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Difference Between Ttg, Ema And Dgp?
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Does anyone here know the difference between TTG, EMA and DGP blood tests? I know they all assess the extent of tissue antibodies but don't assess the body's reaction to gluten.

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Does anyone here know the difference between TTG, EMA and DGP blood tests? I know they all assess the extent of tissue antibodies but don't assess the body's reaction to gluten.

I don't know off hand, but I would highly recommend getting a copy of Dr. Peter Green's book - Celiac Disease a Hidden Epedemic, he covers all of these tests in that book in a way that is easy for the reader to understand.

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I don't know off hand, but I would highly recommend getting a copy of Dr. Peter Green's book - Celiac Disease a Hidden Epedemic, he covers all of these tests in that book in a way that is easy for the reader to understand.

Some of us know just fine off hand. She doesn't need to go buy a book!

Does anyone here know the difference between TTG, EMA and DGP blood tests? I know they all assess the extent of tissue antibodies but don't assess the body's reaction to gluten.

TTG is an antibody against tissue transglutaminase, an enzyme involved in tissue repair. It is autoimmune and while the most common cause of anti-TTG is celiac, it can appear in rheumatoid arthritis, autoimmune liver disease, and inflammatory bowel disease as well. (There may be others; that list is off the top of my head.)

Anti-EMA is an autoantibody against endomysium, a type of connective tissue. Anti-EMA is HIGHLY specific for celiac disease.

DGP is an antibody against deamidated gliadin peptide (DGP), a fragment of gluten that has been processed in the intestine by TTG. It is not an autoantibody, but DGP is only produced in individuals with celiac so it's 100% specific for celiac disease.

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Some of us know just fine off hand. She doesn't need to go buy a book!

Actually, that book should be required reading by everyone with a gluten problem. It is full of excellent information that would benefit many.

Then we wouldn't have people being scared by those who think there is gluten in vegetables! Or that everything is contaminated with gluten! :blink:

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That's interesting that DGP is definitive for celiac. Can you reference that? The reason I ask is I had all the testing, and all the labs were normal except DGP, which was 4x the upper limit. I've had two separate biopsies and both were negative. I have mega-stomach issues with bloating and constipation. So, I've always wondered if I really am celiac due to that one test. Of course, the doctors tell me no because of the negative biopsies. I just began gluten-free yesterday.

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    • I think the posters above have given you very good information and I will throw in my 2 cents worth.  I am surprised that they did not test her DGP IgA also.  I am sure that would have been positive.  They switched off with antibody classes and usually they do both tests for both antibodies.  IgA is more specific to Celiac but the IgG is also useful.  The testing shows your daughter is producing antibodies to the gluten in her diet. (DGP IGG). THe tTg shows positive for some damage or inflammation. You know........your daughter is only 4.  She hasn't been on the planet or eating gluten that long. It can take years for enough damage to occur for it to be able to be found on biopsy.  I would say it is highly likely that this is Celiac, especially with her symptoms. But because the damage hasn't graduated to bad enough yet, they won't diagnose her. I think you need to do what others have said and get all copies of testing and find someone else who will take a look and give a diagnosis, especially if they have you do a dietary trial and her symptoms go away.  That might be the only recourse if you want faster proof. I know I would want faster.  I would not really be happy if I thought I had to keep feeding her something that was making her sick.  If you keep her on gluten long enough, the diarrhea will probably show up. BTW.........the criteria mentioned regarding diagnosis does not apply to kids.  I know it's silly and stupid but most leading Celiac specialists do not go by this criteria for kids.......adults only.  Keep that in mind because it might come up.  You could recognize it but they might not. Have you considered gene testing, to help bolster a diagnosis? As far as false positives go, it's the other way around. False negatives happen more frequently than many people think.  It's a recurring theme here.  With her symptoms, which is what I had, a bloated belly and tummy aches are telling.  Have they tested her for lactose intolerance?  That can cause similar symptoms, although it sure won't raise those 2 blood tests.  Keep looking for Celiac because there are many red flags here.
    • This 4 out of 5 criteria does not apply to children. I was never given a reason why, but it isn't.     That said, you may try to get a second opinion from another GI who may be willing to give her a firm dx.  We were in your boat 6 years ago and while I'm sure I'll get slammed for it, I wish we had kept gluten in our kiddos diet till he scoped positive for a variety of reasons.  Again, even family is different and you have to find what is best for you!
    • Mnoosh, I had swollen lymph nodes prior to celiac dx and for a while after going gluten free. My neck as well as groin. The groin ones were the worst. Guess what? All gone! It's hard to recall a time line & consider that everyone is different but I think mine completely resolved within a year.  You've been given great information. Just breathe and then again, breathe. You're going to be fine. 
    • It is the only thing you have eaten, so it can't be anything else?  I eat it with no issues so I am not sure how you can be certain that is the problem.  All I am saying is that its sort of "your word against mine and the company's word".  
    • Thanks cyclinglady & manasota! I appreciate it. I came to give an update...... I'm still 99% itch free. I get a "place" like a bug bite once in a while that itches and I just use the prescription steroid cream on it & that takes care of the itch. My rash is healing up rapidly everywhere. Almost clear skin now! Yaaaaayyyyyyyyyy! Now for a rundown of the "treatment". For 20 days I took a 100mg doxycycline twice a day. Then we upped it to two 100mg doxy twice per day. I took those for 5 days & made rapid progress and the itching stopped. The doxy was getting my tummy though. It was getting really rough despite my eating yogurt. So on day 6 and day 7, I took two 100mg doxy in the am but in the pm I just took 1 of them. On day 7, I was nauseous for hours on end. So since I was still doing well without itching and the rash was healing everywhere, I decided to cut back some more. On days 8, 9, & 10 I have only taken two 100mg doxy in the am and none at night. I'm doing good and my tummy is much, much happier! No more nausea!  I'll update as things go along.
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