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Testing Question


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15 replies to this topic

#1 flex9198

 
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Posted 02 July 2012 - 03:46 PM

Hi All -

Quick question...I got an EMA, TTG IGA, DGP IGG and IGA and Total IGA test last Monday (that all came back negative). Prior to that, I went gluten free for about 5/6 days. Would that cause a false negative?

Thanks
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#2 nvsmom

 
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Posted 02 July 2012 - 05:06 PM

I don't think it would affect it that quickly but I'm not sure. Hopefully someone more knowledgeable can comment.

I would guess that you really are negative for celiac, but that doesn't mean you aren't intolerant or sensitive to gluten.
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#3 squirmingitch

 
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Posted 02 July 2012 - 05:42 PM

Yes, it could certainly skew the tests. Sorry to tell you.
Why don't you post the test results anyway along with the reference ranges. It might give some clue. Or if your total IGA was off then you could be IGA deficient which could mean the rest of the tests will not show correctly.

And finally, like nvsmom says you could still be non celiac gluten intolerant. And that can make you very sick.
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Self diagnosed dh Sept. 2011~~~ confirmed dx July 18, 2012
Gluten free Dec. 2011
Soy free Dec. 2011
Hubs self diagnosed dh March 30, 2012
Hubs gluten free March 30, 2012

Summer 2013 We both have added back a little soy which is near unavoidable & we are doing okay with that small amount.

 


#4 flex9198

 
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Posted 02 July 2012 - 07:22 PM

Yes, it could certainly skew the tests. Sorry to tell you.
Why don't you post the test results anyway along with the reference ranges. It might give some clue. Or if your total IGA was off then you could be IGA deficient which could mean the rest of the tests will not show correctly.

And finally, like nvsmom says you could still be non celiac gluten intolerant. And that can make you very sick.


Thanks for the reply! My results were as follows:

IGA, Serum - Negative (I was 280 and the ref range is 84 to 463)
TTG AB IGA - Negative (I was <3 and the ref range is <5)
EMA - Negative
Gliadin Deamidated (DGP) IGG - Negative (I was 3 and the ref range is <20)
Gliadin Deamidated (DGP) IGA - Negative (I was 4 and the ref range is <20)

I had a Gliadin IgG done two weeks prior to that test and it came back positive (but iga and ema were negative) and it was 84 (ref range of <20). But I don't know if that was a DGP or an AGA (that test was done by BioReference and the most recent test above was done by Quest).

Thanks!
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#5 squirmingitch

 
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Posted 03 July 2012 - 04:32 AM

Well, I'm no expert on interpreting the very fine points of the tests but others here are very good at spotting discrepancies. Keeping in mind that the 5-6 days gluten-free may have blown the test; it looks to me like it's negative. Now, there is a 20% false neg. rate (maybe a little more than that) anyway. But you could still have problems with gluten. Try the gluten-free diet & see if things improve for you. You have nothing to loose & everything to gain.
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Self diagnosed dh Sept. 2011~~~ confirmed dx July 18, 2012
Gluten free Dec. 2011
Soy free Dec. 2011
Hubs self diagnosed dh March 30, 2012
Hubs gluten free March 30, 2012

Summer 2013 We both have added back a little soy which is near unavoidable & we are doing okay with that small amount.

 


#6 flex9198

 
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Posted 03 July 2012 - 05:28 AM

Well, I'm no expert on interpreting the very fine points of the tests but others here are very good at spotting discrepancies. Keeping in mind that the 5-6 days gluten-free may have blown the test; it looks to me like it's negative. Now, there is a 20% false neg. rate (maybe a little more than that) anyway. But you could still have problems with gluten. Try the gluten-free diet & see if things improve for you. You have nothing to loose & everything to gain.


Thanks for the advice! I don't have a negative reaction to gluten (I thought I was a "silent" celiac). So whether I'm on or off gluten really won't have any overt physical effects. I'm going to stay on a gluten containing diet for a few months and then get re-tested. I've done extensive research on the different types of tests and I'm assuming that I am gluten sensitive but not celiac (crossing my fingers). I've come to this conclusion because my initial IgG Test was positive but I believe that one to be a AGA IgG and not the more accurate, more celiac specific, DGP IgG test.
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#7 squirmingitch

 
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Posted 03 July 2012 - 05:53 AM

Sounds like a plan to me!Posted Image
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Self diagnosed dh Sept. 2011~~~ confirmed dx July 18, 2012
Gluten free Dec. 2011
Soy free Dec. 2011
Hubs self diagnosed dh March 30, 2012
Hubs gluten free March 30, 2012

Summer 2013 We both have added back a little soy which is near unavoidable & we are doing okay with that small amount.

 


#8 nora_n

 
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Posted 03 July 2012 - 06:24 AM

Do you have low vitamin D or other issues like low iron etc? High liver numbers? A rash from gluten or Dermatitis herpetiformis, or neuro issues from gluten?

I notice your AGA was positive.
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gluten-free since may 06 after neg. biopsy symptoms went away and DH symptoms which I had since 03 got gradually better.
daughter officially diagnosed celiac and casein intolerant.
non-DQ2 or DQ8. Maybe DQ1? Updated: Yes, double DQ5
Hypothyroid since 2000, thyroxine first started to work well 06 on a low-carb and gluten-free diet
Lost 20 kg after going gluten-free and weighing 53 kg now. neg. biopsy for DH. Found out afterwards from this forum that it should have been taken during an outbreak but it was taken two weeks after. vitaminD was 57 nmol/l in may08)

#9 roxieb73

 
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Posted 03 July 2012 - 06:55 AM

Do you have low vitamin D or other issues like low iron etc? High liver numbers? A rash from gluten or Dermatitis herpetiformis, or neuro issues from gluten?

I notice your AGA was positive.


Nora I love your question here...... lol I have ALL of the above.

Ok my 2 cents for what it is worth. I think since you had a positive result pre gluten free and negative afterward a gluten challenge is in order. I only say that because it sounds like you are one of the rare people who can actually withstand it without getting sick. IMHO

Roxie
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GI confirmed Celiac 08/2012
Double DQ1 subtypes(5,6)
Severe Vit D defiency
Iron Defiency Anemia
Gluten Free and on my way back to good health

#10 flex9198

 
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Posted 03 July 2012 - 08:25 AM

Do you have low vitamin D or other issues like low iron etc? High liver numbers? A rash from gluten or Dermatitis herpetiformis, or neuro issues from gluten?

I notice your AGA was positive.


none of the above except high liver but that came back down to normal very quickly (before i went off gluten for a few days).
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#11 flex9198

 
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Posted 03 July 2012 - 08:26 AM

Do you have low vitamin D or other issues like low iron etc? High liver numbers? A rash from gluten or Dermatitis herpetiformis, or neuro issues from gluten?

I notice your AGA was positive.



Also, I've read that a positive AGA IGG could either be celiac or just gluten sensitivity (without the damage to your vili) while the DGP IGG test is celiac specific (which mine was negative).
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#12 nora_n

 
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Posted 03 July 2012 - 11:10 AM

those with neuro issues from gluten, have ttg-6 antibodies, DH have ttg-3 antibodies (but we do not get those tests)

Hadjivassiliou found that gluten ataxia patients often have antigliadin antibodies. Now when they often have phased out AGA testing, those with neuro issues and AGA will have the more specific tests for celiac in the gut, and miss celiac in the skin or the brain.....
  • 0
gluten-free since may 06 after neg. biopsy symptoms went away and DH symptoms which I had since 03 got gradually better.
daughter officially diagnosed celiac and casein intolerant.
non-DQ2 or DQ8. Maybe DQ1? Updated: Yes, double DQ5
Hypothyroid since 2000, thyroxine first started to work well 06 on a low-carb and gluten-free diet
Lost 20 kg after going gluten-free and weighing 53 kg now. neg. biopsy for DH. Found out afterwards from this forum that it should have been taken during an outbreak but it was taken two weeks after. vitaminD was 57 nmol/l in may08)

#13 roxieb73

 
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Posted 03 July 2012 - 11:46 AM

those with neuro issues from gluten, have ttg-6 antibodies, DH have ttg-3 antibodies (but we do not get those tests)

Hadjivassiliou found that gluten ataxia patients often have antigliadin antibodies. Now when they often have phased out AGA testing, those with neuro issues and AGA will have the more specific tests for celiac in the gut, and miss celiac in the skin or the brain.....


Do you happen to know about Lichen Planus? I have been told that is an autoimmune gluten rash similar to DH but not exclusive to Celiac. Of course they have just begun research. That is the rash I have. Curious just because I love to learn about these things where do you find this information? What is ttg-3&6?
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GI confirmed Celiac 08/2012
Double DQ1 subtypes(5,6)
Severe Vit D defiency
Iron Defiency Anemia
Gluten Free and on my way back to good health

#14 nora_n

 
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Posted 04 July 2012 - 11:36 AM

ttg-3 is tissue transglutaminase 3 for example.

The one for gut celiac is tissue transglutaminase 2.

I have not run across Lichen Planus.

But another thing related to gluten is HS, Hidradenitis Herpetiformis and doctors do not know about the connection.

So lots of things are gluten related, like sometimes pancreatitis and migraines
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gluten-free since may 06 after neg. biopsy symptoms went away and DH symptoms which I had since 03 got gradually better.
daughter officially diagnosed celiac and casein intolerant.
non-DQ2 or DQ8. Maybe DQ1? Updated: Yes, double DQ5
Hypothyroid since 2000, thyroxine first started to work well 06 on a low-carb and gluten-free diet
Lost 20 kg after going gluten-free and weighing 53 kg now. neg. biopsy for DH. Found out afterwards from this forum that it should have been taken during an outbreak but it was taken two weeks after. vitaminD was 57 nmol/l in may08)

#15 Skylark

 
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Posted 04 July 2012 - 12:03 PM

Also, I've read that a positive AGA IGG could either be celiac or just gluten sensitivity (without the damage to your vili) while the DGP IGG test is celiac specific (which mine was negative).

I've read the same, particularly with IgG rather than IgA in someone with normal IgA. I find it hard to imagine that gluten-free for only 5-6 days would throw off the rest of your celiac panel.
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