Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Interesting New Research On Corn
0

21 posts in this topic

There is a really interesting new paper on corn and celiac.

http://www.springerlink.com/content/d6723t3n722317x5/

This paper carefully identifies fragments of corn gluten (zein) that could potentially bind to HLA-DQ2 and HLA-DQ8 in a subset of people with celiac disease. They removed all the gluten IgA antibodies from sera of some celiac volunteers and found some antibodies to corn zein were still present. They carefully tracked down what the antibodies were binding to, using mass spectrometry, and found the antibodies were recognizing poorly digested peptides from corn zein. This is similar to gluten, where the most immunogenic peptides are the ones that are not fully digested. Some computer work supported that the peptides would bind best to DQ2.5, and that they are similar but not identical to wheat gluten fragments.

The reaction is NOT a cross-reaction to corn. Let me repeat that lest there is any confusion. THIS IS NOT A CROSS-REACTION TO CORN. It is a completely separate set of anti-zein antibodies in some teens and adults with celiac disease. Interestingly, two of the five corn-sensitive people were still sick gluten-free. They don't mention in the paper if they got well off corn.

First, if you're feeling OK, don't freak out about corn. Corn is still safe for most celiacs. Only 5 out of 24 people they tested had the antibodies. Also, the corn antibodies don't tend to show up in kids suggesting that corn is not inflammatory like wheat. There is no evidence for corn causing celiac in someone who grows up without wheat. The authors suggest that a person needs to be untreated celiac for a while for the corn antibodies to show up.

There have been flaws in little bit of other corn research that has been done (like the one with 80 ppm gluten in their cornmeal), but this seems to be really solid study. It does raise a lot of questions though. Did the people who were still sick recover off corn? Is corn processed by TTG, triggering autoimmunity? Do the corn epitopes the authors identified stimulate T-cells? Can corn cause TTG antibodies to stay elevated in people with anti-zein IgA? If so, can corn trigger villous atrophy in people who have the anti-zein IgA?

This is extremely important for those of you who are gluten-free and still not well, or potentially being diagnosed with refractory celiac disease. We always tell people to eliminate casein. It's looking like we should also be suggesting people try a period of time eliminating corn (which is unfortunately even harder than eliminating gluten or casein).

2

Share this post


Link to post
Share on other sites


Ads by Google:

Thanks for posting this Skylark. :) I have been gluten and casein free for a couple months now. I have had a huge relief of crippling symptoms that went far beyond GI troubles. However, I was still experiencing intermittent digestive upsets, and abdominal bloating with tenderness. Four days ago, I tossed corn to the curb. (It's scary how many ingredients have corn hidden in them.) I'm happy to report that the upsets, bloating, and tenderness are all gone. (I realize that I am fortunate to see results as quickly as I do. Everyone is different.) Since the end of January, I have been gaining strength and muscle back, and dropping weight from being ill for so long. Knowledge is power. Keep it coming. Thanks again. Cheers :)

0

Share this post


Link to post
Share on other sites

I started reacting to gluten-free corn based granola and fritos. I've dropped corn for now..but it seems like corn is in most medicines and supplements? I haven't stopped those. Isn't dextrose and caramel color made from corn too? :o

0

Share this post


Link to post
Share on other sites

I started reacting to corn a few months ago. Honestly I have no idea if it's a separate intolerance or if it has something to do with the GMO freakshow in corn. I just know, a year ago I could eat it just fine. Then over time if I ate "too much" popcorn I would get a slight stomach ache. Then a couple months ago if I even had a handful of popcorn or any corn-containing snack my upper stomach would erupt in pain so intense that it would wrap around to my back (behind my ribs). I don't usually get back pain from glutening. I've quit corn as best I can since then.

Skylark I read the abstract, it looks very interesting. I just wish I understood it :P I need to take a class to learn how to read that stuff!

0

Share this post


Link to post
Share on other sites

Thanks Skylark, very interesting stuff! Might explain a few mild reactions for me. Guess we are still learning every day. :)

0

Share this post


Link to post
Share on other sites




Well, that was why I was so confuzzled when I first started reacting to foods. It was after my introduction to Mexican cuisine, so I initially didn't know what to think, then I thought it was the beans, but no, so I thought, gee, I've only ever eaten corn on the cob before and that was okay, but corn became a question mark??? Then I ate corn on the cob in New Zealand and I was fine. Then I definitely reacted to corn in the U.S. I reacted to corn chips when we went out, or pretzels when we snacked when we were out, and every time I went to a Mexican restaurant, whether I had corn or flour tortillas (with or without beans). Hey, this was over 30 years ago when we didn't know much about food intolerances, okay? And I just thought I had a weird stomach and nervous system.

So this pattern continued for a long while, reacting (in retrospect) to both corn and gluten, and not figuring out where it was coming from :rolleyes: By the time I gave up gluten in hopes of curing my psoriatic arthritis I had already given up 99% of corn (including the non-GMO New Zealand corn) - I only ever ate popcorn. Then I had one of my infamous fainting/syncope spells at a party after eating popcorn so I had to quit that too (plus a lot of other things). I will not be at all surprised (if I live long enough to be surprised) if they do not found other zeins or similar proteins (like the lectins I am sure I react to) that are messing us up.

Hey, jess_gf, I was just this morning looking at the topic you started that has been runing all this time, and wondered what had happened to you. Good to see ya!

0

Share this post


Link to post
Share on other sites

Skylark I read the abstract, it looks very interesting. I just wish I understood it :P I need to take a class to learn how to read that stuff!

It took me more than one class. :lol: I do science for a living.

I started reacting to gluten-free corn based granola and fritos. I've dropped corn for now..but it seems like corn is in most medicines and supplements? I haven't stopped those. Isn't dextrose and caramel color made from corn too? :o

Yes, that's why I was saying it would be hard to totally eliminate corn. It's in everything in the US. :unsure:

0

Share this post


Link to post
Share on other sites

Thanks for posting that. I have heard about people with severe reactions to corn, so that would explain it.

0

Share this post


Link to post
Share on other sites

Hey, jess_gf, I was just this morning looking at the topic you started that has been runing all this time, and wondered what had happened to you. Good to see ya!

Oh I've been around, mostly lurking. Thanks!

0

Share this post


Link to post
Share on other sites

I am one of those corn reactive people. Corn is as bad for me as gluten. Makes so much sense. Thanks for posting this. ;)

0

Share this post


Link to post
Share on other sites

Thanks for taking the time to decipher it all for us, Skylark! I always appreciate your research. :)

I am also glad you made it clear this is not about "cross-reactivity".

I was worried about corn at the beginning of my gluten-free life because nothing seemed to agree with me for many months. I had removed dairy and soy and I still felt lousy. I thought, oh crappers, corn too? :rolleyes: geesh, but it just took me a looooong time to heal my gut. I still have off days, but corn is not the problem.

Corn is one of my favorite summer pleasures and luckily, corn and I seem to be at peace with each other. :)

0

Share this post


Link to post
Share on other sites

I had GI and DH flares on corn. I only realised the link, though, when I started getting the nerve shocks in my feet (which had stopped very soon after going gluten free). I knew I hadn't been glutened. I never eat out and rarely eat any processed foods (even gluten-free). GMO sucks. Excuse my language - I rarely swear. There is too much crap on the market and I'm sick of cooking/washing up .. being hungry ..unable to eat enough calories to keep my weight stable/healthy (I was overweight my entire life!!) etc etc <_<

0

Share this post


Link to post
Share on other sites

some people react ok to wheat starch and is considered gluten free because it obviously contains less gluten, would the same apply to corn? has anybody had experience with reacting to corn but not the starch?

0

Share this post


Link to post
Share on other sites

some people react ok to wheat starch and is considered gluten free because it obviously contains less gluten, would the same apply to corn? has anybody had experience with reacting to corn but not the starch?

I react to corn which has been dried and processed..like Fritios..but ate corn on the cob last week with no reaction. :blink:

There's also corn starch in my medications and supplements, which I don't seen to react to?

0

Share this post


Link to post
Share on other sites

I react to corn which has been dried and processed..like Fritios..but ate corn on the cob last week with no reaction. :blink:

There's also corn starch in my medications and supplements, which I don't seen to react to?

Same here. I can eat plain corn and use corn starch in baking, but sometimes feel "off" after eating a processed product like corn chips. For me, it may be some of the oils.

...which leads me to wonder if the Fritos have something else in them that makes them bothersome for you? maybe? just thinking out loud with you :)

0

Share this post


Link to post
Share on other sites

Aren't corn chips usually made with lime-treated corn? Lime treatment may change the corn enough that your body sees it differently.

0

Share this post


Link to post
Share on other sites

Yes, the more highly refined the corn is the more likely that I can eat it. So the starches in pills don't bother me and I can have some starch in baked goods now. It is any corn product that has any of the outer skin covering, like corn chips, masa harina, etc. that get me. Sometimes I don't know where to draw the line. As in sometimes some corn in pasta will get me and other times it won't. I guess I should judge it by its color :huh:

0

Share this post


Link to post
Share on other sites

Same here. I can eat plain corn and use corn starch in baking, but sometimes feel "off" after eating a processed product like corn chips. For me, it may be some of the oils.

...which leads me to wonder if the Fritos have something else in them that makes them bothersome for you? maybe? just thinking out loud with you :)

Ingredients in Fritos..Whole corn, corn oil, and salt.

No preservatives.

Makes me wonder about the drying process? :huh:

0

Share this post


Link to post
Share on other sites

Ingredients in Fritos..Whole corn, corn oil, and salt.

No preservatives.

Makes me wonder about the drying process? :huh:

hmm....maybe.

Skylark is better informed that I am about this...Sky? :)

0

Share this post


Link to post
Share on other sites

I don't even know what the phrase "drying process" means. If you have questions about Fritos you might write Frito-Lay.

0

Share this post


Link to post
Share on other sites

Interesting as I was checking here to see if anyone else has had a reaction to corn flour... I had bought Zatarain's seasoned fish-fri while vacationing in Florida.. I used it on lean pork chops baking them in the oven, plus we had freezer corn and fried potatoes... I knew I was in trouble instantly starting with stomach cramps and diarrhea... This really irked me... We had company and here I am sitting on the toilet... I was in misery as it was because, I had made a homemade apple pie and chocolate chip cookies

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,358
    • Total Posts
      920,531
  • Topics

  • Posts

    • Here's another thing.  Feeling deprived?  Order two of the same item.  I was hungry by the time dinner arrived! 
    • The doctors just made me feel like I was crazy because they did not have a clue of what was wrong with me. I did a stool test (positive) and I did a genes test (positive for two gluten sensitive genes, one in each chromosome).  Blood test are not so foolproof, if you read the comments/experiences in such topic you will see the problems. Biopsy can give a false negative if taken from an undamaged area. If you have medical problems that go away once on a gluten free diet then gluten is the problem. The medical establishment profit from managing your medical problems and big pharma makes money by pushing pills so we need to be careful because they won't benefit if a gluten-free diet solve your problems. Since I started a Gluten free diet I have been free of the following: (all related to Celiac)  Irregularity, Intestinal noise, Irregular stool, Tooth enamel defects, Rash in upper arms, Abdominal swelling, depression, fatigue, irritability, lactose intolerance, 
      loss of memory, dandruff, uncontrollable bladder, suicidal thoughts, unable to sleep, Canker sores/ Mouth ulcers, high blood pressure, and probably others that I did not realize. I was at the end of my rope, thanks to Google and the people that are able to talk about this I was able to get my life back. I am passionate about this because I know how bad its can get. 
    • Well, I have never cruised on Carnival, but I am sure they can accommodate you.  I assume that you have already alerted them that you require gluten free meals.  If not, please contact Carnival immediately. Here are my own tips.  Some folks eat off the buffet line, but not me or hubby except for coffee/drinks and baked potatoes (jacketed) and fruit that we wash in the restroom (people touch everything!)  Okay, I am OCD, but my last glutening which occurred the previous summer made me sick for three months (GI tested my antibodies to prove it).   When we board, I go to the buffet restaurant ASAP and ask to speak to the Head Waiter (they are usually there greeting customers and often trying to up sell to specialty restaurants.   Let them know you have celiac disease and must be gluten free.  They may try to tell you that each dish is clearly marked gluten free, but really?  Who's to say that some other passenger is not going to switch spoons (or I have seen passengers wandering around with serving spoons...I kid you not!  The staff usually will  go downstairs and fetch a gluten free meal for me from the main dining room's kitchen as there is usually a dedicated area for allergies.  We have to wait up to 20 minutes or so but it is worth it.  Starving?  Get a baked potato wrapped in foil until your gluten-free meal arrives.  Now, do not do this every single time.  Those folks have to go down several levels to fetch food and you don't want to be a pain.  But if the main dining area is closed, they need to make an effort to keep you safe.  On our last cruise, we were advised not to eat anywhere but the main dining room and that included room service (they are not trained to handled allergies).  My headwaiters have sent goodies (prepackaged gluten free rolls and cookies for us to keep in our room.  We can always grab whole fruit (I wash it first) to snack on.  I bring gluten-free non-perishable items with me to eat while at port in case we can't find anything (which can be often).  Again, when we get back to our ship, we contact our headwaiter and he/she can prepare some snacks until we have dinner.   Be grateful and not picky.   We eat all meals in the dining room (or at least as much as possible).  Our headwaiter had a few other celiacs on our cruise this summer, so they prepared some gluten-free waffles, etc. for our breakfast!  What a treat!  At breakfast, we'd have different waiters, so our headwaiter would always instruct our waiters each and every time!  They even let me tour the kitchen and showed me the allergy section.   The only time I did not feel safe was at the buffet.  We once ordered gluten-free pizza and I realized (I watched) that that restaurant didn't really have the gluten-free thing down), do I called him on it.  Got the manager etc.  So, be careful.  Other cruises made us frozen Udi"s which was just fine with us.  They covered it up in foil so that we would not get any cross contamination from their pizza oven. So, have fun!   Tipping?  We prepaid our gratuities, but we gave our headwaiter an extra $200.00 for his time.  For us, it was well worth the service and safety of our food.  It does not hurt to slip some of the tip ahead of time (like after your first meal!)   Oh, I checked your ship.  You must eat in the diningroom if you have special dietary needs.
    • French Celiac / Coeliac Gluten Free Restaurant Card <strong>What is ... What to know about celiac disease, gluten sensitivity, and gluten-free diets. View the full article
    • <strong>Celiac Disease & Gluten-free Diet Information at Celiac.com. Gluten Free Diabetes ::The 3 Step Trick that Reverses Diabetes Permanently in ... View the full article
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

    There are no registered users currently online

  • Member Statistics

    • Total Members
      61,432
    • Most Online
      1,763

    Newest Member
    rbeckler60
    Joined