Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

My Enterolab Results
0

13 posts in this topic

I finally got my results back.

The results of my gene test were:

HLA-DQB1 Molecular analysis, Allele 1 0302

HLA-DQB1 Molecular analysis, Allele 2 0301

Serologic eqivalent: HLA-DQ 3,3 (Subtype 8,7)

My fecal IgA was positive for gluten and eggs.

I'm curious about the gene stuff. Can someone who is smarter than me tell me what it means?

0

Share this post


Link to post
Share on other sites


Ads by Google:

I finally got my results back.

The results of my gene test were:

HLA-DQB1 Molecular analysis, Allele 1 0302

HLA-DQB1 Molecular analysis, Allele 2 0301

Serologic eqivalent: HLA-DQ 3,3 (Subtype 8,7)

My fecal IgA was positive for gluten and eggs.

I'm curious about the gene stuff. Can someone who is smarter than me tell me what it means?

Usually Enterolab results include an interpretation and recommendations. What did Elab say about your results? If you paid money for those tests, you may just as well trust their interpretation and recommendations.

0

Share this post


Link to post
Share on other sites

I did read what it means. It said that I have one of the main genes that predisposes to gluten sensitivity and celiac sprue. It also said I have a non-celiac gene predisposing to gluten sensitivity.

I guess I was just curious if anyone knew more about the specific genes I have, but it doesn't matter too much.

This might be a stupid question...but why exactly do I feel so bad when my results don't look very serious? My anti-gliadin IgA is 14 units (normal is <10). And my anti-ovalbumin Iga is at 17 units (normal range is less than 10 units). I probably shpuld be glad that it's not serious yet, but it feels really serious to me. My symptoms are primarily mental (I've had brain fog and depressive ADD since as long as I can remember), and around punerty I became nervous, brain fog increased, and I pretty much lost enjoyment of everything. It's made life hard for me for the last 5-7 years.

I guess I was wondering if there is any other testing I should look into? I read somewhere on here that having low total IgA can give the IgA results a false negative. I've just felt off for so long. Should I look into IgG testing for gluten as well? I want a definitive diagnosis if gluten is a problem for me.

0

Share this post


Link to post
Share on other sites

I did read what it means. It said that I have one of the main genes that predisposes to gluten sensitivity and celiac sprue. It also said I have a non-celiac gene predisposing to gluten sensitivity.

I guess I was just curious if anyone knew more about the specific genes I have, but it doesn't matter too much.

u have a DQ8 and a DQ7. (that's their simply subtype name- which i understand better).

the DQ8 is a Celiac-specific gene, doesnt necessarily mean u will have Celiac- but you definitely have a gene for it, so it's possible. (DQ2 is the other "specific" gene).

your DQ7 is a "Gluten sensitive" gene... predisposes u to gluten sensitivity or intolerance. **but keep in mind, this is still just the tip of the iceberg. in Europe they are already diagnosing Celiacs who do not have the DQ2 or DQ8, but the other numbers - perhaps even a DQ7.

thats all i know... it's been a while since i paid attention on here, and understand the fecal tests at Enterolab.

0

Share this post


Link to post
Share on other sites

I did read what it means. It said that I have one of the main genes that predisposes to gluten sensitivity and celiac sprue. It also said I have a non-celiac gene predisposing to gluten sensitivity.

I guess I was just curious if anyone knew more about the specific genes I have, but it doesn't matter too much.

This might be a stupid question...but why exactly do I feel so bad when my results don't look very serious? My anti-gliadin IgA is 14 units (normal is <10). And my anti-ovalbumin Iga is at 17 units (normal range is less than 10 units). I probably shpuld be glad that it's not serious yet, but it feels really serious to me. My symptoms are primarily mental (I've had brain fog and depressive ADD since as long as I can remember), and around punerty I became nervous, brain fog increased, and I pretty much lost enjoyment of everything. It's made life hard for me for the last 5-7 years.

I guess I was wondering if there is any other testing I should look into? I read somewhere on here that having low total IgA can give the IgA results a false negative. I've just felt off for so long. Should I look into IgG testing for gluten as well? I want a definitive diagnosis if gluten is a problem for me.

Enterolab testing is not particularly reliable. Fine's own data show that the test is not very predictive of how you will feel gluten-free. You have borderline results on a borderline test.

Assuming you've had a celiac panel blood test through your doctor, the definitive test is to go off gluten and see how you feel. The celiac panel should have included total IgA and if you are low, the IgG versions of anti-TTG and probably anti-gliadin. Anti-gliadin is older, but preferable if your problems are primarily neurological/mental. As far as non-celiac gluten intolerance, there is no diagnostic test other than eliminating gluten from your diet and then challenging later. You need to abandon your search for a piece of paper that tells you what to do and simply trust your body and how you feel. There is nothing more definitive than recovering your health off gluten.

You have the DQ8 (DQB1*0302) gene, which is associated with celiac. It does give some reason why you might be gluten intolerant. DQ7 (DQB1*0301) is an interesting one, as you can sometimes have the celiac gene, DQA1*0505 with it. Problem is, Enterolab only tests B subunits and not A and the non-celiac DQA1*0303 is also reasonably common with DQ7. There is no way for you to know without a more detailed genetic analysis. It's not worth wasting money, as the genetic tests are in no way diagnostic; they only asses risk.

0

Share this post


Link to post
Share on other sites




Enterolab testing is not particularly reliable. Fine's own data show that the test is not very predictive of how you will feel gluten-free. You have borderline results on a borderline test.

Assuming you've had a celiac panel blood test through your doctor, the definitive test is to go off gluten and see how you feel. The celiac panel should have included total IgA and if you are low, the IgG versions of anti-TTG and probably anti-gliadin. Anti-gliadin is older, but preferable if your problems are primarily neurological/mental. As far as non-celiac gluten intolerance, there is no diagnostic test other than eliminating gluten from your diet and then challenging later. You need to abandon your search for a piece of paper that tells you what to do and simply trust your body and how you feel. There is nothing more definitive than recovering your health off gluten.

You have the DQ8 (DQB1*0302) gene, which is associated with celiac. It does give some reason why you might be gluten intolerant. DQ7 (DQB1*0301) is an interesting one, as you can sometimes have the celiac gene, DQA1*0505 with it. Problem is, Enterolab only tests B subunits and not A and the non-celiac DQA1*0303 is also reasonably common with DQ7. There is no way for you to know without a more detailed genetic analysis. It's not worth wasting money, as the genetic tests are in no way diagnostic; they only asses risk.

We have a lot in common. I'm also taking the EmpowerPlus supplement. Although it's expensive, I'll probably only try one bottle. I also have hashimoto's but my Frees are still in the normal range. I'm curious if I have thyroglobulin antibodies as well, since I have a great aunt who had graves and got a thyroidectomy in her 50's. I know I should just bit the bullet and try gluten-free. I'm planning on doing it in the near future. I never had the Celiac panel done. I'm hoping my doctor could order it.

0

Share this post


Link to post
Share on other sites

We have a lot in common. I'm also taking the EmpowerPlus supplement. Although it's expensive, I'll probably only try one bottle. I also have hashimoto's but my Frees are still in the normal range. I'm curious if I have thyroglobulin antibodies as well, since I have a great aunt who had graves and got a thyroidectomy in her 50's. I know I should just bit the bullet and try gluten-free. I'm planning on doing it in the near future. I never had the Celiac panel done. I'm hoping my doctor could order it.

Your doctor can order it. Don't go gluten-free until you've had the bloodwork. I'd be surprised if it comes up positive with the low Enterolab results though. Just remember that you can be very sick from gluten without much in the way of antibodies. In some people it has a natural inflammatory action that causes a lot of havoc.

I'm sorry to say, but most people can't evaluate EMPowerPlus with one bottle. If you're trying to treat bipolar, you need to be on the loading dose (15/day) for three months to really get an idea of whether EMPowerPlus works for you. You also may go through a time of feeling worse before you feel better. TrueHope will explain all this if you talk to someone at the call center, and they carry the probiotics, free aminos, phosphatidyl serine, and mild yeast treatments that help you get through the rough spots. I started on it in mid-June, and all hell broke loose in July with detox and yeast. I started to improve overall in August, and I finally felt really good with normal mood in September. I understand the cost issues, but you just can't get an idea in two weeks, especially if you are taking it below the loading dose.

0

Share this post


Link to post
Share on other sites

Enterolab testing is not particularly reliable. Fine's own data show that the test is not very predictive of how you will feel gluten-free. You have borderline results on a borderline test.

What research tells you that? I didn't think there was any research that predicts how you will feel after gluten free. "How you feel" is very subjective. Changes in intestinal villae and presence of gluten antibodies and/or Ttg antibodies are measureable. "How you feel" (except by psychological battery) isn't measurable.

0

Share this post


Link to post
Share on other sites

What research tells you that? I didn't think there was any research that predicts how you will feel after gluten free. "How you feel" is very subjective. Changes in intestinal villae and presence of gluten antibodies and/or Ttg antibodies are measureable. "How you feel" (except by psychological battery) isn't measurable.

It's right on his website. Perhaps you should take a look?

0

Share this post


Link to post
Share on other sites

It's right on his website.

Now I'm confused ... I agree that Elab's stool test doesn't predict how you feel after going gluten free. However, I don't believe ANY test (blood test, endoscopy, etc.) can predict how you will feel after abstaining from gluten. "How you feel" is subjective. Also, people (like me) may have other allergies (or intolerances) or even gastrointestinal infections from bacteria, parasites and/or candida, which can affect how they feel. I went through many tests and treatments before my IBS symptoms completely resolved. Gluten free was just the first step for me. Nevertheless, Elab tests show the presence of gluten and Ttg antibodies, which is similar to standard blood tests, which show antibodies. For many people, who don't want to return to eating gluten just so they can damage their intestines enough to let gluten antibodies leak into their blood stream, Elab stool tests are a viable, noninvasive alternative.

1

Share this post


Link to post
Share on other sites

Now I'm confused ... I agree that Elab's stool test doesn't predict how you feel after going gluten free. However, I don't believe ANY test (blood test, endoscopy, etc.) can predict how you will feel after abstaining from gluten. "How you feel" is subjective. Also, people (like me) may have other allergies (or intolerances) or even gastrointestinal infections from bacteria, parasites and/or candida, which can affect how they feel. I went through many tests and treatments before my IBS symptoms completely resolved. Gluten free was just the first step for me. Nevertheless, Elab tests show the presence of gluten and Ttg antibodies, which is similar to standard blood tests, which show antibodies. For many people, who don't want to return to eating gluten just so they can damage their intestines enough to let gluten antibodies leak into their blood stream, Elab stool tests are a viable, noninvasive alternative.

You are making the assumption that small amounts of fecal anti-gliadin are meaningful. I don't believe any research has proven that or even come close. To the contrary, published studies suggest that only very high measurements are meaningful. Fine has his cutoff set far too low.

http://www.ncbi.nlm.nih.gov/pubmed/16377644

I had another study where the authors suggested that fecal anti-gliadin comes and goes, but I'm sick and I can't find it right now. They suggested small amounts of fecal anti-gliadin IgA are a normal immune function. (Fine's data suggest that too, since he gets it in so many gluten tolerant people.)

Anti-TTG is more worrisome, but but the whole reason Fine developed that test was to find microscopic colitis, not celiac. Fecal anti-TTG comes up in any bowel disease where there is inflammation, including infection, Crohn's, or microscopic colitis. Fecal anti-EMA is diagnostic of celiac, but that test would not be practical for Enterolab becasue it's done manually. So, you can have small amounts of fecal anti-gliadin no matter what, and anti-TTG from just about anything that damages the intestine. This is not necessarily diagnostic of celiac and the one certain test, anti-EMA, is not available at Enterolab. If your anti-gliadin is well above Fine's ridiculously low reference range and you have anti-TTG, yes, you need a celiac workup. If your results are borderline, it's anyone's guess what's going on.

As far as wellbeing, are you really going to tell me that if you ask 100 people "do you feel better gluten-free, yes, no, or maybe"? you will not get a useful metric? Give me a break. People know when they feel better and you don't need a sophisticated QOL measure to capture it. That fallacy of thinking you need to quantitate well-being has lead to insanity like endocrinologists treating people with only T4. Funny, when someone asked "Which did you prefer, treatment 1 or treatment 2" in a double-blinded, crossover trial with T3/T4 and T4 you get the answer you would expect - people preferred T3/T4 over T4. QOL measures were not different, nor was Hamilton. (Turns out there is one item on HDI that does come out different for folks on T3.) These measures are broken, in dangerous ways.

0

Share this post


Link to post
Share on other sites

As far as wellbeing, are you really going to tell me that if you ask 100 people "do you feel better gluten-free, yes, no, or maybe"? you will not get a useful metric? Give me a break. People know when they feel better and you don't need a sophisticated QOL measure to capture it. That fallacy of thinking you need to quantitate well-being has lead to insanity like endocrinologists treating people with only T4. Funny, when someone asked "Which did you prefer, treatment 1 or treatment 2" in a double-blinded, crossover trial with T3/T4 and T4 you get the answer you would expect - people preferred T3/T4 over T4. QOL measures were not different, nor was Hamilton. (Turns out there is one item on HDI that does come out different for folks on T3.) These measures are broken, in dangerous ways.

I never said you can't quantify well-being. Plenty of psychological tests already do that. I just responded to your comment that Enterolab tests couldn't predict how you will feel after going off gluten. Elab considers the contents of stool samples and DNA swabs. They don't use psychological tests to predict well-being. So Elab tests as well as blood tests and endoscopies can't predict how people feel after going off gluten. However, all those tests are still helpful to persuade people with IBS symptoms to abstain from gluten.

However, I do like your example concerning T3/T4 preference. Many people don't easily convert T4 to T3 (which the cells utilize). So they need T3 as well as T4. However, medical practices are very slow to change. Despite evidence to the contrary doctors very slowly accept new ideas. SIGH ...

0

Share this post


Link to post
Share on other sites

SIGH is right!

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,116
    • Total Posts
      919,451
  • Topics

  • Posts

    • I figured I would update those who were wondering.  I have gotten the appt. so far moved up to August 30. I am waiting to have gene testing done via swab for all 3 of my kiddos tomorrow. My daughters celiac antibodies came up negative but her IgA is low which the ped said could cause false negative antibodies for celiac so she will need to see a GI dr. also. The pediatrician is going to call the GI to try to get them in sooner. I am keeping them all on a gluten diet until the GI dr. decides what to do. I am on the cancellation list already for my son, however I am not going to be persistent with my phone calls to them until I have the results of the gene test. I really want that result in my hand before going to the GI dr if I can. Maybe if he is positive, along with his bloodwork and my history they can forgo the endoscopy. But he will eat gluten till then.  My husband and I have been very honest and upfront with him as to what is going on and the possibility of the endoscopy and what that entails and although scared in general he seems ok after assuring him that since I have it he has me to help him every step of the way.  Going through his current diet with him I realized that he is truly on such a low gluten diet that I am actually surprised his bloodwork shows antibodies at all!  So I told him to make a list of allllll the gluten he could possibly think of eating and he needs to pound it until the GI visit or endoscopy. Funny thing is everything he keeps thinking of to want to eat...is already gluten free!  The other night we were at a friends and he asked if he could be done with his hotdog. I made him finish just the bread 😂 Thanks for your help and advise and I will keep y'all posted on both kids!  My oldest is a ok as far as all his antibodies. Just actually had a follow up for other immune issues and all his levels are now normal!
    • I like your plan Cara, I may have to include it in my sons.    Poor little guy is still very very sick. I think he is resisting and cheating, despite having the support of two other siblings and a 100% gluten-free home. 
    • Despite it being a nightmare, I did wait for my kids to get biopsies. At one point I had one severely ill child gluten-free and two more waiting having to eat it. It was worth the wait though and I think long term a biopsy may be worthwhile, especially for school. I have already had issues with schools and camps so having a firm diagnosis has been helpful. 
    • Knowing that the reaction to gluten in celiacs is an uncalled for immune system reaction, I was thinking of how a cure would be possible. Maybe a medicine that somehow turns off the immune system. The only thing that i've heard do that... HIV.  obviously that's way worse than celiac. Just some food for thought.
    • Well, you can probably get an apple or something.  You might be able to get someone to boil you some eggs.  But be careful of things like nuts that should be naturally gluten free.  They have almost always been soaked in a flavor solution that usually containes caramel coloring, "soy" (wheat) sauce and other aditives.  If I am really hungry and must eat in a Chinese restaurant, I order plain white rice and steamed vegetables.  But even so, you must monitor it carefully.  The rice sometimes has other substances added to give it a better texture, and very often the vegetables have in fact had "just a little bit" of soy sauce added.  To be fair, celiac disease is hardly ever found in East Asians, so understandably people are not tuned it to it.  Also, culturally, with the exception of fruits, it is generally thought that the flavor of foods needs to be enhanced, so it is had to find anything natural even in the "western" gorceries. Even in the western restaurants, be careful.  Fish and meat and often vegetables are usually pre-marinated. I will not even attempt to address the issue of cross-comtamination, since that is a whole higher order of things. I do know what I am talking about; I have celiac and have worked here for nearly 7 years.  
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,154
    • Most Online
      1,763

    Newest Member
    calla84
    Joined