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Is It Celiac?


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4 replies to this topic

#1 nicoleashleee

 
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Posted 05 December 2012 - 02:19 PM

Immunoglobulin A, Qn, Serum: value, 65 reference range: 91-414
t-Transglutaminase (tTG) IgG: value, <2 Reference range: 0-5
t-Transglutaminase (tTG): value <2 reference range: 0-5
Deamidated Gliadin Abs, IgA: value 2units reference range 0-19
Deamidated Gliadin Abs, IgG: value 9units reference range 0-19

Okay. So. Here I am three months later still in pain. want to know the story?
I start passing out at work. Abdominal pain. shaking chills sweating etc. EVERYTHING I EAT MAKES ME SICK.
9 ER VISITS.
5 CT scans.
3 ABDOMINAL XRAYS
1 ENDOSCOPY
2 ULTRA SOUNDS
all normal.

Except the HIDA scan, that was normal except for increased pain. So they removed my gallbladder. It went badly. Hospitalized for a week. They kept telling me to wait, not getting better. go to a specialist. says I have IBS, does full celiac panel everything is normal except my immunoglobulin A is 65 and normal range is 90-414

Is my low immunoglobulin a causing a false negative for celiac? i just can't take this anymore.
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#2 nicoleashleee

 
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Posted 05 December 2012 - 02:42 PM

Here is an email from my doctor regarding the test:

Your total IgA (Immunoglobulin) was a little low, it's indicative that your immune system isn't overly active. The other two values that are part of the Celiac panel were negative and those are the improtant ones to look for when trying to identify Celiac disease. We can discuss it further at your follow up as far as what it all means in regards to your symptoms. With these findings and also knowing you had a normal appearance of the small bowel tissue on EGD, it's very unlikely that you have Celiac disease.
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#3 Little Joe

 
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Posted 05 December 2012 - 02:55 PM

I am very new to this, but my understanding is that a low Immunoglobulin A count can cause the ttg (and other?) count(s) to appear low or normal in people who, in fact, do have celiac disease. I think that is why the total Immunoglobulin A count is taken. That is not to say that low IgA *is* causing a false negative, but I think it *can* contribute to or lead to a false negative.

The negative/normal endoscopy would lead me to think that you do not have celiac disease, but even with endoscopy several samples must be taken from suspect tissue in order to maximize the likelihood of finding extant disease, and I think it is still possible to miss damaged tissue when taking the tissue samples for biopsy.

Do not take my words to the bank... check back often and I suspect several people more knowledgeable than me will post replies. Best of luck with all this.
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#4 nicoleashleee

 
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Posted 05 December 2012 - 03:02 PM

Well thank you. According the the endoscopy report I have chronic gastritis and they only did a biopsy for Hpylori as far as I know.
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#5 shadowicewolf

 
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Posted 05 December 2012 - 03:03 PM

Not nessisarily, the low iga can throw off the TTG tests (the iga one i believe). There are some on here that have had that happen.

Ask for another endoscopy and get a biopsy done. Also consider getting the genetic test done as well.

Then regardless of those tests outcome, go gluten free for a good 3-6 months. Do this after you have finished testing. If it clears up, you have your answer.
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