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Curious About Genetics
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In the research I have done about Celiac Disease it seems that it affects people of Northern European decent more frequently than others but not exclusively. My Dad's side of the family is Swedish and my Mom's side is Irish and they are both northern European countries. I have had genetic testing and it came back with HLA-DQ 2,3 (Subtype 2,8) which seems to be the main genes associated with Celiac and said both my parents passed the gene to me so I have two copies of each. My question is that do most of you have northern European ancestry or is that kind of a myth. Most of my wife's ancestors are from the Czech Republic which isn't as far north and she has no issues. So, Celiacs what is your ancestry? Are most of you from northern Europe or is that kind of a myth. I am curious to see where these genes come from.

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Ads by Google:

You might find this older thread interesting:

They way people come & go on here, you should get some new entries.

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Thanks Karen. I have been on this site for a year but missed this one. I thought it wasn an interesting thought, but I guess with all the forums and all the people on this site it doesn't surprise me this has been covered already. It's like an episode of South Park where every idea that they came up with has already been done on the Simpsons because after hundreds of episodes of the Simpsons almost everything has been covered.

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Thanks Karen. I have been on this site for a year but missed this one. I thought it wasn an interesting thought, but I guess with all the forums and all the people on this site it doesn't surprise me this has been covered already. It's like an episode of South Park where every idea that they came up with has already been done on the Simpsons because after hundreds of episodes of the Simpsons almost everything has been covered.

But this place can be a revolving door. Maybe some who didn't post preciously would like to add on?

I saw something that said that the biggest group of Celiacs are from North African descent. It was a reputable source but, I can't find it again! Not sure even what they were counting as N. African descent.

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I've heard that same thing about Northern European descent. it seems supported by that like kareng provided. Interesting...

I'm Canadian with a German and Ukranian/Polish background. My family all came over in the early 1900's. I haven't had genetic testing done but there is celiac on the Ukranian/Polish side of the family.

Nicole S

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Scotch/Irish on both sides.don't know of anyone else that has Celiac in my family, but I strongly suspect that my Mom did from symptoms I remember.

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I'm French, Italian, greek, and Scandinavian. I have heard from many people and sources that its most common in Europeans!

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German/Irish here. Family history suggests my ancestors moved from somewhere in Scandinavia to Germany before coming to America although we haven't been able to confirm that for certain.

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Recently they discovered that in parts of northern Aftica, up to 7-8% have celiac, and in the mediterranian countries 1% or more, and in India and Iran also.

Just that they do not get tested because doctors only suspect celiac with northern Europeans.

By the way, there is much celiac in Austria, which is not northern european.

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Scottish and Irish on my mom's side (she also has Celiac) English and Native American on Dad's side (he probably has celiac, at least is gluten intolerant- never tested)

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Interesting to see everything from Native American to Northern Africa to Ukraine. I guess by this time most of us have had a variety of different nationalities mixed into our genes.

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I'm 50% Polish (mom's side) and the rest Irish/German/Scottish (dad)....have no idea what side it came from, as it doesnt seem like anyone in my family has Celiac but me. :(

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    • I'll give my PCP a call tomorrow and see what they can offer. My only worry is the expense as anymore tests will put me behind in being able to afford to see the GI. I have high deductible insurance but get money put into my HSA. I'm still trying to pay off the CT scan though. Which is why I'm trying to pick and choose which poses the greatest risk for me right now and what can wait. (Though I would prefer not to wait on any of it.)

      I really do hope its only IBS. Though I always worry IBS is more or less a doctors way of saying "I have no clue" at that point. :C

      Again, I'll be sure to give my PCP a call tomorrow then and see what the options are. I can feel a lot better trying the blood work first. however, once that is done, do I still need to be on a gluten diet before the endoscopy? Also, is it ok if I still mildly reduce the gluten. As in, can I avoid a whole wheat pasta dinner, but still be eating the peanut butter crackers? That sort of thing. Again I guess that is more of a doctor related question. I just wasn't sure if in order to raise your chance, you have to mass consume gluten or not. (Its already in just about everything to begin with.)
       
    • Excellent point, GFinDC!!! I just assumed that Steph had the endoscopy and not just the antibodies tests.    
    • She (your PCP)  can order a celiac blood panel.  It might not be a complete panel, but it's a start.  Any medical doctor can order one.  A GI is needed for the endoscopy (ulcers, Celiac disease, h.pylori, etc.), HIDA scan (gallbladder)  or colonoscopy (IBS).   Since you just saw her, email/call/write a letter and ask her to order (lab) the celiac panel.  You could go to the lab before or after work.  Pretty easy!  
    • I just now saw the second reply and I see what you mean. Again, the issue is that I may have to go with the gluten until close to the end of the year.

      However, an idea did just come to mind, and that is, can my primary care doctor do such a test? I had normal blood work done, but they didn't really say anything about testing for celiacs. I can get an appointment with my primary care doctor much sooner than a GI.

      When I was talking to my PCP last, I asked her what I should expect as far as testing goes or what she may have been concerned about. Her reply was about a HIDA scan for the gallbladder but also any test needed in case of IBS or Celiacs. Just the way she threw that in there like an after thought and left me hanging kinda had me worried.
    • I am not a doctor that's for sure.  So, I can't even answer your questions.  If you know you have pre-diabetes, you probably are working with a doctor.  Can you email them and ask for a celiac blood panel?   You can work on the weight loss and diabetes -- that you can handle yourself now and take action.  I have diabetes and my glucose readings are fairly normal now without medication and I'm thin.  Being overweight does not cause diabetes.  It's either autoimmune (type 1) or you become insulin resistant (type 2).  You can cut out all sugar and  processed stuff ASAP to help take action and start walking 10,000 steps (helps with the insulin resistance).    But the prediabetes is not going to kill you in the next year.  Whatever's in your gut is more likely going to get you much sooner.  But heck, I'm not a doctor and I don't even know you!    
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