Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Negative Ttg Iga Test
0

5 posts in this topic

I went to my doctor last week because I suspected Celiac disease, and she ordered just one test for me, the TTG IgA one. I got my results today and my levels are at 3.42, where less than 20 is negative. So that's a very obvious negative, and I eat gluten like nobody's business (I love bread, it just doesn't love me)!

But I guess that that one test alone isn't very accurate, right? Should I trust that I'm negative with just the one test, or should I pursue more? I already emailed my doctor to see if there are any more tests that she can order for me, but if she doesn't know then I'm not sure what to do. She's going to refer me to a gastroenterologist, but I don't know if they will do any better. I know that I have a problem with gluten somehow , but I don't want to try going gluten-free until I've gotten my testing out of the way!

I'm just kind of disappointed - not that I want Celiac disease, I just want answers and I want them now! I'm sick and tired of being sick and tired, you know?

0

Share this post


Link to post
Share on other sites


Ads by Google:

I went to my doctor last week because I suspected Celiac disease, and she ordered just one test for me, the TTG IgA one. I got my results today and my levels are at 3.42, where less than 20 is negative. So that's a very obvious negative, and I eat gluten like nobody's business (I love bread, it just doesn't love me)!

But I guess that that one test alone isn't very accurate, right? Should I trust that I'm negative with just the one test, or should I pursue more? I already emailed my doctor to see if there are any more tests that she can order for me, but if she doesn't know then I'm not sure what to do. She's going to refer me to a gastroenterologist, but I don't know if they will do any better. I know that I have a problem with gluten somehow , but I don't want to try going gluten-free until I've gotten my testing out of the way!

I'm just kind of disappointed - not that I want Celiac disease, I just want answers and I want them now! I'm sick and tired of being sick and tired, you know?

You guessed correctly. The TtG IgA is not sufficient. They should at least have run a total serum IgA along with your TtG. You might be one of the percentage who are IgA deficient, rendering your test useless.

You should get a full celiac panel:

TtG IgA (if you turn out to be IgA deficient, you will also need the IgG version of this test)

Deamidated Gliadin Peptides (IgG and IgA)

anti-endomysial antibodies (anti-EMA)

Total serum IgA

You could also ask for anti-gliadin antibodies (AGA), both IgG and IgA.

0

Share this post


Link to post
Share on other sites

You guessed correctly. The TtG IgA is not sufficient. They should at least have run a total serum IgA along with your TtG. You might be one of the percentage who are IgA deficient, rendering your test useless.

You should get a full celiac panel:

TtG IgA (if you turn out to be IgA deficient, you will also need the IgG version of this test)

Deamidated Gliadin Peptides (IgG and IgA)

anti-endomysial antibodies (anti-EMA)

Total serum IgA

You could also ask for anti-gliadin antibodies (AGA), both IgG and IgA.

This exactly. My ttg was normal, but my DGP was sky high. You need a complete panel done.

0

Share this post


Link to post
Share on other sites

Now I'm curious as to what I should do. I began having celiac symptoms from Thanksgiving all the way through February (at which point I googled my symptoms and began a gluten-free diet).I was tested a week after starting the gluten-free diet and these are the tests my GP performed on my blood.

Tissue Transglutaminase

IgA,

Total IgA,

Gliadin Antibody IgA,

Then he tested my blood for antibodies to Rye, Barley, Rice, Buckwheat and Gluten.

All of those came back negative.

I was unhappy with these results and I had read in several books that these tests can come back negative and you could still have celiac disease.

I got a referral for a gastroenterologist who drew labs for a HLA-DQ2 which came back positive. My doctor said that 95% of people with Celiac disease test positive for that marker but only 20 - 40 % of people with this marker actually develop celiac disease.

I do not want to do the gluten challenge but that is truly the only way I'll find out. PLease advise what you would do in my situation.

A very sad, frustruated mother,

SoutherGirlGlutened (aka Faith)

0

Share this post


Link to post
Share on other sites

Neither of you got the full panel so neither of you can rule out celiac.

Also, even a week of being gluten free can make the blood tests less reliable.

Cara

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,096
    • Total Posts
      920,333
  • Topics

  • Posts

    • I've had a range of symptoms in the last 2 months and in the past few weeks I have discovered that my TTG abs (igA) levels were 41 (my igA tests were fine). The doctor said that he is pretty much certain that it is celiac disease and I am awaiting an endoscopy to confirm it.  Before I found out that my TTG abs (igA) levels were high, I noticed that my body was reacting really badly to dairy products. I went on an elimination diet and stopped all gluten and dairy products and felt much better. I carried this on after my results and thought that I must have developed a dairy intolerance due to my celiac. 2 days ago I accidentally consumed a glass of wine which I thought was dairy free but it contained Milk. I have not had any gluten.  I am currently in the middle of a flare up. All of a sudden rashes have started to appear on my hands and my anxiety has returned (usually not a anxious person). No diarhhoea, vomiting or digestive issues. I am currently suffering from muscle twitching, rashes predominantly on hands and feet, brain fog, pins and needles/numbness on hands, feet and arms. However, I have been tested for milk allergy and this came back negative. Is it possible that it is dairy that is causing my symptoms/autoimmune reaction and could this be a reason for elevetated TTG abs (igA) levels. Or has the doctor only picked up my celiac and missing something else. If it was dairy intolerance then I would have digestive issues but I don't seem to have any. Could it be the casein protein?  Anyone been in a similar situation or can anyone provide some insight? 
    • Hello Everyone, This is my first post here and I am writing to seek help from experienced people here. I have been suffering for over 4 years now and still no where close to having a solution/ satisfactory diagnosis of my problem. My problems started in Mar 2012 with sudden diarrhea which would not go away for days. At first, I was given general antibiotics medication which would help bring down the frequency for some days and then it would come back. Since then it has been going on. I am giving a time line and the series of tests and procedures I have gone through. Would like opinion from experienced and experts here. I can send the scans and reports if required. Would really appreciate the help. Male, Indian origin Mar 2012 - onset of symptoms - multiple bouts diarrhea - spaced 3-4 weeks, bloating, weight loss (to start with I was 74 Kgs), GP managed with antibitocs and loperamide for months Dec 2012 - consulted a GI doc towards end of 2012, Colonoscopy done - conclusion was "IBS" - was advised to manage stress. use Rifaximin and immodium Jan 2013 - Aug 2013 kept moderately fine for 3-4 months ..again started getting frequent diarrhea + weight loss (was around 70 Kgs) Oct 2013 - Consulted another doc, MD - stool and blood test - Ecoli and high Eosinophil Count, medication done for 5-6 months, montinored eosinophil from nov - Mar: always kept high.. came down but then again shot up in a month Mar 2014 - Consulted another GI expert - Endoscopy and duodenal biopsy done - H Pylori and Unremarkable Villious pattern, (weight 68 Kgs) - On and Off diarrhea continued. Given: Ivermectin July 2014 - again same doc - Blood test done: High Eosinophil count,  Colonoscopy and Ileum biopsy - preserved villous architecture, features of eosinophilic enteritis; Endoscopy  + duodenal biospy again - numerous H pylori bacteria, Preserved villous crypt ratio, features of eosinophilic enteritis > conclusion: I have eosinophilic enteritis. Started on Prednisolone (steroids) Aug 2014 - 3-4 days of severe diarrhea> weight came down to 65 Kgs. Hospitalised for 3 days - continued on Prednisolonerios Sep 2014 - After 10 days only again a serious bout of diarrhea - hospitalized again - put on IV fluid for 8 days - weight 59 Kgs. Colonoscopy + biopsy done: features of superimposed c. difficile colitis, non-specific mild colitis > c. difficle test came out negative. CT Enterolysis +Scan done: mesenteric lymphadenopathy > nothing wrong acc to docs. IgA deficiency found - diagnosed Celiac - advised for Gluten free diet.   Sep 14 - May 16: continued gluten-free diet, gained weight upto 63 Kg in Jan 16, but then started losing again and came to 59 Kgs in May. No signficant diarrhea. Minor issues. June 16 onwards: Again diarrhea started, still on gluten-free diet, weight lost - 54 Kgs now. hospitalised again under same GI doc - blood test - eosinophil high, CT Enterolysis done: Showing mucosal thickening in Jejunum and Ileum; Enteroscopy (going in jejunum) + jejunal biopsy - jejunal erosions + villous blunting, marked atrophic with V:C ratio of 0.5: 1 to 0:1. HttG blood test done - Came out negative> Conclusion : No gluten exposure (how?) + Refractory Celiac disease. June - July - have been suffering from continuous diarrhea (goes off for 5-6 days and comes back, bloating, trappings in abdomen - waiting for I don't know what. On Rifaximin + Ivermectin + Codeine Sulphate (for diarrhea) I am very depressed and have no clarity on what's going on. If it is celiac, why am I not doing better on gluten-free diet. If the villous damage is still there in small intestine, then why did I kept fine for Sep - May period? HTTG - negative now but was NOT taken in Sep when I was first diagnosed with celiac. Can we trust negative HTTG now and conclude that it has come down? I am 20 kgs down from my ideal weight and still going down. Have no clue what NOT to eat to stop this. Why is eosinophil always high. Can any of you expert help me to put my case to docs in other countries? With lots of hope, Alok          
    • So, I know I'm obsessing but...... University of Chicago Celiac Disease Center website says any total IgA result over 20 won't affect the celiac test.   If this is so,  I'm still confused as to what a weak positive ttg iga means even though her result was barely in this category.  Why bother having a weak positive anyway?   I just don't get it and our doc is on vacation so I won't know what he'll recommend for another week.  I'll be finding out this week if we can see a GI without a referral. Our lyme doc (she's had lyme, may still have it, like I said it's a long story) is having her do an IgG wheat test but I don't think that has any bearing on celiac does it?    
    • Hi!  I've had good luck at the Minnesota state fair because most food booths are only doing one thing so there is no cross-contamination. For example: french fries or chocolate covered bacon or Indian kebabs.   But I live in California and I am heading to the state fair today! Does anybody have any great food suggestions that are definitely gluten-free there? Thanks, Celiac C.
    • Hi.  I have been reading your post and thinking about how my pain was around diagnosis.  It was above the belly button, I think where you are describing.  At the time I assumed I had a stomach ulcer.   I had been taking Neurofen for an ear problem and assumed it was the NSAID that had caused my stomach ulcer (which I actually didn't have, when I had an endoscopy a few weeks later my stomach was looking great! My small intestine was not!).   Going back to the pain, it was a burning feeling.   My doctor prescribed Omeprazole but it didn't touch it.   In fact I ended up with bad D. which eventually lead to me having all the tests for Celiac Disease.   I still get that pain if I eat oats (pure oats) that are supposed to be OK for most Celiacs.     I get various pains in different places in my digestive tract from time to time, but that burning pain is something I won't forget. The other thing I had that you mention was that pain between the shoulder blades.  I had that - I felt almost like someone was pushing my shoulders down.  So odd. I get palpitations when I am anemic.    I hope you get some answers soon.  It is pretty tough having to keep going from one doctor to another, but sometimes it is the only way.   
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,132
    • Most Online
      1,763

    Newest Member
    Feralgurl
    Joined