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Mouth Ulcers?

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Posted 23 June 2012 - 04:25 AM

I have to disagree with this conclusion, I'm sorry.

In fact, that article is so poorly written and disjointed, and sprinkled with random statements that I found it worthless. I cannot conclude that gluten intolerance CAUSES herpes simplex from what was written there. ? where was the clinical data? It said: "the herpes simplex 1 virus initially causes cold sores, also known as fever blisters, but many factors contribute to recurrences."

This is mixing apples and oranges and does not mean anything.

Cold sores are very different from mouth ulcers which are known as
aphthous stomatitis. And the herpes simplex virus is very different from recurrent mouth sores (aphthous stomatitis)

Although the process in idiopathic recurrent aphthous ulcers is usually self-limiting, in some individuals, the ulcer activity can be almost continuous. Similar ulcers can be noted in the genital region. Behet syndrome, systemic lupus erythematosus, and inflammatory bowel disease are systemic diseases associated with oral recurrent aphthous ulcers.

In Gluten-sensitive enteropathy, oral lesions occur in most cases of gluten-sensitive enteropathy (GSE) and can often precede abdominal symptoms. Less than 5% of patients with recurrent aphthous ulcers have celiac disease, or other minor mucosal abnormalities of the small intestine.

of interest:

Celiac disease in patients having recurrent aphthous


In summary:

Recurrent aphthous stomatitis was found in 10-
40% of untreated celiac disease patients (14-16). The prevalence
of RAS in the general population is approximately
20% (5; 16). As RAS is frequently seen in
celiac disease patients, evaluation of individuals with this
symptom may reveal the patients with undiagnosed
celiac disease.
Although the exact cause for aphthous stomatitis
is still unknown, nutritional factors play a well defined
role, and contribute to the relationship between
celiac disease and RAS (10;16;17).
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Posted 23 June 2012 - 04:32 AM

I used to get these frequently before starting a gluten free + dairy free + low sugar diet. About that time I was told to add Bronson's "Super B" vitamin complex and it has really made a difference. Now I hardly ever have mouth ulcers...and the few times they have popped out, they were much milder and didn't last near as long. So, I would suggest talking to your doctor about adding this. Digestive problems usually lead to poor vitamin absorption in the small intestine, so added vitamins and minerals are important for optimizing health.
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Gluten + Dairy + Fructose Intolerant, Osteoporosis, Hasi's/ Hypothyroid, Sjogren's, Migraine Deviate with Visual Aura, Peripheral Neuropathy, DQ2 and DQ8 negative [Prometheus Labs]



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Posted 23 June 2012 - 06:20 AM

I used to get these aphthous ulcers inside my mouth or throat regularly, and they cleared completely after going gluten free. I got them again once when I tried using a particular toothpaste, which did not gluten me, so I have to think chemical sensitivity must also be involved.

Those things SUCK! I used to eat a bunch of tomato sauce when I got them, it hurts like the dickens at first but drastically reduced general pain and longevity.
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Posted 23 June 2012 - 08:37 AM

For advice and support, I direct you to a thread from our own members in 2009, who talked about the prescriptions they used in treating their own mouth sores.


The drugs mentioned are abreva, and valtrex. Valtrex is an actual antiviral used specifically for herpes simplex and zoster infections, and can be obtained easily from a primary care physician. Apparently a one day treatment is enough to make them vanish. Abreva can be bought over the counter, and was actually the first antiviral approved for over the counter sale in the U.S.

I should also note that gluten intolerant/ Celiac persons in this case did get tested for herpes simplex and came back POSITIVE. Given the general population infection rates, just because one person doesn't have it, doesn't mean YOU don't have it.

As far as gluten intolerance and herpes simplex:

"Because side effects common in gluten intolerance, such as stress, chronic illness and dietary problems can cause cold sore recurrences, you may have an increased risk of developing cold sores if you're gluten intolerant. If you find that certain foods act as trigger foods for cold sores, check to make sure they don't contain hidden gluten. Some sources of gluten you may not have considered include rice syrup, gum bases, malt vinegar, corn starch, baking powder and some soy sauces, fillers and colorings.

Read more: http://www.livestron.../#ixzz1ydH5Tlf5

-Seems pretty much like the same advice given to every member, every day on this forum.

"Getting frequent cold sores does not necessarily mean that you have gluten intolerance. Cold sores are common; between 45 and 80 percent of people have had at least one outbreak of cold sores, according to the National Institute of Dental and Craniofacial Research. Gluten intolerance is also relatively common, affecting around one in every 133 Americans, according to the National Institute of Diabetes and Digestive and Kidney Diseases. Sores inside your mouth associated with gluten intolerance are more likely to be canker sores than cold sores, although cold sores can occur inside the mouth, usually on the roof of the mouth or on the gums.

Read more: http://www.livestron...#ixzz1ydHa0XOh"

-What this is saying is that you're probably getting a CANKER SORE, not a cold sore. It's also saying that just because you have Celiac disease, you're not immune from getting cold sores (caused by herpes), and that getting contaminated or eating the wrong things are not helping you in that regard.

Finally, I'll quote a source from the National Institute of Dental and Craniofacial Research

<b>What causes fever blisters?</b>

Fever blisters are caused by a contagious virus called herpes simplex. There are two types of herpes simplex virus. Type 1 usually causes oral herpes, or fever blisters. Type 2 usually causes genital herpes. Although both type 1 and type 2 viruses can infect oral tissues, more than 95 percent of recurrent fever blister outbreaks are caused by the type 1 virus.

Herpes simplex virus is highly contagious when fever blisters are present, and the virus frequently is spread by kissing. Children often become infected by contact with parents, siblings or other close relatives who have fever blisters.

A child can spread the virus by rubbing his or her cold sore and then touching other children. About 10 percent of oral herpes infections in adults result from oral-genital sex with a person who has active genital herpes (type 2). These infections, however, usually do not result in repeat bouts of fever blisters.

Most people infected with the type 1 herpes simplex virus became infected before they were 10 years old. The virus usually invades the moist membrane cells of the lips, throat or mouth. In most people, the initial infection causes no symptoms. About 15 percent of patients, however, develop many fluid-filled blisters inside and outside the mouth 3 to 5 days after they are infected with the virus. These may be accompanied by fever, swollen neck glands and general aches. The blisters tend to merge and then collapse. Often a yellowish crust forms over the sores, which usually heal without scarring within 2 weeks.

The herpes virus, however, stays in the body. Once a person is infected with oral herpes, the virus remains in a nerve located near the cheekbone. It may stay permanently inactive in this site, or it may occasionally travel down the nerve to the skin surface, causing a recurrence of fever blisters. Recurring blisters usually erupt at the outside edge of the lip or the edge of the nostril, but can also occur on the chin, cheeks, or inside the mouth.

The symptoms of recurrent fever blister attacks usually are less severe than those experienced by some people after an initial infection. Recurrences appear to be less frequent after age 35. Many people who have recurring fever blisters feel itching, tingling or burning in the lip 1 to 3 days before the blister appears.

What causes a recurrence of fever blisters?

Several factors weaken the body's defenses and trigger an outbreak of herpes. These include emotional stress, fever, illness, injury and exposure to sunlight. Many women have recurrences only during menstruation. One study indicates that susceptibility to herpes recurrences is inherited.

********What I got from this*********
I really didn't know about the disease transmission in children. Tres interesante! It doesn't specifically discuss gluten exposure in there, but I can easily see how gluten exposure would make one more susceptible to a cold sore outbreak.

From the same article:

"<b>Canker Sores</b>

Recurrent canker sores afflict about 20 percent of the general population. The medical term for the sores is aphthous stomatitis.

Canker sores are usually found on the movable parts of the mouth such as the tongue or the inside linings of the lips and cheeks. They begin as small oval or round reddish swellings, which usually burst within a day. The ruptured sores are covered by a thin white or yellow membrane and edged by a red halo. Generally, they heal within 2 weeks. Canker sores range in size from an eighth of an inch wide in mild cases to more than an inch wide in severe cases. Severe canker sores may leave scars. Fever is rare, and the sores are rarely associated with other diseases. Usually a person will have only one or a few canker sores at a time.
{Canker sores graphic}

Most people have their first bout with canker sores between the ages of 10 and 20. Children as young as 2, however, may develop the condition. The frequency of canker sore recurrences varies considerably. Some people have only one or two episodes a year, while others may have a continuous series of canker sores.

<b>What causes canker sores?</b>

The cause of canker sores is not well understood. More than one cause is likely, even for individual patients. Canker sores do not appear to be caused by viruses or bacteria, although an allergy to a type of bacterium commonly found in the mouth may trigger them in some people. The sores may be an allergic reaction to certain foods. In addition, there is research suggesting that canker sores may be caused by a faulty immune system that uses the body's defenses against disease to attack and destroy the normal cells of the mouth or tongue.

British studies show that, in about 20 percent of patients, canker sores are due partly to nutritional deficiencies, especially lack of vitamin B12, folic acid and iron. Similar studies performed in the United States, however, have not confirmed this finding. In a small percentage of patients, canker sores occur with gastrointestinal problems, such as an inability to digest certain cereals. In these patients, canker sores appear to be part of a generalized disorder of the digestive tract.

Female sex hormones apparently play a role in causing canker sores. Many women have bouts of the sores only during certain phases of their menstrual cycles. Most women experience improvement or remission of their canker sores during pregnancy. Researchers have used hormone therapy successfully in clinical studies to treat some women.

Both emotional stress and injury to the mouth can trigger outbreaks of canker sores, but these factors probably do not cause the disorder."

There are some great pictures in there that can help you determine which type of sore you have. I know I get both canker sores and cold sores, at different times. I did not know cankers were caused by a B12 deficiency. That probably explains why I never got them, once I started supplementing with B vitamins.

I also get angular cheilitis, which is another one that is a sign of B vitamin deficiencies. That one causes sores at the corners of your mouth only, and man, it's extremely painful. By far, worst of the three for me.

Just for giggles here are the Wikis on cold sores, canker sores, and angular cheilitis.

1) http://en.wikipedia....gular_cheilitis
2) http://en.wikipedia....Herpes_labialis
3) http://en.wikipedia..../Aphthous_ulcer

All of these articles have an enormous reading list if you are so inclined, but I prefer to avoid argumentation through jargon. Suffice to say, these three articles probably cover the type of sore you're experiencing.

Things to be aware of:

1)Gluten exposure
2)B12 deficiency
3)Zinc deficiency
4)B2 deficiency
5)Iron deficiency anemia

Basically, if you're still getting cold or canker sores and are strictly gluten free, then there is something nutritionally deficient in your diet or you are reacting to another food. Eat whole foods, get plenty of rest and relaxation, wear sunscreen especially on the face, and supplement where necessary to make up for dietary shortfalls. Pretty much the same advice given to every new member of the forum.
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