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Negative Dgp Igg And Negative Dgp Iga


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#1 MoMof2Boyz

 
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Posted 16 November 2012 - 10:50 AM

had ds retested a few months ago, GI doc refused to do IgG versions(TtG IgG and EMA IgG) because #1 DGP IgG is negative

#2 celiac gene test came back extremely low risk

my question: since he has a low total serum IgA, should I go ahead and ask his pediatrician for IgG versions? or does his GI doc know what he's talking about? Does a negative DGP IgG and negaive DGP Iga definitley mean no celiac?
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#2 DonnaMM

 
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Posted 16 November 2012 - 10:59 AM

What is a GDP test?
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Hodgkins Lymphoma-2006 at age 18, now 25
Disagnosed with IBS and anxiety (related to my treatment they say)-2007
Allergies to corn, tree nuts, shellfish, bees- 2010
Positive Lupus Anticoagulant-2011
Erosive esophagitis-2011
Severe iron deficiency anemia- 2012
Inappropriate sinus tachycardia-2013
Tested for celiac three times, blood and biopsies all negative
Now encouraged to undergo testing again due to malabsorption

#3 MoMof2Boyz

 
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Posted 16 November 2012 - 11:10 AM

What is a GDP test?


mistyped it. it's DGP
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#4 megsybeth

 
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Posted 16 November 2012 - 07:23 PM

MoMof2Boyz, I would keep pushing until you get all the tests if not an endoscopy (I assume there's a reason they are testing). There are many others that know much better about these tests but I happen to have been reading up about DBP IGA because that's the only test my son tested positive on (and he's "low risk" genetically, exactly as low risk as I am, with full celiac on all blood work and strong symptoms). Anyway, the DGP tests are great because they are highly SPECIFIC but not highly SENSITIVE. It's really important to know the difference because many doctors don't. With the DGP IGA, only 80% of celiacs will test positive, it's not very sensitive, but 96.5% or so who do test positive do have celiac, unlike TTG IGA which has lots of false positives, relatively.

My son's GI does not think he has it despite a highly specific test, my dx and every symptom in the book. But I'm pushing forward and waiting to get into a celiac specialist. I think you should at least get all the tests done, if not an endo.
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