Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Negative Ttg Iga Test
0

5 posts in this topic

I went to my doctor last week because I suspected Celiac disease, and she ordered just one test for me, the TTG IgA one. I got my results today and my levels are at 3.42, where less than 20 is negative. So that's a very obvious negative, and I eat gluten like nobody's business (I love bread, it just doesn't love me)!

But I guess that that one test alone isn't very accurate, right? Should I trust that I'm negative with just the one test, or should I pursue more? I already emailed my doctor to see if there are any more tests that she can order for me, but if she doesn't know then I'm not sure what to do. She's going to refer me to a gastroenterologist, but I don't know if they will do any better. I know that I have a problem with gluten somehow , but I don't want to try going gluten-free until I've gotten my testing out of the way!

I'm just kind of disappointed - not that I want Celiac disease, I just want answers and I want them now! I'm sick and tired of being sick and tired, you know?

0

Share this post


Link to post
Share on other sites


Ads by Google:

I went to my doctor last week because I suspected Celiac disease, and she ordered just one test for me, the TTG IgA one. I got my results today and my levels are at 3.42, where less than 20 is negative. So that's a very obvious negative, and I eat gluten like nobody's business (I love bread, it just doesn't love me)!

But I guess that that one test alone isn't very accurate, right? Should I trust that I'm negative with just the one test, or should I pursue more? I already emailed my doctor to see if there are any more tests that she can order for me, but if she doesn't know then I'm not sure what to do. She's going to refer me to a gastroenterologist, but I don't know if they will do any better. I know that I have a problem with gluten somehow , but I don't want to try going gluten-free until I've gotten my testing out of the way!

I'm just kind of disappointed - not that I want Celiac disease, I just want answers and I want them now! I'm sick and tired of being sick and tired, you know?

You guessed correctly. The TtG IgA is not sufficient. They should at least have run a total serum IgA along with your TtG. You might be one of the percentage who are IgA deficient, rendering your test useless.

You should get a full celiac panel:

TtG IgA (if you turn out to be IgA deficient, you will also need the IgG version of this test)

Deamidated Gliadin Peptides (IgG and IgA)

anti-endomysial antibodies (anti-EMA)

Total serum IgA

You could also ask for anti-gliadin antibodies (AGA), both IgG and IgA.

0

Share this post


Link to post
Share on other sites

You guessed correctly. The TtG IgA is not sufficient. They should at least have run a total serum IgA along with your TtG. You might be one of the percentage who are IgA deficient, rendering your test useless.

You should get a full celiac panel:

TtG IgA (if you turn out to be IgA deficient, you will also need the IgG version of this test)

Deamidated Gliadin Peptides (IgG and IgA)

anti-endomysial antibodies (anti-EMA)

Total serum IgA

You could also ask for anti-gliadin antibodies (AGA), both IgG and IgA.

This exactly. My ttg was normal, but my DGP was sky high. You need a complete panel done.

0

Share this post


Link to post
Share on other sites

Now I'm curious as to what I should do. I began having celiac symptoms from Thanksgiving all the way through February (at which point I googled my symptoms and began a gluten-free diet).I was tested a week after starting the gluten-free diet and these are the tests my GP performed on my blood.

Tissue Transglutaminase

IgA,

Total IgA,

Gliadin Antibody IgA,

Then he tested my blood for antibodies to Rye, Barley, Rice, Buckwheat and Gluten.

All of those came back negative.

I was unhappy with these results and I had read in several books that these tests can come back negative and you could still have celiac disease.

I got a referral for a gastroenterologist who drew labs for a HLA-DQ2 which came back positive. My doctor said that 95% of people with Celiac disease test positive for that marker but only 20 - 40 % of people with this marker actually develop celiac disease.

I do not want to do the gluten challenge but that is truly the only way I'll find out. PLease advise what you would do in my situation.

A very sad, frustruated mother,

SoutherGirlGlutened (aka Faith)

0

Share this post


Link to post
Share on other sites

Neither of you got the full panel so neither of you can rule out celiac.

Also, even a week of being gluten free can make the blood tests less reliable.

Cara

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,665
    • Total Posts
      921,655
  • Topics

  • Posts

    • You're welcome! Yes, I too, hate waiting for lab results. Ugh!
    • I understand this is not a doctor's office and that I need proper testing done to rule out Celiac disease, however, I am stuck waiting until November to even see a GI doctor. So I need some suggestions soon on which test to go for first and what to do as I wait. Also do note, I am 28 years old.

      Right now, the most suspecting culprits to my symptoms have been Gallbadder, Celiac disease, and IBS. I have also been recently diagnosed with pre-diabetes and I am obese.  My Ultrasound and CT scan have all come up as normal and no signs of gallstones. However, I was in extreme pain as my upper abdomen was examined during the ultra sound. My white blood cell count also seems to be high at 12,000 but all blood work came back normal for liver and everything else.

      Symptoms included are: diarrhea
      yellow-stools (Sometimes foul smelling but always sink)
      light gnawing pain in area a few inches above belly button
      burning in chest
      sometimes pain below upper right rib cage.
      Tenderness all around the upper abdomen, but more so on the right and center.
      burping frequently after meals
      Gassy
      bloating in abdomen The pains used to come and go for the past few years as something very mild, but then the yellow stools happen at least four months ago and at a constant rate. Everyday it is either yellow or orange.  Sometimes the stools are lose and other times they are not. Two months in, I was finally diagnosed with pre-diabetes and have been having a strict low calorie and non fatty diet.

      So far the upper right pain has subsided but the pain above my belly button would continue. The gassy and bloated feeling would come and go as well. I get severe heart burn after almost every meal. But I felt it especially after eating whole wheat sandwiches or whole wheat pasta. I however don't feel it when I eat a Nature Valley granola bar, or pack of peanut butter crackers. I also had a chicken and vegetable stir fry with soy sauce cooked in that also had little effect on me. A bowl of cereal also made the heart burn act up pretty bad. I sometimes feel numb or light headed after various meals. Especially larger ones. In fact, it seems the more I eat, the worse I feel. But the less in the stomach, the more the pain above my belly button starts to act up.

      It is usually in the morning and afternoon I feel the most with gas and bloating. Especially after any large meals from the previous day. Despite the diet and work outs I have had, nothing has changed the stools. However, taking fish oil pills has greatly reduced the pain in my upper abdomen as well as the pain  in the the area above my belly button. My question now is, is there a very likely chance of this being celiac disease? Should I go on a gluten free diet to test since I Have to wait so long? Also, which test should I ask the doctor for first, as it will take a GREAT deal of time to pay off each one. Colonoscopy, HIDA scan, or endoscopy. 

      Again, I understand this isn't a site to get compete medical advice or to know exactly what my illness is, but I am trying to narrow down the possibility or what is most likely. If this has a chance of being celiac disease, I would rather know sooner than later.
    • Thank you very much for all the info Squirmingitch. The doctor told me as we were talking he was going to order some tests with urine so I don't know why he didn't mark that. Maybe he forgot as we were talking? Duly noted about the bladder Cancer to watch out for too. Doctor said it will take about a week to get the lab results back usually from this lab. The wait will seem like forever I'm sure. Yes I will press to have the other tests done too if this one comes back negative.
    • http://www.cureceliacdisease.org/screening/ Was your hubs tested for total IgA to see if he's IgA deficient? Read this thread: http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83660
    • Yes, bone density problems are all part of the celiac "umbrella" so to speak and yes, osteoporosis tends to happen more rapidly and at earlier ages than normal when malabsorption is happening. At age 43, it's not normal to have osteoporosis as you describe so that's another part of the jigsaw puzzle. Time to receive blood test results back from the doc are entirely dependent on the particular lab they were sent to. Yep, it's time for you to start keeping a very close check on the PSA in light of your father having had prostrate cancer. I would think you should get a PSA every year. I really would have liked to see him do a urinalysis. With the prostrate cancer your father had, it would seem a close watch should be kept on you for bladder cancer as well. The first symptom of that is blood in the urine but it's generally microscopic before you're ever able to actually see it. That happens to be the 8th most common cancer in men & it's moving up in the rankings. I know this because my hubs had it. The good news is that it's also one of the easiest and most successfully treated provided it's caught early. Certainly starting @ age 50, men should see a urologist every year. BTW, in the last year before I found out I was celiac, I turned up with microscopic blood in my urine. I got it checked out thoroughly since I know about bladder cancer & all tests, ultrasounds, cystoscopy, CT scan etc... turned out fine. The docs were stumped & finally said, "apparently that's just what your body does". Guess what? That's not "just" what MY body does. Once I went gluten-free, I have had no more microscopic blood in my urine. Interesting eh? Before now I didn't realize you are in Canada. The doc didn't do the full celiac panel but I understand the initial screening protocols in Canada only order the TTG but if that comes back negative be sure & press for the full panel as cyclinglady said. We have several here who tested like cyclinglady so it's not a rare thing, it's just not the norm. I'm glad he's doing the B-12 & Ferritin -- those can be big clues.
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,663
    • Most Online
      3,093

    Newest Member
    Steph0903
    Joined