What Do Test Results Mean?
Posted 06 April 2012 - 09:16 AM
Celiac Disease Complete Panel:
Immunoglobulin A, Qn, Serum 218 mg/dL reference interval 70-400
Deamidated Gliadin Abs, IgA 76 High units (>30 is moderate to strong positive)
Deamidated Gliadin Abs, IgG 3 units 0-19 reference interval
t-Transglutaminase (tTG) IgA <2 U/mL 0-3 reference interval
Tissue Transglutaminase (tTG)has been identified as the endomusial antigen. Studies have demonstrated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy.
t-Transglutaminase (tTG) IgG <2 U/mL 0-5 reference interval
I am wondering what the High Deamidated Gliadin Abs, IgA means? Thank-you for any help.
Posted 06 April 2012 - 07:11 PM
I guess I am of no real help b/c I am still trying to figure out exactly what it means too...(; Nice to know you aren't along though, huh? Do you have a follow up appt soon?
Posted 06 April 2012 - 07:39 PM
Anti-Gliadin (AGA) IgA
Anti-Gliadin (AGA) IgG
Anti-Endomysial (EMA) IgA
Anti-Tissue Transglutaminase (tTG) IgA
Deamidated Gliadin Peptide (DGP) IgA and IgG
Total Serum IgA
The first two are the older generic-type tests not relied upon much any more. The Anti Tissue Transglutaminase (tTG) is the all-time favorite of doctors; although this test can be positive in conditions other than celiac disease. If this test is positive and you subsequently run the Anti-Endomysial (EMA) and that is positive, then the two tests together confirm celiac (the EMA is not run automatically (because it's expensive) if the tTG is negative). The Deamidated Gliadin Peptide (DGP) is the newest of the celiac tests and has a 99% specificity for celiac disease. If this test is high, it pretty much means you have celiac disease. Nevertheless, most doctors (especially the GI's) still like to do the endoscopy with biopsy to confirm the diagnosis. The last test, total serum IgA, is a control test to make sure you produce normal amounts of IgA antibodies. If you fall within the normal range it validates the results of the other tests. If the IgA versions of the tests are invalidated by a low total IgA, and your results are negative, then they run the IgG tests. You both had normal total lgA. In mary's case they went ahead and ran both IgA and IgG versions of the tests.
I believe you can both anticipate notification from your doctors that you are celiac positive, and will probably be referred to a gastroenterologist (if that was not the person who did the testing) for an upper endoscopy with biopsy.
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Self-diagnosed gluten intolerant, gluten-free Nov. 2007
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Posted 07 April 2012 - 08:52 AM
Posted 07 April 2012 - 09:35 AM
Your immune system is recognizing gluten and even if your doctor decides you don't have celiac right now, you would be at serious risk for getting it. Once you have your biopsy you should try gluten-free. I bet it will help you feel better.
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