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Hla Results-Gi Appt Tuesday. Need Help Figuring This Out!
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I posted in the babies/kids section, but I thought this could go here because genetics don't change with age! My son is six and we think he has multiple Celiac symptoms. His ttIG was low, so his GI wanted to drop the Celiac idea. We persisted and he decided to check him for the gene. I also looked at all of his old blood work and found a ttIG from Feb.

Gene results are as follows:

HLA Class II, Locus DQB*, Allele 1 02:01

Results: Positive for HLA-DQA*05 and HLA-DQB*02 alleles

HLA Class II, Locus DQB*, Allele 2 05:01

Patient has the HLA-DQ2 antigen, but does not have the HLA-DQB antigen

HLA_DQB Genotyping Interpretation

If less than 2 alleles are reported for a locus , the patient is likely homozygous.

I am wondering if he has copies of the gene from both of us based on his results. I don't really understand the Allele 2 part of it.

I also found out his overall IgA had gone from 71 to 59 since Feb. and his ttIG went from .8 to 2.6. I thought his overall IgA should be going up since he is growing!

I feel like I am really going to have to work on his GI for a diagnosis and need all the back up info I can get. Thanks in advance. This site is amazing!

Jess

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