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Anatomy Question On Gluten Intolerance
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Hi, I took a celiac test (biocard) and got negative, not sure if accurate as I have been gluten free for past two weeks and only went back on gluten on Friday evening? Gonna keep eating for two weeks then take again. However have been pondering, my understanding is that celiac disease causes damage to gut, because of this malnutrition and lactose intolerance are risks (think I have both of these body not enjoying dairy just now). However intolerance which as far as I understand does not do any damage to digestive system can also have the same symptoms (lactose intolerance and malnutrition). My question is how can intolerance cause these if it is not doing the damage required to cause these? Is there any significant research into possible damage that intolerance is doing, most of what I have read is based on celiac disease. Just confused how the same symptoms can be caused but without the same damage.

Thank for any info anyone can provide.

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A gluten intolerance, celiac or not, DOES cause intestinal damage until it has time to heal. I have had damage and the same symptoms as celiacs, even though my blood test was negative. The blood test, I hear, is not sensitive enough to diagnose everyone. I don't know what the bio card is. Either way, the cure is the same - a gluten free diet.

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Have done more research and from what I understand intolerance is caused by the general not specific immune system, (not antigen related), what confuses me is if I have intolerance and therefor no lining damage why lactose intolerance can still be a symptom and inability to digest fat? Confused as to how intolerance can cause same symptoms without the same cause.

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Not meaning to add more confusion but some consider gluten intolerance and celiac to be the same thing. Some doctors would define me as gluten intolerant because I had false negative blood tests but the damage done was still autoimmune and severe although it was my brain and skin that were attacked before my gut. As the previous poster stated it doesn't matter what they call what is going on any amount of gluten is off limits.

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As you probably gathered by now, there is no definite answer yet, but theories abound. One that was written about in the book "healthier without wheat" made the most sense to me, so I will share it.

When gluten protein is put in a petro dish with healthy tissue, the tissue suffers damage. Gluten itself is toxic to tissue. Now, if you have a healthy mucosal barrier in your intestine then theoretically, gluten would pass harmlessly thru. However, most everyone suffers SOME danage to that barrier, whether by antibiotics, illness, surgery, even stress can damage it. Once the tissue is exposed, gluten comes into contact with it, and voila, damage. In celiac disease, you have an auto-immune response where your own immune system is putting holes in your intestine, in addition to outside causes.

So...the root cause is different, but the end result is the same. Damaged intestines, and a permeable intestinal barrier, ie "'leaky gut" that allows harmful proteins, like gliadin, to enter the bloodstream where they can wreak havoc not just on the intestine, but the entire body.

If you subscribe to that theory, then you would possibly, with extreme care, maybe be able to restore your intestinal lining to health and it could again do its job. It seems doubtful to me though, that perfect restoration and maintenance would ever be likely unless you happen to live in a stress free, organic, non-inflammatory bubble....but....you know, its something to strive for! Anyway, if that happened, you could go back to eating gluten without issue. Which I think few people would be willing to risk.

A celiac, of course, could NEVER do that because any ingested gluten would just trigger the process all over again.

Now...your lactose issue there IS hope for. You don't need PERFECT intestines to digest lactose- just enough healthy villi that they produce lactase to digest it. That IS attainable, usually within 6 mos to a year of a gluten-free diet. But not always. Some peoples bodies simply don't work the way they should in that regard.

Hope this helped!

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Well, I've read somewhere GI is a lighter form of celiac (can't remember where for my life). Personally, I agree with this view. Fatigue and quick weight loss are signs of malabsorption, and I've been getting more sensitive to gluten even though not that much.

However, in comparision to what the celiacs go through, I actually have it pretty easy. Bloating, discomfort, occasional stomachache which doesn't last for even an hour and soft stools are barely nothing, in comparision. And I have lived with lactose intolerance for six years before discovering the GI.

It is worst, and better. The symptoms were harsher, but I recovered with time, not to mention they would go away pretty quickly (in a matter of 8 hours maximum). With GI, once I am glutened, my diet has to go back to the safe foods list for a week before I'm well enough to handle any possible small CC: the symptoms go away slowly and I react even to the safe foods, although in a considerably smaller dose.

I can even eat some gluten and "get away" with it (though it usually comes from CC and once I start eating the food in question in a bigger frequence, I feel the pain).

BUT I am merely myself and these are my experiences. I doubt they can beat scientific researches on the matter of what exactly is non-celiac GI. :P

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  • Posts

    • Yes, you are negative which means you don't have celiac disease. You could however be non celiac gluten intolerant which there is no test for at this time. What are your symptoms that led to you being tested?
    • I think it's absolutely worth exploring the possibility of celiac disease. Your PCP can order the tests -- any doctor can. This is the full, current serum panel and you must be eating a gluten diet, not a gluten light diet or a gluten free diet or you will get false negatives. Anti-Gliadin (AGA) IgA
      Anti-Gliadin (AGA) IgG
      Anti-Endomysial (EMA) IgA
      Anti-Tissue Transglutaminase (tTG) IgA
      Deamidated Gliadin Peptide (DGP) IgA and IgG
      Total Serum IgA   
      Also can be termed this way: Endomysial Antibody IgA
      Tissue Transglutaminase IgA 
      GLIADIN IgG
      GLIADIN IgA
      Total Serum IgA 
      Deamidated Gliadin Peptide (DGP) IgA and IgG Get copies of your results when they come in. If any are positive, then you would move on to an endoscopy and you need to just keep eating gluten until that is done or again, you will get a false negative. My husband was on Ritalin for years due to his fatigue (before dx). He used to complain to the docs that he felt like all the blood had been sucked out of his body. He hasn't been on the Ritalin for years now & he no longer feels the overwhelming fatigue.
    • egs1707. Are you in Canada?  It's NOT a good idea to go gluten free between now & the GI appt. and here's why.... MOST of us have MUCH stronger reactions to gluten when we go back on it for the endoscopy. A lot of people have had such strong reactions that they have been entirely unable to complete the challenge and have to call it quits. This means they never get an official dx. It's your call, you make the choice. However, I will say that you don't have to eat a lot of gluten, a couple saltines or a slice of bread per day. 
    • You mentioned the tight head. Yes, both my celiac sibling and I had head pressure. Mine was horrible last glutening with eye pain as well. Like someone put a vice around my temples. I swore it felt like a parasite infected my gut, thyroid and brain. It is going away mostly, still have it on and off a bit.  My brother said his naturopath informed him some celiacs get a bit of inflammation in the brain.   
    • Hi All this is my blood test result 1.immunogloblulin serum 203 ( 87-350) 2.Deamidated Gliadin IGA  4 ( 0-19 negative) 3.Deamidated Gliadin IGG 3(0-19 negative) 4.Transglutainase IGA <2 ( 0-3 negative) 5.Transglutainase IGG <2 ( 0-3 negative) does it mean most likely no celiac ? thanks.  
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