Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Anyone Dq2.5/dq2.5 Or De2.5/dq2.2 ?
0

4 posts in this topic

Hi everyone,

my mother 48 years old was diagnosed with celiac recently she had biposy which showed marsh 3B and gene test which showed she has DQ2.5 and DQ2.2 which from what i have read means she is at higher risk for refractory celiac Aand lymphoma according to one study !!

She has gone gluten free and i am trying to encourage her as much as i can, does anyone here have double copies of DQ2.5 or DQ2.5 with DQ2.2 ? And if so, then did you respond to GFD and how long did it take you to recover ?

my mother didnt have symptoms prior to diagnosis so it is hard to tell if she is respoing. I am just worried for her.

0

Share this post


Link to post
Share on other sites


Ads by Google:

Hi everyone,

my mother 48 years old was diagnosed with celiac recently she had biposy which showed marsh 3B and gene test which showed she has DQ2.5 and DQ2.2 which from what i have read means she is at higher risk for refractory celiac Aand lymphoma according to one study !!

She has gone gluten free and i am trying to encourage her as much as i can, does anyone here have double copies of DQ2.5 or DQ2.5 with DQ2.2 ? And if so, then did you respond to GFD and how long did it take you to recover ?

my mother didnt have symptoms prior to diagnosis so it is hard to tell if she is respoing. I am just worried for her.

Hi PersianCeliac, and welcome.

I hope you (and your mom) can not worry too much. The risk of refractory celiac is low and she's on the right track, so try not to worry. The best thing to do is to eat naturally gluten-free whole foods - meats, veggies, fruits, rice, potatoes - and limit eating out to start with, and then see how she does. Is the doctor going to re-test her blood/biopsy in 6-12 months?

As far as I know, I only have one DQ copy, so I can't help you there.

Do you have a link to the study?

0

Share this post


Link to post
Share on other sites

Hi PersianCeliac, and welcome.

I hope you (and your mom) can not worry too much. The risk of refractory celiac is low and she's on the right track, so try not to worry. The best thing to do is to eat naturally gluten-free whole foods - meats, veggies, fruits, rice, potatoes - and limit eating out to start with, and then see how she does. Is the doctor going to re-test her blood/biopsy in 6-12 months?

As far as I know, I only have one DQ copy, so I can't help you there.

Do you have a link to the study?

Thank you for your response. Well doctor didn't day after how long she should be re-tested, but from what I have read I guess 1 year would be reasonable given the damage that has been caused and her off the charts blood results ttg >800 !

The link to the study is : http://www.ncbi.nlm.nih.gov/m/pubmed/16527694/

0

Share this post


Link to post
Share on other sites

A celiac researcher told me in a private e-mail that double DQ2.5 genes are associated with super sensitivity.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,352
    • Total Posts
      920,501
  • Topics

  • Posts

    • Thankyou both! I was wondering if my high levels left much doubt on the diagnosis. I don't see the GI until the 15th Sep and I don't think I can stand to eat gluten in that time. If he tells me to I will do so after then. After 25 years of symptoms I don't think there is much chance of healing my bowel In a couple of weeks. I'm actually terrified of the damage they might find. But I think I will need the endo since there may be other things going on with me. So great they didn't put your son through the biopsy! Once I have a formal diagnosis I have my kids to worry about also. I can't even stand the thought of my daughter having a blood test. I think she would need to be sedated as she is so fearful and pain sensitive. My son is not yet 2 so I don't think they will test him. I'm feeling so off at the moment. I think I have some anxiety and reflux going on complicating things quite a bit.
    • My son's antibodies were 300. Based on his extremely high levels, his pediatric GI suggested genetic testing instead of the biopsy. Genetic testing can't diagnose celiac on its own but combined with such high levels, the gi dr was confident a positive genetic test would confidently diagnose celiac. He warned that biopsies are small snapshots of the intestine and can miss damage. He said this is an approach used very often in Europe but not as much in the US. What sold me on that approach was the ability to put my son directly on a gluten free diet instead of waiting three weeks for the biopsy, during which time he would continue to eat gluten and feel terrible. I'm not sure if this is more common with younger patients though (our son is two), based on the idea that he's had less time to inflict damage that would show in a biopsy? We are very happy that we immediately started the gluten free diet and chose the genetic testing. Our son got the proper diagnosis and his recent number shows a drop to 71 after only 4.5 months gluten free! Not sure if this helps. Good luck and I hope you feel better soon!
    • We have been off gluten for a while now, and symptoms return when I've allowed gluten full meals… so something still isn't sitting right with me.  Checking with her doc about seeing a pediactric GI although I'm not sure how long that will take since we live in small town America. I know she didn't get at least one of the recommended full panel tests but maybe two, can someone help clarify, or is she missing two? DGP for sure and possibly EMA? And if I understand what I'm reading in other posts that the DGP can be more accurate? Thanks Her blood panel results: Ttg ab iga <.5u/ml ttg igg <.8u/ml aga ab iga <.2 u/ml aga an igg <.7u/ml iga 61mg/dL  
    • I was tested for the full panel, I believe. I had normal values for t-transglutaminase (ttg) igg,t-transglutaminase (ttg) iga, deamidated gliadin abs igg, deamidated gliadin abs iga, and immunoglobulin a qn serum.  
    • Going gluten free may be beneficial if you're among the roughly 10 percent of people who suffer from celiac disease, a genetic immune disorder, ... View the full article
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,416
    • Most Online
      1,763

    Newest Member
    djs2117
    Joined