Posted 11 May 2011 - 06:14 PM
Posted 11 May 2011 - 07:43 PM
They have completed a phase IIb trial which studies the efficacy of the drug although they don't appear to have released the results. And there's some stuff going on with another company:
and there's an article on this website:
A new drug called Larazotide Acetate, has been called 'revolutionary' to the celiac and gluten sensitive community, and may be what celiacs need to live a more normal life. While it is not a cure, Larazotide Acetate has been proven in clinical trials to greatly reduce the negative reactions celiacs have with gluten. Clinical test patients displayed a decrease in intestinal damage, from 50% to 15%, when ingesting gluten after taking Larazotide Acetate.
and there's more news:
larazotide acetate (formerly AT1001), at an earlier stage of development, managed to capture $25 million up front in a potential $325 million ex-U.S. deal with Shire plc in 2007. Shire also was to have picked up half of the product's global development costs and shoulder its share of a Phase III program. (See BioWorld Today, Dec. 17, 2007.)
But the Shire partnership "was dissolved about a year ago," a Cephalon spokesperson told BioWorld Today.
No reason for the termination of that deal was given, but it could have stemmed from mixed Phase II data. Cephalon CEO Kevin Buchi told investors on the firm's earnings call that the earlier Phase II results had shown a "signal of efficacy" for Alba's drug, but the endpoint used might not have been adequate for use in celiac patients.
The new Phase IIb study, set to start this year, will use a different endpoint, he said, though he did not disclose what that endpoint might be.
I'd say it's not looking terribly promising.
Posted 11 May 2011 - 08:35 PM
Posted 11 May 2011 - 10:53 PM
And knowing that EVERY MEDICATION has a side effect...
I wouldn't bother with it.
Before I went gluten-free I had vitamin deficiencies & frequent illness. Gluten was destroying my ability to absorb nutrition and it was KILLING me. Literally.
There isn't one thing in the world I want to put in my mouth so badly that I will risk all of that again. For only 50% improvement, at best? So my intestines would only be 50% destroyed? No way.
And I'm wondering how long before they discover the side effect is pancreatic cancer, or dementia, or your teeth falling out, or something equally fun.
Posted 12 May 2011 - 03:15 AM
"I will try again tommorrow" (Mary Anne Radmacher)
celiac 49 years - Misdiagnosed for 45
Blood tested and repeatedly negative
Diagnosed by Allergist with elimination diet and diagnosis confirmed by GI in 2002
Misdiagnoses for 15 years were IBS-D, ataxia, migraines, anxiety, depression, fibromyalgia, parathesias, arthritis, livedo reticularis, hairloss, premature menopause, osteoporosis, kidney damage, diverticulosis, prediabetes and ulcers, dermatitis herpeformis
All bold resoved or went into remission with proper diagnosis of Celiac November 2002
Some residual nerve damage remains as of 2006- this has continued to resolve after eliminating soy in 2007
Mother died of celiac related cancer at 56
Twin brother died as a result of autoimmune liver destruction at age 15
Children 2 with Ulcers, GERD, Depression, , 1 with DH, 1 with severe growth stunting (male adult 5 feet)both finally diagnosed Celiac through blood testing and 1 with endo 6 months after Mom
Positive to Soy and Casien also Aug 2007
Gluten Sensitivity Gene Test Aug 2007
HLA-DQB1 Molecular analysis, Allele 1 0303
HLA-DQB1 Molecular analysis, Allele 2 0303
Serologic equivalent: HLA-DQ 3,3 (Subtype 9,9)
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