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Iga Deficient, What Tests?
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Hello,

I have a friend who wants to have her son tested but he is IgA deficient (apparently she had him screened as an infant due to signs of Celiac, but he turned up IgA deficient and the doctor would do no further testing). Anyway, he's now 8 and she wants to have him re-tested. Are there tests that will work in spite of an IgA deficiency, or is biopsy the only definitive diagnostic tool?

Thanks,

Alissa

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People with IgA deficiency require a different version of the antibody tests. The tTG and EMA tests have IgG versions and these tests will then be accurate for someone with IgA deficiency. IgA deficiency is diagnosed when someone has a total serum IgA test and the results are very close to zero (less than 10mg/dl).

Sounds like the doctor didn't know anything about Celiac or how to test someone who is IgA deficient. If he had called his lab they would have told him there are differenct versions.

Here's a fact sheet she can print off and take in when she goes to have her son retested.

http://www.cureceliacdisease.org/wp-content/uploads/2011/09/CDCFactSheets3_Antibody.pdf

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There is also a newer test, the DGP (deamidated gliadin peptide) which has an IgG version and is very specific for celiac.

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