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Kimball Genetics Testing


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#1 gigimom

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Posted 28 August 2005 - 08:03 PM

I've been reading past posts about Enterolab testing and the genetic testing but haven't seen much about Kimball Genetics. We had the celiac disease DNA test done hoping it would give us some answers -- it did, but ended up giving us more questions. Three of my children had very high IgG levels in their initial bloodwork. Only one came back with a positive biopsy. One of the children with a negative biopsy has frequent headaches with vomiting so I put her on the gluten-free diet hoping it would take care of the headaches. It didn't seem to change anything (maybe 3-4 months wasn't long enough?) To give us answers, we thought we'd find out if she carried the gene for celiac disease but hadn't developed full blown celiac disease.

We tested me, my husband and this one child. My husband and daughter tested negative for DQ2 (DQA1*05/DQB1*02) and DQ8 (DQB1*0302). They detected one of the DQA1*05 alleles in me but that alone was not enough to result in celiac disease. So...according to Kimball Genetics, neither me nor my husband has the celiac disease associated molecules necessary to result in celiac disease and therefore our children do not posess the necessary genes for celiac disease. My doctor doesn't want to put full faith in these tests and so celiac disease remains the diagnosis for my biopsy positive child.

Can anybody tell me if the Enterolab testing is more specific for possible gluten intolerance genes? (There seem to be more gene types with Enterolab).Has anybody else had a positive biopsy without a celiac gene?
I know people will say to just follow the gluten-free diet and if it works let that be enough. But I keep thinking that there may be some other factors making my children sick.
Can anything else elevate an IgG level other than gluten?
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#2 Rachel--24

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Posted 28 August 2005 - 08:34 PM

I was reading something yesterday (I don't remember the site) that was saying that the IgG is the least specific of all the bloodtests. Apparantly a positive IgG alone does not conclude celiac disease because people with other intestinal conditions can also have a raised IgG. Also your daughter could have gluten intolerance w/out celiac disease. I find it interesting that your biopsy positive child can't carry the celiac disease gene...are you sure? Does Kimball only test for DQ2 and DQ8? I tested w/ Enterolab and came back positive for everything w/ high malabsorption but with NO celiac genes...I have DQ1 and DQ3. I have all the symptoms but have been wondering if something other than gluten could be making me sick since I don't carry the celiac disease genes. I think obviously if your child had a positive biopsy then he/she does have celiac disease.
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