Son With Weak Positive Score And High Immunoglobulin, What Does That Mean?
Posted 20 November 2012 - 03:19 PM
My 13 yr old daughter's score was in the negative range (2 on a range of 0-3) for the (tTG) IgA and her Immunoglobulin A was in the normal range as well. My 10 yr old son's score was a 4 (4-10 is considered a weak positive) and his Immunoglobulin A score was high (not sure of that number yet). My 8 yr old sons score was >100 (so very high positive) and his Immunoglobulin A score was in the normal range.
None of my kids have a huge amount of symptoms. They all have eczema to some degree and have had speech delays as well. The older two no longer have speech therapy though, just my younger son still continues with speech therapy, and his speech was the most delayed of the three. My yonger son has also had digestion problems, with intermittent diarhea but he has had normal growth. He is delayed in reading and has a shorter than normal attention span as well. I think brain fog might very well apply to him at times.
My understanding so far is that my younger son clearly has celiac disease, and futher testing may even be avoided with a sympathethic doctor. We have a Ped GI appt for him in two weeks and plan on starting him gluten free in January. My daughter is negative for now - should I insist on more testing for her with other tests, or settle for this assesment and retest in a year or so? I have told her this is something she will have to retest for throughout her life. My older son probably needs more testing at this time- I'm not sure what my next step should be, further blood tests? I am confused at his score the most really, I'm not clear on what the high Immunoglobulin A score might mean coupled with the weak positive on the (tTG). Does that score indicate celiac disease, or something else? I confuse why that score would be high on him and low on his younger brother, so further insight on that would really be helpful. Thanks so much for any help you can give me!
Posted 20 November 2012 - 03:59 PM
Posted 20 November 2012 - 04:19 PM
Posted 20 November 2012 - 05:32 PM
PS...all first degree relatives of a diagnosed Celiac should be tested every 3-5 years and more frequently should symptoms arise.
Undiagnosed Celiac Disease ~ 43 years
3/26/09 gluten-free - dignosed celiac - blood 3/3/09, biopsy 3/26/09, double DQ2 / single DQ8 positive
10/25/13 - MCAS
Health history since celiac diagnosis became too long -- moved to the "about me" section of my profile
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Posted 20 November 2012 - 05:41 PM
Posted 20 November 2012 - 05:50 PM
With the other kids, more testing makes sense to me...not sure I can convince my pediatrician, but I think the Ped GI will probably order it if she won't.
Can anyone tell me if the high Immunoglobulin A, Qn, Serum for my older son means anything? From what I understand a low score would be significant, not sure what a high score means.
Posted 20 November 2012 - 06:25 PM
Posted 20 December 2012 - 08:13 AM
Posted 20 December 2012 - 11:03 AM
Posted 20 December 2012 - 07:53 PM
tTG antibodies are usually associated with coeliac disease, but can be elevated in other disease processes too. They are a marker of tissue inflammation usually involving the gut.
endomysial antibodies (EMA) are highly specific to coeliac disease, and the skin manifestation of gluten intolerance, dermatitis herpetiformis. A positive result for EMA would point to celiac disease or DH.
IgA is tested to ensure that the patient is not IgA deficient. If a coeliac individual has low total IgA, then they may not be able to produce the antibodies that the coeliac panel is based on, therefore the results of the coeliac panel may be falsely negative.
DS 1: TTG 262, DGP 170 in June 2012. Eventually diagnosed coeliac by biopsy Dec 2012 (aged 3 yrs 9 months).
Heart breaking that we kept him on gluten all that time. If I had to do it again, I would not agree to continue feeding him gluten for 6 months just so that the "gold standard" for diagnosis could be met.
DS 2: HLA - DQ8 gene.
Gluten free, as I am not willing to risk his health by allowing him to become coeliac.
Posted 20 December 2012 - 08:12 PM
The second set of labs he came up with a score of 51 on the Tissue Trans. AB, IgA (with a score of 19 or less negative and 20-30 weak positive, and 31 or greater Moderate to Strong Positive). So his was clearly positive this time. His IgG and Endomysial tests were both negative. So we're still not sure what to think. He's got another appt with the gastroentronologist on Jan 15
You did not mention the DGP; did he run that one also, as it is very specific for celiac?
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Caffeine free 1973
Lactose free 1990
(Mis)diagnosed IBS, fibromyalgia '80's and '90's
Diagnosed psoriatic arthritis 2004
Self-diagnosed gluten intolerant, gluten-free Nov. 2007
Soy free March 2008
Nightshade free Feb 2009
Citric acid free June 2009
Potato starch free July 2009
(Totally) corn free Nov. 2009
Legume free March 2010
Now tolerant of lactose
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Posted 20 December 2012 - 09:04 PM
Can anyone explain to me why the two IGA tests would be so different? I understand that the scales are different, but still his first was barely a weak positive, then a test just a few weeks later shows a score that is a moderatley high positive. I though the test was more standardized than that. It made me question my other kids who scored negative on the first IGA test, so I ended up doing the panel over for them as well. I think our pediatrician thinks I've gone a bit crazy!
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