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Blood Test Interpretation

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Hello all! I am new to this site and have an endoscopy and biopsy scheduled in two weeks. Unfortunately, my doctor did not explain my blood results to me and I don't have another appointment with him to go over it. He simply said some results were positive and the biopsy is the next step. (He is a Celiac Specialist so although I'm upset he didn't explain more, I'm hoping he is still a capable doctor).

I have a biology degree and an understanding of the basics..but if anyone can give me some insight, I would be grateful. Especially the TTG results. I am soooo stressed about the biopsy, mostly the sedation.

Here are my results:

-IGA serum: 191 (normal)

-IGA AB group: 191 (normal)

-endomysial IGA anibody: POSITIVE titer (high)

-Gliadin (Demidated) AB, IGA: 152.5 (high)

-Gliadin (Demidated) AB, IGG: <20 (normal)

-Transglutaminase IGA : 47 (high)

-Transglutaminase IGG: 8 (high)

I'm so glad I found this website. I don't have much support for this and am glad I can find this support! :) :)


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Just going by your blood work it seems like you have celiac. The EMA and Deamidated gliadin are specfic to celiac. The tTG can be elevated in other autoimmune diseases also, but since the others are positive it's safe to say the elevated tTG is from celiac also. Some doctors will diagnose on blood work alone.

The EGD isn't that bad. You won't remember a thing. Just make sure the doctor takes enough samples to check for celiac. I think it is recommended to have 8-10 taken from different areas in the small bowel. They will also look at other things besides celiac. They look at the esophagus and will take biopsies if necessary and examine the stomach. It's pretty routine to have a biopsy in the stomach to look for H Pylori. Even if the biopsy comes back negative doesn't mean you don't have celiac. You can get a false negative biopsy due to an inexperienced doctor performing the biopsy, inexperienced pathologist looking at the samples, not enough samples taken, samples not taken in damaged areas(damage can't be seen with the naked eye and it can be patchy with normal areas and damaged areas) or damage is in another area of the small bowel that is beyond the reach of the scope. The scope only goes into the first portion of the duodenum(small bowel) and it's not very far.

After your scope I would go gluten free. No need to wait on the biopsy results. With blood work like yours I wouldn't hesitate to go gluten free and call it celiac and I'm not a doctor.

I put my youngest son gluten free without a scope/biopsy based on a postive IgA tTG alone. He does not have any other autoimmune diseases so it was safe to say it was because of celiac and the fact that I'm blood and biopsy diagnosed. My oldest son hasn't had any positive blood work in the past 4 years and even had a negative biopsy. He went gluten free almost a year ago and has done wonderful. I had toyed with the idea for two years to put him gluten free also but was hard to commit without anything positive. Now if he gets CC'd he is miserable. So he can't be diagnosed celiac, but he is definately gluten intolerent.


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Ditto what Roda said. Lots of positive antibody tests, especially the anti-EMA, scream celiac.


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The Biopsy is easy!

go to sleep for 10 min then feel great after. :-)

its only sedation, not anaesthetic

good luck.


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    • Hi AWOL, Since you weren't able to complete the 2 weeks gluten challenge for the endoscopy the results are not necessarily reliable.   So to be err on the side of caution I think you should assume you have celiac disease.  Your doctor should not assume you don't have it either since the challenge was not completed.  He has no proof that you don't have celiac disease.  He does have evidence that you have negative reactions to eating gluten though.
    • Hi Ironic Truth, Thanks for Replying. Wow I get bad joint pain too. So my opinion especially if he is eating gluten is to get him tested. I wish I had been tested when I was eating gluten 8 years ago .  I had tried 8 years ago initially to figure out what the heck was going on with me and my immune system. I started with a GP, went to Allergist/Immunologist etc. I gave up 4 doctors later when nothing seem to be found and you sense they start thinking lady you're a nut job . My cousin a diagnosed Celiac took over 2 years to be diagnosed and she is a nurse. My husband said for years "I think bread is bad for you" and in a desperate attempt to help myself -I gave up wheat after 2 weeks felt better 2 months later I went total gluten-free and felt very much better that was 4 years ago. So I have suspected NCGS or Celiac for a few years now. However getting someone to test you for it when you were classified IBS 20 years prior-well as is chronically heard on the forums here is perhaps the biggest challenge of all. One then just finally says ok I will just try this gluten-free thing myself. I was gluten-free for 3 1/2 years and improving. Then  I got gluten-ed in March of 2016 and I had worse symptoms then ever the joint pain arrived. I went to a new allergist who refereed me to another Allergist/Immunologist who deals with Celiacs and Food Intolerances. I did see a Rheumotologist in July 2016 since the muscle and joint pain was still lingering, who tested me and reported no antibodies. Back to the specialist who did more test and suggested the gluten challenge. It's likely me failing to complete 2 weeks caused it but the symptoms got real bad and I thought I'm going to have worse issues if I don't stop this.  Today my fingers are just starting to heal they were peeling during the gluten challenge among all the other symptoms I get, which I attribute to dehydration. The dry peeling fingers did not improve until I got the IV the day of the scope. Bizarrely I was looking forward to the scope hoping I'd get an IV with Meds and fluids becaus eI felt I needed it. I did see one abstract, I can't get my hands on the full article as you stated their is a link: Dig Dis Sci. 2005 Jan;50(1):126-9. Celiac disease and intestinal metaplasia of the esophagus (Barrett's esophagus). Maieron R1, Elli L, Marino M, Floriani I, Minerva F, Avellini C, Falconieri G, Pizzolitto S, Zilli M So I will pursue the path of monitoring the  Barrett's. Despite no official diagnosis for me, you are right Gluten is bad for me, I should avoid it, I will, and I'll stay on the forums. Good luck with you Boyfriend he is lucky to have you looking out for him.
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    • Thank you everyone. I appreciate all of the information and support.  I am feeling overwhelmed right now and it was really getting me down yesterday. I don't feel so hopeless now. 
    • Okay. I think I will start with an allergist and a dietitian. 
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