Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Thyroid "totally Looks Like" Gluten?
0

6 posts in this topic

Nerdchick at work again...

I keep coming across references to an alleged structural similarity between gluten and thyroid cells (the proteins that constitute the thyroid, I assume), which would explain why Hashimoto patients do better on a gluten-free diet regardless of having Celiac or not.

The rationale would be that when gluten enters the body, the antithyroid antibodies take gluten for an extra thyroid, freak out, and scream "OMG! There's ANOTHER ONE! We need more squads!" and the body increases the production of antibodies, and therefore the attack to the thyroid.

Can anyone point me to the medical source/study for this diffused claim? I am seeing my endo soon for a new set of tests, and I want something to torture her with... ;)

0

Share this post


Link to post
Share on other sites


Ads by Google:

Hm...I don't know about it looking like gluten. I have seen this page, where a guy talks about why the antibodies involved in celiac also attack the thyroid:

"I knew that attack on the thyroid was common in celiacs, because the celiac autoantigen tTG (it has a basic triplet) is also present in the thyroid and the celiac autoantibodies to tTG also cause an attack on the thyroid. But the autoantigen for Hashimoto’s Thyroiditis is thyroid peroxidase (TPO)."

http://coolinginflammation.blogspot.jp/2009/07/celiac-causes-allergies-and-autoimmune.html

It's a bit greek to me, but it seems like you might be onto something with your idea.

0

Share this post


Link to post
Share on other sites

The only autoimmune disease we know the trigger for is celiac disease. All the others are not known at this point. We do know that people with celiac have a higher chance of getting other auto-immune diseases. My own personal "hunch" is that leaky gut plays a role in that. Protein fragments get in the blood stream and can cause an immune reaction in various parts of the body where they end up. But that's just a guess, there is no proof of that. I don't think the thyroid looks like gluten tho, that seems like a stretch. The leaky gut idea would mean gluten protein fragments end up in the thyroid, and then are attacked by the immune system. Then the body attacks the thyroid tissue where those gluten protein fragments are lodged. Same basic process as in the gut. In the process of attacking the gluten fragments in the thyroid, the immune system may learn to attack the thyroid also. This kind of process could cause rhuematoid arthritis to develop also. That's my 2 cent theory for today.

0

Share this post


Link to post
Share on other sites

Nerdchick at work again...

I keep coming across references to an alleged structural similarity between gluten and thyroid cells (the proteins that constitute the thyroid, I assume), which would explain why Hashimoto patients do better on a gluten-free diet regardless of having Celiac or not.

The rationale would be that when gluten enters the body, the antithyroid antibodies take gluten for an extra thyroid, freak out, and scream "OMG! There's ANOTHER ONE! We need more squads!" and the body increases the production of antibodies, and therefore the attack to the thyroid.

Can anyone point me to the medical source/study for this diffused claim? I am seeing my endo soon for a new set of tests, and I want something to torture her with... ;)

Most organs in the human body have the ability to produce tTg antibodies. The thyroid, heart and liver are some, along with the pancreas. When you have undiagnosed Celiac, your body is in a constant state of inflammation. If you go long enough, this inflammation will aggravate other organs and they start to produce tTg antibodies. This is why when some people go gluten-free and still have elevated tTg antibodies, you need to be tested for other AI conditions. Elevated thyroid antibodies can keep your tTg levels high, even on the gluten-free diet. It took me 6 years to get my thyroid antibodies into the normal range and they were ridiculously high when diagnosed. I think that the problem stems from too much inflammation and the gluten-free diet brings inflammation way down so everything else begins to heal.

I did have a good laugh about torturing your endocrinologist, though! :lol:

0

Share this post


Link to post
Share on other sites

The only autoimmune disease we know the trigger for is celiac disease. All the others are not known at this point... My own personal "hunch" is that leaky gut plays a role in that. Protein fragments get in the blood stream and can cause an immune reaction in various parts of the body where they end up.

I second that - I do think there are triggers for other disorders as well. How does one diagnose leaky gut? I have found some contrasting information...

Elevated thyroid antibodies can keep your tTg levels high, even on the gluten-free diet. It took me 6 years to get my thyroid antibodies into the normal range and they were ridiculously high when diagnosed. I think that the problem stems from too much inflammation and the gluten-free diet brings inflammation way down so everything else begins to heal.

I did have a good laugh about torturing your endocrinologist, though! :lol:

Oh, she had to get used to my paranoia :) I am wondering if the gluten-free diet also reduces inflammation/tTg in patients who have not been diagnosed with celiac disease, though... I don't know what my next thyroid panel going to find (to be true, I am scared of finding out) but, in short, if there is anything I can do to prevent/delay the distruction of a vital organ, well, I guess I would be willing to go to some lengths, and if that means eating gluten-free for life, so be it!

"I knew that attack on the thyroid was common in celiacs, because the celiac autoantigen tTG (it has a basic triplet) is also present in the thyroid and the celiac autoantibodies to tTG also cause an attack on the thyroid. But the autoantigen for Hashimoto’s Thyroiditis is thyroid peroxidase (TPO)."

http://coolinginflam...autoimmune.html

Thank you, I will show this to my doctor. And I will keep doing more research.

Does anyone else here feel like they are desperately trying to get better?

0

Share this post


Link to post
Share on other sites




"Does anyone else here feel like they are desperately trying to get better?"

Yes, please read as much as you can.

I have spent years learning the keys to my health. I do hope your answers are quicker, but know there have been MANY before you that havve struggled each day to obtain health and there will be many more that follow.

You are not alone - learn all you can.

1

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,334
    • Total Posts
      920,437
  • Topics

  • Posts

    • Thank you cyclinglady! We'll just keep pushing forward and we'll get things figured out one way or another. You have been most helpful and informative and given me some great resources and things to consider. I really appreciate it! I definitely feel better as I've felt like a crazy mom lately thinking through the test results and everything. Even if it turns out to not be celiac or gluten related, at least I can say we did our due diligence and looked under every rock to find the source of his troubles. Thanks again!  Take care! 
    • Anxiety is quite a common symptom with undiagnosed celiacs. It should improve if not disappear when you go gluten free. Be sure to CONTINUE eating gluten until the endoscopy!   Welcome to the club!
    • Although serological tests are useful for identifying celiac disease, it is well known that a small minority of celiacs are seronegative, and show no blood markers for celiac disease. A team of researchers wanted to define the prevalence and features of seronegative compared to seropositive celiac disease, and to establish whether celiac disease is a common cause of seronegative villous atrophy. View the full article
    • This was absolutely me before diagnosis.  The worst of all of my Celiac symptoms occurred in the morning.  The anxiety was terrible in the mornings, I had horrible nausea, no appetite, felt light headed, dizzy and shaky, diarrhea, stomach cramps... the works.  Honestly, I don't know if it was the symptoms causing the anxiety, the anxiety making my symptoms worse, or a combination.  I almost dropped out of school because I felt so terrible every morning I didn't want to leave the house to go to class.  The first few doctors I saw insisted all of my symptoms were psychological and tried to give me anti-depressants/anti-anxiety meds, but I knew there was something else wrong with me.  I had always been a bit "high-strung," but for the year I was really sick before diagnosis, the anxiety got out of control. I was diagnosed with celiac disease 6 months ago and have been gluten free ever since.  It took time, but everything is gradually improving.  The morning anxiety is much improved and some mornings, is completely gone.  I realized a month or two ago that I no longer spend the first hour after waking up gagging and dry-heaving, something I had done for so many years that I just thought it was normal for me.  I can brush my teeth and my tongue without feeling like I'm going to puke.  I eat breakfast now, which I have never done, because I was always too anxious and nauseous in the mornings to be hungry.  I am not "all better."  I still have bad days and even bad weeks.  If I get glutened the anxiety comes back full force.  If I'm super-stressed out or letting my health slide (not eating well, not sleeping enough) the AM anxiety seems to return.  But, it has been slowly improving over the last 6 months and has become so much more manageable.   Your anxiety could be a separate disorder from the celiac disease, but for me, it seems it was absolutely related and continues to get better.  Don't get discouraged if you don't see an immediate improvement or experience relapses after improving.  Often, I feel like it's a two-step-forward, one-step-back kind of thing, but it is getting better.
    • I have suffered with GERD for 20 years and accidently found out it was a gluten intolerance. I had gone on Atkins years ago and noticed that I had no GERD symptoms while on the diet. I didn't make the connection at that time. Then I went on the Mayo Diet back in the winter and once again, the constant was having no bread primarily. I had also noticed that I would have major attacks anytime I ate Italian food. I blamed it on the onions, the tomatoes, herbs...but I could tolerate all those foods separately. Then, like a lightning bolt...it hit me...the culprit was the "innocent" pasta. BINGO!!  I went gluten-free in March 2016 and I have had no GERD now in 5 months. I feel as if it is a gift to me.   
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,389
    • Most Online
      1,763

    Newest Member
    EJ653
    Joined