Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Only Igg High....am A Celiac?
0

13 posts in this topic

Was told I was not Celiac by my GI. I went back to gluten. I feel horrible. Nauseaus all day plus much more. I dug and found my old results. So do you think I have Celiac?

Found my old results (Oct/06)

Gliadin Antibody IGG 31 High Range <11

Gliadin Antibody IGA 6 Range <6

Reticulin igg ab <1:10 Range <1:10

Reticulin IGA AB <1:10 Range <1:10

Tissue Transglut. IGA <3 Range <5

Then found 03/07/11 Everything the same but Gliadin IgG 23.4 High Range <10

What does it mean that eveything is normal BUT the Gliadin IgG?

0

Share this post


Link to post
Share on other sites


Ads by Google:

Was told I was not Celiac by my GI. I went back to gluten. I feel horrible. Nauseaus all day plus much more. I dug and found my old results. So do you think I have Celiac?

Found my old results (Oct/06)

Gliadin Antibody IGG 31 High Range <11

Gliadin Antibody IGA 6 Range <6

Reticulin igg ab <1:10 Range <1:10

Reticulin IGA AB <1:10 Range <1:10

Tissue Transglut. IGA <3 Range <5

Then found 03/07/11 Everything the same but Gliadin IgG 23.4 High Range <10

What does it mean that eveything is normal BUT the Gliadin IgG?

Well, first of all, since they do not appear to have done a total serum IgA, none of the IgA results mean a thing. If your total IgA is insufficient, ALL your IgA tests will most likely be low.

Second, your body is making antibodies against gluten. Your body does not like gluten. Your doc is a twit who should have done further testing. Especially considering you feel sick while eating gluten!

We can't answer the question definitively because we are not doctors, but there is an extremely high likelihood that yes, in spite of what your doctor said, you might have celiac.

Is there anything on your lab report that indicates whether the gliadin antibodies are "deamidated gliadin peptides"? Those are newer and more sensitive/specific than the old AGA (anti-gliadin antibody) tests. If your test was DGP, the likelihood is even higher for celiac.

0

Share this post


Link to post
Share on other sites

Thank you. I am going to a new Dr tomorrow.

Nothing else on the test results. I plan to get retested IF my insurance will cover it. Last visit the dr only used promethius and my insurance wouldnt pay. They said it would be about $1000!

Can I assume that with high IGG I am gluten intolerant? Not necessarily celiac?

0

Share this post


Link to post
Share on other sites

Thank you. I am going to a new Dr tomorrow.

Nothing else on the test results. I plan to get retested IF my insurance will cover it. Last visit the dr only used promethius and my insurance wouldnt pay. They said it would be about $1000!

Can I assume that with high IGG I am gluten intolerant? Not necessarily celiac?

Well, you can probably safely assume gluten intolerance at this point. Gluten is obviously making you feel sick. It's hard to say "celiac" for sure, because the IgG antibodies are less specific than the IgA ones, and without the EMA or TtG being positive, there is a chance your IgG elevation could be from another condition (see paragraph below). Still, you can see, there is a 91% chance it IS celiac.

Unfortunately, that leaves you in the boat of "maybe yes, maybe no". I've seen you wrestling with this on some other threads. If you are going to do more testing, you really need to make sure they do the total IgA along with everything else.

Gluten intolerance is a real condition, and can have a lot of negative effects on your life just like full-blown celiac; just without the flattened villi. Do you need a hard-copy celiac diagnosis for some reason?

Here's an explanation of the antibodies from an article on this site:

Anti-Gliadin Antibodies:

Both IgA and IgG anti-gliadin antibodies (AGA) are detected in sera of patients with gluten sensitive enteropathy (celiac disease). IgG anti-gliadin antibodies are more sensitive but are less specific markers for disease compared with IgA class antibodies. IgA anti-gliadin antibodies are less sensitive but are more specific. In clinical trials, the IgA antibodies have a specificity of 97% but the sensitivity is only 71%. That means that, if a patient is IgA positive, there is a 97% probability that they have celiac disease. Conversely, if the patient is IgA negative, there is only a 71% probability that the patient is truly negative for celiac disease. Therefore, a positive result is a strong indication that the patient has the disease but a negative result does not necessarily mean that they don not have it. False positive results are rather uncommon but false negative results can occur. On the other hand, the IgG anti-gliadin antibodies are 91% specific and have an 87% sensitivity. This means that they will show positive results more readily but there is not as strong a correlation with celiac disease. It is less specific. Patients with other conditions but not afflicted with celiac disease will occasionally show positive results. IgG anti-gliadin antibodies are detectable in approximately 21% of patients with other gastrointestinal disorders. This test might yield false positive results but is less likely to yield false negative results.

0

Share this post


Link to post
Share on other sites

Well, you can probably safely assume gluten intolerance at this point. Gluten is obviously making you feel sick. It's hard to say "celiac" for sure, because the IgG antibodies are less specific than the IgA ones, and without the EMA or TtG being positive, there is a chance your IgG elevation could be from another condition (see paragraph below). Still, you can see, there is a 91% chance it IS celiac.

Unfortunately, that leaves you in the boat of "maybe yes, maybe no". I've seen you wrestling with this on some other threads. If you are going to do more testing, you really need to make sure they do the total IgA along with everything else.

Gluten intolerance is a real condition, and can have a lot of negative effects on your life just like full-blown celiac; just without the flattened villi. Do you need a hard-copy celiac diagnosis for some reason?

Here's an explanation of the antibodies from an article on this site:

Anti-Gliadin Antibodies:

Both IgA and IgG anti-gliadin antibodies (AGA) are detected in sera of patients with gluten sensitive enteropathy (celiac disease). IgG anti-gliadin antibodies are more sensitive but are less specific markers for disease compared with IgA class antibodies. IgA anti-gliadin antibodies are less sensitive but are more specific. In clinical trials, the IgA antibodies have a specificity of 97% but the sensitivity is only 71%. That means that, if a patient is IgA positive, there is a 97% probability that they have celiac disease. Conversely, if the patient is IgA negative, there is only a 71% probability that the patient is truly negative for celiac disease. Therefore, a positive result is a strong indication that the patient has the disease but a negative result does not necessarily mean that they don not have it. False positive results are rather uncommon but false negative results can occur. On the other hand, the IgG anti-gliadin antibodies are 91% specific and have an 87% sensitivity. This means that they will show positive results more readily but there is not as strong a correlation with celiac disease. It is less specific. Patients with other conditions but not afflicted with celiac disease will occasionally show positive results. IgG anti-gliadin antibodies are detectable in approximately 21% of patients with other gastrointestinal disorders. This test might yield false positive results but is less likely to yield false negative results.

Thank you for the great response! I dont know IF there is a hard reason that I NEED to know. It would suck to be the 3% the is negative and eat gluten free ON ONE HAND. On the other hand I feel better off of gluten. Maybe I wonder if gluten intolerant can cause the same diseases? Maybe I am wanting someone to say my symptoms are something else. I honestly have no interest in going to the dr tomorrow. I kinda hope you would say yep you have it! And I would be done :)

0

Share this post


Link to post
Share on other sites




Thank you for the great response! I dont know IF there is a hard reason that I NEED to know. It would suck to be the 3% the is negative and eat gluten free ON ONE HAND. On the other hand I feel better off of gluten. Maybe I wonder if gluten intolerant can cause the same diseases? Maybe I am wanting someone to say my symptoms are something else. I honestly have no interest in going to the dr tomorrow. I kinda hope you would say yep you have it! And I would be done :)

I do hope that the new doctor is a little more intuitive and a little more curious than the one you've been working with! It is definitely unpleasant to be going through all this. It is expensive, and it is a huge hassle. On the other hand, getting health improvements is worth it!

It is extremely important to get that total serum IgA. Finding out that is insufficient would push this more in the direction of celiac. Here's another description of how the tests are used...might be a little more informational than the other one.

I sure wish, for your sake, this could be more cut and dried. Celiac diagnosis is just not all that exact for a lot of people. :huh:

Seeing the difference in yourself on and off gluten is a huge factor but I know what you mean about being the 3%. It was difficult for me to allow myself to think I had to be off gluten forever because I also have a weird test presentation (positive only on TtG Igg). I LOVE and ADORE sourdough bread. No gluten-free substitute for a good,crusty San Francisco sourdough! My doc made it a lot easier for me to get on the gluten-free path.

0

Share this post


Link to post
Share on other sites

One thing shalnuts; if you still intend to go to the doc & get tested again. You MUST be consuming & HAVE BEEN consuming gluten. You can not have been off gluten for even a week. Otherwise the tests get screwed up b/c of that.

0

Share this post


Link to post
Share on other sites

Most "gliadin IgG" these days is deamidated gliadin peptide, not the AGA Beachbirdie posted about. That is a very sensitive and specific test for celiac and it's the IgG that tends to be positive. If you know what lab ran the 2011 test you can call them and check what you got. If you have gliadin peptide IgG positive and feel awful on gluten I'd say you can consider yourself celiac.

0

Share this post


Link to post
Share on other sites

Skylark, here's the whole story:

http://www.celiac.com/gluten-free/topic/94090-lost-and-confused-so-sick-please-advise/page__p__804336__fromsearch__1#entry804336

She was dx'd celiac 9 years ago. Went gluten-free for 5 yrs. but still felt bad, went back to doc & doc said go back to gluten & take immodium. She's just had a series of BAD docs.

0

Share this post


Link to post
Share on other sites

Thanks for the rest of the story. Yeah, it sure sounds like celiac. Damn doctors. :blink:

0

Share this post


Link to post
Share on other sites

Really. It's like there's a secret society of them which is determined to not diagnose people. Pardon me, I wasn't skeletal and I had neuropathy and was falling over my own feet literally so therefore it just couldn't be that ! blah, blah, blah. <_<

To original poster. You were diagnosed, so stop eating the ****ed gluten ! None of us get to "100% normal" even if we eat perfectly, because we can be temporarily knocked down by cross contamination, or still have some other related diseases or conditions which we have to deal with, but most of us get to very high or at least acceptable functioning.

1

Share this post


Link to post
Share on other sites

Most "gliadin IgG" these days is deamidated gliadin peptide, not the AGA Beachbirdie posted about. That is a very sensitive and specific test for celiac and it's the IgG that tends to be positive. If you know what lab ran the 2011 test you can call them and check what you got. If you have gliadin peptide IgG positive and feel awful on gluten I'd say you can consider yourself celiac.

Not if you get it from my doctor's lab. :blink: It's why I asked for clarification.

She has been frustrated because she cannot get them to do the DGP. She's now going to be sending her celiac testing outside the local health conglomerate collective monopoly errr....system, even though people will likely have to drive 25 miles to get the tests.

0

Share this post


Link to post
Share on other sites

You know, I really wish people would keep their story in one thread. It's impossible to help someone with all the relevant info scattered about. :(

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      103,874
    • Total Posts
      919,420
  • Topics

  • Posts

    • So I've been glutened....
      Yeah I did all the bone broths and sauerkraut after my challenge. Although I wasn't very good at making sauerkraut... Its summer here now so I've eased up on the bone boiling, plus my local butcher is struggling to obtain them. As you say healing to the point where microscopic cross contamination doesn't get you would be a big win.  I was ok with coffee until last few days. I drank decaff black and would have several cups a day without issue. I'll be gutted if I can't handle it any more. I hadn't realised you could get gluten-free miso soup. Will have to look for that    
    • So I've been glutened....
      Coffee is a no-no for me!  I actually gave up coffee since my diagnosis back on 2/2016.  I was diagnosed by a biopsy in the stomach...no villi.   Coffee is a stimulant to the GI system and it really irritates your GI when you are having a flare up.  I was tested by stools and was informed I barely had good bacteria in my gut which is typically for people with celiac. I went on a high dose of probiotic (just started) twice a day, multivitamin, lots of fermented vegetables like sauerkraut, kimchi, miso soup and tons of bone broth.  I am going to a local farm today to pick up organic bones to make my broth.  I am so desperate to heal my gut, not to introduce gluten but to be able to tolerate an exposure without being knocked out by it....Eat very light, I stick to vegetable juice, resistance starch food such as banana, apples, potatoes boiled until my diarrhea subsides.  I am currently in a flare up stage; did something and I have been glutened I am on day 7 and my symptoms peak after a few days, around day 4-5 and it last a few days of Diarrhea, nausea, sensation of feeling full, back pain in the rib cage on left side and hip/lower back pain on left side.  Its horrible!  I feel weak right now due to the diarrhea and since I am not hungry it makes it worse.  Hope this gets better.
    • DNA Testing
      I got the print out and took it to my new dr because what my RA was saying didn't seem to add up.  When I pressed him for more info, he said I didn't have any of the markers. Turns out he read the test wrong!  Since then, my new doc also questioned all my previous bloodwork and asked why I hadn't been told that my counts were really low or tested for ferritin levels. My ferritin was at 10, so, yeah, 4 other Dr's missed anemia on my labs. It's been frustrating to say the least, but I am finally feeling a little bit hopeful with my new primary doc. She's just referred me to a specialist focusing on celiac. Considering my former gp told me "that whole celiac thing is just a fad", I'm feeling a bit more secure. 
    • So I've been glutened....
      Thanks for the kind responses  Last night I went out and had a black coffee, non decaf.   Big mistake... I started getting gas almost immediately and it went on for the rest of the evening. It seems like anything which might annoy my stomach at the moment results in churning and an uncomfortable feeling. the weird thing is that I ate a huge lunch including gluten-free bread earlier with no effects whatsoever. Just as well as I couldn't face food last night and am not enthused with breakfast now.  C i think I'll dig out some probiotics and try and eat simply for a few days and hope things settle down. I'm just worried that something has changed and this is the new normal... That would suck...  
    • Toblerone
      It's on the safe list here in the uk and I eat it without a problem. theres also a really nice almondy toblerone cake available now. 
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

    • Jmg  »  admin

      Hello Admin!
      I don't know whether this is of interest to post on your articles feed:
      http://pratt.duke.edu/about/news/window-guts-brain
      Kind Regards,
      Matt
      · 2 replies
    • celiac sharon  »  cyclinglady

      Hello cycling lady, have you noticed my picture is showing up as you?  Have no idea why but it's rather disconcerting to see my picture and your words 😉  Do you know how to fix it?  You seem to have far more experience with this board than I do
      · 1 reply
    • Larry Gessner  »  cyclinglady

      Hi There, I don't know if there is a place for videos in the forum. I just watched "The Truth About Gluten" I think it is a good video. I would like to share it somewhere but don't know where it should go. Any help would be greatly appreciated.
      Here is the link if you have never watched it.
      https://youtu.be/IU6jVEwpjnE Thank You,
      Larry
      · 2 replies
  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      60,909
    • Most Online
      1,763

    Newest Member
    Fourpeople
    Joined