Does Anyone Know?
Posted 05 September 2011 - 05:55 PM
Posted 05 September 2011 - 07:10 PM
Posted 07 September 2011 - 10:12 AM
Based on what I've read, I have a couple of guesses. Note the word guesses. Sorry. (They aren't totally blind guesses, though!)
-Inflammation. We know that gluten causes inflammation of the gut. Having an auto-immune disease means that we react (and over-react?) to normally "safe" substances. This is an article on inflammation in general. I don't know the mechanism, but I wouldn't be surprised if the inflammation does not limit itself to the gut.
-This might be more controversial, but intestinal permeability ("leaky gut") could play a role - substances cross over the gut barrier that are not supposed to, leading to multi-systemic issues. Traditional western medicine is starting to recognize and research intestinal permeability, and some studies indicate that inflammation leads to permeability. That pretty much "allows" the gluten dominos to start to fall and reach other body parts.
-This article: http://charlotteceli...ew_Cellular.pdf is a bit scientific, but it explores the neurologic connection in Celiac. What it comes down to is that there is a lot they don't know. It's not about joint/muscle pain per se, but more related to brain/nerves:
"While advances have been made in understanding the pathogenesis of the intestinal lesions in celiac disease, the patho- genesis of the neurologic manifestations has yet to be elucidated. Current data point to molecular mimicry and intermolecular help as two possible mechanisms that could explain how ingested gluten can result in damage to the neuraxis." In other words, they are starting to understand fully how the gut gets messed up, but they're trying to figure out why the rest of it happens.
Negative blood tests (following gluten light diet)
Still healing with time, harmony, and good food.
Posted 07 September 2011 - 11:06 AM
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