Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Testing Question
0

16 posts in this topic

Hi All -

Quick question...I got an EMA, TTG IGA, DGP IGG and IGA and Total IGA test last Monday (that all came back negative). Prior to that, I went gluten free for about 5/6 days. Would that cause a false negative?

Thanks

0

Share this post


Link to post
Share on other sites


Ads by Google:

I don't think it would affect it that quickly but I'm not sure. Hopefully someone more knowledgeable can comment.

I would guess that you really are negative for celiac, but that doesn't mean you aren't intolerant or sensitive to gluten.

0

Share this post


Link to post
Share on other sites

Yes, it could certainly skew the tests. Sorry to tell you.

Why don't you post the test results anyway along with the reference ranges. It might give some clue. Or if your total IGA was off then you could be IGA deficient which could mean the rest of the tests will not show correctly.

And finally, like nvsmom says you could still be non celiac gluten intolerant. And that can make you very sick.

0

Share this post


Link to post
Share on other sites

Yes, it could certainly skew the tests. Sorry to tell you.

Why don't you post the test results anyway along with the reference ranges. It might give some clue. Or if your total IGA was off then you could be IGA deficient which could mean the rest of the tests will not show correctly.

And finally, like nvsmom says you could still be non celiac gluten intolerant. And that can make you very sick.

Thanks for the reply! My results were as follows:

IGA, Serum - Negative (I was 280 and the ref range is 84 to 463)

TTG AB IGA - Negative (I was <3 and the ref range is <5)

EMA - Negative

Gliadin Deamidated (DGP) IGG - Negative (I was 3 and the ref range is <20)

Gliadin Deamidated (DGP) IGA - Negative (I was 4 and the ref range is <20)

I had a Gliadin IgG done two weeks prior to that test and it came back positive (but iga and ema were negative) and it was 84 (ref range of <20). But I don't know if that was a DGP or an AGA (that test was done by BioReference and the most recent test above was done by Quest).

Thanks!

0

Share this post


Link to post
Share on other sites

Well, I'm no expert on interpreting the very fine points of the tests but others here are very good at spotting discrepancies. Keeping in mind that the 5-6 days gluten-free may have blown the test; it looks to me like it's negative. Now, there is a 20% false neg. rate (maybe a little more than that) anyway. But you could still have problems with gluten. Try the gluten-free diet & see if things improve for you. You have nothing to loose & everything to gain.

0

Share this post


Link to post
Share on other sites




Well, I'm no expert on interpreting the very fine points of the tests but others here are very good at spotting discrepancies. Keeping in mind that the 5-6 days gluten-free may have blown the test; it looks to me like it's negative. Now, there is a 20% false neg. rate (maybe a little more than that) anyway. But you could still have problems with gluten. Try the gluten-free diet & see if things improve for you. You have nothing to loose & everything to gain.

Thanks for the advice! I don't have a negative reaction to gluten (I thought I was a "silent" celiac). So whether I'm on or off gluten really won't have any overt physical effects. I'm going to stay on a gluten containing diet for a few months and then get re-tested. I've done extensive research on the different types of tests and I'm assuming that I am gluten sensitive but not celiac (crossing my fingers). I've come to this conclusion because my initial IgG Test was positive but I believe that one to be a AGA IgG and not the more accurate, more celiac specific, DGP IgG test.

0

Share this post


Link to post
Share on other sites

Sounds like a plan to me!smile.gif

0

Share this post


Link to post
Share on other sites

Do you have low vitamin D or other issues like low iron etc? High liver numbers? A rash from gluten or Dermatitis herpetiformis, or neuro issues from gluten?

I notice your AGA was positive.

0

Share this post


Link to post
Share on other sites

Do you have low vitamin D or other issues like low iron etc? High liver numbers? A rash from gluten or Dermatitis herpetiformis, or neuro issues from gluten?

I notice your AGA was positive.

Nora I love your question here...... lol I have ALL of the above.

Ok my 2 cents for what it is worth. I think since you had a positive result pre gluten free and negative afterward a gluten challenge is in order. I only say that because it sounds like you are one of the rare people who can actually withstand it without getting sick. IMHO

Roxie

0

Share this post


Link to post
Share on other sites

Do you have low vitamin D or other issues like low iron etc? High liver numbers? A rash from gluten or Dermatitis herpetiformis, or neuro issues from gluten?

I notice your AGA was positive.

none of the above except high liver but that came back down to normal very quickly (before i went off gluten for a few days).

0

Share this post


Link to post
Share on other sites

Do you have low vitamin D or other issues like low iron etc? High liver numbers? A rash from gluten or Dermatitis herpetiformis, or neuro issues from gluten?

I notice your AGA was positive.

Also, I've read that a positive AGA IGG could either be celiac or just gluten sensitivity (without the damage to your vili) while the DGP IGG test is celiac specific (which mine was negative).

0

Share this post


Link to post
Share on other sites

those with neuro issues from gluten, have ttg-6 antibodies, DH have ttg-3 antibodies (but we do not get those tests)

Hadjivassiliou found that gluten ataxia patients often have antigliadin antibodies. Now when they often have phased out AGA testing, those with neuro issues and AGA will have the more specific tests for celiac in the gut, and miss celiac in the skin or the brain.....

0

Share this post


Link to post
Share on other sites

those with neuro issues from gluten, have ttg-6 antibodies, DH have ttg-3 antibodies (but we do not get those tests)

Hadjivassiliou found that gluten ataxia patients often have antigliadin antibodies. Now when they often have phased out AGA testing, those with neuro issues and AGA will have the more specific tests for celiac in the gut, and miss celiac in the skin or the brain.....

Do you happen to know about Lichen Planus? I have been told that is an autoimmune gluten rash similar to DH but not exclusive to Celiac. Of course they have just begun research. That is the rash I have. Curious just because I love to learn about these things where do you find this information? What is ttg-3&6?

0

Share this post


Link to post
Share on other sites

ttg-3 is tissue transglutaminase 3 for example.

The one for gut celiac is tissue transglutaminase 2.

I have not run across Lichen Planus.

But another thing related to gluten is HS, Hidradenitis Herpetiformis and doctors do not know about the connection.

So lots of things are gluten related, like sometimes pancreatitis and migraines

0

Share this post


Link to post
Share on other sites

Also, I've read that a positive AGA IGG could either be celiac or just gluten sensitivity (without the damage to your vili) while the DGP IGG test is celiac specific (which mine was negative).

I've read the same, particularly with IgG rather than IgA in someone with normal IgA. I find it hard to imagine that gluten-free for only 5-6 days would throw off the rest of your celiac panel.

1

Share this post


Link to post
Share on other sites

I've read the same, particularly with IgG rather than IgA in someone with normal IgA. I find it hard to imagine that gluten-free for only 5-6 days would throw off the rest of your celiac panel.

Thanks!!

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,661
    • Total Posts
      921,636
  • Topics

  • Posts

    • pablito, here is the full serum (blood) panel. Make sure your doc runs ALL of the tests on it, not just 1 or 2. Insist!!!!! YOU are in charge. Remember that. Some people test negative on the most common 1 or 2 tests they run so it's always better to have the full panel run. Anti-Gliadin (AGA) IgA
      Anti-Gliadin (AGA) IgG
      Anti-Endomysial (EMA) IgA
      Anti-Tissue Transglutaminase (tTG) IgA
      Deamidated Gliadin Peptide (DGP) IgA and IgG
      Total Serum IgA   
      Also can be termed this way: Endomysial Antibody IgA
      Tissue Transglutaminase IgA 
      GLIADIN IgG
      GLIADIN IgA
      Total Serum IgA 
      Deamidated Gliadin Peptide (DGP) IgA and IgG Remember that celiac disease is a genetically inherited disease so it's important for you to find out if you have it and if so, then your kids & all first degree relatives (siblings, parents) need to be tested every 2 years in the absence of symptoms but right away if symptoms present. Do not go gluten free after the blood work as if you get positive blood work, you will need an endoscopy which you'll need to continue eating gluten for. The pimple things may or may not be the celiac rash as there are many skin problems associated with celiacs.
    • Hi, I've been experiencing on and off left side abd pain and bloating for about 3-4 years (doctors in the past didn't help much, just said I have IBS). My new doctor did some blood work and found out  my vitamin D was low, CRP was high.  Antigiladin Igg was a weak positive. I had an endoscopy done and the doctor confirmed I don't have Celiac, but she found very small ulcers (took Pepcid for 2 weeks). She also told me I have a leaky gut and non celiac gluten sensitivity. I'm taking probiotics for the leaky gut.  So for the past 3 months I've been eating gluten free and the pain came back 2 times.  The pain is always on the left side of my abdomen. Makes me feel weak, starts with constipation and usually ends with diarrhea. Tylenol helps the pain.  I'm waiting on my food allergy tests results to see if it can be anything other than gluten. So my question is, what does a weak positive Antigiladin IGG mean if a gluten free diet is not helping?  Could the "leaky gut" cause my Antigiladin IGG to rise? Really confused here, just want to start feeling better and not have the pain come back ever again.     Thanks
    • Thank you very much for the reply and advice I assume doctors didn't know or check into this disease too much back in the early 80's or my family doctor would have easily seen these symptoms and discussed this with me then. If I do have this disease it would explain a lot about my health and overall physical discomfort all my life. Pretty sad if it is the case and it could have been prevented but thankful I know about it now. I have made an apt with my doctor so shouldn't be long before I know for sure. Thanks again for your help
    • I continue to do more research but only found 3 journal articles which discuss the reversal of the fold pattern, possibly why I can't find answers I was waiting on on my latest celiac panel to come back so here it is, expecting slight cross contamination from eating out and possible several recent dentist visits. All three tests are based on a normal scale of 0-20 being within range.  DPG IgA - 24.5 DPG IgG – 6.84 tTg IgA – 22
    • Coffee giant Starbucks looks to feature more and better dietary specialty options, including gluten-free products. Will they succeed? View the full article
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,660
    • Most Online
      3,093

    Newest Member
    Ashey
    Joined