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How Accurate Is The Ttg Blood Test?

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Posted 07 September 2005 - 04:52 AM

Celiac Disease Comprehensive Panel tests are back...I AM FLABBERGASTED TO SAY THE LEAST...Charity, Bethany and I all tested NEGATIVE for Celiac Disease.

Bethany - TTG Antibody IGA <3 (negative is anything <5)
Bethany - Gliadin Antibody (IGA <3 (negative is anything <11)
Charity - TTG Angibody IGA <3 (negative is anything <5)
Charity - Gliadin Antibody <3 (negative is anything <11)
The lab did not perform the rest of the panel based on this information.

Me - TTG Antibody, IGA <3
Me - Gliadin Antibody (IGA) 8
IGA, Serum 212
The lab did not perform the rest of the panel based on this information.

I don't know what to think now. Of course, I am thankful we do not have celiac disease. However, I was certain this was the answer to my babies problems. What do I do now? Bethany is obviously thriving on a gluten free diet so I know there must be some kind of sensitivity. She is still scheduled to see a GI doctor next week.

The above tests did not even show a SENSITIVITY to gluten, right?
What should I do now?

You can read more about my situation in "11 Month Old Starving To Death" in the parents of kids with celiac forum here at glutenfreeforum.com.
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Posted 07 September 2005 - 07:59 AM

The tTG test is pretty accurate.
Were you all on gluten before testing? If you were gluten free then that can really screw up tests.
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Positive bloodwork
Gluten-free since January 2004

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Posted 07 September 2005 - 03:23 PM

False positives can occur - a gluten free diet can cause a false positive, and individuals deficient in IGA antibodies and cause a false positive.
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Carrie Faith

Diagnosed with Celiac Disease in March 2004
Postitive tTg Blood Test, December 2003
Positive Biopsy, March 3, 2004



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Posted 07 September 2005 - 04:56 PM

All of the celiac tests can be inaccurate in children under 2 years. Also, there is some question about accuracy under 5 years of age. If your child is thriving on a gluten free diet, I would leave her on it for now. Or you could put her back on gluten and pursue an endoscopy and biopsy. Just be sure to get someone who knows how to do the biopsy properly - 4-6 samples from the 3rd portion of the duodenum. There are cases where intestinal damage is apparent, even when blood work is negative.
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Mom to:
Hayley age 4, gluten-free at 26 months
Clark age 3, negative celiac bloodwork

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