Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Test Result Interpretation Help Please!
0

4 posts in this topic

Hi,

I am new here. My 5 yr old son was negative for all celiac disease bloodwork in 2010 and July 2012. He used to have mild GI symptoms that improved drastically after determining he is lactose intolerant, but he still had some ongoing, occassional issues until I realized that he also has an issue with fructose. I'm happy to report that since I started limiting his fructose intake in August, all of his symptoms have completely resolved and he is doing well, gaining weight, and growing :) I should mention that he was borderline anemic in July (10.8hgb) that has gone up to 12.2 with a low dose iron supplement. Likewise, since I started limiting his fructose, his appetite has increased tenfold (he never was hungry before!) and he is the happiest I've ever seen him. All of this has really made me believe in the fructose malabsorption diagnosis.

We have seen 2 GIs (NJ/NYC) and both were not concerned with celiac disease any longer; they felt we had ruled that out. Both agreed that if I saw complete resolution of symptoms with the new low fructose diet, that is it. However, my pediatrician decided to throw a wrench in the works and said, "Why don't we do the DNA testing for celiac disease? It will show us for certain that he doesn't have the gene and you can forget about it." Well, now I get these results. And of course, the pediatrican doesn't know how to interpret them other than to read the paper to me and tell me that not everyone with the gene will get celiac disease. I'd also like to know what these results may mean for my other 2 children (healthy).

Please help! I'm waiting to hear from the specialist.

Thank you so much in advance.

Lab Corp results:

Celiac HLA-DQ Result

DQ Alpha 1 01, 03

DQ Beta 1 03:02, 05

Interpretation:

These genes are permissive for celiac disease. The absence of HLA celiac permissive genes would make the presence of celiac disease unlikely. However, these genes can also be present in the normal population.

0

Share this post


Link to post
Share on other sites


Ads by Google:

I'm not the gene person, I'm just bumping this up and hoping someone else more literate sees it. But, I think that means he's got the DQ2 gene, just like 30% (roughly) of the population. However, having the gene does not mean one automatically goes on to become celiac, it just means that the person is capable of it. Most celiacs have DQ2, but, obviously, not all DQ2's have celiac, or we'd see nearly a third of the population having a "gluten" problem with their digestive enzymes not being able to handle wheat family proteins. Also, one does not HAVE to have the DQ2 genes for celiac, there are the DQ8 genes, and there are a few rare people with more unusual types (DQ1 and they are celiac) or which seems to predispose them for what can only be called gluten intolerance (shorthand for "had bad symptoms, flunked the tests, responded to diet anyway.)

So don't panic, but be aware of the symptoms for celiac and gluten intolerance, and be vigilant.

http://en.wikipedia.org/wiki/HLA-DQ2

0

Share this post


Link to post
Share on other sites

Thank you so much for responding, Takala. This is all very confusing and I'm so eager for answers. From what I've read today, I thought that having the combination of A1*03 with B1*0302 gives him DQ8.

I am reading his results as:

A1*03

A1*01

B1*0302

B1*0305.

I don't know at all if this is correct, but I am trying. If I look at it this way, that one gene combo I mentioned above =DQ8. I don't know what to make of the other 2 (A1*01 and B1*0305).

I didn't see anything for DQ2, but again, I am new to this. I'm not sure what to look for! I do know that DQ2 and DQ8 are both higher risk genes for Celiac.

Thanks again-

0

Share this post


Link to post
Share on other sites

Ok, so the GI nurse just called me and told me that he has DQ2 and DQ8. I don't know how she got DQ2 (can someone please help explain it?)

She said that since all his current bloodwork is negative for Celiac, they will not do anything now and instead will re-test him every few years.

Any advice? Help? Please!

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,358
    • Total Posts
      920,531
  • Topics

  • Posts

    • Here's another thing.  Feeling deprived?  Order two of the same item.  I was hungry by the time dinner arrived! 
    • The doctors just made me feel like I was crazy because they did not have a clue of what was wrong with me. I did a stool test (positive) and I did a genes test (positive for two gluten sensitive genes, one in each chromosome).  Blood test are not so foolproof, if you read the comments/experiences in such topic you will see the problems. Biopsy can give a false negative if taken from an undamaged area. If you have medical problems that go away once on a gluten free diet then gluten is the problem. The medical establishment profit from managing your medical problems and big pharma makes money by pushing pills so we need to be careful because they won't benefit if a gluten-free diet solve your problems. Since I started a Gluten free diet I have been free of the following: (all related to Celiac)  Irregularity, Intestinal noise, Irregular stool, Tooth enamel defects, Rash in upper arms, Abdominal swelling, depression, fatigue, irritability, lactose intolerance, 
      loss of memory, dandruff, uncontrollable bladder, suicidal thoughts, unable to sleep, Canker sores/ Mouth ulcers, high blood pressure, and probably others that I did not realize. I was at the end of my rope, thanks to Google and the people that are able to talk about this I was able to get my life back. I am passionate about this because I know how bad its can get. 
    • Well, I have never cruised on Carnival, but I am sure they can accommodate you.  I assume that you have already alerted them that you require gluten free meals.  If not, please contact Carnival immediately. Here are my own tips.  Some folks eat off the buffet line, but not me or hubby except for coffee/drinks and baked potatoes (jacketed) and fruit that we wash in the restroom (people touch everything!)  Okay, I am OCD, but my last glutening which occurred the previous summer made me sick for three months (GI tested my antibodies to prove it).   When we board, I go to the buffet restaurant ASAP and ask to speak to the Head Waiter (they are usually there greeting customers and often trying to up sell to specialty restaurants.   Let them know you have celiac disease and must be gluten free.  They may try to tell you that each dish is clearly marked gluten free, but really?  Who's to say that some other passenger is not going to switch spoons (or I have seen passengers wandering around with serving spoons...I kid you not!  The staff usually will  go downstairs and fetch a gluten free meal for me from the main dining room's kitchen as there is usually a dedicated area for allergies.  We have to wait up to 20 minutes or so but it is worth it.  Starving?  Get a baked potato wrapped in foil until your gluten-free meal arrives.  Now, do not do this every single time.  Those folks have to go down several levels to fetch food and you don't want to be a pain.  But if the main dining area is closed, they need to make an effort to keep you safe.  On our last cruise, we were advised not to eat anywhere but the main dining room and that included room service (they are not trained to handled allergies).  My headwaiters have sent goodies (prepackaged gluten free rolls and cookies for us to keep in our room.  We can always grab whole fruit (I wash it first) to snack on.  I bring gluten-free non-perishable items with me to eat while at port in case we can't find anything (which can be often).  Again, when we get back to our ship, we contact our headwaiter and he/she can prepare some snacks until we have dinner.   Be grateful and not picky.   We eat all meals in the dining room (or at least as much as possible).  Our headwaiter had a few other celiacs on our cruise this summer, so they prepared some gluten-free waffles, etc. for our breakfast!  What a treat!  At breakfast, we'd have different waiters, so our headwaiter would always instruct our waiters each and every time!  They even let me tour the kitchen and showed me the allergy section.   The only time I did not feel safe was at the buffet.  We once ordered gluten-free pizza and I realized (I watched) that that restaurant didn't really have the gluten-free thing down), do I called him on it.  Got the manager etc.  So, be careful.  Other cruises made us frozen Udi"s which was just fine with us.  They covered it up in foil so that we would not get any cross contamination from their pizza oven. So, have fun!   Tipping?  We prepaid our gratuities, but we gave our headwaiter an extra $200.00 for his time.  For us, it was well worth the service and safety of our food.  It does not hurt to slip some of the tip ahead of time (like after your first meal!)   Oh, I checked your ship.  You must eat in the diningroom if you have special dietary needs.
    • French Celiac / Coeliac Gluten Free Restaurant Card <strong>What is ... What to know about celiac disease, gluten sensitivity, and gluten-free diets. View the full article
    • <strong>Celiac Disease & Gluten-free Diet Information at Celiac.com. Gluten Free Diabetes ::The 3 Step Trick that Reverses Diabetes Permanently in ... View the full article
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,432
    • Most Online
      1,763

    Newest Member
    rbeckler60
    Joined