't like the last sentence. Gluten free diet can in most cases return people to good health also. It also stated that it is to have a reduction in reactions. So does that mean on some level there is autoimmunity still going on? I don't miss gluten filled food that bad.

I don't like the last sentence either.

As for why they are developing the vaccine, they make that quite clear on their website:

"It has been predicted that 50-60% of affected patients will be diagnosed in developed countries by 2019, creating a potential pharmaceutical market worth US$8 billion."

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"The drug triggers the death of the cells that cause the damaging immune response,'' he said. ''By doing that you switch the immune reaction from a damaging one to a tolerant one.''"

I also wonder what else this affects if cells which are a normal part of our immune response are killed. What else are these cells responsible for (long term)? Its like taking out the squeaky hinge.. and then finding out the door falls off.

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I agree with those who are skeptical. The vaccine wouldn't be for me anyway because I'm not DQ2. But either way, knowing what I now know about nutrition and our food system, even if I could eat gluten and processed foods and everything else, I still wouldn't. Even if they can guarantee zero autoimmune response and no other consequences from the vaccine, that doesn't mean there aren't plenty of other health consequences to eating a "normal" diet again. I think of celiac as forcing me back to a healthy, natural human diet, and away from the food system that is making people sick, celiac or otherwise. The vaccine is just feeding into the mentality that we should be fitted to the system, instead of the system being fitted to us. It makes a lot of dollars, but not a lot of sense.

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These are some of the new stories thta have appeared in Australia leading up to this latest announcement:

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And these just got posted up on Youtube:

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    • I figured I would update those who were wondering.  I have gotten the appt. so far moved up to August 30. I am waiting to have gene testing done via swab for all 3 of my kiddos tomorrow. My daughters celiac antibodies came up negative but her IgA is low which the ped said could cause false negative antibodies for celiac so she will need to see a GI dr. also. The pediatrician is going to call the GI to try to get them in sooner. I am keeping them all on a gluten diet until the GI dr. decides what to do. I am on the cancellation list already for my son, however I am not going to be persistent with my phone calls to them until I have the results of the gene test. I really want that result in my hand before going to the GI dr if I can. Maybe if he is positive, along with his bloodwork and my history they can forgo the endoscopy. But he will eat gluten till then.  My husband and I have been very honest and upfront with him as to what is going on and the possibility of the endoscopy and what that entails and although scared in general he seems ok after assuring him that since I have it he has me to help him every step of the way.  Going through his current diet with him I realized that he is truly on such a low gluten diet that I am actually surprised his bloodwork shows antibodies at all!  So I told him to make a list of allllll the gluten he could possibly think of eating and he needs to pound it until the GI visit or endoscopy. Funny thing is everything he keeps thinking of to want to eat...is already gluten free!  The other night we were at a friends and he asked if he could be done with his hotdog. I made him finish just the bread 😂 Thanks for your help and advise and I will keep y'all posted on both kids!  My oldest is a ok as far as all his antibodies. Just actually had a follow up for other immune issues and all his levels are now normal!
    • I like your plan Cara, I may have to include it in my sons.    Poor little guy is still very very sick. I think he is resisting and cheating, despite having the support of two other siblings and a 100% gluten-free home. 
    • Despite it being a nightmare, I did wait for my kids to get biopsies. At one point I had one severely ill child gluten-free and two more waiting having to eat it. It was worth the wait though and I think long term a biopsy may be worthwhile, especially for school. I have already had issues with schools and camps so having a firm diagnosis has been helpful. 
    • Knowing that the reaction to gluten in celiacs is an uncalled for immune system reaction, I was thinking of how a cure would be possible. Maybe a medicine that somehow turns off the immune system. The only thing that i've heard do that... HIV.  obviously that's way worse than celiac. Just some food for thought.
    • Well, you can probably get an apple or something.  You might be able to get someone to boil you some eggs.  But be careful of things like nuts that should be naturally gluten free.  They have almost always been soaked in a flavor solution that usually containes caramel coloring, "soy" (wheat) sauce and other aditives.  If I am really hungry and must eat in a Chinese restaurant, I order plain white rice and steamed vegetables.  But even so, you must monitor it carefully.  The rice sometimes has other substances added to give it a better texture, and very often the vegetables have in fact had "just a little bit" of soy sauce added.  To be fair, celiac disease is hardly ever found in East Asians, so understandably people are not tuned it to it.  Also, culturally, with the exception of fruits, it is generally thought that the flavor of foods needs to be enhanced, so it is had to find anything natural even in the "western" gorceries. Even in the western restaurants, be careful.  Fish and meat and often vegetables are usually pre-marinated. I will not even attempt to address the issue of cross-comtamination, since that is a whole higher order of things. I do know what I am talking about; I have celiac and have worked here for nearly 7 years.  
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