Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Benefits Of Gluten Challenge Before Genetic Testing?
0

6 posts in this topic

Hi there,

I'm in the midst of getting diagnosed, mainly to find out whether I have celiac or non-celiac gluten intolerance. I went off gluten to see if it would improve my symptoms, not realizing I would have to be on it in order to do testing. My PCP didn't want me to suffer by going back on for the blood work, so I did the first round of blood tests without having ingested gluten for over a month.

I'm wondering, since I can't get a straight answer, what the benefit is of doing a gluten challenge to get blood work done versus doing the genetic test first. (My insurance will cover the genetic test...) It seems like the blood tests with celiac are so unreliable...

Anyway, I'd appreciate any insight you all have gotten over the years!

Thanks in advance!

0

Share this post


Link to post
Share on other sites


Ads by Google:

The genetic test, while interesting, can not diagnose celiac disease. Many people carry one or more of the genetic markers usually associated with celiac disease, but never actually develop the disease. Most doctors believe that an negative result on the gene test rules out celiac disease, but there is evidence that there may be other genes. Doctors in Europe are more likely to recognized those factors than those in North America.

Your genes are your genes, and eating or not eating gluten will not affect the results of genetic testing.

1

Share this post


Link to post
Share on other sites

Thanks psawyer... I know that the genetic test won't diagnose, but I guess I was curious as to why it isn't done first to find out whether it's even possible I have it before I put myself through the awfulness of eating gluten again. It's helpful to know it isn't conclusive, though.

0

Share this post


Link to post
Share on other sites

The genetic test really doesn't give you much helpful information and in some cases, (my son) can lead your doctor to believe you DON'T have it. There are always exceptions, so having the common genes or not really doesn't mean much. My son's genes said "not likely" but his intestines said "absolutely".

What tests did the doctor do after you were gluten free? Any blood test other then the genetic one will be useless. You are not likely to have any antibodies after being gluten free for so long. My blood tests went from positive to negative after only 10 days.

cara

1

Share this post


Link to post
Share on other sites

Thanks, Cara. My doc wants to avoid having me suffer as much as possible, so she wanted to try the initial antibody tests, knowing that they would probably come out negative.

I guess I'll know to question the genetic test results when they come... I'm sure you can all understand my unwillingness to gluten myself!

0

Share this post


Link to post
Share on other sites




Thanks, Cara. My doc wants to avoid having me suffer as much as possible, so she wanted to try the initial antibody tests, knowing that they would probably come out negative.

I guess I'll know to question the genetic test results when they come... I'm sure you can all understand my unwillingness to gluten myself!

It is always beneficial to do genetic testing because if positive, can add 1 more test to your arsenal of knowledge. Yes, it can come out negative for the predisposition for celiac but that just may mean you are NCGI....which means you still need to be gluten-free if you feel a lot better on the diet. If you really suffer when eating gluten to the point where your doctor does not want you to do a gluten challenge, I think you have your answer.....no gluten for you! ;) Honestly, I know people who are NCGI and their symptoms are as bad as mine when glutened.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,345
    • Total Posts
      920,488
  • Topics

  • Posts

    • Karen, the iodine test was a test for DH used in the 'olden' days. Iodine would be swabbed onto a spot and then it would be covered with a bandage. If someone had DH the iodined area would break out in lesions. I don't know how but we do know iodine can activate the antibodies. That is why some of us with DH have to avoid iodine in foods until the antibodies have cleared the dermis. OP, if you haven't been tested for celiac you should be and if you have active lesions a biopsy done next to a lesion by a DH knowledgable dermatologist may help in diagnosis.
    • The gluten-free diet (GFD) is the only validated treatment for celiac disease (celiac disease), but despite strict adherence, complete mucosal recovery is rarely ... View the full article
    • What's an " iodine test"?  Haven't heard doctors doing that to diagnose DH.
    • Hello! I've just been given my blood results and told they are highly suggestive of coeliacs but will have to wait till next month to see the gastroenterologist and who knows how much longer for a biopsy. My igA, igG and tissuetrans igA were all over 250 and tissuetrans igG was the only one that was normal. These results don't mean much to me yet but I'm told they are very high. I'm now quite fearful of how much damage I've gone to myself. I've had stomach problems for 25 years (just turned 40) and have often steered clear of too much bread and pasta for how bloated it made me feel but the symptoms were always vague and inconsistent so I kept eating. I had a couple of boats of gastro in the past few months (thanks kids) which I took a lot longer than normal to recover from which looking back may have been related. Then last Friday I had a blowout with wine, cheese, crackers, pizza and chocolate cake. I'm sure I've probably had blowouts like that before but I have never felt so sick before and am still slowly recovering. This is what finally prompted me to go back to my GP after being fobbed off so many times over the years. So I guess my question and my concern is whether there is still  chance of a false positive with levels like this? I worry what else it might be if not coeliac. I'm also worried that I may have done so much damage to myself that I will have several disorders going on! I'm also still recovering from last Friday and wondering when I'm going to feel better. I've stayed off gluten and dairy since my blood result a couple of days ago but feel like I'm allergic to food in general.  Thankyou!!    
    • Here's what the Klondike Bar makers say on the FAQ page of their website (August 2016): Are your products gluten free? Nope. They are not. We have not validated for gluten free. We do not operate allergen-free manufacturing sites, however we do have allergen management programs in all our facilities. The intent of these programs is to avoid unintentional cross-contamination of allergens between products. Our product labels adhere to the FDA’s strict regulations regarding declaration of ingredients and allergens. We do not use the terms “Natural” or “Artificial Flavorings” to hide the existence of any allergens. RECIPES CAN CHANGE. We strongly recommend that allergic consumers refer to ingredient declarations EVERY TIME they purchase processed foods.
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

    There are no registered users currently online

  • Member Statistics

    • Total Members
      61,415
    • Most Online
      1,763

    Newest Member
    Ails123
    Joined