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Difference Between Ttg, Ema And Dgp?
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Does anyone here know the difference between TTG, EMA and DGP blood tests? I know they all assess the extent of tissue antibodies but don't assess the body's reaction to gluten.

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Does anyone here know the difference between TTG, EMA and DGP blood tests? I know they all assess the extent of tissue antibodies but don't assess the body's reaction to gluten.

I don't know off hand, but I would highly recommend getting a copy of Dr. Peter Green's book - Celiac Disease a Hidden Epedemic, he covers all of these tests in that book in a way that is easy for the reader to understand.

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I don't know off hand, but I would highly recommend getting a copy of Dr. Peter Green's book - Celiac Disease a Hidden Epedemic, he covers all of these tests in that book in a way that is easy for the reader to understand.

Some of us know just fine off hand. She doesn't need to go buy a book!

Does anyone here know the difference between TTG, EMA and DGP blood tests? I know they all assess the extent of tissue antibodies but don't assess the body's reaction to gluten.

TTG is an antibody against tissue transglutaminase, an enzyme involved in tissue repair. It is autoimmune and while the most common cause of anti-TTG is celiac, it can appear in rheumatoid arthritis, autoimmune liver disease, and inflammatory bowel disease as well. (There may be others; that list is off the top of my head.)

Anti-EMA is an autoantibody against endomysium, a type of connective tissue. Anti-EMA is HIGHLY specific for celiac disease.

DGP is an antibody against deamidated gliadin peptide (DGP), a fragment of gluten that has been processed in the intestine by TTG. It is not an autoantibody, but DGP is only produced in individuals with celiac so it's 100% specific for celiac disease.

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Some of us know just fine off hand. She doesn't need to go buy a book!

Actually, that book should be required reading by everyone with a gluten problem. It is full of excellent information that would benefit many.

Then we wouldn't have people being scared by those who think there is gluten in vegetables! Or that everything is contaminated with gluten! :blink:

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That's interesting that DGP is definitive for celiac. Can you reference that? The reason I ask is I had all the testing, and all the labs were normal except DGP, which was 4x the upper limit. I've had two separate biopsies and both were negative. I have mega-stomach issues with bloating and constipation. So, I've always wondered if I really am celiac due to that one test. Of course, the doctors tell me no because of the negative biopsies. I just began gluten-free yesterday.

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    • You're welcome! Yes, I too, hate waiting for lab results. Ugh!
    • I understand this is not a doctor's office and that I need proper testing done to rule out Celiac disease, however, I am stuck waiting until November to even see a GI doctor. So I need some suggestions soon on which test to go for first and what to do as I wait. Also do note, I am 28 years old.

      Right now, the most suspecting culprits to my symptoms have been Gallbadder, Celiac disease, and IBS. I have also been recently diagnosed with pre-diabetes and I am obese.  My Ultrasound and CT scan have all come up as normal and no signs of gallstones. However, I was in extreme pain as my upper abdomen was examined during the ultra sound. My white blood cell count also seems to be high at 12,000 but all blood work came back normal for liver and everything else.

      Symptoms included are: diarrhea
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      It is usually in the morning and afternoon I feel the most with gas and bloating. Especially after any large meals from the previous day. Despite the diet and work outs I have had, nothing has changed the stools. However, taking fish oil pills has greatly reduced the pain in my upper abdomen as well as the pain  in the the area above my belly button. My question now is, is there a very likely chance of this being celiac disease? Should I go on a gluten free diet to test since I Have to wait so long? Also, which test should I ask the doctor for first, as it will take a GREAT deal of time to pay off each one. Colonoscopy, HIDA scan, or endoscopy. 

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    • Thank you very much for all the info Squirmingitch. The doctor told me as we were talking he was going to order some tests with urine so I don't know why he didn't mark that. Maybe he forgot as we were talking? Duly noted about the bladder Cancer to watch out for too. Doctor said it will take about a week to get the lab results back usually from this lab. The wait will seem like forever I'm sure. Yes I will press to have the other tests done too if this one comes back negative.
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